CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
26362504	2015	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 50 colorectal cancer patients Stage : -	RT-PCR,RNA interference,Transwell invasion assay,Immunohistochemistry ,Western blotting	Mutation	-	In colorectal adenocarcinomas, p53 mutation correlated with high NF-?B, Fascin and low E-cadherin expression.
25945089	2015	Cell line : - Source : Adnan Menderes University Hospital, Aydin, Turkey Sample Type : CRC Tumor and adjescent tissue No. of Sample : 457 Stage : Duke Stage A-C	Immunohistochemistry	Up-regulation	-	NF-?B, p53, and Ki-67 expressions were significantly higher in the metastatic lymph nodes compared to the primary tumor tissues .
25973304	2015	Cell line : RKO, HT 29, DLD1, LOVO, HCT116, SW480, SW620 Source : Chinese PLA General Hospital. Sample Type : CRC Tumor No. of Sample : 102 Stage : TNM Stage I-IV	real time RT-PCR, methylation specific PCR, Flow cytometry and western blotting	Up-regulation	-	BCL6B suppresses colorectal cancer growth by activating P53 signaling.
9539318	1998	Cell line : HCT116 Source : - Sample Type : - No. of Sample : - Stage : Duke Stage B,C,D.	ELISA	Up-regulation	-	Mutant p53 protein might be used as a potential biomarker in the management of patients with colorectal cancer. Serum levels of the mutant p53 protein in patients with colorectal cancer (mean=0.97+/-0.14 ng/ml, ranged from 0.7 ng/ml to 1.37 ng/ml, n=50) were significantly greater than those in patients with adenomatous polyp (mean=0.73+/-0.06 ng/ml, ranged from 0.69 ng/ml to 0.83 ng/ml) (p<0.001).

Gene Details

Chromosome 17 - NC_000017.11 (7668402..7687550, complement)
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Gene Type	protein coding
Gene Family
Description	This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).
Chromosome	17
Location	17p13.1
Start	7668402
End	7687550
Strand	-
Gene Sequence	>gi|568815581:c7687550-7668402 Homo sapiens chromosome 17, GRCh38.p2 Primary Assembly GATGGGATTGGGGTTTTCCCCTCCCATGTGCTCAAGACTGGCGCTAAAAGTTTTGAGCTTCTCAAAAGTC TAGAGCCACCGTCCAGGGAGCAGGTAGCTGCTGGGCTCCGGGGACACTTTGCGTTCGGGCTGGGAGCGTG CTTTCCACGACGGTGACACGCTTCCCTGGATTGGGTAAGCTCCTGACTGAACTTGATGAGTCCTCTCTGA GTCACGGGCTCTCGGCTCCGTGTATTTTCAGCTCGGGAAAATCGCTGGGGCTGGGGGTGGGGCAGTGGGG ACTTAGCGAGTTTGGGGGTGAGTGGGATGGAAGCTTGGCTAGAGGGATCATCATAGGAGTTGCATTGTTG GGAGACCTGGGTGTAGATGATGGGGATGTTAGGACCATCCGAACTCAAAGTTGAACGCCTAGGCAGAGGA GTGGAGCTTTGGGGAACCTTGAGCCGGCCTAAAGCGTACTTCTTTGCACATCCACCCGGTGCTGGGCGTA GGGAATCCCTGAAATAAAAGATGCACAAAGCATTGAGGTCTGAGACTTTTGGATCTCGAAACATTGAGAA CTCATAGCTGTATATTTTAGAGCCCATGGCATCCTAGTGAAAACTGGGGCTCCATTCCGAAATGATCATT TGGGGGTGATCCGGGGAGCCCAAGCTGCTAAGGTCCCACAACTTCCGGACCTTTGTCCTTCCTGGAGCGA TCTTTCCAGGCAGCCCCCGGCTCCGCTAGATGGAGAAAATCCAATTGAAGGCTGTCAGTCGTGGAAGTGA GAAGTGCTAAACCAGGGGTTTGCCCGCCAGGCCGAGGAGGACCGTCGCAATCTGAGAGGCCCGGCAGCCC TGTTATTGTTTGGCTCCACATTTACATTTCTGCCTCTTGCAGCAGCATTTCCGGTTTCTTTTTGCCGGAG CAGCTCACTATTCACCCGATGAGAGGGGAGGAGAGAGAGAGAAAATGTCCTTTAGGCCGGTTCCTCTTAC TTGGCAGAGGGAGGCTGCTATTCTCCGCCTGCATTTCTTTTTCTGGATTACTTAGTTATGGCCTTTGCAA AGGCAGGGGTATTTGTTTTGATGCAAACCTCAATCCCTCCCCTTCTTTGAATGGTGTGCCCCACCCCGCG GGTCGCCTGCAACCTAGGCGGACGCTACCATGGCGTGAGACAGGGAGGGAAAGAAGTGTGCAGAAGGCAA GCCCGGAGGTATTTTCAAGAATGAGTATATCTCATCTTCCCGGAGGAAAAAAAAAAAGAATGGGTACGTC TGAGAATCAAATTTTGAAAGAGTGCAATGATGGGTCGTTTGATAATTTGTCGGAAAAACAATCTACCTGT TATCTAGCTTTGGGCTAGGCCATTCCAGTTCCAGACGCAGGCTGAACGTCGTGAAGCGGAAGGGGCGGGC CCGCAGGCGTCCGTGTGGTCCTCCGTGCAGCCCTCCGGCCCGAGCCGGTTCTTCCTGGTAGGAGGCGGAA CTCGAATTCATTTCTCCCGCTGCCCCATCTCTTAGCTCGCGGTTGTTTCATTCCGCAGTTTCTTCCCATG CACCTGCCGCGTACCGGCCACTTTGTGCCGTACTTACGTCATCTTTTTCCTAAATCGAGGTGGCATTTAC ACACAGCGCCAGTGCACACAGCAAGTGCACAGGAAGATGAGTTTTGGCCCCTAACCGCTCCGTGATGCCT ACCAAGTCACAGACCCTTTTCATCGTCCCAGAAACGTTTCATCACGTCTCTTCCCAGTCGATTCCCGACC CCACCTTTATTTTGATCTCCATAACCATTTTGCCTGTTGGAGAACTTCATATAGAATGGAATCAGGCTGG GCGCTGTGGCTCACGCCTGCACTTTGGGAGGCCGAGGCGGGCGGATTACTTGAGGATAGGAGTTCCAGAC CAGCGTGGCCAACGTGGTGAATCCCCGTCTCTACTAAAAAATACAAAAATTAGCTGGGCGTGGTGGGTGC CTGTAATCCCAGCTATTCGGGAGGGTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTG AGCCAAGATCGTGCCACTACACTCCAGCCTGGGCGACAAGAACGAAACTCCGTCTCAAAAAAAAGGGGGG AATCATACATTATGTGCTCATTTTTGTCGGGCTTCTGTCCTTCAATGTACTGTCTGACATTCGTTCATGT TGTATATATCAGTATTTTGCTCCTTTTCATTTAGTATAGTCCATCGATTGTATATCCGTCCTTTTGATGG CCTTTTGAGTTGTTTCCCATTTGCGGTTATGAAATAAAGCTGCTATAAACATTCTTGTACAATTCTTTTT GTGATCATATGTTTTCGTGTTTCTTGGAGAAATACTTAGGAGGGGAATTGCGAGTTTGGAAGTAAAAAGT AGCTGTATTTTGAACTTTTTCAGAAGCTCTGAGTTTTCCAGAGCGGTTGTACCATTTTACACTCCAACTA GCAAGGTATGGGAGTTATTATGGTTGTGCCACAGCCTTCCGGACATTAGGTATTGTCAGTCTTTCTAATG TGGTATATCCTTGTGGTTGTAATTTACAGTTCTCTATTGACTAAGGATGTTCAGCATTTTTTCATGTGCC TATTGGCCATTCGTATTTTGTTTGTAAAGTAGCTCTTCGAGTCTTTTACCTGTTATTTTGGTTTTTTGTT TGTTTTTATTGTTCAGTTGTGGGACTGCTTTATACATTCTGGATACAAGTCCTTTATCAGATCCATGTGT CGTGAATGTTTTCTTCTGATCTGTTGCTTGCCTATTTGTTTGCTTTACAGAGTTTACAGTATCTTAAGAG GAGTGGATTTATCTTTTTTATGTTCAGTATTTGCCTTGTCCTGTTTAGGACATCTTTTTTTTTTTTTTTA ACCCCAGGGTCATGAAGATATTATCTTACATTTTCTTTTAGGACCTTTATGGTTGTAAGTTTTACAGTAA GGTCCTTGAGCCATTAATTAATTCTTAAAATTAATTGTTTATGGTGTGAGGTGTAGGAGTCAGTCTCTGG TATCTTTCCTGTATGGAAATCCAGTTATTCTGTCTCCACTTGTTGAAATAGGCTTCCTTTCTCTACTGAA TGCTTTTAATTTTAATTATTTTACAGTTGGAGTATAGGGCTACCATTTTAGTGCTATTTTCTTTTTTTCT TTGTTAATTTTTGAGACAGGGACTCACACTGTTGCCCAGGCTAGAGTACAATGGCACAATCAAGGCTTAC TGCAGCCTCGAACCCCTGGGCTCAAGCAGTCCTCTAGCAGCCTCACGAGTAGCTGGGATTACTCCACCAC ACCCAGCTAACTATTTTATTTTTTTGTATTGACAGGATCTCACTATGTTGCCCAGGCTGGTCTCAAACTG CTGGCCTCAAGCTTTCATCCCATCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCATGCCT GACCTCTTAGTGCTATTTTCTATTTATCTCCTCTGTTCTCTGCTCTCTTTAAACGTTGGAGGAAGAAACA GTACCCATCTTACACAAACTCTTCAGAAAACAGAGGAACAGACTGGGCGCGGTGGCTCATACCTGTAATC TCAGCACTTTGGTACGCTGAGGCAGGGGATCATTTGAGGTCGGGAGTTCGAGACCAGCCTGGCCAACACG GCGAAACCCCATCTCTACTAAAAATACAAAAAGTAGCTAGGCGTGGTGACACATACCTGTAATGCCAGTT ACTCAGGAGGCTGAGGCACAAGAATCCCTTGAACCTGGGAAGCGGAGGTTGCAGTGAGCCGAGATTGCGC CACTGCACTCCAGCCTGGGCAACAGAGTGAGACCCTGTCTCAGAAAAAAAAAGAAAGAAAGAAAAAATAG AGGAATATTTCCCAACTTGTTTTCGAAGCCAGCATAATCCTGGTACCAAAACCAAACAAGGACATTATAA GAAAAGAAAATATAGACCAATATTCCTGTTAGCATAGACATGCAACAGCTAACCAATTTTAGCAAACCAA ACCTGGTAATATAGAAAAAAGGATAAATAGGCCAGTCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTG GGAGGCTGAGGCAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCC GTTTCTAATAAAAATACAAAAATCAGGCTGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAG GCCGAGGTGGGCAGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATGTGGTGAAACGCCATCTCT ACTAAAAATACAAAAATCAGCCGGTGTGGTGGCACCTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGC AGAATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGC GACAGAGCAAGACTTCATCTCAAAAAAAAAAAAAAATTAGCTGGGCATGGTGGTGGGCACCTGAAATCCC AGCTACTCGGGAGTCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAAGTTGCACTGAGCTGGGATC ACACCATTGCACTCCAGCCTGGGCAACAGAGTGAGACTCCATCTCAAAAAAAGAAAAAGAAAAAGGATAA ATACATTCTAACCAAATAATGTTTATCTCATGATTGTAGCTGATTCAACATTCAAAAATTGGCCTGGTGC AGTAGCTCAGGCCTGTAATCCCAACATTTTAGGAGGCTGAGGCAGGAAGATCTCTTGAGCCCAGGATTTC AAGACCAGCCTGGGCAACATAGTCAGACTGGTCTTTACTGGGGGGAAAAAAATCAGTCTGTGTAATTCAC CACATTAACAAAGGGAAACATAAAAACCCTATGATCATTTCAACAGATGTAGCAAAAGCAGTTAATGATA TTCAACACATATGCATGATTACAAACCAACCAACCTCCTAGCAAACTAGGGAAAGGAAACTTAACCTAGT TTGATAACAGGGCGTCCACAGTCGGAGTTCCACTAGCAGCATACATAATGGTAGAAAACTCAGTGCTGCC GGGCGCGGTGGCTCACGCCTGTAATGCCAGCACTTTGGGAGGCCTAGGCGGGCGGATCACGAGGTCAGGA GATCGAGACTGTCCTGACTAGCATGCTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAAAATTAGCC GGGCATGGTGGCGGGCGCCTATAGTCCCAGCTACTCGGGAGGCTGAGGCGAGAGAATGGCGTGAACCCGG GAGGCGGAGCTTGCAGAGCCTAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTTCGTCT CAAAAAAAAAAAAAAAAAAAAAAGAAAAGAAAACTCAACGCTTTTTCCTCTAAGATCAGGAACTAGAAAA GGATTTGACTCTCACAACGTTGATACCATACTGGAGGTTTTAACCAGGCAAGAAAAAGAAATAATGAGGG CCGGGTGCGGTGGCTCAGGCCTGTAATCCCAGCACTTTGGGAAGCCGAGACGGGTGGATCACGAGGTCAG GAGATCGAGACCATCCTGGCTAACACGGTGAAACCCTGTCTCTACTAAATATACAAAAAATTAGCCGGGC GTAGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACTCAGGGGG CGGAGCTTGCAGTGAGCTGAGATCGAGCCACTGCACTCCAGCCTGGGCGACAGAGCAAGACTGTGTCTCA AAAAAAAAAAAAGAAAAAGAAATAATGATTAGTGGCCCGATGTCTCACGCCTATAATCCCAGCACTTTGG GAGGCCGAGGTGGGCAGATCACCTGAGGTCTGGAGTTGGAGACCAGCCTGACAAAGATGGTGAAACCTCG TCTCTATTAAAATATTAAAAAAATAGCCAGGCGTTGGCCGGGTACAGTGGCTCATGCCTGTAATCCCAGC ACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGTTCAACACCAGCCTGGCCAACATGGTGA AACCCCATCTCTACTAAAAATACAAAAATTAGCCGGGCGTAGTGGCGGGCGCCTGTAATCCCAGCTACTT GGGAGGCTTAGGCAGGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGTAGTGAGCCGAGATTGCACCATT GCACTCCAGCCTGGGTGACAAAAGCAAAAACTCCGTCTCAAAAAAAAAAGAATTAGCCAGGGGTAGTGGT GAACGCCTGTAGTCCCAGCTACTCAGGAGGCAGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTT GCAGTGAGCCGAGATTGTCCCATTGCACTCCAGCCTAGGCGACAAGAGCAAAATTCCATGTCAAAAAAAA AAAAAAAAAAGGAAAGAAAAAAAATAACGATTAGAAAGGAAGAAATAAAACACATTCACAGCCAGTATGA TTCTATACATACATGTCCTAATGGGGCCAGGCGTGGTGGCTCATGCCTGTAATCCTAGCACTTTTAGGAG GCTGAGGCAGGTGGCTTCCCTGGGACCAGCCTGGCCAACATGGTGAAACCCCAACTCTAATAAAAATACA AAAAATCAGCCAGGCGTGGTGACGGGCACCTCTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTG CTTGGACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCGCTATTGCACTCCAGCCTGGGCAACAAGA GTGAAACTCCGGCAGGGTGTGGTGGCTTACGCCTGTAATCCCAGCACTTCGGGAGGCTGAGGCAGGCCGA TCACCTGAGGTCAGGAGTTTGAGACCAACCTAACATGGTGAAACCCCGTCTCTACTAAAAATACAAGAAT TAGCTGGGTGTAGTGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGACAGAAGAATTGCTTGAA CCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCATGCCATTGCACACCACGCCGGGCAACAGAGCGAGAT TCCGTCTCAAAAAAAAAAAAAAAGAGTGAAACTCTATCTCAAAAAAAAAAAAAAGTCCTAATGGAAAATC CATAAAAAGCTACCAAAACTAATAAATAAATATAGCAGGGTTGCAGGTTACAGGGCAATATAGTTATCCC TCTATCTGTAGGGGCTTGGTTCTGGGACTCCTCACACACCAAACCCACAGATGTCTAAGTCCCATATATA AGACGGTATAGTATTTGGATTTAACCTACACATATCCTCCCATATAGTTTAAATTATCTCTAGATTACTT ACATTACCCCCATACAATGAAAATGCTAATGTACATGCAAGTATGTATGTAAGTACTTGTACTATATTGT TTAGGGAATCACTGGACATATAGGCCTTCAAGACTGATACCAGCAGCCACTGTTAAGATTCTGGTCAGGC CTGCCCCTGTTTGGGGTCTCAGTTGATCTCATTGCCTTCCCACCCAGCCAAGGGCACCTGCATTTCTCTT GGCTCCCTGGCCATTTGGAAGGCCTAGTTCAGCCTGGCACATTTGTATCCTGGCCCACTGATGCTGGTAC CCCTGGGAAGGTCCTGCTCTGAAAAACACGGAGATTTTAGTTGCTACTGAAGATTTGAGAGATAAAGACA GGGAGACCTGTCTGTAGACCTGTGTCCCTCCAAGTGGGATTGAGACTTTGGGCCCCCCATTTCAGGACAG CACCTCCTGGCCTGTTGACTGAATAGATCCCTGAAGGAGGTGTACTTGCATTAATGGAGTGGGGGTGGGA GCAGTACCACAGATCCGCACTAACAATCACACAGTTCTCTCTAGAATAATAATATAGAACAAGTGAAATA GAACAATTGCAGAAAGAGCTAACCTTTGTTGAGCTCTTACTGTGTGCCCAGCACTTTCCTCAACTCTACA TTTCCCATAATACACAGAGTACTAGGTAGGCCAGGCTTGGTGGCTCACGCCTGTAATCCCAGCACTTTAG GAGGCCAAGGGGGGTGGATCACCTGAGGTCGGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACCCCG TCTCTACTAGAAGTACAAAATTAGCCAGGTGTGGTGGCACATGCTTGTAGTCCTAGCTACTCAGCAGGCT GAGGCAGGAGAATCATTTGAATCCGGGAGGAGGTTGCAGTAAGCGGAGATAGTGCCACTGTACTCCAGCC TGGGCAATAAGAGCTGAGACTCCGTCTCAAAATAAAATAAAATAAAATAAAATAAAATAAAATAAAATAA AAAAAGAAAAGAGCCTGCCATTAAAGGAGCTGTTTGGTAGGGGATGTTTTGTCAGTGCAAACAACAGAAA AGTGGGCTGGGCACAGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCGGATCACCT GAAGTTGGGAGTTCAAGACCAGCCTGACCAATATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAG CCGGGCGCAGTGGCGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCT GGGAGGCAGAGGTTGCGGTGAGCCGAGATCGCACCATTGCACTCCAGCCTGGACGAGAGCAAAACTCTGT CTCAAAAAAAAAAAAAAACAGAAAAGTGTAACAAACACTTACAGTAGGCATGTTTCTTAGCAAATCTGAT GACAAATTTGGCATAAAGAAAGAGAGCATCCCTGAAAAAAAAAAAAAGAAAAAGAAAGAGAGCATCCTGC CTGGGCAACATAGTGAAACCCTGCCTCTACAAAAAAACTCAAAAATTGGCCGGGTGCAGTGGCTCACACC TGTAATCCCAGCACTTTGGGAGTCGGAGGCGGGAGGATCACCTGAGGTCAGGAGTTCGAAACCAGCCTGG CCAACATGGCAAAACCCCATCTCTACTAAAAATACAAAAAATTAATCAGGCGCATTGGTGGGCGCCTGTA ATCCCAGCTACTCAGGAAGTTGAGGCAAGAGGATCGCTTGAATCTGGGAGGTGGAGGTTACAGTGAGTCG AGATCACACCACTGCACTCTAGCCTGGGTGACAGGGCGAGACTCCGTCTCCAAAAAAAAAAAGAAAAAGA AAAAGACTAAAAAATTAGCCAGGCAGGCCTCTGTGGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATC ACTGAGCCCAGGAGTCCGAGGCTGTAGTGAGCCATGATTGCACCACTGTACCCTAGCTTGGGCAACAAAG CAAGACCCTGCCTCAAAAGAAAAAAGAAAGAAAGAAAGAACATGGCGGGCCAGGCACAGTGGCTCACACC TGTAATCCCAGCGCTTTGAGAGGCCGAGGCAGGTGGATCACAAGGTCAGGAGTTCCACACCAGCCTGGCC AACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATCAGCCAGGCATGGTGGCAGGGGCCTGTAAT CCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAAACCAGAAGGCAGAGGTTGCAGTGAGCCTAG ACTGCACCACTGCACTCCAGCCTGGGCGAAAAGAGCCAAACTCCATCTCAAAAAACAAACAAAAAAACAA AACAAAAGAAAACATGGCAAAGCCTTTGAAAGCTTGTCTGGGAGAAGGTGCGATGATAGTTGCATAACTT CGTGCAAGATGCTGGTCCACACAGGGGCTGCCCCTTGCTCTTTCTCGCTCTCTTAACCTCTCATATAACA GGCTTGTGTGTTATTCACATTTATTGAGCCCAAGCAGGTGCAAGGCATTGTGATCTAATACTTTGGTCAG CAAGACAACAAGATAGATCACTGCCCTGCCCTTAGGAAGTGTATATGCTATTAGAGGAAACAGATAAAAT AAACAAGGAAAAGTATCAGACAATGTAAGTGCTATGAGAATGCAAATGAGGTGATGTGAATTAAAATAGG ATGACTTAAAGTCTGCACGGGAAGGAGCCTACCCCCATGTTCCTGGCTAGCCAAGGAACCACCAGTTGAT TAGCAGAGAAGGGCAGCCAGTCTAGCTAGAGCTTTTGGGGAAGAGGGAGTGGTTGTTAAGAGATGAGATT AAAGAAGCCGAGACGGGCCATTCGTGAGGGGTTTGTAATGCAGGGCTGAGGAGTGTCCGAAGAGAATGGG CAGGTGAGCGGTGAGACAGTTGTTCTTCCAGAAGCTTTGCAGTGAAAGGAATCAAAGAAATGGAGCCGTG TATCAGGTGGGGAAGGGTGGGGGCCAAGGGGGTGTCCTTCCCCATACAGAGATTGCAGGCTGAGAATGAC TATATCCTTGTTAACAGGAGGTGGGAGCAGGGCACGGTAGCTCACACCTGTAATCTTGGCACTTTAGGAG GCTGAGGCGGGCCGATCACCTGAAGTAAGGAGTTCGAGACCAGCCTGGCCAACATGCAAAGCCCTGTCTC TACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTACTCGCCTGTAATCCCAGCTACTCGGGAGACTGAG GCAGGAGAATGGCTTGAACCCGGAAGGTAGAGGTTGCAGTGAGCTGAGATCATGCCACTGTGCTCCAGCC TAGGTGACAGAGAGAGACTCCATCTCAAAAAAAAAAAAAAAATACAGGAAGGGAGTTGGGAATAGGGTGC ACATTTAGGAAGTCTTGGGGATTTAGTGGTGGGAAGGTTGGAAGTCCCTCTCTGATTGTCTTTTCCTCAA AGAAGTGCATGGCTGGTGAGGGGTGGGGCAGGAGTGCTTGGGTTGTGGTGAAACATTGGAAGAGAGAATG TGAAGCAGCCATTCTTTTCCTGCTCCACAGGAAGCCGAGCTGTCTCAGACACTGGCATGGTGTTGGGGGA GGGGGTTCCTTCTCTGCAGGCCCAGGTGACCCAGGGTTGGAAGTGTCTCATGCTGGATCCCCACTTTTCC TCTTGCAGCAGCCAGACTGCCTTCCGGGTCACTGCCATGGAGGAGCCGCAGTCAGATCCTAGCGTCGAGC CCCCTCTGAGTCAGGAAACATTTTCAGACCTATGGAAACTGTGAGTGGATCCATTGGAAGGGCAGGCCCA CCACCCCCACCCCAACCCCAGCCCCCTAGCAGAGACCTGTGGGAAGCGAAAATTCCATGGGACTGACTTT CTGCTCTTGTCTTTCAGACTTCCTGAAAACAACGTTCTGGTAAGGACAAGGGTTGGGCTGGGGACCTGGA GGGCTGGGGACCTGGAGGGCTGGGGGGCTGGGGGGCTGAGGACCTGGTCCTCTGACTGCTCTTTTCACCC ATCTACAGTCCCCCTTGCCGTCCCAAGCAATGGATGATTTGATGCTGTCCCCGGACGATATTGAACAATG GTTCACTGAAGACCCAGGTCCAGATGAAGCTCCCAGAATGCCAGAGGCTGCTCCCCCCGTGGCCCCTGCA CCAGCAGCTCCTACACCGGCGGCCCCTGCACCAGCCCCCTCCTGGCCCCTGTCATCTTCTGTCCCTTCCC AGAAAACCTACCAGGGCAGCTACGGTTTCCGTCTGGGCTTCTTGCATTCTGGGACAGCCAAGTCTGTGAC TTGCACGGTCAGTTGCCCTGAGGGGCTGGCTTCCATGAGACTTCAATGCCTGGCCGTATCCCCCTGCATT TCTTTTGTTTGGAACTTTGGGATTCCTCTTCACCCTTTGGCTTCCTGTCAGTGTTTTTTTATAGTTTACC CACTTAATGTGTGATCTCTGACTCCTGTCCCAAAGTTGAATATTCCCCCCTTGAATTTGGGCTTTTATCC ATCCCATCACACCCTCAGCATCTCTCCTGGGGATGCAGAACTTTTCTTTTTCTTCATCCACGTGTATTCC TTGGCTTTTGAAAATAAGCTCCTGACCAGGCTTGGTGGCTCACACCTGCAATCCCAGCACTCTCAAAGAG GCCAAGGCAGGCAGATCACCTGAGCCCAGGAGTTCAAGACCAGCCTGGGTAACATGATGAAACCTCGTCT CTACAAAAAAATACAAAAAATTAGCCAGGCATGGTGGTGCACACCTATAGTCCCAGCCACTTAGGAGGCT GAGGTGGGAAGATCACTTGAGGCCAGGAGATGGAGGCTGCAGTGAGCTGTGATCACACCACTGTGCTCCA GCCTGAGTGACAGAGCAAGACCCTATCTCAAAAAAAAAAAAAAAAAAGAAAAGCTCCTGAGGTGTAGACG CCAACTCTCTCTAGCTCGCTAGTGGGTTGCAGGAGGTGCTTACGCATGTTTGTTTCTTTGCTGCCGTCTT CCAGTTGCTTTATCTGTTCACTTGTGCCCTGACTTTCAACTCTGTCTCCTTCCTCTTCCTACAGTACTCC CCTGCCCTCAACAAGATGTTTTGCCAACTGGCCAAGACCTGCCCTGTGCAGCTGTGGGTTGATTCCACAC CCCCGCCCGGCACCCGCGTCCGCGCCATGGCCATCTACAAGCAGTCACAGCACATGACGGAGGTTGTGAG GCGCTGCCCCCACCATGAGCGCTGCTCAGATAGCGATGGTGAGCAGCTGGGGCTGGAGAGACGACAGGGC TGGTTGCCCAGGGTCCCCAGGCCTCTGATTCCTCACTGATTGCTCTTAGGTCTGGCCCCTCCTCAGCATC TTATCCGAGTGGAAGGAAATTTGCGTGTGGAGTATTTGGATGACAGAAACACTTTTCGACATAGTGTGGT GGTGCCCTATGAGCCGCCTGAGGTCTGGTTTGCAACTGGGGTCTCTGGGAGGAGGGGTTAAGGGTGGTTG TCAGTGGCCCTCCAGGTGAGCAGTAGGGGGGCTTTCTCCTGCTGCTTATTTGACCTCCCTATAACCCCAT GAGATGTGCAAAGTAAATGGGTTTAACTATTGCACAGTTGAAAAAACTGAAGCTTACAGAGGCTAAGGGC CTCCCCTGCTTGGCTGGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGG ATCACGAGGTTGGGAGATCGAGACCATCCTGGCTAACGGTGAAACCCCGTCTCTACTGAAAAATACAAAA AAAAATTAGCCGGGCGTGGTGCTGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGAAGGAGAATGG CGTGAACCTGGGCGGTGGAGCTTGCAGTGAGCTGAGATCACGCCACTGCACTCCAGCCTGGGCGACAGAG CGAGATTCCATCTCAAAAAAAAAAAAAAAAGGCCTCCCCTGCTTGCCACAGGTCTCCCCAAGGCGCACTG GCCTCATCTTGGGCCTGTGTTATCTCCTAGGTTGGCTCTGACTGTACCACCATCCACTACAACTACATGT GTAACAGTTCCTGCATGGGCGGCATGAACCGGAGGCCCATCCTCACCATCATCACACTGGAAGACTCCAG GTCAGGAGCCACTTGCCACCCTGCACACTGGCCTGCTGTGCCCCAGCCTCTGCTTGCCTCTGACCCCTGG GCCCACCTCTTACCGATTTCTTCCATACTACTACCCATCCACCTCTCATCACATCCCCGGCGGGGAATCT CCTTACTGCTCCCACTCAGTTTTCTTTTCTCTGGCTTTGGGACCTCTTAACCTGTGGCTTCTCCTCCACC TACCTGGAGCTGGAGCTTAGGCTCCAGAAAGGACAAGGGTGGTTGGGAGTAGATGGAGCCTGGTTTTTTA AATGGGACAGGTAGGACCTGATTTCCTTACTGCCTCTTGCTTCTCTTTTCCTATCCTGAGTAGTGGTAAT CTACTGGGACGGAACAGCTTTGAGGTGCGTGTTTGTGCCTGTCCTGGGAGAGACCGGCGCACAGAGGAAG AGAATCTCCGCAAGAAAGGGGAGCCTCACCACGAGCTGCCCCCAGGGAGCACTAAGCGAGGTAAGCAAGC AGGACAAGAAGCGGTGGAGGAGACCAAGGGTGCAGTTATGCCTCAGATTCACTTTTATCACCTTTCCTTG CCTCTTTCCTAGCACTGCCCAACAACACCAGCTCCTCTCCCCAGCCAAAGAAGAAACCACTGGATGGAGA ATATTTCACCCTTCAGGTACTAAGTCTTGGGACCTCTTATCAAGTGGAAAGTTTCCAGTCTAACACTCAA AATGCCGTTTTCTTCTTGACTGTTTTACCTGCAATTGGGGCATTTGCCATCAGGGGGCAGTGATGCCTCA AAGACAATGGCTCCTGGTTGTAGCTAACTAACTTCAGAACACCAACTTATACCATAATATATATTTTAAA GGACCAGACCAGCTTTCAAAAAGAAAATTGTTAAAGAGAGCATGAAAATGGTTCTATGACTTTGCCTGAT ACAGATGCTACTTGACTTACGATGGTGTTACTTCCTGATAAACTCGTCGTAAGTTGAAAATATTGTAAGT TGAAAATGGATTTAATACACCTAATCTAAGGAACATCATAGCTTAGCCTAGCCTGCTTTTTTTTTTTTTT TTTTTGGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCGGGATCTCGGCTCACTGCAAC CTCCGCCTTCTGGGTTCAAGCGATTCTCCTGCCTCAGCCCACTGAGTAGCTGGGATTACAGGCACCTGCC CCGACGCCCAGCTAATTTTTTGTTATTTATTTATTTTTTTTTTTAGTAGAGATGAGGTTTCACCATGTTG GCCAGGCTAGTCTCGAACTCCTGACCTTGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAG GCGTGAGCCACCGCACCCGGCCTGCCTAGCCTACTTTTATTTTATTTTTAATGGAGACAGCATCTTGCTC TGTTGCCCAGGCTGGATTACAGTGATGTGATCATAGCTCATTATACCCTCCTGGGCTCAAGCAATCCCCC TAACTCTGCCTCCCCAGTAGCTAGGACCACAGGCATACACCACCATACCCAGCTAATTTTTAAAATTTTT TGTAGATAGATAGAGTCTCACTATGTTGCCCAGGCTGGTCTCTAGCCTACTTTTTTGAGACAAGGTCTTG CTCTGTCACCCAGGCTGGATAGAGTGCAGTAGTGCAGTCACAGCTCACTGCAGCCTCCACCTCCCAGGCT CCATCCATCCTCCCAGCTCAGCCTCCCAAGTTGCTTCAACTACAGGCCTGCACCACCATGCCTGGCTAAT TTTTATTTATTTATTTTTATTTTATTTTATTTTATTTTTTTGAGACTCAGTCTCACTCTGTCGCCCAGGC TGGAGTGCAGTGGCATGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTC AGCCTCCCGAATAGCTAGGACTACAAGCGCCTGCTACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAG ACAGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTTCTGACCATGTGATCCGCCCGCCTCGGCCTCC CAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCGGCTAATTTTTATTTATTTATTTAAAGACAGAG TCTCACTCTGTCACTCAGGCTAGAGTGCAGTGGCACCATCTCAGCTCACTGCAGCCTTGACCTCCCTGGG CTCCGGTGATTTCACCCTCCCAAGTAGCTAGGACTACAGGCACATGCCACGACACCCAGCTAATTTTTTA TTTTCTGTGAAGTCAAGGTCTTGCTACGTTGCCCATGCTGGTATCAAACCCCTGGGCTCAATCAATCCTT CCACCTCAGCCTCCCCAAGTATTGGGGTTACAGGCATGAGCTACCACACTCAGCCCTAGCCTACTTGAAA CGTGTTCAGAGCATTTAAGTTACCCTACAGTTGGGCAAAGTCATCTAACACAAAGCCCTTTTTATAGTAA TAAAATGTTGTATATCTCATGTGATTTATTGAATATTGTTACTGAAAGTGAGAAACAGCATGGTTGCATG AAAGGAGGCACAGTCGAGCCAGGCACAGCCTGGGCGCAGAGCGAGACTCAAAAAAAGAAAAGGCCAGGCG CACTGGCTCACGCCTGTAATCCCAGCATTTCGGGAGGCTGAGGCGGGTGGATCACCTGAGGTCAGGAGTT CAAGACCAGCCTAGCCAACATGGTGAAACCCCGTCTCTACTAAAATACAAAAATTAACCGGGCGTGATGG CAGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCAGGAGGCGGAGGTT GCAGGGAGCCAAGATGGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAGACTCCGTCTCAGAAAAAAA AGAAAAGAAACGAGGCACAGTCGCATGCACATGTAGTCCCAGTTACTTGAGAGGCTAAGGCAGGAGGATC TCTTGAGCCCAAGAGTTTGAGTCCAGCCTGAACAACATAGCAAGACATCATCTCTAAAATTTAAAAAAGG GCCGGGCACAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGTGGAGGTGGGTAGATCACCTGACGT CAGGAGTTGGAAACCAGCCTGGCTAACATGGTGAAGCCCCATCTCTACTAAAAACACAAAAATTAGCCAG GTGTGGTAGCACACGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCACAAGAATCACTTGAACCCCAGA GGCGGAGATTGCAATCAGCCAAGATTGCACCATTGCACTCCCGCCTGGGCAACAGAGTGAGACCCCATCT CAAAATAAATAAATAAATATTTTTAAAAGTCAGCTGTATAGGTACTTGAAGTGCAGTTTCTACTAAATGC ATGTTGCTTTTGTACCGTCATAAAGTCAAACAATTGTAACTTGAACCATCTTTTAACTCAGGTACTGTGT ATATACTTACTTCTCCCCCTCCTCTGTTGCTGCAGATCCGTGGGCGTGAGCGCTTCGAGATGTTCCGAGA GCTGAATGAGGCCTTGGAACTCAAGGATGCCCAGGCTGGGAAGGAGCCAGGGGGGAGCAGGGCTCACTCC AGGTGAGTGACCTCAGCCCCTTCCTGGCCCTACTCCCCTGCCTTCCTAGGTTGGAAAGCCATAGGATTCC ATTCTCATCCTGCCTTCATGGTCAAAGGCAGCTGACCCCATCTCATTGGGTCCCAGCCCTGCACAGACAT TTTTTTAGTCTTCCTCCGGTTGAATCCTATAACCACATTCTTGCCTCAGTGTATCCACAGAACATCCAAA CCCAGGGACGAGTGTGGATACTTCTTTGCCATTCTCCGCAACTCCCAGCCCAGAGCTGGAGGGTCTCAAG GAGGGGCCTAATAATTGTGTAATACTGAATACAGCCAGAGTTTCAGGTCATATACTCAGCCCTGCCATGC ACCGGCAGGTCCTAGGTGACCCCCGTCAAACTCAGTTTCCTTATATATAAAATGGGGTAAGGGGGCCGGG CGCAGTGGCTCACGAATCCCACACTCTGGGAGGCCAAGGCGAGTGGATCACCTGAGGTCGGGAGTTTGAG CCCAGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAAGTAGCCGGGCGTGGTGATGCA TGCCTGTAATCCCAGCTACCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGT TGCGGTGAGCTGAGATCTCACCATTACACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCAAAAAAG ATAAATAAAGTAAAATGGGGTAAGGGAAGATTACGAGACTAATACACACTAATACTCTGAGGTGCTCAGT AAACATATTTGCATGGGGTGTGGCCACCATCTTGATTTGAATTCCCGTTGTCCCAGCCTTAGGCCCTTCA AAGCATTGGTCAGGGAAAAGGGGCACAGACCCTCTCACTCATGTGATGTCATCTCTCCTCCCTGCTTCTG TCTCCTACAGCCACCTGAAGTCCAAAAAGGGTCAGTCTACCTCCCGCCATAAAAAACTCATGTTCAAGAC AGAAGGGCCTGACTCAGACTGACATTCTCCACTTCTTGTTCCCCACTGACAGCCTCCCACCCCCATCTCT CCCTCCCCTGCCATTTTGGGTTTTGGGTCTTTGAACCCTTGCTTGCAATAGGTGTGCGTCAGAAGCACCC AGGACTTCCATTTGCTTTGTCCCGGGGCTCCACTGAACAAGTTGGCCTGCACTGGTGTTTTGTTGTGGGG AGGAGGATGGGGAGTAGGACATACCAGCTTAGATTTTAAGGTTTTTACTGTGAGGGATGTTTGGGAGATG TAAGAAATGTTCTTGCAGTTAAGGGTTAGTTTACAATCAGCCACATTCTAGGTAGGGGCCCACTTCACCG TACTAACCAGGGAAGCTGTCCCTCACTGTTGAATTTTCTCTAACTTCAAGGCCCATATCTGTGAAATGCT GGCATTTGCACCTACCTCACAGAGTGCATTGTGAGGGTTAATGAAATAATGTACATCTGGCCTTGAAACC ACCTTTTATTACATGGGGTCTAGAACTTGACCCCCTTGAGGGTGCTTGTTCCCTCTCCCTGTTGGTCGGT GGGTTGGTAGTTTCTACAGTTGGGCAGCTGGTTAGGTAGAGGGAGTTGTCAAGTCTCTGCTGGCCCAGCC AAACCCTGTCTGACAACCTCTTGGTGAACCTTAGTACCTAAAAGGAAATCTCACCCCATCCCACACCCTG GAGGATTTCATCTCTTGTATATGATGATCTGGATCCACCAAGACTTGTTTTATGCTCAGGGTCAATTTCT TTTTTCTTTTTTTTTTTTTTTTTTCTTTTTCTTTGAGACTGGGTCTCGCTTTGTTGCCCAGGCTGGAGTG GAGTGGCGTGATCTTGGCTTACTGCAGCCTTTGCCTCCCCGGCTCGAGCAGTCCTGCCTCAGCCTCCGGA GTAGCTGGGACCACAGGTTCATGCCACCATGGCCAGCCAACTTTTGCATGTTTTGTAGAGATGGGGTCTC ACAGTGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAGGCGATCCACCTGTCTCAGCCTCCCAGAGTGC TGGGATTACAATTGTGAGCCACCACGTCCAGCTGGAAGGGTCAACATCTTTTACATTCTGCAAGCACATC TGCATTTTCACCCCACCCTTCCCCTCCTTCTCCCTTTTTATATCCCATTTTTATATCGATCTCTTATTTT ACAATAAAACTTTGCTGCCACCTGTGTGTCTGAGGGGTG    Download   Select all
Length	19149
OMIM ID	191170
HGNC ID	HGNC:11998
Unigene ID	Hs.437460
Ensembl ID	ENSG00000141510
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001126112.2
Exon	join(1..174,10932..11030,11148..11169,11279..11557, 12315..12498,12580..12692,13261..13370,13714..13850, 13943..14016,16836..16942,17861..19149)
mRNA Sequence	>7157 GATGGGATTGGGGTTTTCCCCTCCCATGTGCTCAAGACTGGCGCTAAAAGTTTTGAGCTTCTCA AAAGTCTAGAGCCACCGTCCAGGGAGCAGGTAGCTGCTGGGCTCCGGGGACACTTTGCGTTCGG GCTGGGAGCGTGCTTTCCACGACGGTGACACGCTTCCCTGGATTGGCAGCCAGACTGCCTTCCG GGTCACTGCCATGGAGGAGCCGCAGTCAGATCCTAGCGTCGAGCCCCCTCTGAGTCAGGAAACA TTTTCAGACCTATGGAAACTACTTCCTGAAAACAACGTTCTGTCCCCCTTGCCGTCCCAAGCAA TGGATGATTTGATGCTGTCCCCGGACGATATTGAACAATGGTTCACTGAAGACCCAGGTCCAGA TGAAGCTCCCAGAATGCCAGAGGCTGCTCCCCCCGTGGCCCCTGCACCAGCAGCTCCTACACCG GCGGCCCCTGCACCAGCCCCCTCCTGGCCCCTGTCATCTTCTGTCCCTTCCCAGAAAACCTACC AGGGCAGCTACGGTTTCCGTCTGGGCTTCTTGCATTCTGGGACAGCCAAGTCTGTGACTTGCAC GTACTCCCCTGCCCTCAACAAGATGTTTTGCCAACTGGCCAAGACCTGCCCTGTGCAGCTGTGG GTTGATTCCACACCCCCGCCCGGCACCCGCGTCCGCGCCATGGCCATCTACAAGCAGTCACAGC ACATGACGGAGGTTGTGAGGCGCTGCCCCCACCATGAGCGCTGCTCAGATAGCGATGGTCTGGC CCCTCCTCAGCATCTTATCCGAGTGGAAGGAAATTTGCGTGTGGAGTATTTGGATGACAGAAAC ACTTTTCGACATAGTGTGGTGGTGCCCTATGAGCCGCCTGAGGTTGGCTCTGACTGTACCACCA TCCACTACAACTACATGTGTAACAGTTCCTGCATGGGCGGCATGAACCGGAGGCCCATCCTCAC CATCATCACACTGGAAGACTCCAGTGGTAATCTACTGGGACGGAACAGCTTTGAGGTGCGTGTT TGTGCCTGTCCTGGGAGAGACCGGCGCACAGAGGAAGAGAATCTCCGCAAGAAAGGGGAGCCTC ACCACGAGCTGCCCCCAGGGAGCACTAAGCGAGCACTGCCCAACAACACCAGCTCCTCTCCCCA GCCAAAGAAGAAACCACTGGATGGAGAATATTTCACCCTTCAGATCCGTGGGCGTGAGCGCTTC GAGATGTTCCGAGAGCTGAATGAGGCCTTGGAACTCAAGGATGCCCAGGCTGGGAAGGAGCCAG GGGGGAGCAGGGCTCACTCCAGCCACCTGAAGTCCAAAAAGGGTCAGTCTACCTCCCGCCATAA AAAACTCATGTTCAAGACAGAAGGGCCTGACTCAGACTGACATTCTCCACTTCTTGTTCCCCAC TGACAGCCTCCCACCCCCATCTCTCCCTCCCCTGCCATTTTGGGTTTTGGGTCTTTGAACCCTT GCTTGCAATAGGTGTGCGTCAGAAGCACCCAGGACTTCCATTTGCTTTGTCCCGGGGCTCCACT GAACAAGTTGGCCTGCACTGGTGTTTTGTTGTGGGGAGGAGGATGGGGAGTAGGACATACCAGC TTAGATTTTAAGGTTTTTACTGTGAGGGATGTTTGGGAGATGTAAGAAATGTTCTTGCAGTTAA GGGTTAGTTTACAATCAGCCACATTCTAGGTAGGGGCCCACTTCACCGTACTAACCAGGGAAGC TGTCCCTCACTGTTGAATTTTCTCTAACTTCAAGGCCCATATCTGTGAAATGCTGGCATTTGCA CCTACCTCACAGAGTGCATTGTGAGGGTTAATGAAATAATGTACATCTGGCCTTGAAACCACCT TTTATTACATGGGGTCTAGAACTTGACCCCCTTGAGGGTGCTTGTTCCCTCTCCCTGTTGGTCG GTGGGTTGGTAGTTTCTACAGTTGGGCAGCTGGTTAGGTAGAGGGAGTTGTCAAGTCTCTGCTG GCCCAGCCAAACCCTGTCTGACAACCTCTTGGTGAACCTTAGTACCTAAAAGGAAATCTCACCC CATCCCACACCCTGGAGGATTTCATCTCTTGTATATGATGATCTGGATCCACCAAGACTTGTTT TATGCTCAGGGTCAATTTCTTTTTTCTTTTTTTTTTTTTTTTTTCTTTTTCTTTGAGACTGGGT CTCGCTTTGTTGCCCAGGCTGGAGTGGAGTGGCGTGATCTTGGCTTACTGCAGCCTTTGCCTCC CCGGCTCGAGCAGTCCTGCCTCAGCCTCCGGAGTAGCTGGGACCACAGGTTCATGCCACCATGG CCAGCCAACTTTTGCATGTTTTGTAGAGATGGGGTCTCACAGTGTTGCCCAGGCTGGTCTCAAA CTCCTGGGCTCAGGCGATCCACCTGTCTCAGCCTCCCAGAGTGCTGGGATTACAATTGTGAGCC ACCACGTCCAGCTGGAAGGGTCAACATCTTTTACATTCTGCAAGCACATCTGCATTTTCACCCC ACCCTTCCCCTCCTTCTCCCTTTTTATATCCCATTTTTATATCGATCTCTTATTTTACAATAAA ACTTTGCTGCCACCTGTGTGTCTGAGGGGTG    Download   Select all
Length	2591

CDS Information

   

Location	join(10957..11030,11148..11169,11279..11557,12315..12498, 12580..12692,13261..13370,13714..13850,13943..14016, 16836..16942,17861..17942)
CDS Sequence	>lcl|NM_000546.5_cds_NP_000537.3_1 [gene=TP53] [protein=cellular tumor antigen p53 isoform a] [protein_id=NP_000537.3] [location=203..1384] ATGGAGGAGCCGCAGTCAGATCCTAGCGTCGAGCCCCCTCTGAGTCAGGAAACATTTTCAGACCTATGGA AACTACTTCCTGAAAACAACGTTCTGTCCCCCTTGCCGTCCCAAGCAATGGATGATTTGATGCTGTCCCC GGACGATATTGAACAATGGTTCACTGAAGACCCAGGTCCAGATGAAGCTCCCAGAATGCCAGAGGCTGCT CCCCCCGTGGCCCCTGCACCAGCAGCTCCTACACCGGCGGCCCCTGCACCAGCCCCCTCCTGGCCCCTGT CATCTTCTGTCCCTTCCCAGAAAACCTACCAGGGCAGCTACGGTTTCCGTCTGGGCTTCTTGCATTCTGG GACAGCCAAGTCTGTGACTTGCACGTACTCCCCTGCCCTCAACAAGATGTTTTGCCAACTGGCCAAGACC TGCCCTGTGCAGCTGTGGGTTGATTCCACACCCCCGCCCGGCACCCGCGTCCGCGCCATGGCCATCTACA AGCAGTCACAGCACATGACGGAGGTTGTGAGGCGCTGCCCCCACCATGAGCGCTGCTCAGATAGCGATGG TCTGGCCCCTCCTCAGCATCTTATCCGAGTGGAAGGAAATTTGCGTGTGGAGTATTTGGATGACAGAAAC ACTTTTCGACATAGTGTGGTGGTGCCCTATGAGCCGCCTGAGGTTGGCTCTGACTGTACCACCATCCACT ACAACTACATGTGTAACAGTTCCTGCATGGGCGGCATGAACCGGAGGCCCATCCTCACCATCATCACACT GGAAGACTCCAGTGGTAATCTACTGGGACGGAACAGCTTTGAGGTGCGTGTTTGTGCCTGTCCTGGGAGA GACCGGCGCACAGAGGAAGAGAATCTCCGCAAGAAAGGGGAGCCTCACCACGAGCTGCCCCCAGGGAGCA CTAAGCGAGCACTGCCCAACAACACCAGCTCCTCTCCCCAGCCAAAGAAGAAACCACTGGATGGAGAATA TTTCACCCTTCAGATCCGTGGGCGTGAGCGCTTCGAGATGTTCCGAGAGCTGAATGAGGCCTTGGAACTC AAGGATGCCCAGGCTGGGAAGGAGCCAGGGGGGAGCAGGGCTCACTCCAGCCACCTGAAGTCCAAAAAGG GTCAGTCTACCTCCCGCCATAAAAAACTCATGTTCAAGACAGAAGGGCCTGACTCAGACTGA    Download   Select all
CCDS ID	CCDS11118.1

Protein Information

      

Protein ID	NP_000537.3
Protein Name	tumor protein p53
Molecular Wt. (Da)	43522
Protein Sequence	>7157 MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAP RMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSP ALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQ HLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIIT LEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKK KPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLM FKTEGPDSD    Download   Select all
Length	393
Uniprot ID	Q14623
Ensembl Protein ID	ENSP00000295731

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
W	Proteolytic Cleavage	23
K	Ubiquitination	351
K	Ubiquitination	357
S	Phosphorylation	366
K	Ubiquitination	373
K	Ubiquitination	386
S	Phosphorylation	392
S	Phosphorylation	15
T	Phosphorylation	55
S	Phosphorylation	371
S	Phosphorylation	378
S	Phosphorylation	392
S	Phosphorylation	6
S	Phosphorylation	9
T	Phosphorylation	18
S	Phosphorylation	15
T	Phosphorylation	18
S	Phosphorylation	20
S	Phosphorylation	33
S	Phosphorylation	37
T	Phosphorylation	81
T	Phosphorylation	18
K	Acetylation	305
K	Acetylation	370
K	Acetylation	372
K	Acetylation	373
K	Acetylation	381
K	Acetylation	382
S	Phosphorylation	20
S	Phosphorylation	15
S	Phosphorylation	20
S	Phosphorylation	37
S	Dephosphorylation	315
S	Dephosphorylation	315
S	Phosphorylation	33
S	Phosphorylation	46
S	Phosphorylation	15
S	Phosphorylation	20
S	Phosphorylation	33
S	Phosphorylation	37
S	Phosphorylation	46
S	Phosphorylation	9
K	Acetylation	320
S	Phosphorylation	15
T	Phosphorylation	18
S	Phosphorylation	20
S	Phosphorylation	37
K	Deacylation	382
T	Proteolytic Cleavage	18
S	Proteolytic Cleavage	20
T	Phosphorylation	18
S	Phosphorylation	392
T	Phosphorylation	18
S	Phosphorylation	315
S	Phosphorylation	392
S	Phosphorylation	315
S	Phosphorylation	33
T	Phosphorylation	155
S	Phosphorylation	33
S	Phosphorylation	315
S	Phosphorylation	392
K	Acetylation	292
S	Phosphorylation	15
S	Dephosphorylation	15
K	Methylation	372
S	Phosphorylation	37
K	Deacetylation	373
K	Deacetylation	382
S	Phosphorylation	33
T	Phosphorylation	81
S	Phosphorylation	315
T	Dephosphorylation	55
K	Ubiquitination	319
K	Ubiquitination	320
K	Ubiquitination	321
K	Ubiquitination	370
K	Ubiquitination	372
K	Ubiquitination	381
K	Ubiquitination	386
K	Methylation	370
K	Neddylation	370
K	Neddylation	372
K	Neddylation	373
K	Neddylation	381
K	Neddylation	382
K	Neddylation	386
K	Neddylation	321
K	Neddylation	320
S	Phosphorylation	99;-
S	Phosphorylation	314
K	Acetylation	321
S	Phosphorylation	313

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
25	ABL1	1809	NP_009297.2	in vitro;in vivo	1   071   371   610   629   020
58	ACTA1	30	NP_001091.1	in vitro	11821948
142	PARP1	1435	NP_001609.2	in vitro;in vivo	95   656   081   289   852   300   000   000
328	APEX1	136	NP_542380.1	in vivo	9119221
403	ARL3	5260	NP_004302.1	yeast 2-hybrid	16169070
596	BCL2	1045	NP_000624.2	in vitro;in vivo	12667443
672	BRCA1	218	NP_009231.2	in vitro;in vivo	9   482   880   992   694   210   000   000   000   000   000   000   000
695	BTK	2248	NP_000052.1	in vitro	15355990
890	CCNA2	453	NP_001228.1	in vitro	10884347
959	CD40LG	2311	NP_000065.1	in vivo	12011072
983	CDK1	302	NP_001777.1	in vitro;in vivo	11327730
995	CDC25C	1146	NP_001781.2	in vitro;in vivo	1   085   303   816   753   140
1031	CDKN2C	4534	NP_001253.1	yeast 2-hybrid	16169070
1380	CR2	399	NP_001006659.1	in vitro	7753047
1856	DVL2	3690	NP_004413.1	yeast 2-hybrid	1   618   951   416   713   560
1869	E2F1	1806	NP_005216.1	in vitro;in vivo	11739724
1938	EEF2	561	NP_001952.1	in vivo	12891704
1958	EGR1	549	NP_001955.1	in vitro;in vivo	11251186
2042	EPHA3	1555	NP_005224.2	in vitro	15355990
2071	ERCC3	593	NP_000113.1	in vitro	7663514
2074	ERCC6	596	NP_000115.1	in vitro;in vivo	10882116
2079	ERH	9026	NP_004441.1	yeast 2-hybrid	16169070
2099	ESR1	589	NP_000116.2	in vitro	10766163
2547	XRCC6	1071	NP_001460.1	in vivo	15782130
2908	NR3C1	679	NP_001019265.1	in vitro;in vivo	11080152
2965	GTF2H1	1807	NP_005307.1	in vitro	7935417
3064	HTT	883	NP_002102.4	in vitro;in vivo	10823891
3065	HDAC1	3143	NP_004955.2	in vitro;in vivo	1   077   747   716   959   610
3066	HDAC2	5521	NP_001518.2	in vitro;in vivo	10777477
3146	HMGB1	1228	NP_002119.1	in vitro;in vivo	94   720   151   110   665   400   000   000
3148	HMGB2	1229	NP_002120.1	in vitro	11748232
3164	NR4A1	744	NP_002126.2	in vitro;in vivo;yeast 2-hybrid	17139261
3303	HSPA1A	774	NP_005336.3	in vivo	7811761
3315	HSPB1	9076	NP_001531.1	yeast 2-hybrid	16169070
3320	HSP90AA1	777	NP_001017963.2	in vivo	1   150   708   812   427   750
3428	IFI16	969	NP_005522.2	in vivo	11146555
3910	LAMA4	2532	NP_001098676.1	yeast 2-hybrid	16169070
4087	SMAD2	3221	NP_005892.1	in vitro;in vivo	12732139
4088	SMAD3	4380	NP_005893.1	in vitro;in vivo	12732139
4193	MDM2	1272	NP_002383.2	in vitro;in vivo;yeast 2-hybrid	1   643   219   612   867   030   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000
4691	NCL	1245	NP_005372.2	in vitro;in vivo	12138209
4792	NFKBIA	1235	NP_065390.1	in vivo;yeast 2-hybrid	11799106
4800	NFYA	1793	NP_002496.1	in vivo	16959611
4801	NFYB	1794	NP_006157.1	in vivo	16959611
4904	YBX1	1095	NP_004550.2	in vitro;in vivo	1   117   533   311   973   330
5050	PAFAH1B3	4354	NP_002564.1	yeast 2-hybrid	16169070
5245	PHB	1454	NP_002625.1	in vitro;in vivo	14500729
5272	SERPINB9	3480	NP_004146.1	yeast 2-hybrid	16169070
5347	PLK1	3652	NP_005021.2	in vivo;yeast 2-hybrid	16753148
5371	PML	23	NP_150241.2	in vitro;in vivo	117   048   531   102   566   000   000   000
5499	PPP1CA	15942	NP_001008709.1	yeast 2-hybrid	15231748
5521	PPP2R2B	5059	NP_858062.1	in vivo	17245430
5717	PSMD11	5119	NP_002806.2	yeast 2-hybrid	16169070
5888	RAD51	1557	NP_597994.3	in vitro;in vivo	93   805   108   617   246
6117	RPA1	1565	NP_002936.1	in vitro;in vivo	1   175   142   783   615   420   000   000   000   000   000
6241	RRM2	1587	NP_001025.1	in vivo	12615712
6275	S100A4	15914	NP_002952.1	in vitro	11   527   429   151   160   900   000   000   000   000   000
6285	S100B	1505	NP_006263.1	in vitro	1   152   742   910   876   240
6303	SAT1	2431	NP_002961.1	yeast 2-hybrid	16169070
6362	CCL18	4784	NP_002979.1	yeast 2-hybrid	16169070
6602	SMARCD1	3438	NP_003067.3	yeast 2-hybrid	18303029
6667	SP1	1796	NP_612482.2	in vitro;in vivo	9   492   043   157   903   100   000   000   000   000   000
6670	SP3	3483	NP_003102.1	in vitro;in vivo	15790310
6753	SSTR3	1675	NP_001042.1	in vivo	8961277
6783	SULT1E1	8966	NP_005411.1	yeast 2-hybrid	16169070
6811	STX5	4426	NP_003155.2	yeast 2-hybrid	16169070
7006	TEC	2786	NP_003206.2	in vitro	15355990
7020	TFAP2A	128	NP_003211.1	in vitro;in vivo;yeast 2-hybrid	12226108
7027	TFDP1	1792	NP_009042.1	in vitro;in vivo	8816502
7150	TOP1	535	NP_003277.1	in vitro;in vivo	104   686   128   639   538
7153	TOP2A	536	NP_001058.2	in vitro;in vivo	10666337
7155	TOP2B	537	NP_001059.2	in vitro;in vivo	10666337
7314	UBB	6771	NP_061828.1	in vitro;in vivo	12421820
7572	ZNF24	1921	NP_008896.2	yeast 2-hybrid	16169070
8841	HDAC3	8950	NP_003874.2	in vitro;in vivo	10777477
8894	EIF2S2	4882	NP_003899.2	yeast 2-hybrid	16169070
9522	SCAMP1	6072	NP_004857.4	yeast 2-hybrid	16713569
9587	MAD2L1BP	10065	NP_001003690.1	yeast 2-hybrid	16169070
10063	COX17	5314	NP_005685.1	yeast 2-hybrid	16169070
10200	MPHOSPH6	16111	NP_005783.2	yeast 2-hybrid	16169070
10301	DLEU1	16150	NP_005878.1	yeast 2-hybrid	16169070
10425	ARIH2	9286	NP_006312.1	yeast 2-hybrid	16169070
10524	KAT5	3245	NP_874369.1	in vivo	16601686
10571	-	10240	NP_006771.1	yeast 2-hybrid	16169070
11200	CHEK2	5084	NP_001005735.1	in vitro	17157788
22948	CCT5	6468	NP_036205.1	yeast 2-hybrid	16169070
29903	CCDC106	9995	NP_037433.2	yeast 2-hybrid	16169070
53826	FXYD6	9456	AAQ89335.1	yeast 2-hybrid	16169070
54819	ZCCHC10	15699	NP_060135.1	yeast 2-hybrid	16169070
55339	WDR33	11680	NP_060853.3	yeast 2-hybrid	16169070
55643	BTBD2	12252	NP_060267.2	yeast 2-hybrid	16169070
56144	PCDHA4	7322	NP_061730.1	yeast 2-hybrid	16169070
65990	FAM173A	14500	NP_076422.1	yeast 2-hybrid	16169070
80204	FBXO11	6985	NP_079409.3	in vitro;in vivo	17098746
199745	THAP8	15501	NP_689871.1	yeast 2-hybrid	16169070
286514	MAGEB18	6647	NP_775970.1	yeast 2-hybrid	1   618   951   416   713   560

Pathway Information

                                                                                                                                                                                                                        

Pathway Name	Pathway ID
Amyotrophic lateral sclerosis (ALS)	hsa05014
Apoptosis	hsa04210
Basal cell carcinoma	hsa05217
Bladder cancer	hsa05219
Cell cycle	hsa04110
Central carbon metabolism in cancer	hsa05230
Chronic myeloid leukemia	hsa05220
Colorectal cancer	hsa05210
Endometrial cancer	hsa05213
Epstein-Barr virus infection	hsa05169
Glioma	hsa05214
Hepatitis B	hsa05161
Hepatitis C	hsa05160
Herpes simplex infection	hsa05168
HTLV-I infection	hsa05166
Huntington's disease	hsa05016
Longevity regulating pathway - mammal	hsa04211
MAPK signaling pathway	hsa04010
Measles	hsa05162
Melanoma	hsa05218
MicroRNAs in cancer	hsa05206
Neurotrophin signaling pathway	hsa04722
Non-small cell lung cancer	hsa05223
p53 signaling pathway	hsa04115
Pancreatic cancer	hsa05212
Pathways in cancer	hsa05200
PI3K-Akt signaling pathway	hsa04151
Prostate cancer	hsa05215
Proteoglycans in cancer	hsa05205
Small cell lung cancer	hsa05222
Sphingolipid signaling pathway	hsa04071
Thyroid cancer	hsa05216
Thyroid hormone signaling pathway	hsa04919
Transcriptional misregulation in cancer	hsa05202
Viral carcinogenesis	hsa05203
Wnt signaling pathway	hsa04310

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd08367	109-288	P53
cl14608	109-288	P53 superfamily
pfam00870	95-289	P53
pfam07710	324-359	P53_tetramer
cl06653	324-359	P53_tetramer superfamily
pfam08563	29-May	P53_TAD
cl07246	29-May	P53_TAD superfamily

Ontology Information

   

HPRD ID	988
Molecular Class	Transcription factor
Molecular Function	Cytokine activity (GO:0005125)
Biological Process	Immune response (GO:0006955)

SNP Information

View SNP Geneview Report