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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22196688 | 2012 | Cell line : - Source : Severance Medical Center at Yonsei University (Seoul, Korea) Sample Type : Seruma sample No. of Sample : - Stage : - | MALDI MS | Up-regulation | 5 | TIMP1 in human serum is a potent CRC biomarker candidate. TIMP1 were measured in the pooled CRC serum with about 5 times higher abundance than that in the noncancerous serum. |
| 20799911 | 2011 | Cell line : - Source : - Sample Type : Case control study No. of Sample : 4509 Individuals referred for large bowel endoscopy due to symptoms of CRC. Stage : - | - | Up-regulation | - | The validation study supports the use of the combination of plasma TIMP-1 and CEA protein measurements as a potential aid in early detection of CRC and specifically of CC. |
| 20108216 | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | ELISA | Up-regulation | - | Assessment of serum TIMP-1 can be considered a useful biomarker in colon cancer. Elevated serum TIMP-1 levels were found in patients with advanced disease stage (p=0.0512) and poorly differentiated histopathological tumor grade (p=0.0059). Sample size: 97 colon cancer patients. |
| 23985256 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : TNM Stage I,II | Tissue microarray, immunohistochemistry | Up-regulation | - | Both univariate and multivariate analyses showed that VEGFR-3, HER-2, and TIMP-1 were significant predictors of lymph node metastasis. VEGFR-3, HER2 and TIMP-1 are independent factors for lymph node metastasis in stage T1 and T2 colorectal cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. |
| Chromosome | X |
| Location | Xp11.3-p11 |
| Start | 47582291 |
| End | 47586791 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4501 |
| OMIM ID | 305370 |
| HGNC ID | HGNC:11820 |
| Unigene ID | Hs.522632 |
| Ensembl ID | ENSG00000102265 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_003254.2 |
|---|---|
| Exon | join(1..184,1118..1246,2646..2725,2915..3041,3253..3377, 4231..4501) | mRNA Sequence | Download Select all |
| Length | 931 |
CDS Information
| Location | join(1126..1246,2646..2725,2915..3041,3253..3377, 4231..4401) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS14281.1 |
Protein Information
| Protein ID | XP_005272702.1 |
|---|---|
| Protein Name | TIMP metallopeptidase inhibitor 1 |
| Molecular Wt. (Da) | 27448 |
| Protein Sequence | Download Select all |
| Length | 261 |
| Uniprot ID | P17936 |
| Ensembl Protein ID | ENSP00000275521 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 53 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1891 | ECH1 | 2825 | NP_001389.2 | yeast 2-hybrid | 16169070 |
| 1933 | EEF1B2 | 2804 | NP_001950.1 | yeast 2-hybrid | 16169070 |
| 4312 | MMP1 | 384 | NP_002412.1 | in vivo | 9063449 |
| 4313 | MMP2 | 386 | NP_004521.1 | in vitro | 12475252 |
| 4314 | MMP3 | 1703 | NP_002413.1 | in vitro | 928 897 012 834 347 |
| 9400 | RECQL5 | 4806 | NP_004250.4 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| HIF-1 signaling pathway | hsa04066 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03585 | 24-205 | NTR_TIMP |
| cl02512 | 24-205 | NTR_like superfamily |
| smart00206 | 24-199 | NTR |
| pfam00965 | 22-199 | TIMP |
| cd03577 | 24-146 | NTR_TIMP_like |
| cd03523 | 33-141 | NTR_like |
Ontology Information
| HPRD ID | 912 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Antigen binding (GO:0003823) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.