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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20846368 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 55 matched normal and tumour samples. Stage : - | real time PCR, Immunohistochemistry, Methylation specific PCR | Methylation | - | THBS4 methylation is detectable in normal colonic mucosa and its level may be a biomarker for the occurrence of adenomas and carcinoma. THBS4 shows increased methylation in colorectal cancer, but this is not strongly associated with altered gene expression, either because methylation has not always reached a critical level or because other factors influence THBS4 expression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. |
| Chromosome | 5 |
| Location | 5q13 |
| Start | 79991311 |
| End | 80083637 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 92327 |
| OMIM ID | 600715 |
| HGNC ID | HGNC:11788 |
| Unigene ID | Hs.211426 |
| Ensembl ID | ENSG00000113296 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011543614.1 |
|---|---|
| Exon | join(1..102,7022..7065,48767..48970,64475..64722, 66896..67004,67398..67480,68130..68181,68393..68595, 70385..70522,74099..74167,76663..76815,78996..79100, 79333..79440,79711..79870,80968..81086,81965..82017, 85545..85738,86739..86917,87611..87659,87752..87948, 88595..88767,91096..91235,91770..92327) | mRNA Sequence | Download Select all |
| Length | 3167 |
CDS Information
| Location | join(44228..44315,48767..48970,64475..64722,66896..67004, 67398..67480,68130..68181,68393..68595,70385..70522, 74099..74167,76663..76815,78996..79100,79333..79440, 79711..79870,80968..81086,81965..82017,85545..85738, 86739..86917,87611..87659,87752..87948,88595..88767, 91096..91235,91770..91831) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS4049.1 |
Protein Information
| Protein ID | NP_003239.2 |
|---|---|
| Protein Name | thrombospondin 4 |
| Molecular Wt. (Da) | 103148 |
| Protein Sequence | Download Select all |
| Length | 961 |
| Uniprot ID | P18065 |
| Ensembl Protein ID | ENSP00000233809 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| ECM-receptor interaction | hsa04512 |
| Focal adhesion | hsa04510 |
| Malaria | hsa05144 |
| Phagosome | hsa04145 |
| PI3K-Akt signaling pathway | hsa04151 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00054 | 379-413 | EGF_CA |
| cl21504 | 379-413 | EGF_CA superfamily |
| cd00054 | 326-360 | EGF_CA |
| cl21504 | 326-360 | EGF_CA superfamily |
| pfam05735 | 745-945 | TSP_C |
| cl05347 | 745-945 | TSP_C superfamily |
| smart00210 | 24-192 | TSPN |
| cl22861 | 24-192 | LamG superfamily |
| pfam11598 | 218-262 | COMP |
| cl13107 | 218-262 | COMP superfamily |
| pfam02412 | 497-531 | TSP_3 |
| cl15981 | 497-531 | TSP_3 superfamily |
| pfam02412 | 693-727 | TSP_3 |
| cl15981 | 693-727 | TSP_3 superfamily |
| smart00179 | 379-411 | EGF_CA |
| pfam02412 | 615-651 | TSP_3 |
| cl15981 | 615-651 | TSP_3 superfamily |
| smart00179 | 326-358 | EGF_CA |
| pfam07645 | 379-410 | EGF_CA |
| cd00053 | 382-413 | EGF |
| pfam12947 | 385-413 | EGF_3 |
Ontology Information
| HPRD ID | 9089 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.