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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TNF 7124 Tumor necrosis factor (TNF superfamily, member 2)  6DIF; TNFA; TNFSF2; TNF-alpha 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22480118   2012Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 XMap profiling technology, Up-regulation-During surgery, an increase in serum concentration of all determined mediators was noticed, with positive correlation between TNF-alpha, IL-8, MCP-1 and MIP-1alpha.

22581210   2012Cell line : -

Source : Medical Onchology Unit of Tor Vergata clinical center.

Sample Type : -

No. of Sample : 45 mCRC patients

Stage : TNM Stage IV

ImmunoassayUp-regulation-TNF-B levels were increased, and APC functionality was decreased in mCRC patients compared to age- and sex-matched controls.

TNF-B was confirmed as an independent 0predictor for APC abnormalities at multivariate regression analysis.

23170065   2012Cell line : -

Source : Digestive Diseases Clinic of Emory University.

Sample Type : -

No. of Sample : Colorectal cancer in colorectal adenoma patients 92

Stage : -

Inflammation biomarker analysesUp-regulation-TNF-B was statistically significantly higher in NSAID.


Gene Details



Chromosome: 6; NC_000006.11 (31543344..31546113)

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Gene Type protein coding
Gene Family Tumor necrosis factor (ligand) superfamily
Description This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]  
Chromosome 6
Location 6p21.3
Start 31575567  
End 31578336  
Strand +  
Gene Sequence

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Length 2770  
OMIM ID 191160   
HGNC ID HGNC:11892   
Unigene ID Hs.241570    
Ensembl ID ENSG00000232810   
PharmGKB ID PA435   

mRNA Information


mRNA ID NM_000594.3
Exon join(1..361,968..1013,1201..1248,1550..2770)  
mRNA Sequence

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Length 1686  



CDS Information


   
Location join(176..361,968..1013,1201..1248,1550..1971)
CDS Sequence

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CCDS ID CCDS4702.1



Protein Information


      
Protein IDNP_000585.2
Protein NameTumor necrosis factor (TNF superfamily, member 2)
Molecular Wt. (Da)25513
Protein Sequence

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Length 233  
Uniprot IDQ92608
Ensembl Protein ID ENSP00000256935  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KMyristoylation19
KMyristoylation20
AProteolytic Cleavage74
AProteolytic Cleavage74
SProteolytic Cleavage79
AProteolytic Cleavage76
AProteolytic Cleavage74
AProteolytic Cleavage76
SPhosphorylation2

Enzyme Information


   
EC3.4.24.86
NameADAM 17 endopeptidase
tumor necrosis factor alpha-converting enzyme
TACE
ClassHydrolases; Acting on peptide bonds (peptidases); Metalloendopeptidases
Sysname  
Substrate  
Product  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1435CSF1388NP_000748.3in vivo8336080   
1634DCN501NP_001911.1in vitro12387878   
5657PRTN31512NP_002768.3in vivo10339575   
7132TNFRSF1A1861NP_001056.1in vitro;in vivo106   342   091   474   321   000   000   000   
7133TNFRSF1B1862NP_001057.1in vitro;in vivo7   664   431   215   886   310   000   000   


Pathway Information


                                                                                                                                                                                                                                                                                                
Pathway Name Pathway ID
Adipocytokine signaling pathway hsa04920
African trypanosomiasis hsa05143
AGE-RAGE signaling pathway in diabetic complications hsa04933
Allograft rejection hsa05330
Alzheimer's disease hsa05010
Amoebiasis hsa05146
Amyotrophic lateral sclerosis (ALS) hsa05014
Antigen processing and presentation hsa04612
Apoptosis hsa04210
Asthma hsa05310
Chagas disease (American trypanosomiasis) hsa05142
Cytokine-cytokine receptor interaction hsa04060
Dilated cardiomyopathy hsa05414
Fc epsilon RI signaling pathway hsa04664
Graft-versus-host disease hsa05332
Hematopoietic cell lineage hsa04640
Hepatitis B hsa05161
Hepatitis C hsa05160
Herpes simplex infection hsa05168
HTLV-I infection hsa05166
Hypertrophic cardiomyopathy (HCM) hsa05410
Inflammatory bowel disease (IBD) hsa05321
Influenza A hsa05164
Insulin resistance hsa04931
Legionellosis hsa05134
Leishmaniasis hsa05140
Malaria hsa05144
MAPK signaling pathway hsa04010
mTOR signaling pathway hsa04150
Natural killer cell mediated cytotoxicity hsa04650
NF-kappa B signaling pathway hsa04064
NOD-like receptor signaling pathway hsa04621
Non-alcoholic fatty liver disease (NAFLD) hsa04932
Osteoclast differentiation hsa04380
Pertussis hsa05133
Proteoglycans in cancer hsa05205
Rheumatoid arthritis hsa05323
RIG-I-like receptor signaling pathway hsa04622
Sphingolipid signaling pathway hsa04071
Systemic lupus erythematosus hsa05322
T cell receptor signaling pathway hsa04660
TGF-beta signaling pathway hsa04350
TNF signaling pathway hsa04668
Toll-like receptor signaling pathway hsa04620
Toxoplasmosis hsa05145
Tuberculosis hsa05152
Type I diabetes mellitus hsa04940
Type II diabetes mellitus hsa04930


Structure Information


PDB ID1A8M
Resolution2.3
MethodX-RAY DIFFRACTION
Chains A,B,C  
Molecule TUMOR NECROSIS FACTOR ALPHA  
Model View



Domain Information




ID Location Description
cd0018488-231  TNF
cl0014788-231  TNF superfamily
pfam00229102-233  TNF
smart00207102-233  TNF


Ontology Information


   
HPRD ID544
Molecular ClassLigand
Molecular FunctionTransporter activity (GO:0005215)
Biological ProcessTransport (GO:0006810)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P01375DB00005EtanerceptBiotechDrug
P01375DB00051AdalimumabBiotechDrug
P01375DB00065InfliximabBiotechDrug
P01375DB00608ChloroquineSmallMoleculeDrug
P01375DB00668EpinephrineSmallMoleculeDrug
P01375DB00852PseudoephedrineSmallMoleculeDrug
P01375DB01041ThalidomideSmallMoleculeDrug
P01375DB01296GlucosamineSmallMoleculeDrug
P01375DB01407ClenbuterolSmallMoleculeDrug
P01375DB01411PranlukastSmallMoleculeDrug
P01375DB01427AmrinoneSmallMoleculeDrug
P01375DB02325Isopropyl AlcoholSmallMoleculeDrug
P01375DB05676ApremilastSmallMoleculeDrug
P01375DB06674golimumabBiotechDrug
P01375DB08904Certolizumab pegolBiotechDrug
P01375DB08910PomalidomideSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO