Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TGFBI | 7045 | transforming growth factor, beta-induced, 68kDa | 5 | BIGH3, CDB1, CDGG1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25755764 | 2015 | Cell line : - Source : Sir Run Run Shaw Hospital. Sample Type : CRC tumor and normal tissue No. of Sample : 115 Stage : - | Immunohistochemistry | Up-regulation | - | TGFBI plays an important role in the progression of colorectal cancers and it is an independent poor prognostic factor for colorectal cancer patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008] |
| Chromosome | 5 |
| Location | 5q31 |
| Start | 135364584 |
| End | 135399507 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 34924 |
| OMIM ID | 601692 |
| HGNC ID | HGNC:11771 |
| Unigene ID | Hs.369397 |
| Ensembl ID | ENSG00000120708 |
| PharmGKB ID | PA36484 |
mRNA Information
| mRNA ID | ?NM_000358.2 |
|---|---|
| Exon | join(1..295,4869..4967,15164..15228,17441..17601, 17957..18121,18380..18526,20545..20686,24013..24225, 25049..25186,25822..25967,26786..26922,27771..27901, 30196..30320,31940..32042,32606..32685,33769..33793, 34292..34924) | mRNA Sequence | Download Select all |
| Length | 2805 |
Protein Information
| Protein ID | NP_000349.1 |
|---|---|
| Protein Name | transforming growth factor, beta-induced, 68kDa |
| Molecular Wt. (Da) | 48745 |
| Protein Sequence | Download Select all |
| Length | 683 |
| Uniprot ID | Q8N1F7 |
| Ensembl Protein ID | ENSP00000310668 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2 | A2M | 72 | NP_000005.2 | in vitro | 10681572 |
| 1277 | COL1A1 | 362 | NP_000079.2 | in vitro | 1 203 470 511 867 580 |
| 1278 | COL1A2 | 363 | NP_000080.2 | in vitro | 1 203 470 511 867 580 |
| 1280 | COL2A1 | 361 | NP_001835.3 | in vitro | 9061001 |
| 1282 | COL4A1 | 359 | NP_001836.2 | in vitro | 11867580 |
| 1284 | COL4A2 | 355 | NP_001837.2 | in vitro | 11867580 |
| 1285 | COL4A3 | 354 | NP_000082.2 | in vitro | 11867580 |
| 1286 | COL4A4 | 360 | NP_000083.3 | in vitro | 11867580 |
| 2335 | FN1 | 626 | NP_997647.1 | in vitro | 1 203 470 511 867 580 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02469 | 514-634 | Fasciclin |
| cl02663 | 514-634 | Fasciclin superfamily |
| pfam02469 | 253-373 | Fasciclin |
| cl02663 | 253-373 | Fasciclin superfamily |
| pfam02469 | 133-236 | Fasciclin |
| cl02663 | 133-236 | Fasciclin superfamily |
| smart00554 | 139-236 | FAS1 |
| smart00554 | 538-635 | FAS1 |
| pfam02469 | 386-500 | Fasciclin |
| cl02663 | 386-500 | Fasciclin superfamily |
| smart00554 | 276-373 | FAS1 |
| smart00554 | 411-501 | FAS1 |
| pfam07546 | 45-92 | EMI |
| cl06535 | 45-92 | EMI superfamily |
| COG2335 | 489-636 | FAS1 |
| COG2335 | 242-373 | FAS1 |
| COG2335 | 92-236 | FAS1 |
| COG2335 | 374-505 | FAS1 |
Ontology Information
| HPRD ID | 9561 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Chromatin binding (GO:0003682) |
| Biological Process | Chromosome segregation (GO:0007059) |
Drug Information
No matching records could be found.