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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TPM3 7170 tropomyosin 3  1TRK 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24962792   2014Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR,immunohistochemistryTranslocation Mutation- Identified the TPM3-NTRK1 rearrangement in a CRC clinical sample.

25699276   2015Cell line : -

Source : 150 Central Hospital of PLA.

Sample Type : CRC Tumor and normal tissue

No. of Sample : 3

Stage : TNM Stage I-III

Immunohistochemistry, western blotting Up-regulation- Upregulation of TPM3, ERp29, CAMP, and HSPA8 was validated in 69 CRCs by immunohistochemistry (IHC) analysis.


Gene Details



NC_000001.10 (154127780..154164611, complement)

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Gene Type protein coding
Gene Family Tropomyosins
Description This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]  
Chromosome 1
Location 1q21.2
Start 154127780  
End 154164611  
Strand -  
Gene Sequence

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Length 36832  
OMIM ID 191030   
HGNC ID HGNC:12012   
Unigene ID Hs.535581   
Ensembl ID ENSG00000143549   
PharmGKB ID PA36692   

mRNA Information


mRNA ID ?NM_001043351.1
Exon join(8887..9148,18935..19052,19158..19228,20032..20107, 21425..21487,21667..21736,34415..36832)  
mRNA Sequence

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Length 3078  



CDS Information


   
Location 195..743
CDS Sequence

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CCDS ID CCDS1060.1



Protein Information


      
Protein IDNP_001036816.1
Protein Nametropomyosin 3
Molecular Wt. (Da)46033
Protein Sequence

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Length 285  
Uniprot IDO94844
Ensembl Protein ID ENSP00000338671  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation252
TPhosphorylation253
TPhosphorylation216
TPhosphorylation216
KAcetylation161
KAcetylation162
KAcetylation125
KAcetylation125
KAcetylation125
KAcetylation125
KAcetylation220
KAcetylation221
KAcetylation184
KAcetylation184
KAcetylation184
KAcetylation184
KAcetylation215
KAcetylation215
KAcetylation177
KAcetylation177
SPhosphorylation87
SPhosphorylation88
SPhosphorylation191
SPhosphorylation192
SPhosphorylation155
SPhosphorylation155
SPhosphorylation283
SPhosphorylation284

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
58ACTA130NP_001091.1in vitro;in vivo1   110   662   512   163   010   
60ACTB32NP_001092.1in vivo9108196   
6273S100A21508NP_005969.1in vitro;in vivo9092943   
29844TFPT10266NP_037474.1yeast 2-hybrid16189514   
79036C19orf5014526NP_076974.1yeast 2-hybrid16189514   


Pathway Information


                                    
Pathway Name Pathway ID
Adrenergic signaling in cardiomyocytes hsa04261
Cardiac muscle contraction hsa04260
Dilated cardiomyopathy hsa05414
Hypertrophic cardiomyopathy (HCM) hsa05410
Pathways in cancer hsa05200
Thyroid cancer hsa05216


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam127188-154  Tropomyosin_1
cl228578-154  Tropomyosin_1 superfamily
pfam0026149-285  Tropomyosin
TIGR0216827-285  SMC_prok_B
TIGR0216812-261  SMC_prok_B
COG11962-282  Smc
COG119613-285  Smc
TIGR021681-271  SMC_prok_B
COG11963-267  Smc
COG11962-267  Smc
COG11963-282  Smc
TIGR0216922-276  SMC_prok_A
COG12691-279  NtpI
TIGR0216825-267  SMC_prok_B
COG11962-252  Smc
TIGR0216824-261  SMC_prok_B
TIGR021682-260  SMC_prok_B
TIGR021682-278  SMC_prok_B
TIGR021692-260  SMC_prok_A
COG437257-259  COG4372
COG11962-261  Smc
TIGR0216924-261  SMC_prok_A
PRK022243-276  PRK02224
COG119627-281  Smc
TIGR021691-285  SMC_prok_A
TIGR0216921-260  SMC_prok_A
COG11965-235  Smc
COG119690-276  Smc
COG126914-285  NtpI
COG04195-285  SbcC
TIGR021697-278  SMC_prok_A
TIGR0216894-285  SMC_prok_B
COG494231-249  EnvC
PTZ0012115-225  PTZ00121
COG11961-236  Smc
PTZ001213-270  PTZ00121
COG04193-260  SbcC
PTZ001213-270  PTZ00121
COG320619-244  GumC
TIGR0331916-166  RNase_Y
PRK1092919-234  PRK10929
PTZ0012121-252  PTZ00121
pfam0415624-134  IncA
PRK039183-276  PRK03918
COG43722-217  COG4372
COG156612-184  EmrA
COG041916-281  SbcC
COG119686-276  Smc
PRK0577114-262  PRK05771
PLN029391-284  PLN02939
PTZ001213-248  PTZ00121
TIGR0268019-198  TIGR02680
TIGR0300723-224  pepcterm_ChnLen
COG04192-261  SbcC
PRK0486316-261  mukB
PRK0222419-261  PRK02224
pfam0149613-228  V_ATPase_I
PRK10929105-265  PRK10929
TIGR0421129-143  SH3_and_anchor
TIGR009982-150  8a0101
pfam0583393-195  FbpA
PRK127041-166  PRK12704
COG309617-276  MukB
pfam0411127-119  APG6
pfam04111157-253  APG6
PRK127053-126  PRK12705
pfam024633-273  SMC_N
PTZ001215-227  PTZ00121
TIGR021693-201  SMC_prok_A
PTZ0012113-237  PTZ00121
PRK022242-276  PRK02224
TIGR0216912-197  SMC_prok_A
COG2433113-252  COG2433
PRK05771100-229  PRK05771


Ontology Information


   
HPRD ID4957
Molecular ClassCytoskeletal associated protein
Molecular FunctionSulfotransferase activity (GO:0008146)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
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Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
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Osteosarcoma DatabaseGO
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