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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TNXB | 7148 | Tenascin XB  | 6 | XB; TNX; XBS; EDS3; HXBL; TENX; TN-X; TNXB1; TNXB2; TNXBS  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989    | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Fibrinogen C domain containing, Fibronectin type III domain containing |
| Description | This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]   |
| Chromosome | 6 |
| Location | 6p21.3 |
| Start | 32041155   |
| End | 32109374   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 68220   |
| OMIM ID | 600985    |
| HGNC ID | HGNC:11976    |
| Unigene ID | Hs.485104     |
| Ensembl ID | ENSG00000168477    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_000500.7 |
|---|---|
| Exon | complement(<67705..>68220)   | mRNA Sequence |    Download   Select all |
| Length | 2131   |
CDS Information
| Location | join(11177..11579,11926..13764,14184..14299,19996..20152, 20327..20590,23257..23625,24666..24962,27049..27339, 27702..28007,30010..30342,35423..35728,37077..37385, 38961..39248,39514..39822,40239..40553,40668..40985, 41391..41714,44258..44554,46892..47218,47655..47978, 50985..51317,52472..52789,53201..53524,55670..55987, 56382..56705,59054..59377,59788..60105,60725..61012 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_061978.6 |
|---|---|
| Protein Name | Tenascin XB |
| Molecular Wt. (Da) | 455791 |
| Protein Sequence |    Download   Select all |
| Length | 4242   |
| Uniprot ID | P27487 |    
| Ensembl Protein ID | ENSP00000353731   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 3174;- |
| S | Phosphorylation | 3691 |
| S | Phosphorylation | 122 |
| T | Phosphorylation | 1244 |
| T | Phosphorylation | 1245 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7422 |    VEGFA |    1889 |    NP_001020537.2 |    in vitro |    11122379    |
| 7423 |    VEGFB |    3237 |    NP_003368.1 |    in vitro;in vivo;yeast 2-hybrid |    11122379    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| ECM-receptor interaction |    hsa04512 |    
| Focal adhesion |    hsa04510 |    
| MicroRNAs in cancer |    hsa05206 |    
| PI3K-Akt signaling pathway |    hsa04151 |    
Structure Information
| PDB ID | 2CUH |
|---|---|
| Resolution | - |
| Method | SOLUTION NMR |
| Chains | A   |
| Molecule | Tenascin-X   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00087 | 4023-4233  | FReD |
| cl00085 | 4023-4233  | FReD superfamily |
| cd00063 | 3757-3836  | FN3 |
| cl21522 | 3757-3836  | FN3 superfamily |
| cd00063 | 1156-1238  | FN3 |
| cl21522 | 1156-1238  | FN3 superfamily |
| cd00063 | 1062-1131  | FN3 |
| cl21522 | 1062-1131  | FN3 superfamily |
| cd00063 | 1575-1663  | FN3 |
| cl21522 | 1575-1663  | FN3 superfamily |
| cd00063 | 1472-1560  | FN3 |
| cl21522 | 1472-1560  | FN3 superfamily |
| cd00063 | 3159-3250  | FN3 |
| cl21522 | 3159-3250  | FN3 superfamily |
| cd00063 | 3359-3438  | FN3 |
| cl21522 | 3359-3438  | FN3 superfamily |
| cd00063 | 841-921  | FN3 |
| cl21522 | 841-921  | FN3 superfamily |
| cd00063 | 2837-2928  | FN3 |
| cl21522 | 2837-2928  | FN3 superfamily |
| cd00063 | 2307-2389  | FN3 |
| cl21522 | 2307-2389  | FN3 superfamily |
| cd00063 | 1993-2073  | FN3 |
| cl21522 | 1993-2073  | FN3 superfamily |
| cd00063 | 1671-1739  | FN3 |
| cl21522 | 1671-1739  | FN3 superfamily |
| cd00063 | 3053-3144  | FN3 |
| cl21522 | 3053-3144  | FN3 superfamily |
| cd00063 | 2517-2591  | FN3 |
| cl21522 | 2517-2591  | FN3 superfamily |
| cd00063 | 2101-2181  | FN3 |
| cl21522 | 2101-2181  | FN3 superfamily |
| cd00063 | 3447-3513  | FN3 |
| cl21522 | 3447-3513  | FN3 superfamily |
| cd00063 | 2418-2497  | FN3 |
| cl21522 | 2418-2497  | FN3 superfamily |
| cd00063 | 2623-2714  | FN3 |
| cl21522 | 2623-2714  | FN3 superfamily |
| cd00063 | 1267-1347  | FN3 |
| cl21522 | 1267-1347  | FN3 superfamily |
| cd00063 | 3560-3639  | FN3 |
| cl21522 | 3560-3639  | FN3 superfamily |
| cd00063 | 2743-2822  | FN3 |
| cl21522 | 2743-2822  | FN3 superfamily |
| cd00063 | 1773-1862  | FN3 |
| cl21522 | 1773-1862  | FN3 superfamily |
| cd00063 | 2957-3036  | FN3 |
| cl21522 | 2957-3036  | FN3 superfamily |
| cd00063 | 2188-2277  | FN3 |
| cl21522 | 2188-2277  | FN3 superfamily |
| cd00063 | 3932-4017  | FN3 |
| cl21522 | 3932-4017  | FN3 superfamily |
| cd00063 | 1370-1458  | FN3 |
| cl21522 | 1370-1458  | FN3 superfamily |
| cd00063 | 753-838  | FN3 |
| cl21522 | 753-838  | FN3 superfamily |
| cd00063 | 3843-3929  | FN3 |
| cl21522 | 3843-3929  | FN3 superfamily |
| cd00063 | 1887-1955  | FN3 |
| cl21522 | 1887-1955  | FN3 superfamily |
| cd00063 | 3657-3732  | FN3 |
| cl21522 | 3657-3732  | FN3 superfamily |
| cd00063 | 3266-3346  | FN3 |
| cl21522 | 3266-3346  | FN3 superfamily |
| pfam00147 | 4024-4233  | Fibrinogen_C |
| smart00186 | 4024-4233  | FBG |
| pfam00041 | 3757-3834  | fn3 |
| pfam00041 | 1991-2061  | fn3 |
| pfam00041 | 2307-2377  | fn3 |
| pfam00041 | 2846-2916  | fn3 |
| pfam00041 | 2632-2702  | fn3 |
| pfam00041 | 3062-3132  | fn3 |
| pfam00041 | 1061-1141  | fn3 |
| pfam00041 | 2198-2268  | fn3 |
| pfam00041 | 3357-3426  | fn3 |
| pfam00041 | 1265-1342  | fn3 |
| pfam00041 | 1581-1643  | fn3 |
| pfam00041 | 841-919  | fn3 |
| pfam00041 | 2526-2596  | fn3 |
| pfam00041 | 3168-3238  | fn3 |
| pfam00041 | 1478-1555  | fn3 |
| pfam00041 | 2099-2169  | fn3 |
| pfam00041 | 3451-3513  | fn3 |
| pfam00041 | 3560-3635  | fn3 |
| pfam00041 | 2743-2810  | fn3 |
| pfam00041 | 2418-2485  | fn3 |
| pfam00041 | 762-831  | fn3 |
| smart00060 | 1156-1227  | FN3 |
| pfam00041 | 1163-1240  | fn3 |
| pfam00041 | 2957-3024  | fn3 |
| pfam00041 | 1672-1739  | fn3 |
| smart00060 | 1061-1128  | FN3 |
| smart00060 | 1575-1643  | FN3 |
| smart00060 | 3359-3419  | FN3 |
| pfam00041 | 3657-3736  | fn3 |
| smart00060 | 3756-3832  | FN3 |
| smart00060 | 841-914  | FN3 |
| smart00060 | 2517-2591  | FN3 |
| smart00060 | 3447-3513  | FN3 |
| pfam00041 | 3933-4010  | fn3 |
| pfam00041 | 1376-1446  | fn3 |
| smart00060 | 2837-2911  | FN3 |
| smart00060 | 1472-1539  | FN3 |
| smart00060 | 3159-3233  | FN3 |
| smart00060 | 3560-3620  | FN3 |
| pfam00041 | 3264-3326  | fn3 |
| smart00060 | 1671-1739  | FN3 |
| smart00060 | 3053-3127  | FN3 |
| smart00060 | 2101-2164  | FN3 |
| smart00060 | 1993-2056  | FN3 |
| pfam00041 | 1780-1842  | fn3 |
| smart00060 | 3933-4001  | FN3 |
| smart00060 | 1267-1330  | FN3 |
| smart00060 | 2623-2697  | FN3 |
| smart00060 | 2418-2480  | FN3 |
| smart00060 | 2307-2372  | FN3 |
| pfam00041 | 1885-1955  | fn3 |
| smart00060 | 2188-2263  | FN3 |
| smart00060 | 2957-3019  | FN3 |
| smart00060 | 1773-1842  | FN3 |
| smart00060 | 2743-2805  | FN3 |
| pfam00041 | 3844-3916  | fn3 |
| smart00060 | 1378-1441  | FN3 |
| smart00060 | 3657-3732  | FN3 |
| smart00060 | 3843-3912  | FN3 |
| smart00060 | 1887-1955  | FN3 |
| pfam04885 | 281-357  | Stig1 |
| cl20279 | 281-357  | Stig1 superfamily |
| smart00060 | 753-829  | FN3 |
| smart00060 | 3258-3326  | FN3 |
| pfam04885 | 250-326  | Stig1 |
| pfam07974 | 621-647  | EGF_2 |
| cl21504 | 621-647  | EGF_CA superfamily |
| pfam07974 | 219-244  | EGF_2 |
| cl21504 | 219-244  | EGF_CA superfamily |
| pfam07974 | 405-430  | EGF_2 |
| cl21504 | 405-430  | EGF_CA superfamily |
| pfam07974 | 498-523  | EGF_2 |
| cl21504 | 498-523  | EGF_CA superfamily |
| pfam07974 | 244-275  | EGF_2 |
| cl21504 | 244-275  | EGF_CA superfamily |
| pfam04885 | 365-450  | Stig1 |
| cl20279 | 365-450  | Stig1 superfamily |
| pfam07974 | 554-585  | EGF_2 |
| cl21504 | 554-585  | EGF_CA superfamily |
| pfam07974 | 467-492  | EGF_2 |
| cl21504 | 467-492  | EGF_CA superfamily |
| pfam07974 | 189-213  | EGF_2 |
| cl21504 | 189-213  | EGF_CA superfamily |
| pfam07974 | 368-399  | EGF_2 |
| cl21504 | 368-399  | EGF_CA superfamily |
| pfam07974 | 284-306  | EGF_2 |
| cl21504 | 284-306  | EGF_CA superfamily |
| pfam04885 | 396-481  | Stig1 |
| pfam00757 | 520-658  | Furin-like |
| PTZ00214 | 254-669  | PTZ00214 |
| PTZ00214 | 251-577  | PTZ00214 |
| pfam01500 | 191-348  | Keratin_B2 |
| pfam00757 | 212-342  | Furin-like |
| pfam06247 | 321-468  | Plasmod_Pvs28 |
Ontology Information
| HPRD ID | 10343 |    
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
