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General Information
- Evidence
- Gene
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- Protein
- PTM
- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20033322 | 2010 | Cell line : - Source : - Sample Type : CRC Tumor No. of Sample : 91 Stage : - | real time RT-PCR, Proliferation assay | Up-regulation | - | TGM2 is useful as a predictive marker for patient prognosis and may be a novel therapeutic target for CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Transglutaminases |
| Description | Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 20 |
| Location | 20q12 |
| Start | 36756863 |
| End | 36794910 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 38048 |
| OMIM ID | 190196 |
| HGNC ID | HGNC:11778 |
| Unigene ID | Hs.517033 |
| Ensembl ID | ENSG00000198959 |
| PharmGKB ID | PA36491 |
mRNA Information
| mRNA ID | ?NM_004613.2 |
|---|---|
| Exon | join(1..75,1242..1321,4911..5090,10421..10663, 15453..15571,18421..18549,19616..19793,24311..24446, 25125..25228,26856..27098,28125..28397,34010..34170, 35281..35417,36141..38049) | mRNA Sequence | Download Select all |
| Length | 3967 |
Protein Information
| Protein ID | NP_004604.2 |
|---|---|
| Protein Name | transglutaminase 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 687 |
| Uniprot ID | Q9H2G2 |
| Ensembl Protein ID | ENSP00000336824 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 369;- |
| Y | Phosphorylation | 369;- |
| Y | Phosphorylation | 219;- |
| Y | Phosphorylation | 219;- |
| Y | Phosphorylation | 369;- |
| Y | Phosphorylation | 369;- |
| S | Phosphorylation | 216 |
| S | Phosphorylation | 216 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 60 | ACTB | 32 | NP_001092.1 | in vitro;in vivo | 9252372 |
| 226 | ALDOA | 70 | NP_000025.1 | in vitro | 1353685 |
| 301 | ANXA1 | 1060 | NP_000691.1 | in vitro | 1670773 |
| 387 | RHOA | 1323 | NP_001655.1 | in vivo | 11350930 |
| 2335 | FN1 | 626 | NP_997647.1 | in vitro | 1 182 944 811 686 300 |
| 2950 | GSTP1 | 614 | NP_000843.1 | in vivo | 9973324 |
| 3064 | HTT | 883 | NP_002102.4 | in vivo | 11442349 |
| 3688 | ITGB1 | 628 | NP_391987.1 | in vivo | 10684262 |
| 3690 | ITGB3 | 1428 | NP_000203.2 | in vitro;in vivo | 10684262 |
| 4052 | LTBP1 | 1039 | NP_996826.2 | in vitro | 9060478 |
| 5345 | SERPINF2 | 2029 | NP_000925.2 | in vitro | 1 096 379 010 958 780 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vitro | 9315663 |
| 5970 | RELA | 1241 | NP_068810.3 | in vivo | 16951195 |
| 6278 | S100A7 | 2645 | NP_002954.2 | in vitro | 11258932 |
| 6678 | SPARC | 1631 | NP_003109.1 | in vitro | 7730416 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Huntington's disease | hsa05016 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00868 | 5-124 | Transglut_N |
| cl02994 | 5-124 | Transglut_N superfamily |
| pfam00927 | 587-686 | Transglut_C |
| cl08295 | 587-686 | Transglut_C superfamily |
| pfam00927 | 474-571 | Transglut_C |
| cl08295 | 474-571 | Transglut_C superfamily |
| smart00460 | 269-361 | TGc |
| cl17362 | 269-361 | Transglut_core superfamily |
| pfam01841 | 271-359 | Transglut_core |
| COG1305 | 271-369 | YebA |
Ontology Information
| HPRD ID | 15218 |
|---|---|
| Molecular Class | Enzyme: Aminotransferase |
| Molecular Function | Caspase activator activity (GO:0008656) |
| Biological Process | Apoptosis (GO:0006915); Cell death (GO:0008219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P21980 | DB00130 | L-Glutamine | SmallMoleculeDrug |