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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24879590 | 2014 | Cell line : HCT116, LoVo,SW480, HT29. Source : Dept. of surgery at the Chung shag university medical hospital. Sample Type : - No. of Sample : - Stage : - | qRT-PCR, Western Blott,Immunohistochemistry, Kaplan-Meier test and Cox regression model. | Up-regulation | - | LKB1 loss at the transcriptional level via alteration of the NKX2-1/p53 axis promotes cell invasion, consequently resulting in poor outcome in colorectal cancer patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / ANTP class : NKL subclass |
| Description | This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014] |
| Chromosome | 14 |
| Location | 14q13.3 |
| Start | 36985602 |
| End | 36990894 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5293 |
| OMIM ID | 600635 |
| HGNC ID | HGNC:11825 |
| Unigene ID | Hs.94367 |
| Ensembl ID | ENSG00000136352 |
| PharmGKB ID | PA36531 |
mRNA Information
| mRNA ID | ?NM_001079668.2 |
|---|---|
| Exon | join(1..173,856..1241,2206..3829) | mRNA Sequence | Download Select all |
| Length | 2197 |
Protein Information
| Protein ID | NP_001073136.1 |
|---|---|
| Protein Name | NK2 homeobox 1 |
| Molecular Wt. (Da) | 75031 |
| Protein Sequence | Download Select all |
| Length | 371 |
| Uniprot ID | O43312 |
| Ensembl Protein ID | ENSP00000322804 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 811 | CALR | 169 | NP_004334.1 | in vivo | 9988700 |
| 5594 | MAPK1 | 1496 | NP_002736.3 | in vitro;in vivo | 10733581 |
| 5970 | RELA | 1241 | NP_068810.3 | in vivo | 12040027 |
| 7849 | PAX8 | 1335 | NP_003457.1 | in vitro;in vivo | 1 244 135 714 970 200 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 162-219 | homeodomain |
| cl00084 | 162-219 | homeodomain superfamily |
| pfam00046 | 162-218 | Homeobox |
| smart00389 | 161-217 | HOX |
| COG5576 | 158-221 | COG5576 |
Ontology Information
| HPRD ID | 15304 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Peptidase activity (GO:0008233) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.