Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TNFAIP3 | 7128 | Tumor necrosis factor, alpha-induced protein 3 | 6 | A20; OTUD7C; TNFA1P2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22843550 | 2012 | Cell line : KM 12C, KM 12SM, HT 29 Source : ATCC. Sample Type : - No. of Sample : - Stage : - | SNP selection and real time RT-PCR TaqMan SNP genotyping, RT-PCR, Mutational analyses. | Polymorhpism | - | Anti-inflammatory gene TNFAIP3 may act as a novel tumor suppressor in CRC. A panel of SNPs in genes being involved in inflammation pathways, i.e. rs6920220 in TNFAIP3, Q705K in NLRP3 (rs35829419) and NF?B -94 ATTG ins/del (rs28362491) polymorphism could be used as prognostic markers to identify patients at high risk of rapid CRC progression and poor survival |
| 22930170 | 2012 | Cell line : - Source : County Hospital Ryhov, Jnk ping and University Hospital, Linkping, Sweden. Sample Type : Tissue and blood sample No. of Sample : Normal intestinal mucosal from the tumor 235 and/or normal blood samples 223 Stage : - | Microarray analysis,Real time RT-PCR and Flow cytometry | Up-regulation | - | Gene differentially expressed and analysed bye by Microarray. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | OTU domain containing |
| Description | This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012] |
| Chromosome | 6 |
| Location | 6q23 |
| Start | 137866317 |
| End | 137883314 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 16998 |
| OMIM ID | 191163 |
| HGNC ID | HGNC:11896 |
| Unigene ID | Hs.211600 |
| Ensembl ID | ENSG00000118503 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011536095.1 |
|---|---|
| Exon | join(1..237,544..656,4897..5206,8529..8719,9372..9519, 9680..9850,10760..10940,12116..13035,13755..13936, 14719..16996) | mRNA Sequence | Download Select all |
| Length | 4731 |
CDS Information
| Location | join(4912..5206,8529..8719,9372..9519,9680..9850, 10760..10940,12116..13035,13755..13936,14719..15003) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS5187.1 |
Protein Information
| Protein ID | NP_001257436.1 |
|---|---|
| Protein Name | Tumor necrosis factor, alpha-induced protein 3 |
| Molecular Wt. (Da) | 89483 |
| Protein Sequence | Download Select all |
| Length | 790 |
| Uniprot ID | P16444 |
| Ensembl Protein ID | ENSP00000261615 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 649;- |
| S | Phosphorylation | 575;- |
| S | Phosphorylation | 459 |
| Y | Phosphorylation | 306 |
| T | Phosphorylation | 321 |
| T | Phosphorylation | 322 |
| S | Phosphorylation | 645 |
| S | Phosphorylation | 573 |
| S | Phosphorylation | 578 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7533 | YWHAH | 215 | NP_003396.1 | in vitro;in vivo;yeast 2-hybrid | 87 027 219 299 557 |
| 7763 | ZFAND5 | 5302 | NP_005998.1 | in vivo | 14754897 |
| 8737 | RIPK1 | 4583 | NP_003795.2 | in vitro;in vivo | 15258597 |
| 148022 | TICAM1 | 6350 | NP_891549.1 | in vivo | 15474016 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Epstein-Barr virus infection | hsa05169 |
| Measles | hsa05162 |
| NF-kappa B signaling pathway | hsa04064 |
| NOD-like receptor signaling pathway | hsa04621 |
| TNF signaling pathway | hsa04668 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02338 | 98-257 | OTU |
| cl19932 | 98-257 | OTU superfamily |
| smart00259 | 759-784 | ZnF_A20 |
| cl23050 | 759-784 | ZnF_A20 superfamily |
| smart00259 | 475-500 | ZnF_A20 |
| cl23050 | 475-500 | ZnF_A20 superfamily |
| smart00259 | 604-629 | ZnF_A20 |
| cl23050 | 604-629 | ZnF_A20 superfamily |
| pfam01754 | 759-784 | zf-A20 |
| cl23515 | 759-784 | zf-A20 superfamily |
| pfam01754 | 384-407 | zf-A20 |
| cl23515 | 384-407 | zf-A20 superfamily |
| pfam01754 | 475-500 | zf-A20 |
| cl23515 | 475-500 | zf-A20 superfamily |
| smart00259 | 654-679 | ZnF_A20 |
| cl23050 | 654-679 | ZnF_A20 superfamily |
| smart00259 | 384-409 | ZnF_A20 |
| cl23050 | 384-409 | ZnF_A20 superfamily |
| smart00259 | 713-738 | ZnF_A20 |
| cl23050 | 713-738 | ZnF_A20 superfamily |
Ontology Information
| HPRD ID | 539 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.