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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TIAM1 7074 T-cell lymphoma invasion and metastasis 1  21- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19276682   2009Cell line : HT 29

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Immunohistochemistry,RT-PCR and western blottingDown-regulation-Tiam1 gene may act as a crucial therapeutic target for Lymphangiogenesis in CRC.

17822624   2007Cell line : HCT116

Source : -

Sample Type : CRC Tumor

No. of Sample : 50

Stage : -

-Up-regulation 2.5 fold Tiam1 gene plays an important role in the proliferation, invasion and metastasis of colorectal cancer. It may serve as a useful clinical marker for tumor progression and metastasis of colorectal cancer.


Gene Details



NC_000021.8 (32490736..32931290, complement)

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Gene Type protein coding
Gene Family Rho guanine nucleotide exchange factors, "Pleckstrin homology (PH) domain containing"
Description -  
Chromosome 21
Location 21q22.1
Start 32490736  
End 32931290  
Strand -  
Gene Sequence

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Length 440555  
OMIM ID 600687   
HGNC ID HGNC:11805   
Unigene ID Hs.517228   
Ensembl ID ENSG00000156299   
PharmGKB ID PA36514   

mRNA Information


mRNA ID ?NM_003253.2
Exon join(1..59,95943..95995,220556..220735,283070..283246, 292995..293968,307789..308236,314318..314490, 334028..334252,336387..336572,342279..342425, 346506..346580,349763..349933,356966..357070, 364673..364754,372891..372977,377333..377557, 394913..395016,405552..405731,406844..406912, 407217..407342,412975..413083,418474..418653, 418742..418860,423937..424045,429030..429088, 429663..429765,432826..432913,435284..435456, 439141..441560)  
mRNA Sequence

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Length 7206  



CDS Information


   
Location 481..5256
CDS Sequence

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CCDS ID CCDS13609.1



Protein Information


      
Protein IDNP_003244.2
Protein NameT-cell lymphoma invasion and metastasis 1
Molecular Wt. (Da)41606
Protein Sequence

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Length 1591  
Uniprot IDP50749
Ensembl Protein ID ENSP00000368684  



Post-translational Modification Information (Source : HPRD)


Residue Type site
GMyristoylation2
TPhosphorylation1542;-
SPhosphorylation356
SPhosphorylation358
SPhosphorylation231
SPhosphorylation1466
SPhosphorylation1506

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                    
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
286ANK11693NP_001135918.1in vitro;in vivo10893266   
960CD44115NP_000601.3in vitro;in vivo10636882   
1947EFNB12072NP_004420.1in vitro;in vivo14988728   
1969EPHA21494NP_004422.2in vitro;in vivo14988728   
3265HRAS1813NP_005334.1in vivo12134164   
4609MYC1818NP_002458.2in vitro;in vivo12446731   
4830NME11131NP_937818.1in vivo11274357   
5578PRKCA1498NP_002728.1in vitro;in vivo10212259   
5580PRKCD1501NP_006245.2in vitro10212259   
5581PRKCE1500NP_005391.1in vitro10212259   
5582PRKCG1502NP_002730.1in vitro10212259   
6714SRC1819NP_005408.1in vitro;in vivo12810717   


Pathway Information


                                    
Pathway Name Pathway ID
cAMP signaling pathway hsa04024
Chemokine signaling pathway hsa04062
Proteoglycans in cancer hsa05205
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Regulation of actin cytoskeleton hsa04810


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd012551235-1406  PH2_Tiam1_2
cl171711235-1406  PH-like superfamily
cd01230432-558  PH1_Tiam1_2
cl17171432-558  PH-like superfamily
cd001601041-1232  RhoGEF
cl025711041-1232  RhoGEF superfamily
cd01818766-841  TIAM1_RBD
cl00155766-841  UBQ superfamily
cd00992846-925  PDZ_signaling
cl00117846-925  PDZ superfamily
smart003251044-1233  RhoGEF
pfam006211044-1233  RhoGEF
cd01760766-841  RBD
pfam02196765-832  RBD
smart00455766-832  RBD
pfam00169452-547  PH
smart00233452-547  PH
cd13295443-548  PH_EFA6
cd00821452-542  PH
cd10571450-545  PH_beta_spectrin
cd01253435-544  PH_ARHGAP21-like
smart00228858-901  PDZ
pfam15410459-547  PH_9
cd00136856-909  PDZ
cd13298447-544  PH1_PH_fungal
pfam00595859-919  PDZ
cd01260450-545  PH_CNK_mammalian-like
cd13301445-545  PH1_Pleckstrin_2
pfam13180859-908  PDZ_2
cd13378453-542  PH_RhoGAP2
cd13258452-545  PH_PLEKHJ1
pfam001691279-1395  PH
cd13310462-550  PH_RalGPS1_2
cd13215431-542  PH-GRAM1_AGT26
cd13288451-570  PH_Ses
cd13233451-545  PH_ARHGAP9-like
cd00987873-902  PDZ_serine_protease
COG54221033-1266  ROM1


Ontology Information


   
HPRD ID18040
Molecular ClassGuanine nucleotide exchange factor
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO