CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
TLR2	7097	Toll-like receptor 2	4	TIL4; CD282

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
22999059	2013	Cell line : - Source : Portuguese Institute of Oncology, Porto (IPOP) and Coimbra (IPOC). Sample Type : CRC tumor and normal tissue No. of Sample : 471 participants: 193 histologically confirmed CRC patients and 278 cancer-free controls Stage : -	polymorphisms genotyping, RT-PCR	Polymorhpism	-	The CC genotype of the TLR2??>C SNP was associated with 5-fold decreased risk of CRC development (OR = 0.21), which is a remarkable result for a SNP. LR2??>C and TLR4 Asp299Gly SNPs significantly influence the risk of CRC development, suggesting that these TLRs SNPs may be genetic susceptibility markers for CRC.

Gene Details

Chromosome: 4; NC_000004.11 (154605441..154627243)
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Gene Type	protein coding
Gene Family	CD molecules
Description	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]
Chromosome	4
Location	4q32
Start	153684256
End	153706091
Strand	-
Gene Sequence	>gi\|568815594:153684256-153706091 Homo sapiens chromosome 4, GRCh38.p2 Primary Assembly TTTGCTTACTTCCTAGTCCCGGGCAGGCCGGCTCGGAGGCAGCGAGAAAGCGCAGCCAGGCGGCTGCTCG GCGTTCTCTCAGGTGACTGCTCGGAGTTCTCCCAGGTACGTCGTGCGCTCCCCACTCGTGTGGTCTCTCT GCACCCCTTCCTGGGGTCGGGTCGGGCAGGGGCGGAGGGGAGCCGCAGCCCGGTCACGGGCTCTGGGGAA CCCGGGCTCCCGTTCGGCTGCACCTGGGCCCCTAGCTCCTGTCCGGGCGGGGATAGCGGGAAGCGCACCA GGCCCCCGGGACGCCGGTGCTTCTTTGCACGGCCCAGCGCGGGAATGTGGACACCAGCGAAGCCGGCTCA GGTCGGCCCTCGGGAGAAGCAGGGGCTACACGGAAAGGGAGCCCGAGGGTCCTGCAGAGCCCGAGGTCGG GACCCCGCGCGTGCAGTGCCAATGGGCTGCGGCTGGGCTGAGCGCCCTTCCAACCTTGCAGGCCCCGGGG GGGTTGCCGCGGAGAGCTTCCGCTGGGGCTCCGGGCCTCTGGCCGCCACCTCCCTCGGGAGGCCGAGGGG GGCGGTGGCCCCGGCCCGGCCCTCCCGCTTCCCTCACGGCCTGGCCCTCCCGCTTCCCTGATTCCCGGTA GGGTCGCTCTCCCCGCCTCCTGGCCCCTCTTGGCTCGGATGACAAAGATTGGGTAAAGGCTTTCAACGAG CTAGCGTCTGGCAGGGGGTGTGTCCTCGCTCACTGGTTACTGCTAGGACGGAGCTTGGATTTTGGTCACC GTGGCTCAGAGGTGGGAAAGGTTCCGTGCTCTGGGTCTGTCCAGGACCCTGGCTCCCTAACCCAAGTCTG ACCTCTGCTCCCTGGCAGGCTTCGCCCCACCTCTGCGTTCCTTCATTCTTAGGATGTGTGAGTTAGGTCT CTGATTAGAAAACAACTTACAGCGTTTAAGCAAAGTCGAGTCCTTCAAGTAAGAATGCTTTGAAGTGCCC TTTACAACTTCTTCAACTTCTATAAATATGAACTTGTGTTTAGAACTTAAATGCAAGCCAGGAAAGTCTT TTTCCTGTTTGAAAGAGAGAGAAAGAGAGAGAAAGAGGTGATTGGAAGTGGTGGGTGGGGGCGGAGAAAG AGAAGGAGAGTAATCTGGGTGTAGACAACTCAAAGTTTGCTGAGATGACTTTAATCTTTTGACTCTGTTA TTAAGATTTTTACCAAAGAGCAACTGTAGCTATGGTGGCCTGACTTGAAGGGACAGACCAAACAAACAAC AAAACACAAAACAAAACAAACAAACAACAAAAGCAAGAGCAGAAACTATTGGAAAATGATTTATTCACCA ATATTTTAAAGGTTCTTCCTGTTCTAAGCAAGGAACATCTTTAAGTTCTTTATAATGTACCCATTTTACA TTTACAAAAACTGCCAGAAGTTGACAGCATGTTTTGGGGGTTTCTAAGCTATCAGTTAATTTTTTGGGGT ACAGTTTTATTGATAAACTAACAGAGTAGAAAAAATCTAATGGAATACCCCCAAATTTAAAAGAGGGCAA GAAAAGAGAGACAATAGAACATAAAACAAATGGGACAAGAATAAAGTACATAGTTGTCACAGTCCCTTGG GTGCTGCTGTAACAAAATACCTGAGACTGGGTAATTTACAAAGAACAGAAATTTATCCATTCATGGTTCT GGAGTCTGGGAAGTCCAAGATTGAAGGGCTGCATCTGGTGAGGGTCATCTGGCTACATTATAACATGATG GAAAGCATCACATGGTGAGAGAGAGCAAGAGAGGACAGAACTTACTTTTATAACAAACTCATTCTCACAA TAAACTGCTCCCTTGGTGATAACATTAATCCATTTATGAGGGTACAGCCTTCATAACCTAATCACCTCTT AAAAGGTTCCACCTCTCAGCTCGCAGTGAGCCGAGATCATGCCACTGCACTCCAGCCTGGGTGACAGAGC GAGACTCTGTCTCAAAACAAACAAACAAACAAAAATTCCACCTCTCAACACTGTTGCATTGAAGATGAAA TTTCCAATACATGAGCTTTGGGGCACACATTCAAACCATAGCAATAGTTCAATTACTTTAAAGCCCAAAA TGTCAGTAATTATATTAAATGCAATTTAATACATCAGTAACTAAATGAGATAGACTAAATTTTATGATAA TCAGACTAATATTATCAGACTAGACTTCAAAACAACCCAACAATCATATGCTGTTTACAAGAGACACATT TATGGATACTAAAAGGTATAAAGTGAACAGATGCAACCATTTATCAAAAGAAAGCTGTTGTGGCAATATT ACTATTAGACAAAATAGAATTAGGAAAAAAATCATAACTGTAGATAAACGTTTCACTAAGTTAAAGGTTT CACTGAGAAGAAATAAAAATTTTGAATTTATAAGTACTTATAACAACATTAAGAAACTAGAAAATAGAAA AAGAATAGAGCCAAATTGACTGAACTAGAAAAATAGAAAATTCATAGAAAAATCCACAATCATAGTGGGA GATTTTATCATACATCTCTCAGTAACTGATAGAAAAACCAGACAAAAATCAATAAGGATAAAGAAAATGC GAACACAATGTAGTTCACATAAGGAACCTATACTACTTCCAACAGCAGCTGAAATCACAGAGCATACTTA AAATCTGACCATATACTGGCTCATAGAGTAAATTGCAATACATTTTAAAGAATTTAAATCATACAGAATA TGTCTTCTGACCATAATGCAATTAAAGTAGAAAAGAACAGAAAAACTTATAGAAAATTCTCATATATTTG GAAATTAGTAAATTTCTAAATAACCCATGGGTCAAAAAATAATCAGAATGAAAATCAGAAAATATTTTTA ATGACTTATGAAAAAAATTACATATAAAAACTTGTCAGATGCACCTAAACTGTTGCTTAAAGGAAACTTA CAACCTTAAGTGCATATATTAGAAATGAAGAGTGACGAAAAATGAATGAGCAAGCAAATACCTTAAAAAC TGGAAAAGGAATAGTAAAATAAATCCAGAGAAATCAGAACAGGGGAAATAATAATATAAGAATAGAAATT AATGTGCTAGAAAATAGGGGATCTATCAAGTCAGAAGTTGATTTTTTGAAAATGCTAATAAAAATGATGA ACCTCTGGCAAGACAATAAAAGCTGGTACAAATAACTCATCTAAGGAATAAAATTGAGGACCTCTCTTTT GTTAAATGACATAAGCAGGAGGCCATTATCCTGAGACTGTCTCTACACTTTGAGTTCTTACATAATAAAC TGCAACCTAATTTAGTATACTACATAAACAAACTGAAACCTAACTTAGGAGCTTTTTTTTTGTAATTAAT AGCTAAATTTCCACCAAATCATAAATAGCCAAGCTTTAGCCAATCACAGGCAGCCAACTGATCAGACTAT GCCCAAACAAGGTAAATGCCTATTACACCATACCCAAATAAGGCAGACTCCTAGCTGAAGCCAATCAGGT GATTACTATGCTCTTGTGTTTGGCCTATAAAAGCTCACTGCTCACACTGTTGGATGCTCTCTGAAACTTT TGTGAATCTGAGTGCTGCCTGATTCATGAATCATTCTTTGCTAAAATAAACTCTGTCAAATTTAATTTGT CTGAAGTTTCTCTTTTAACAGTGTTTGGTGTTGCAAGCAGGATCCAAAGGAGACCTATAGTGACTCCCAG GAGCTCTTAGTGACCAAGTGAAGGTACCTGTGGGGCTCATTGTGCCCATTGCTCTTTCACTGCTTTCAAC TGGTAGTTGTGGGTAAGTTCCTGCTCAGACTTGAGCACTATACATTTGCATTTTCAGCTCTCTGACTTTA TTTGAGCAATTCTTTGATGGATTGGCTCCAGAATTGGATTGGATTCAGTGAAGAAACTGAAACTGGACTG GTGCTCTAGGAGGCCTCAAGTAGATAAGGTTACTAGAAGACAGGGAATCCTGGGCTTATCTGGATTTAAG GAGTCTACAACTCCATCTGCAACTCCAGCCGATTTCATTTATAAGAATTATGGACCAAGAACCTGTGCTT TTCTAGAGAAATGTGTGAGCCTTACTAAAGGTAACTTAGAATTACAATGGACTGCTGAGACCAGCTCGGT CGTGGAGACCCTAACCCAGCAGCGCTAGAGGAATCAAAGACACACACACAGAAATGTAGAGTGTGGAGTG GGAAATCAGGGGACTCACAGCCTTCAGAGCTGAGAGCCCCTAACAGAGATTTACCCACATATTTACTGAC AGCAAGCCAGTGATAAGCATTATCGCTATAGATTATAGATTAACTAAAAGTATTCCTTACAGGAAACAAA GGGATGGGCCGAAACAAAGGGATAGGCTCTGGCTAGATGTCTGCAGCAGGAACACGTCCTTAAGGCACAG ATTGCTCATGCTATTGTTGTGGCTTAGGAACACGTTAAGCGGTTTTCTGCCCTGGGTGGGCCAGGTGTTC CTTGCCCTCATTCCAGTAAACCCACAACCTTCAGCGTGGGCGTCATGGCTGTCACAAACATGTCACAGTG CTGCAGAGATTTTGTTTATGGCCAAATCTGGGGCTAGTTTATGGCCAGGTTTGGGAGCCTGTTCCCACAT GTCCCCCTTTTTTGTTTTGCAAAGCAATAAAAGCAAAGGCAGCTTTGTCACAGTGAGCTACTTCTTGCAG GAGTCGGGATTCGCATATGCATACTATACAAAGACAAACAACACAGATTAAAAGCACAACCATCATTGAA ATCACAGAGCTTCCAAGTGTCTTTATCTATTTTAATGGGTTAATCACTGCTAATCTGTCTGCAGCTCCTT CAAGCACTCCAGTTCCTGGCATTAAGGTCTGGTGTGCCTGGAATGCTTTAAATATTTGTTCTTTTAATAT TGCAATATGGAAAGACAAGTTTGTAGAGTGTCTTCTAGGTGCTTTTTTATTCTTTCCTGAATTTGGTCTT ATTTAAGAGCCATTAATAGTTTCCACAAATCCTTATGTTTAGCTCCTACAGCGGGCCATATCATTTGAGG GTGAGGTGCCACTATACCATCATGTTTCCAGATAATAGGAACTCTTGCCATATTTCTTGCTATTTCTACC ATCTGACCATTTTGTTTAGACCAGCTAAACATAGTGTGGCCATGGCACGCAGACTGAGAGGTGCAATTTA AGCTAAACATCCCCTTAGGGGACCAATCAATAATGATTCCATAGGAATCACTGCGCAGCACCTCTGCCTA TTCTGCAATGCAATCTTCCCAAACAAGTATGTTCATTATTTCTGGCCAGGTCCAATTCTGTTTACAAATA GGTTTTTGAGGGCAATATGCCTCAATTATAGAAACAGATTTATTATGGTAAATACTGAGATCAGAAAGCA TGTGTAACTGTGTCATAGAATGATTACATCCAGGCATTATTGCCAGCCAAGATTGATAAATATGCCCAAT AAGTATAATTGTTCTCTGTGTTAGCCCTTGTTGAAGGAATACTAATGGCAATGGTGATCACTGCTATCAT AGCTATCATTAAATTACTCATTGTGACTGGTTGTCCCACTTTCCTCAGGTTTTCTTCCACCCTCTATGGC AGTTTCTTGATCTGTCCCCAGGTAGATGGCTGTGTTTGATGGTTGTTGCTCGTGATAGTTTGGGTCCTCC TCAGCATCAGTCTCGACATGGCTGCAACCAGAGGGTCCTCGGGATCCTCCCAGAATCTCTTCCTTGGCAT CTGGCTCATGATAAGGTTTCAGGTGTCTTGATGGTATCCAAATCAGCTATTGATTCTGGCCTGGAGAAAC ACAAGCATAACCTCTACCCCAAGTTATTATTTTACCTATTTCCCAACTTTTTGTTGTCAGATCTCTGCAC CAAGCCAGTTGTTCTGCTTCTGTTTTTGCAGCTGGTTTCTGTAGATGCTCTTCAGCTGCTGATAGCATCT GGCCTTTAGGCAGGCTCAAAAAATTTAAAGTCATTAATGCTAGATTCAGTTGTATATGGGGTGTCCTGTA ATCCCTGTTTCCCCTTTTTGCTTTTGCAACTGCTGTTTCAGGGAGAGATTCATTCTTTCTACAATGGTTT GTCCTTGAGAATTATATGGGATGCCAGTAATGTGTTTAATATTCCATATAGAGAAAAATGTAGCTAGAGC TTGGCTAGTATAGCCTGGGGCATTATCTGTTTTAACAGAAGTTGGAATTCCTATCACCACAAAACACTGC AAAAGGTGATGCTTAACACATGCAGTCTCCTGATTGGCATGTAGCCCAGACAAAGTGAGAAAAGGTGTCC ACACATACATGTACATAAGCTAGTCTCCCAAACGAGGGAACGTGTGACATCCATTTGCTAAAGATAATTA GGTTCCAATCCTCGAGGATTAACTCCTCCTGTTAAAGATGAGGAATGCACCATTTGGCAAGTTGGGCATC ACTGGATAATAGCTTTAGCTTCTTTCCAGGTACTGTTATATCTGCATTTGAGACCAGAGGCATTAACATG GGTTAAATTGTGAAAGTGTCTAGCATTAGATATTGCAGTAGCAACTAGGCGATCAGCCATTTGATTCCCT TCAGTTAAAGGTCCTGGAAGAGGTGTATGAGCCCTAATGTGAGTGATGTAAAAAGGGTGCATTCTACTCC TAAATGCTGTTTGCAATTGGGTAAATAAAGTCATCAGTTGTTCATCTGTATGAAGTCATAACTGAGCATT TTCAATTAATTGTATGGAATGAACCACATAGGAAGAATCAGAAATCACATTAATAGGCATATCAAAAGCA GTCAATACCTCAATTACAGCTAAAGCTCCACTTTTTGAGCTGAAGTATAGGGCGTGTGAAAAACTTTACC TTTTGATCCAGAATAAGAGGCTTTACCATTACAAGACCCATCTGTAAAAACATTCTCAGCACCTTCAGTT GGTTTAAATTTAGTTATTTTGGGGAGAATCCAATTAGTTAATTTCAAAAATTGAAATAATTTCATTTTAG GAAAATGATTATCAAGAATACCCACAAAGTCAGCTAAATGGGTTTGCCAAGTAAGACTATTTATAGAAGC TTGCTGTATTTGTGCCTTTGTGAGAGGGACAATAATTTTTCCAGGATCATATCCATGTAATTTAACAATC CGAATTCTCCCATTTCTTATCATCGTAGCCATTTGATCCAAATAAGGAGTTAGAGTCTGTGAATTAGTAT GTGGAAGAAAAAGCCACTGTACAAAGTCTTGCTCTTATACAATAACACCAGTAAGTGAATGCTGAGTTGG AAAAATTAGCAAATCTAGGGTCTTTTTTGGATCTATTCTATTTATTTGAGATTTATGGATTTGCTTTTTG ATTAGCTGCAGCTCTGCCTCAGCTTCTTTTGTTAATTGCTGAGGGCTAATGAGACTAGGATCTCCTCTAA GGATAGAAAATAGATTACTCAGGGCATAGGTGGGAATGCCTAGAGCAGGTCATATCCGATTAATGTCCCC TAGTAATTTTTGAAAGTCATTTAATGTTTTCAATTGATCCCTACGTATAGTTACTTTCTGTGGCACAATG GTAGTGTCATTTACTAAGGTCCCCAAGTAGGAGTAAGGAGTAGTAGTCTGAATTTTGTCAGGAGCTATAT AATTAAACTGGCATGAGAAATCGAGTTTTGCAAGTGATCATAACATTGGAGTAATATTTCTTGAGTGGGG GCAGCACAAAGTATATTATCCATATAATGAATAATGTAACACTGTGAAAATTTTTTACGAGTAGGTTCAA TTGCTTGCCCTTCATAAGTCTGGCAAATTTTTGAACTGTTTCACATGCCTTGTAGCAACACTTTCCAATA CAAATGCTTTAGTATGCTGCAGGTTTTTTACTGCAGGAATTGTAAATGCAAACAGTTCACAGCCTTGCTC AGCTAAGGGGATAGTAAAGAAACAGTCTTTTAAATTTATGACTATTAAAGGCCAATTTTTTGGAATCATA GCAGAAGAAGGCAGTCCCGGCTGCAATGTCCCCATAGGTTGTATAACTGAATTAATGGCTCTTAAGTCAG TTAACATTCTGCATTTACCTGATTTTTTCTTAATTACAAAAACTGGAGAATTCCAAGGGGAAAATGTTGA GCTATGTGTCCTTTTTCTAATTGTTCAGCAACTAAGTCCTCTAAAGCCTCCAGTTTCTCTTTACTCAGCA GCCATTGTGCTATCCAAATTGGCTTATCTGTTAACCATTTTAAAGGTATATAGGTTCTGGAGGCTTAACA ATGGCCACCATCAAAAATGATATCCTAAACCTTGGTGGGAACTTTGTCTTTCCGCTTGAAGCATTTCCTT CAAAGCTTGCAAATTTTTTCCTAGTCCCATACCAGGGACATACCCCATTTCATGCATCATATGTTGACTT TGAGGGCTGTATAATTATTCTGGAATTAGAACTTGTGATCCCCATTGTTGTAATAAATCTCTTCCCTATA AATTTATAGGTACAGAAGTTATAATTTTTTGTATAGTCCCAGGTTGTCCATTGGGCCCTTCACAATGCAA AATATAACTACTTTGATATACTTTAAGGGCTTTACCAACTCCAACTATGTTAAATTGAGCAGGTTGAATT GACCATGCAGATGGCCAGTGCTGTACAGAAATGATTGAAATGTCCGCTCCTGTATCTACCAAACTTTTAA ATTTCTTTCCCTGAATAGTTATTTCACCAGTAGGATGTTTATCAGTAATTTGATTCACCCAATAAGCTGC TTTGCCTTGTTTATTTGTGCTTCCAAATCTTCCTGTTCATTTAATTTCACTTTTCCCCATTTCCACATAT GGCATAATCAGGAGCTGTGCTATATGCTCTCCTGGCTCTGCTTTCCAGGGAACAGAAGTAGATATAACAA TTTGAATTTCCCCTTTGTAATCTGAATCAATGACTCCTGTTTGTACTTGCACGCCTTTTAAATTTAAACT AGACCTACCTAGAAGTAATCCTACCATCCCCGCTGGCATCATCTGACTGGAGACAGCAACCTTCTTTAAC AGTCCCATTACAAAAGGAGAACCTGTTCCATATGGATTAATAGCTTGTTTAAATTCTTTGAGTAATTTAA AAGGAAAAGGCTCAAATGTAGCTATAATATTTCCCTGTTGATCTACGGGGTATATTCTAACAGGGAACTG CTAAGCCTCTATATCACCCTCTCTTCTAACTTGCTGAATTCCTGGCTGAATAGAACTGAGAGTGGTCGCT CGAGGTGCTGCTCAGTCACTGGGGCGACTACTTTTTGCCCAGTGTCCTCTGGAAAAGAAAGATCTGGAGG ATCAGGCTACTCTTTTGCTTCGAAATAATGAGGGGGTGCAGAAGGGTAGGGACAAACCTCTCCCTCCTTT GCCACTTTAGCTTTAGCTGGCAAACAAACCTGCTCTGTCACCTCTTCTGTTACTTCATTATACTTTCCTT CCTCCTCATCTTTAGTGTGAAAAGGTTCCAAGGTGGAATGAGCTAGAGCCCACACTTGCCCATTGTTACC CTGATGCTTCCGAGCTCCCCTTCTTACTCACCATGGGGATTGCTTAAGAGTACTCGGGTATCCTCCAGCT TTGTTCCACGTTTTCCAACCATTGCTCCAGCGAGCCTTCATCCTGGGTTTGAGTCCCCACGTTGGGCGCC ACTTGCCGAGACCAGCTCGGTCGTGGAGACCCTAACCCAGCAGTGCTAGAGGAATTAAAGACACACACAC AGAAACATAGAGTGTGGAGTGGGAAATCAGGGGATTCACAGCCTTCAGAGCTGAGAGCCCTGAACAGAGA TTTACCCACGTATTTATTGACAGCAAGCCGGTGATAAGCATTATTTCTGTAGATTATAGATTAACTAAAA GTATTCCTTACAGGAAACAAAGGGATGGGCCAAAACAAAGCGATGGGCTCTGGCTAGATATCTGCAGCAG GAACACGTCCTTAAGGCACAGATCGCTCATGCTATTGTTTGTGGCTTAGGAATGCCTTAAGTGGTTTTCC ATCTTGGGTGGACCAGGTGTTCCTTGCCCTCATTCCAGTAAACCCACAACCTTCAGTGTGGGCGTCATGG CCATCACAAACATGTCACAGTGCTGCAGAGATTTTGTTTATGGCAAGATCTGGGGCCAGTTTATGGCCAG ATTTGAGGGCCTGTTCCCAACAGTGGACAAAGAAGAAAAGCTGCTTAAGGCAAACAGGCACATATTTTTT AAAGCTACAATAGCTAGACAAACTAAGAGAATCCTGTGTATGTTTTACTTTTGTATTTTTATTTTTAATA TTTGTGGATACATAGTAGATGTATATATTTATGGGGCACTTGAGATATTTTGATACAGGCATACAATGGA TAATAATAACATCACGGTAAAAGGGGTATCCATTACCTCAAGCATTTATCCTTTCTTTGTGTTATAAACA ATCCAATTAAACCTTTTATCATAAAATGTACAATAATGTTGACTGTGGTCACCCTGTTTTGCTATCAAAG AATAAATCTTATTCATTTTATCTAAGTATATTTGTGTACCCATTAACCATCCCAGTCCCCCTGCTCCTCC AACTACACTTCCCAGCCTCTGTTAACCATCATTCTACTCTCTTATCTCCATGAGTTCAATTGTTTTAATT TGTAGCTCCCACAAATAAGCGAGAACATGGGATGTTTGTCTTTCTGTGCCTTATTTCACTTAACATAATA TCCTCCAGTTCCATCCATGTTGTTATATGACAGAATTTCATTCTTTCTTATGGCTGAATAGTACCCCATT GTATATATATACCACATTTTCTTTATCCATTCATGTGTAGGTGGACACTTGGATTGCTTCTAGATCTTGG CTACTGTGAATAGTGCAGCACTAAACATGGGCGTGCAGATATCTCCTTGATATATTGATTTCCTTTATTT TGGGTATATACCTAGCAGTGGGATTGCTGGATTGTGTGGTAGCTCTACTGTTAGTCTTTTGAGGAACCTC CAAATTGTTCTCCATAGTGGTTGTACTAATTTACATTCCCAACCAACAACAGTGTACAGGGTTCTGTTTT CTCCACATCCTTGCAGCATTTTTATTGCCTGTCTTTTGGATAAAAGCCATTTTAACTGGGGTGAAATGAT ATCTCATTGTAGTTTTGATTAGCATTTCTCTGATGATCATTGATGTTGAGCACCTTTTTATATATCTGTT TGCCATTCATGTGCCTTCTTTTGAGAAATGTCTATTTAGATCTTTTGCCCATTTAAAAAATTGGATTATT AGATTTTTTTCCTATTGAGTTATTTGATCTCCTTATATATTCTGGTTATTAATCCCCTTTCAAATGGATA GTTTGTGAATATTTTCTCCCATTCTGTGTATTGCCTCTGCACTTTGTTGATTATTTAATTTGCTATGCAG AAACTTTTTAACTTGATGTGATCCCTTTTGCTCATTTTTGCTTTGGTTGCCTATGCTTGTGGGGTATGAC TTAAGAAATCTTTGCCCAGACCAATGTCATGGAGAGTTTTCTTAATGTTTTCTTTTAATAGTTTCATAGT TTGATGTCTTAGATTTAAGTCTTTAATCTATTTTGTTTTTATTTTTGTATATGGCAAGATATAGGGGTCT AGTTTCTTCCGCATATGGATATCTACTTTTCCCAGTACCATTTGTTGAAGAGACTGTCCTTTCTGCAATG TATGTTCTTGACACTTTTATTGAAAATGAATTCACTGTAGATGTGTGGATTTGTTTCTGGGTTCTCTATT CTGTTCTGTTGTTCTGTGTGTCTGTTTTTATGCCAGTACCATTCTGTTTTAGTTACTATAGCTCTGTAGT ATAATTTTAAGTCAGATAATGTGATTCCTCCAGTTTTGTTCTTTTTGCTCAGAATAGCTCTGGCTATTCT GGGTCTTTTGTGGTTTCATGTAAATTTTAGGATTATATTTTATTAACATATTTCTGTGAAGAATGTCATT GGTATTTTGATAGGAACTGCATTAAATCTATAGATTGCTTTGGGTAGTAAGGATATTTTAACAATATTGA TTTTTCCAATCCATGAACATGGAATATCTTTCCATTTTTTGGTGTCCTCTTTAATTTCTTGCATCAGTGT TTATAGTGTTTCTTTCATCAGTGTTTATAGTTTTCATTGTAGAGATCTTTTACTCCTTTGATTAAGTTTA TTCCTGGGTATTTTATTTGTAGCTGTTGTAGACGAGATTACTATCTTGATTTCTTTTTCAGATTGTTCAC TGTTGGCATATACAAATGCTACTGATTTTTGTATGTTGATTTTGTATACTACAATTTCACTGAATTTGCT TATTACAGAGAGACTAAAGATAGTTAGGTCCATTACCAAATGTGTTTTCTGTCACATTGAAAAATTATAC CATGAGAAGGCACATGCTTCTAGTAATTACAGTTCATAGATATGTCAATGTACAGAATGCTGGTGTGACA GTTCACAATTGTTTGCTTTATAGTTTTCACTGGAAATTAAATTACTAAGGGTAAAGTAATCCCAGCACTG TGGGAAGCTGAGGCAGGATGATTGCTTAATGCCAGGAGTTTGAGACCAGCTGGGGCAATGTAGCATGAGC CCATCTACAAAAAAAAAAAGGAATTCTAATTAATATGTGGTACTAGAATTACCAGAAATAATAAGGGAAA CAACTCGGAAAAGAAGGTAAGATGTGTTTTGGGTAAGAACAGCTATAAAGTATGAGGGGATGTTTTGTTT TGTTAAGGAAAAAATAAAATAATATTTGTCCTAAAGTAGAATGCCTGGTTGTTAAGACAATGAGAAAGAG AAAGAGTATAGAAGAAAAACTGAATGGATATAAGAAAGTTGTAGAAGGTTGTGGGATAGGAATCCTGGAA AGGGAATTTTATATGTGATCAAACTAAGATTTGAAGAAAATTCTAAGTTTTTTTTTAAAAAAATTGAGCA TGAATATCAAAAACATACTGACACAGAACTAGAAATTTGTCCTCTATGTTAAAACAACAAGGTTTTCTTG GAGTATTGGTCTGCTCTTAATAAGAAATTGAAAGACTTTTCTTTACCTGCTAAGTAATTGGCCTAGGAAA TGAAGATTCTGTGTTTTATTGAGATAATTTATTGTGCTTCATGTTGTCTTTATTAGATCTTTGACTGCCT CAGAGACCTGAGTTCACCTTATTAAAAGAGAAAGAGTTTCTACAATTATGTGGCTTTCTTTATTTGCCTT TGAAGTCTTTTACCAATCACTCTAGTTAAATGAATAAATATTGTTTCATAGGGACCTGTGATCCTATTTT AATCAGATATTTTAAACCTTTTGATATTTTTGACTTCTCAAAATCAAATTCTAAATTAAAACCTTTTGAC GTTGAACAAACTTTGGAAGCTTCTAGATGGGCTTCTGGAATATCTCAAAAGAAATTGTTTTCTCTCCTGA TAAAAAAGAGAGATATTAAACTAATTGGGCTTATTTGATATGTTATATTGCATGGGAAGAATTGTTAAAT TATAAGTGATGCTGAACTTTCTTTAAGTCATATTGTATGGGTATGTTATTAATATGTGCTTCAGAAATTA TATGAAATTCTTAGAAACCAGATAGTCGTGGTATAATACTATCAGCCAAAATTCTAATTATCGTGAAATA TTATGTGTTGCAGAAGTAATACAATTTCCTTATCAATTGCATTATTGTGAACTCTCATCATATCTTTAAC CAAGTCCATTTTAAGCTTTGTCATCTACAAAGAGTCACTTGTTTTACTCTGGTACTTTCCGGAACACTGT GAAAAACAATTATATAAAGGGTGTGGACCTATAAGACAAACAACCAAACAAAAATCGTAAAGTGTTCTTT TAAAAGATTCGTGGAAAGGACTCTGATAAGTACAGGTTTCTGATAACTTTAAGATCATACTACTGGACTG GGTAAGAATTTCCAGAACTCTAGCAAAGAAGTGGATTGGTTCATAAAACTGCCAACCCAACATGAAGCAG AATAAGAATTAATTGAATACCAGGGAAATGCTTTGGCAGATTTTCATGCTAAGTCAGCCAGTACTGAAAT TGTTAAGATATGCAATTTGAAAGAACACTATAATATTCATCTGAATCAAATTATCTATGATAACCTATTT AAATGAACAGCATCATGCACCTGAATTGGAGAAACAAAACTGATATTTAAAATGATATAAATTTAGTGTT AAATGTGGCCTCATGGATCAGACAGCTATCTGGTCCTTTCTGAGTCCATATAGCTGCCATTATTAAAAGT TCTGCACTCTATGACTCATCACAGAATAGATAACGTGAAATTATGAAAAAATATTGGTGTTATGACTGTT CTAAAATTGCTAAAATGGCTTATAATCAATGTTTGGTTTGTCAAATCCACAATTTTTATAAGATAATAAA AACCTCAGTTGGTACATTTCCACCATCCACTGGACTATTTGAACATTTACAGATGGATTGCATTCAGTTG CCTCATTGGGAATCTGCAGGAAACTTAAGTAAATGCTGGATATGTCATGTTGAACCAAATACTAATATGC TTTTAAAGATCTTCTAATTCACCCTATAGCAGATTTCACTGATATTCCAAGTGTGACTACCTGTTCAAAT TGCACATCTGGTCTTTCTATAGGGTTAGGCTTTTTGAGTCACATATTCAGATTTCATGTTTAAAGCTAAC AGTAGACAAAACATATAGGAGAGGCTTTACAGTTAAATTATTCCAGAAACTGAATAATAAAACCAAAAGG AGAGATAATTAGACAGTTTGTAGACGAATTCATAACCCTAATTCTCTAATTGTTGGTAGCCTCCATTGAT GATAATTAATAGTGGAGCCTTAGATAAATACTACTATTGCTTCCCCGTTGATGACCCCTGTAGCACACAG TGTCCCACAGGGAACTGTCTCTTGTGCCCCTCTAGCATATATTTTTATCTATGAAGGATTTAACTATCAA TCATAGGCACAGGCAACTCCATGTCCCAGTCAGTAGGAAATAAGAAGTCAGTGTGGATTAGGGATTCTAA CAGTACCACTGTCACTCCATAACCAACTGAAAATTTGACATTGTTCTATACCTCTTAATTTGCACTATGG TATAAAAAGGAACTTTCTAGCAGGTACGAATCCCTCTAAATGGGCATCTTTTGTTCAAATGCTCCTTCCC TGGCTTGGAATAAATGTAAATGAGGTTATGATTAGAAATCCCCTTCAAACATTAGCTACTACAGCTCACT CTACTGCAAAGGCTATATAGTTGCCCAGTGAAGTTCTCTAAATTCTCTTGCTAAAGTTTCTTTAAATAAC AGGATTGCCTTGAACTATCTGTTGGTTTGTAGTGGGGCAGGGGGTGTGATAGGGGACACTGTGTATAATA GCTAATACATCCTACTGCACTTGCATAAAGGAATCTGTTATAAAGAAAATGAAATAAAGGTATAAAAGTT GGCAAGAAGAAAACCATCATTATGTCTTGAGGATGATTGGGGATACAGAAAATGAGAAGAATCCACAAAC TATTAGAATTACTAAGTTAATTTAGCAAGGTTGCTCAATGCATGGTCAGTATACAAAATTTAATTGAATT TCTACATATATGTATATGCCATATTGTGTTAGATTGTTTTGCATTGCTATAAGGGAATACCTGAAGCTGG GTAATTTATAAAGAAAAGAGGCTTATTTGGCTCATGGTTCTGCAGGCTGTACAAGCATGGCACTAGCATC TGTTTGACCTTAGGAAGCCTTTACTCATGGTGGAAGAAGGGGGAGCAGGCATGTCATATAGTGAGAGAGG GAGTGAGAGGGAGGGAGCAAGAGTGAAGGGGGAGGTCCCAGACTCTTTTTAAATAACCTGAAATCCTGTG AACAGAGTGAAAACTAACTTATTACCATGAAGAGCACACCAAGCCATTCATGAGGGGTATACCTTCATGA CCCAAACGCTTTCCACCAGGTCCTACCTTCAACACTGGGGATCACATTTCAACATGAGATTTGGAGAGGA CAAACATCCAAATCATATCACATATATAAATATGTAAAACTATTTTAAATGTTTTTAAAGTATCGAATAG AAATAAATCTCACAAAATATGCTTAAGAACTTTAAGCAAAAACCATAAAATACTATTGTGATAAGTTAAA GAAGACCTAAATAAATGGAGAGATCTGTCATGCTCATGGATTGGAAGATTCAATACTGTAATGATATGAA TAGTTCCCAAATTGTTCTATAGATTCAAAACATTGCCAGTTAAAATCTCAGTGGACTTTGTTTTTTTGAA ACTGACAAGCTGATTCTGCCATTTATAATAATATTCAAAGGGGCAAGAATAACCAAGACACATTTGAAGA AGAACAAGGAGGAAGAAGAACGTATTTGAAGAAGAATAAGGAACTCTATTAAGTGTATATCTCCTATATA TTGAGATACACATTTGAAATACATCTATCACCTAGATATTGAGATATATTATACATTTAATATAGTGTGT TGCTGGTATAGGGATAGACAAATGAACATTGGATCAGAATAGCACTGAAACAAGATCTACCCCTATATGG GCATGTCCCTATTAACAAAAAAATATTGTTGATTATTTCCTCAAGATGATCTGTAAAAAACAAGTTAATT GAACATCCATATGGGAAAAAAGTGAATCCTTCTGCTACCTCAAATATCAACCCCAGGTAGATTATAGATC TAAAAGTGAAAGGCAAAGCAATAAAGATTTTAGAAAATAACAAAGAGAATATCTTTATGAAAATACAGGA AATATTTTAAAAATAGGCTAGAAAACTCACTATTAAAATATATAAAATATAAGAACATCTGTTCATCAAA AGTACTATAGTTTGAATAGCAGTGTCTCCTCCAAAATTCATATTGAAACTTAATCCCCATTGTAACAGTA CTAATCCTAAAACTAAGTATTAAGAGGTGTGACCTGTGGGAAGTGACTAAGTCATGAGGGGTCTTTCCTC AGGTATGGGATTAGCATCCTTATAAAAGGCCTTGAGATGGAATGTAGTGCCCCCTTGCCCTCTTGCGTTC TCCCATGTGAGGACACAGCAACAAGGCACCATCTTGGAAGGAGAGAGAAGCCCTCACCAGACAACAGTGC ACATGCCTTGATCTTAGACTTCCCAGCCTCCAGAGCTATAATAAATACATTTCTGTTCTTTATAAATTAC TTGGTCTCTGGTATTTTGTTACAGAAGCACTAATGGACTAAGACAAAAAGATTCCATTATGAAAGTGAAA AGGCAACCGCAGAGTGGCAGAAGCTTTTGGAGATGATGAATATGTTTACTTCCTGGATTGCGGTGATGAT ACCATGAGTGTATACATATGTGTGTATACATAATGTATACAAATTGTGTTCATTGATTATGTACAGTTTC TTTGTATACCAATTATACCTTAATAAAGCTAAGGAAAAAAAAAAGAAAATCCAGAATAAATATGCATGGT ATGACCCATTTATTTAAAAAAAAAAAGAGGGAATGCGAAGCAGTGGTTTTGGTGCGAACACAAAAATTCT GGCTTCAACAGCATTTAAATTCCCAAACCAAGCATGTTTGTGTTTTAATTCTTTGTGGCCATAAATTGTA CAGCTCAGGCCTTTATAGTCTCTCAGATTCTGTGAATGTGGGGAATTAGTTTTACTCATAAAAAGTTTTG TTCTTGGGGATAAATTTTTTAAAAAAATTTTTGTATAGTTAGCACACTGAGAAAATACAGACAAAGGCAT ACAGATGCAAGAAATGAGGTAGCTGAATAGACCAAAGAATGATATAGGGCCCAGAAGGTAGGCAAAGAGA AAGTTGTTGGGTTTATGGTTACAAGTAAACTAGCAGTTGTGGTGCAGATAGTTTTATTTCCCCCACATTA ATCTGAACAGCCCATCCAGACTTAAACACTGCTTTTTGCATTTACTTCTAGGCAGGAAGACAGGGTTCTG ATGGTGTGAGTCTCCTTCAACTCAGCAAACCACCTTGGTCTGCCTCGAGTTTCCAACACCCCTCCTGCCT GCTAGTGATAGGTGTGAGGCAGGTTGATGAACATGGAACTTTTTTCTTTTGGTCCCAAAGCATGCTACTC CTGGAGTTTCATTCAGTGAATGAGAACTATAGTTTGGTTCTGTGAGATCTCTATGAATCAAGGCGGCCAC TGAAGCGGAGAAAAGAAATGCTTAAATGTTAAGAAAGTTTGAAGTGCAGAAAAAGGTGATTGTAAATCCA TATGGTTAAGCTTAGCCCATTTCTTAAAAGGCTTGATTGCTCATTCCTCCATTCATTGATTTACTCACTC TTCCAATCCATGTTATTGAGTCTTGCTCTGTAATTCCGGATGGTTGTGCTTTTAAGTACTGCATAGTGGT TGTATGTCTGTGTTAGCATTGCTGAATGTATCAGGGAATTCATTTTTTTATCCCCATTCATTCGTTCCAT TCATCTGTTTCTCTCTCTCTCTCTCTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT GTTATGCCTAGAAAACATTTCTCAAGAATTAGAATTACGATATGCTGTCAAACACAATGACTTATTTGAA CCTCTTTTATTTGTAGGTTGAAGCACTGGACAATGCCACATACTTTGTGGATGGTGTGGGTCTTGGGGGT CATCATCAGCCTCTCCAAGGAAGAATCCTCCAATCAGGCTTCTCTGTCTTGTGACCGCAATGGTATCTGC AAGGGCAGCTCAGGATCTTTAAACTCCATTCCCTCAGGGCTCACAGAAGCTGTAAAAAGCCTTGACCTGT CCAACAACAGGATCACCTACATTAGCAACAGTGACCTACAGAGGTGTGTGAACCTCCAGGCTCTGGTGCT GACATCCAATGGAATTAACACAATAGAGGAAGATTCTTTTTCTTCCCTGGGCAGTCTTGAACATTTAGAC TTATCCTATAATTACTTATCTAATTTATCGTCTTCCTGGTTCAAGCCCCTTTCTTCTTTAACATTCTTAA ACTTACTGGGAAATCCTTACAAAACCCTAGGGGAAACATCTCTTTTTTCTCATCTCACAAAATTGCAAAT CCTGAGAGTGGGAAATATGGACACCTTCACTAAGATTCAAAGAAAAGATTTTGCTGGACTTACCTTCCTT GAGGAACTTGAGATTGATGCTTCAGATCTACAGAGCTATGAGCCAAAAAGTTTGAAGTCAATTCAGAATG TAAGTCATCTGATCCTTCATATGAAGCAGCATATTTTACTGCTGGAGATTTTTGTAGATGTTACAAGTTC CGTGGAATGTTTGGAACTGCGAGATACTGATTTGGACACTTTCCATTTTTCAGAACTATCCACTGGTGAA ACAAATTCATTGATTAAAAAGTTTACATTTAGAAATGTGAAAATCACCGATGAAAGTTTGTTTCAGGTTA TGAAACTTTTGAATCAGATTTCTGGATTGTTAGAATTAGAGTTTGATGACTGTACCCTTAATGGAGTTGG TAATTTTAGAGCATCTGATAATGACAGAGTTATAGATCCAGGTAAAGTGGAAACGTTAACAATCCGGAGG CTGCATATTCCAAGGTTTTACTTATTTTATGATCTGAGCACTTTATATTCACTTACAGAAAGAGTTAAAA GAATCACAGTAGAAAACAGTAAAGTTTTTCTGGTTCCTTGTTTACTTTCACAACATTTAAAATCATTAGA ATACTTGGATCTCAGTGAAAATTTGATGGTTGAAGAATACTTGAAAAATTCAGCCTGTGAGGATGCCTGG CCCTCTCTACAAACTTTAATTTTAAGGCAAAATCATTTGGCATCATTGGAAAAAACCGGAGAGACTTTGC TCACTCTGAAAAACTTGACTAACATTGATATCAGTAAGAATAGTTTTCATTCTATGCCTGAAACTTGTCA GTGGCCAGAAAAGATGAAATATTTGAACTTATCCAGCACACGAATACACAGTGTAACAGGCTGCATTCCC AAGACACTGGAAATTTTAGATGTTAGCAACAACAATCTCAATTTATTTTCTTTGAATTTGCCGCAACTCA AAGAACTTTATATTTCCAGAAATAAGTTGATGACTCTACCAGATGCCTCCCTCTTACCCATGTTACTAGT ATTGAAAATCAGTAGGAATGCAATAACTACGTTTTCTAAGGAGCAACTTGACTCATTTCACACACTGAAG ACTTTGGAAGCTGGTGGCAATAACTTCATTTGCTCCTGTGAATTCCTCTCCTTCACTCAGGAGCAGCAAG CACTGGCCAAAGTCTTGATTGATTGGCCAGCAAATTACCTGTGTGACTCTCCATCCCATGTGCGTGGCCA GCAGGTTCAGGATGTCCGCCTCTCGGTGTCGGAATGTCACAGGACAGCACTGGTGTCTGGCATGTGCTGT GCTCTGTTCCTGCTGATCCTGCTCACGGGGGTCCTGTGCCACCGTTTCCATGGCCTGTGGTATATGAAAA TGATGTGGGCCTGGCTCCAGGCCAAAAGGAAGCCCAGGAAAGCTCCCAGCAGGAACATCTGCTATGATGC ATTTGTTTCTTACAGTGAGCGGGATGCCTACTGGGTGGAGAACCTTATGGTCCAGGAGCTGGAGAACTTC AATCCCCCCTTCAAGTTGTGTCTTCATAAGCGGGACTTCATTCCTGGCAAGTGGATCATTGACAATATCA TTGACTCCATTGAAAAGAGCCACAAAACTGTCTTTGTGCTTTCTGAAAACTTTGTGAAGAGTGAGTGGTG CAAGTATGAACTGGACTTCTCCCATTTCCGTCTTTTTGATGAGAACAATGATGCTGCCATTCTCATTCTT CTGGAGCCCATTGAGAAAAAAGCCATTCCCCAGCGCTTCTGCAAGCTGCGGAAGATAATGAACACCAAGA CCTACCTGGAGTGGCCCATGGACGAGGCTCAGCGGGAAGGATTTTGGGTAAATCTGAGAGCTGCGATAAA GTCCTAGGTTCCCATATTTAAGACCAGTCTTTGTCTAGTTGGGATCTTTATGTCACTAGTTATAGTTAAG TTCATTCAGACATAATTATATAAAAACTACGTGGATGTACCGTCATTTGAGGACTTGCTTACTAAAACTA CAAAACTTCAAATTTTGTCTGGGGTGCTGTTTTATAAACATATGCCAGATTTAAAAATTGGTTTTTGGTT TTTCTTTTTTCTATGAGATAACCATGATCATAAGTCTATTACTGATATCTGAATATAGTCCCTTGGTATC CAAGGGAATTGGTTGCAGGATCCTCGTGGATATCAAAATTCATAGATGATCAAGTCCCTTATAAGAGTGG CATAGTATTTGCATATAACCTGTGTACATTCTCCTGTATACTTTAAATCATCTCTAGATTACTTATGATA CCCAATACAATGTAAATACTATGTAAATAGTTGTACTGTCTTTTTATTTATATTATTATTGTTATTTTTT ATTTTCAAAATTTTTAAAACATACTTTTGATCCACAGTTGGTTGACTTCATGGATGCAGAACCCATGGAT ATAGAGGGCCAACTGTAATCTGTAGCAACTGGCTTAGTTCATTAGGAAACAGCACAAATGAACTTAAGAT TCTCAATGACTGTGTCATTCTTTCTTCCTGCTAAGAGACTCCTCTGTGGCCACAAAAGGCATTCTCTGTC CTACCTAGCTGTCACTTCTCTGTGCAGCTGATCTCAAGAGCAACAAGGCAAAGTATTTGGGGCACTCCCC AAAACTTGTTGCTATTCCTAGAAAAAAGTGCTGTGTATTTCCTATTAAACTTTACAGGATGAGAAA Download Select all
Length	21836
OMIM ID	603028
HGNC ID	HGNC:11848
Unigene ID	Hs.519033
Ensembl ID	ENSG00000137462
PharmGKB ID	-

mRNA Information

mRNA ID	XM_005263197.2
Exon	join(1..105,3647..3733,18637..21200)
mRNA Sequence	>7097 TTTGCTTACTTCCTAGTCCCGGGCAGGCCGGCTCGGAGGCAGCGAGAAAGCGCAGCCAGGCGGC TGCTCGGCGTTCTCTCAGGTGACTGCTCGGAGTTCTCCCAGTTTCTCTTTTAACAGTGTTTGGT GTTGCAAGCAGGATCCAAAGGAGACCTATAGTGACTCCCAGGAGCTCTTAGTGACCAAGTGAAG GTTGAAGCACTGGACAATGCCACATACTTTGTGGATGGTGTGGGTCTTGGGGGTCATCATCAGC CTCTCCAAGGAAGAATCCTCCAATCAGGCTTCTCTGTCTTGTGACCGCAATGGTATCTGCAAGG GCAGCTCAGGATCTTTAAACTCCATTCCCTCAGGGCTCACAGAAGCTGTAAAAAGCCTTGACCT GTCCAACAACAGGATCACCTACATTAGCAACAGTGACCTACAGAGGTGTGTGAACCTCCAGGCT CTGGTGCTGACATCCAATGGAATTAACACAATAGAGGAAGATTCTTTTTCTTCCCTGGGCAGTC TTGAACATTTAGACTTATCCTATAATTACTTATCTAATTTATCGTCTTCCTGGTTCAAGCCCCT TTCTTCTTTAACATTCTTAAACTTACTGGGAAATCCTTACAAAACCCTAGGGGAAACATCTCTT TTTTCTCATCTCACAAAATTGCAAATCCTGAGAGTGGGAAATATGGACACCTTCACTAAGATTC AAAGAAAAGATTTTGCTGGACTTACCTTCCTTGAGGAACTTGAGATTGATGCTTCAGATCTACA GAGCTATGAGCCAAAAAGTTTGAAGTCAATTCAGAATGTAAGTCATCTGATCCTTCATATGAAG CAGCATATTTTACTGCTGGAGATTTTTGTAGATGTTACAAGTTCCGTGGAATGTTTGGAACTGC GAGATACTGATTTGGACACTTTCCATTTTTCAGAACTATCCACTGGTGAAACAAATTCATTGAT TAAAAAGTTTACATTTAGAAATGTGAAAATCACCGATGAAAGTTTGTTTCAGGTTATGAAACTT TTGAATCAGATTTCTGGATTGTTAGAATTAGAGTTTGATGACTGTACCCTTAATGGAGTTGGTA ATTTTAGAGCATCTGATAATGACAGAGTTATAGATCCAGGTAAAGTGGAAACGTTAACAATCCG GAGGCTGCATATTCCAAGGTTTTACTTATTTTATGATCTGAGCACTTTATATTCACTTACAGAA AGAGTTAAAAGAATCACAGTAGAAAACAGTAAAGTTTTTCTGGTTCCTTGTTTACTTTCACAAC ATTTAAAATCATTAGAATACTTGGATCTCAGTGAAAATTTGATGGTTGAAGAATACTTGAAAAA TTCAGCCTGTGAGGATGCCTGGCCCTCTCTACAAACTTTAATTTTAAGGCAAAATCATTTGGCA TCATTGGAAAAAACCGGAGAGACTTTGCTCACTCTGAAAAACTTGACTAACATTGATATCAGTA AGAATAGTTTTCATTCTATGCCTGAAACTTGTCAGTGGCCAGAAAAGATGAAATATTTGAACTT ATCCAGCACACGAATACACAGTGTAACAGGCTGCATTCCCAAGACACTGGAAATTTTAGATGTT AGCAACAACAATCTCAATTTATTTTCTTTGAATTTGCCGCAACTCAAAGAACTTTATATTTCCA GAAATAAGTTGATGACTCTACCAGATGCCTCCCTCTTACCCATGTTACTAGTATTGAAAATCAG TAGGAATGCAATAACTACGTTTTCTAAGGAGCAACTTGACTCATTTCACACACTGAAGACTTTG GAAGCTGGTGGCAATAACTTCATTTGCTCCTGTGAATTCCTCTCCTTCACTCAGGAGCAGCAAG CACTGGCCAAAGTCTTGATTGATTGGCCAGCAAATTACCTGTGTGACTCTCCATCCCATGTGCG TGGCCAGCAGGTTCAGGATGTCCGCCTCTCGGTGTCGGAATGTCACAGGACAGCACTGGTGTCT GGCATGTGCTGTGCTCTGTTCCTGCTGATCCTGCTCACGGGGGTCCTGTGCCACCGTTTCCATG GCCTGTGGTATATGAAAATGATGTGGGCCTGGCTCCAGGCCAAAAGGAAGCCCAGGAAAGCTCC CAGCAGGAACATCTGCTATGATGCATTTGTTTCTTACAGTGAGCGGGATGCCTACTGGGTGGAG AACCTTATGGTCCAGGAGCTGGAGAACTTCAATCCCCCCTTCAAGTTGTGTCTTCATAAGCGGG ACTTCATTCCTGGCAAGTGGATCATTGACAATATCATTGACTCCATTGAAAAGAGCCACAAAAC TGTCTTTGTGCTTTCTGAAAACTTTGTGAAGAGTGAGTGGTGCAAGTATGAACTGGACTTCTCC CATTTCCGTCTTTTTGATGAGAACAATGATGCTGCCATTCTCATTCTTCTGGAGCCCATTGAGA AAAAAGCCATTCCCCAGCGCTTCTGCAAGCTGCGGAAGATAATGAACACCAAGACCTACCTGGA GTGGCCCATGGACGAGGCTCAGCGGGAAGGATTTTGGGTAAATCTGAGAGCTGCGATAAAGTCC TAGGTTCCCATATTTAAGACCAGTCTTTGTCTAGTTGGGATCTTTATGTCACTAGTTATAGTTA AGTTCATTCAGACATAATTATATAAAAACTACGTGGATGTACCGTCATTTGAGGACTTGCTTAC TAAAACTACAAAACTTCAAATTTTGTCTGGGGTGCTGTTTTATAAACATATGCCAGATTTAAAA ATTG Download Select all
Length	2756

CDS Information

Location	18653..21007
CDS Sequence	>lcl\|XM_005263197.2_cds_XP_005263254.1_1 [gene=TLR2] [protein=toll-like receptor 2 isoform X1] [protein_id=XP_005263254.1] [location=209..2563] ATGCCACATACTTTGTGGATGGTGTGGGTCTTGGGGGTCATCATCAGCCTCTCCAAGGAAGAATCCTCCA ATCAGGCTTCTCTGTCTTGTGACCGCAATGGTATCTGCAAGGGCAGCTCAGGATCTTTAAACTCCATTCC CTCAGGGCTCACAGAAGCTGTAAAAAGCCTTGACCTGTCCAACAACAGGATCACCTACATTAGCAACAGT GACCTACAGAGGTGTGTGAACCTCCAGGCTCTGGTGCTGACATCCAATGGAATTAACACAATAGAGGAAG ATTCTTTTTCTTCCCTGGGCAGTCTTGAACATTTAGACTTATCCTATAATTACTTATCTAATTTATCGTC TTCCTGGTTCAAGCCCCTTTCTTCTTTAACATTCTTAAACTTACTGGGAAATCCTTACAAAACCCTAGGG GAAACATCTCTTTTTTCTCATCTCACAAAATTGCAAATCCTGAGAGTGGGAAATATGGACACCTTCACTA AGATTCAAAGAAAAGATTTTGCTGGACTTACCTTCCTTGAGGAACTTGAGATTGATGCTTCAGATCTACA GAGCTATGAGCCAAAAAGTTTGAAGTCAATTCAGAATGTAAGTCATCTGATCCTTCATATGAAGCAGCAT ATTTTACTGCTGGAGATTTTTGTAGATGTTACAAGTTCCGTGGAATGTTTGGAACTGCGAGATACTGATT TGGACACTTTCCATTTTTCAGAACTATCCACTGGTGAAACAAATTCATTGATTAAAAAGTTTACATTTAG AAATGTGAAAATCACCGATGAAAGTTTGTTTCAGGTTATGAAACTTTTGAATCAGATTTCTGGATTGTTA GAATTAGAGTTTGATGACTGTACCCTTAATGGAGTTGGTAATTTTAGAGCATCTGATAATGACAGAGTTA TAGATCCAGGTAAAGTGGAAACGTTAACAATCCGGAGGCTGCATATTCCAAGGTTTTACTTATTTTATGA TCTGAGCACTTTATATTCACTTACAGAAAGAGTTAAAAGAATCACAGTAGAAAACAGTAAAGTTTTTCTG GTTCCTTGTTTACTTTCACAACATTTAAAATCATTAGAATACTTGGATCTCAGTGAAAATTTGATGGTTG AAGAATACTTGAAAAATTCAGCCTGTGAGGATGCCTGGCCCTCTCTACAAACTTTAATTTTAAGGCAAAA TCATTTGGCATCATTGGAAAAAACCGGAGAGACTTTGCTCACTCTGAAAAACTTGACTAACATTGATATC AGTAAGAATAGTTTTCATTCTATGCCTGAAACTTGTCAGTGGCCAGAAAAGATGAAATATTTGAACTTAT CCAGCACACGAATACACAGTGTAACAGGCTGCATTCCCAAGACACTGGAAATTTTAGATGTTAGCAACAA CAATCTCAATTTATTTTCTTTGAATTTGCCGCAACTCAAAGAACTTTATATTTCCAGAAATAAGTTGATG ACTCTACCAGATGCCTCCCTCTTACCCATGTTACTAGTATTGAAAATCAGTAGGAATGCAATAACTACGT TTTCTAAGGAGCAACTTGACTCATTTCACACACTGAAGACTTTGGAAGCTGGTGGCAATAACTTCATTTG CTCCTGTGAATTCCTCTCCTTCACTCAGGAGCAGCAAGCACTGGCCAAAGTCTTGATTGATTGGCCAGCA AATTACCTGTGTGACTCTCCATCCCATGTGCGTGGCCAGCAGGTTCAGGATGTCCGCCTCTCGGTGTCGG AATGTCACAGGACAGCACTGGTGTCTGGCATGTGCTGTGCTCTGTTCCTGCTGATCCTGCTCACGGGGGT CCTGTGCCACCGTTTCCATGGCCTGTGGTATATGAAAATGATGTGGGCCTGGCTCCAGGCCAAAAGGAAG CCCAGGAAAGCTCCCAGCAGGAACATCTGCTATGATGCATTTGTTTCTTACAGTGAGCGGGATGCCTACT GGGTGGAGAACCTTATGGTCCAGGAGCTGGAGAACTTCAATCCCCCCTTCAAGTTGTGTCTTCATAAGCG GGACTTCATTCCTGGCAAGTGGATCATTGACAATATCATTGACTCCATTGAAAAGAGCCACAAAACTGTC TTTGTGCTTTCTGAAAACTTTGTGAAGAGTGAGTGGTGCAAGTATGAACTGGACTTCTCCCATTTCCGTC TTTTTGATGAGAACAATGATGCTGCCATTCTCATTCTTCTGGAGCCCATTGAGAAAAAAGCCATTCCCCA GCGCTTCTGCAAGCTGCGGAAGATAATGAACACCAAGACCTACCTGGAGTGGCCCATGGACGAGGCTCAG CGGGAAGGATTTTGGGTAAATCTGAGAGCTGCGATAAAGTCCTAG Download Select all
CCDS ID	CCDS3784.1

Protein Information

Protein ID	NP_003255.2
Protein Name	Toll-like receptor 2
Molecular Wt. (Da)	87516
Protein Sequence	>7097 MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRI TYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTF LNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPK SLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTF RNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIP RFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACED AWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRI HSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAIT TFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQ DVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNIC YDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLS ENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDE AQREGFWVNLRAAIKS Download Select all
Length	784
Uniprot ID	P24855
Ensembl Protein ID	ENSP00000246949

Post-translational Modification Information (Source : HPRD)

No matching records could be found.

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
929	CD14	1151	NP_000582.1	in vivo	10395652
3146	HMGB1	1228	NP_002119.1	in vitro;in vivo	16267105
3654	IRAK1	2235	NP_001560.2	in vivo	10395652
6435	SFTPA1	1521	NP_005402.3	in vitro	11724772
7096	TLR1	3119	NP_003254.2	in vivo	12077222
7184	HSP90B1	1860	NP_003290.1	in vivo	11912201
8767	RIPK2	4585	NP_003812.1	in vivo	11894098
23162	MAPK8IP3	12014	NP_055948.2	in vivo	12941697
81793	TLR10	5884	NP_112218.2	in vivo	15728506
148022	TICAM1	6350	NP_891549.1	in vivo	12471095

Pathway Information

Pathway Name	Pathway ID
Amoebiasis	hsa05146
Chagas disease (American trypanosomiasis)	hsa05142
Hepatitis B	hsa05161
Herpes simplex infection	hsa05168
Inflammatory bowel disease (IBD)	hsa05321
Legionellosis	hsa05134
Leishmaniasis	hsa05140
Malaria	hsa05144
Measles	hsa05162
Phagosome	hsa04145
PI3K-Akt signaling pathway	hsa04151
Proteoglycans in cancer	hsa05205
Rheumatoid arthritis	hsa05323
Toll-like receptor signaling pathway	hsa04620
Toxoplasmosis	hsa05145
Tuberculosis	hsa05152

Structure Information

PDB ID	1FYW
Resolution	3
Method	X-RAY DIFFRACTION
Chains	A
Molecule	TOLL-LIKE RECEPTOR 2
Model	View

Domain Information

ID	Location	Description
smart00255	640-784	TIR
cl22869	640-784	TIR_2 superfamily
pfam01582	643-781	TIR
pfam13676	644-741	TIR_2
smart00082	533-586	LRRCT
cl15307	533-586	LRRCT superfamily
pfam13855	77-135	LRR_8
pfam13855	477-535	LRR_8
pfam13855	387-448	LRR_8
pfam13855	54-112	LRR_8
PRK15370	324-558	PRK15370
PLN03150	54-134	PLN03150
pfam13855	101-154	LRR_8
pfam13306	55-177	LRR_5
PRK15387	387-533	PRK15387
PLN00113	40-206	PLN00113
PLN00113	22-113	PLN00113
PLN00113	40-535	PLN00113
pfam13855	52-88	LRR_8

Ontology Information

HPRD ID	1563
Molecular Class	Cell surface receptor
Molecular Function	Peptidase activity (GO:0008233)
Biological Process	Protein metabolism (GO:0019538)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
O60603 DB00045 OspA lipoprotein BiotechDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO