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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TOP2A 7153 topoisomerase (DNA) II alpha 170kDa  17- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25777966   2015Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

FISH Amplification-TOP1 and TOP2A gene copy numbers are increased in the pMMR subgroup.

20813715   2010Cell line : -

Source : -

Sample Type : CRC Tumor

No. of Sample : 18 proficient MMR CRC and 18 deficient MMR CRC, FFPE 154

Stage : TNM Stage III

Immunohistochemistry and real-time RT-PCR .Up-regulation-TOP2A plays an important role in the invasion and metastasis of the colorectal carcinomas, and may serve as a valuable indicator for the diagnosis, treatment and the prognostic evaluation of the malignancy.


Gene Details



NC_000017.10 (38544773..38574202, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]  
Chromosome 17
Location 17q21-q22
Start 38544773  
End 38574202  
Strand -  
Gene Sequence

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Length 29430  
OMIM ID 126430   
HGNC ID HGNC:11989   
Unigene ID Hs.156346   
Ensembl ID ENSG00000131747   
PharmGKB ID PA354   

mRNA Information


mRNA ID ?NM_001067.3
Exon join(1..180,1056..1211,1439..1529,1883..1946,4326..4471, 4659..4756,4980..5192,6133..6306,6496..6597,6705..6842, 9321..9459,9827..9984,10277..10402,11009..11119, 11262..11367,11458..11567,13068..13160,13460..13574, 13678..13799,14897..15045,16870..17101,17288..17422, 17542..17742,17884..18079,18820..18911,19014..19178, 19310..19393,21486..21668,22412..22502,25214..25366, 25610..25733,25840..25883,26311..26445,27787..27986, 28304..29430)  
mRNA Sequence

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Length 5753  



CDS Information


   
Location160..4755
CDS Sequence

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CCDS ID CCDS45672.1



Protein Information


      
Protein IDNP_001058.2
Protein Nametopoisomerase (DNA) II alpha 170kDa
Molecular Wt. (Da)69493
Protein Sequence

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Length 1531  
Uniprot IDO60315
Ensembl Protein ID ENSP00000386854  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1106
SPhosphorylation1474
TPhosphorylation1343
SPhosphorylation1377
SPhosphorylation1469
SPhosphorylation1525
SPhosphorylation1213
SPhosphorylation1247
SPhosphorylation1354
SPhosphorylation1361
SPhosphorylation1393
SPhosphorylation29
SPhosphorylation29
SPhosphorylation29
SPhosphorylation1469
SPhosphorylation1247
SPhosphorylation1377
SPhosphorylation1354
SPhosphorylation1213
SPhosphorylation1295
SPhosphorylation1297
SPhosphorylation1351
SPhosphorylation1387
SPhosphorylation1213;-
SPhosphorylation1525;-
TPhosphorylation1244
TPhosphorylation1327
SPhosphorylation1337
SPhosphorylation1332
TPhosphorylation1358
SPhosphorylation1374
SPhosphorylation1391
SPhosphorylation1392
TPhosphorylation1397
SPhosphorylation1449
SPhosphorylation1452
TPhosphorylation1470
SPhosphorylation1471
SPhosphorylation1491
SPhosphorylation1495
SPhosphorylation1504
SPhosphorylation4
SPhosphorylation1302
SPhosphorylation1476
TPhosphorylation282
SPhosphorylation1303
TPhosphorylation1403
SPhosphorylation1115
SPhosphorylation1117
SPhosphorylation1162
SPhosphorylation1164
SPhosphorylation1306
SPhosphorylation1299
SPhosphorylation285
TPhosphorylation1205
SPhosphorylation230
TPhosphorylation1360
SPhosphorylation1365
YPhosphorylation1521
SPhosphorylation707

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
6732SRPK115992NP_003128.3in vivo15034300   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00187711-1174  TOP4c
cl19084711-1174  TOP4c superfamily
cd03481265-417  TopoIIA_Trans_ScTopoIIA
cl02783265-417  TopoII_MutL_Trans superfamily
cd03365455-575  TOPRIM_TopoIIA
cl00718455-575  TOPRIM superfamily
cd0007581-182  HATPase_c
cl0007581-182  HATPase_c superfamily
cd01030455-575  TOPRIM_TopoIIA_like
pfam080701435-1523  DTHCT
cl068991435-1523  DTHCT superfamily
pfam00204266-425  DNA_gyraseB
cd03366455-565  TOPRIM_TopoIIA_GyrB
cd00329267-379  TopoII_MutL_Trans
pfam0251880-193  HATPase_c
smart0038780-180  HATPase_c
cd00822266-379  TopoII_Trans_DNA_gyrase
pfam01751456-571  Toprim
cd00188455-566  TOPRIM
pfam1358987-194  HATPase_c_3
PTZ0010825-1497  PTZ00108
PLN0312829-1179  PLN03128
PLN032378-1480  PLN03237
smart0043380-669  TOP2c
smart00434693-1169  TOP4c
pfam00521713-1171  DNA_topoisoIV
COG018734-672  GyrB
PHA0256941-666  39
PHA02592691-1179  52
COG0188697-1080  GyrA
PRK0555940-617  PRK05559
TIGR0105940-617  gyrB
TIGR0105840-617  parE_Gpos
PRK0564440-617  gyrB
TIGR0105579-665  parE_Gneg
PRK09631712-1073  PRK09631
PTZ00109266-655  PTZ00109
TIGR01063713-1089  gyrA
PRK14939105-586  gyrB
PRK09630712-934  PRK09630
TIGR01062712-1038  parC_Gneg
TIGR01061712-874  parC_Gpos
PRK12758712-867  PRK12758
PRK05561712-958  PRK05561
PRK13979712-884  PRK13979
PRK05560713-902  PRK05560
PRK138081353-1491  PRK13808


Ontology Information


   
HPRD ID14391
Molecular ClassEnzyme: Topoisomerase
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P11388DB00218MoxifloxacinSmallMoleculeDrug
P11388DB00276AmsacrineSmallMoleculeDrug
P11388DB00380DexrazoxaneSmallMoleculeDrug
P11388DB00385ValrubicinSmallMoleculeDrug
P11388DB00444TeniposideSmallMoleculeDrug
P11388DB00445EpirubicinSmallMoleculeDrug
P11388DB00467EnoxacinSmallMoleculeDrug
P11388DB00487PefloxacinSmallMoleculeDrug
P11388DB00537CiprofloxacinSmallMoleculeDrug
P11388DB00685TrovafloxacinSmallMoleculeDrug
P11388DB00694DaunorubicinSmallMoleculeDrug
P11388DB00773EtoposideSmallMoleculeDrug
P11388DB00970DactinomycinSmallMoleculeDrug
P11388DB00978LomefloxacinSmallMoleculeDrug
P11388DB00997DoxorubicinSmallMoleculeDrug
P11388DB01059NorfloxacinSmallMoleculeDrug
P11388DB01137LevofloxacinSmallMoleculeDrug
P11388DB01165OfloxacinSmallMoleculeDrug
P11388DB01177IdarubicinSmallMoleculeDrug
P11388DB01179PodofiloxSmallMoleculeDrug
P11388DB01204MitoxantroneSmallMoleculeDrug
P11388DB01208SparfloxacinSmallMoleculeDrug
P11388DB04576FleroxacinSmallMoleculeDrug
P11388DB04967LucanthoneSmallMoleculeDrug
P11388DB09047FinafloxacinSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO