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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TNXB 7148 Tenascin XB  6XB; TNX; XBS; EDS3; HXBL; TENX; TN-X; TNXB1; TNXB2; TNXBS 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysisUp-regulation-This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.

CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands.


Gene Details



Chromosome: 6; NC_000006.11 (32008932..32077151, complement)

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Gene Type protein coding
Gene Family Fibrinogen C domain containing, Fibronectin type III domain containing
Description This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 6
Location 6p21.3
Start 32041155  
End 32109374  
Strand +  
Gene Sequence

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Length 68220  
OMIM ID 600985   
HGNC ID HGNC:11976   
Unigene ID Hs.485104    
Ensembl ID ENSG00000168477   
PharmGKB ID -   

mRNA Information


mRNA ID NM_000500.7
Exon complement(<67705..>68220)  
mRNA Sequence

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Length 2131  



CDS Information


   
Locationjoin(11177..11579,11926..13764,14184..14299,19996..20152, 20327..20590,23257..23625,24666..24962,27049..27339, 27702..28007,30010..30342,35423..35728,37077..37385, 38961..39248,39514..39822,40239..40553,40668..40985, 41391..41714,44258..44554,46892..47218,47655..47978, 50985..51317,52472..52789,53201..53524,55670..55987, 56382..56705,59054..59377,59788..60105,60725..61012
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_061978.6
Protein NameTenascin XB
Molecular Wt. (Da)455791
Protein Sequence

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Length 4242  
Uniprot IDP27487
Ensembl Protein ID ENSP00000353731  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation3174;-
SPhosphorylation3691
SPhosphorylation122
TPhosphorylation1244
TPhosphorylation1245

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
7422VEGFA1889NP_001020537.2in vitro11122379   
7423VEGFB3237NP_003368.1in vitro;in vivo;yeast 2-hybrid11122379   


Pathway Information


                        
Pathway Name Pathway ID
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
MicroRNAs in cancer hsa05206
PI3K-Akt signaling pathway hsa04151


Structure Information


PDB ID2CUH
Resolution-
MethodSOLUTION NMR
Chains A  
Molecule Tenascin-X  
Model View



Domain Information




ID Location Description
cd000874023-4233  FReD
cl000854023-4233  FReD superfamily
cd000633757-3836  FN3
cl215223757-3836  FN3 superfamily
cd000631156-1238  FN3
cl215221156-1238  FN3 superfamily
cd000631062-1131  FN3
cl215221062-1131  FN3 superfamily
cd000631575-1663  FN3
cl215221575-1663  FN3 superfamily
cd000631472-1560  FN3
cl215221472-1560  FN3 superfamily
cd000633159-3250  FN3
cl215223159-3250  FN3 superfamily
cd000633359-3438  FN3
cl215223359-3438  FN3 superfamily
cd00063841-921  FN3
cl21522841-921  FN3 superfamily
cd000632837-2928  FN3
cl215222837-2928  FN3 superfamily
cd000632307-2389  FN3
cl215222307-2389  FN3 superfamily
cd000631993-2073  FN3
cl215221993-2073  FN3 superfamily
cd000631671-1739  FN3
cl215221671-1739  FN3 superfamily
cd000633053-3144  FN3
cl215223053-3144  FN3 superfamily
cd000632517-2591  FN3
cl215222517-2591  FN3 superfamily
cd000632101-2181  FN3
cl215222101-2181  FN3 superfamily
cd000633447-3513  FN3
cl215223447-3513  FN3 superfamily
cd000632418-2497  FN3
cl215222418-2497  FN3 superfamily
cd000632623-2714  FN3
cl215222623-2714  FN3 superfamily
cd000631267-1347  FN3
cl215221267-1347  FN3 superfamily
cd000633560-3639  FN3
cl215223560-3639  FN3 superfamily
cd000632743-2822  FN3
cl215222743-2822  FN3 superfamily
cd000631773-1862  FN3
cl215221773-1862  FN3 superfamily
cd000632957-3036  FN3
cl215222957-3036  FN3 superfamily
cd000632188-2277  FN3
cl215222188-2277  FN3 superfamily
cd000633932-4017  FN3
cl215223932-4017  FN3 superfamily
cd000631370-1458  FN3
cl215221370-1458  FN3 superfamily
cd00063753-838  FN3
cl21522753-838  FN3 superfamily
cd000633843-3929  FN3
cl215223843-3929  FN3 superfamily
cd000631887-1955  FN3
cl215221887-1955  FN3 superfamily
cd000633657-3732  FN3
cl215223657-3732  FN3 superfamily
cd000633266-3346  FN3
cl215223266-3346  FN3 superfamily
pfam001474024-4233  Fibrinogen_C
smart001864024-4233  FBG
pfam000413757-3834  fn3
pfam000411991-2061  fn3
pfam000412307-2377  fn3
pfam000412846-2916  fn3
pfam000412632-2702  fn3
pfam000413062-3132  fn3
pfam000411061-1141  fn3
pfam000412198-2268  fn3
pfam000413357-3426  fn3
pfam000411265-1342  fn3
pfam000411581-1643  fn3
pfam00041841-919  fn3
pfam000412526-2596  fn3
pfam000413168-3238  fn3
pfam000411478-1555  fn3
pfam000412099-2169  fn3
pfam000413451-3513  fn3
pfam000413560-3635  fn3
pfam000412743-2810  fn3
pfam000412418-2485  fn3
pfam00041762-831  fn3
smart000601156-1227  FN3
pfam000411163-1240  fn3
pfam000412957-3024  fn3
pfam000411672-1739  fn3
smart000601061-1128  FN3
smart000601575-1643  FN3
smart000603359-3419  FN3
pfam000413657-3736  fn3
smart000603756-3832  FN3
smart00060841-914  FN3
smart000602517-2591  FN3
smart000603447-3513  FN3
pfam000413933-4010  fn3
pfam000411376-1446  fn3
smart000602837-2911  FN3
smart000601472-1539  FN3
smart000603159-3233  FN3
smart000603560-3620  FN3
pfam000413264-3326  fn3
smart000601671-1739  FN3
smart000603053-3127  FN3
smart000602101-2164  FN3
smart000601993-2056  FN3
pfam000411780-1842  fn3
smart000603933-4001  FN3
smart000601267-1330  FN3
smart000602623-2697  FN3
smart000602418-2480  FN3
smart000602307-2372  FN3
pfam000411885-1955  fn3
smart000602188-2263  FN3
smart000602957-3019  FN3
smart000601773-1842  FN3
smart000602743-2805  FN3
pfam000413844-3916  fn3
smart000601378-1441  FN3
smart000603657-3732  FN3
smart000603843-3912  FN3
smart000601887-1955  FN3
pfam04885281-357  Stig1
cl20279281-357  Stig1 superfamily
smart00060753-829  FN3
smart000603258-3326  FN3
pfam04885250-326  Stig1
pfam07974621-647  EGF_2
cl21504621-647  EGF_CA superfamily
pfam07974219-244  EGF_2
cl21504219-244  EGF_CA superfamily
pfam07974405-430  EGF_2
cl21504405-430  EGF_CA superfamily
pfam07974498-523  EGF_2
cl21504498-523  EGF_CA superfamily
pfam07974244-275  EGF_2
cl21504244-275  EGF_CA superfamily
pfam04885365-450  Stig1
cl20279365-450  Stig1 superfamily
pfam07974554-585  EGF_2
cl21504554-585  EGF_CA superfamily
pfam07974467-492  EGF_2
cl21504467-492  EGF_CA superfamily
pfam07974189-213  EGF_2
cl21504189-213  EGF_CA superfamily
pfam07974368-399  EGF_2
cl21504368-399  EGF_CA superfamily
pfam07974284-306  EGF_2
cl21504284-306  EGF_CA superfamily
pfam04885396-481  Stig1
pfam00757520-658  Furin-like
PTZ00214254-669  PTZ00214
PTZ00214251-577  PTZ00214
pfam01500191-348  Keratin_B2
pfam00757212-342  Furin-like
pfam06247321-468  Plasmod_Pvs28


Ontology Information


   
HPRD ID10343
Molecular ClassExtracellular matrix protein
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO