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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TRAF6 7189 TNF receptor-associated factor 6, E3 ubiquitin protein ligase  11RNF85 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24755241   2014Cell line : RKO, HeLa

Source : -

Sample Type : -

No. of Sample : -

Stage : TNM Stage I-IV

Transient transfection and luciferase assay,Immunoblotting and immunohistochemistry,Real-time RT-PCR,Cell proliferation and apoptosis assay,Tissue-array analysis.Up-regulation-TRAF6 promotes proliferation of colon cancer cells and it may serve as a potential target for therapy of colon cancer.


Gene Details



NC_000011.9 (36505317..36531863, complement)

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Gene Type protein coding
Gene Family RING-type (C3HC4) zinc fingers
Description The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012]  
Chromosome 11
Location 11p12
Start 36505317  
End 36531863  
Strand -  
Gene Sequence

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Length 26547  
OMIM ID 602355   
HGNC ID HGNC:12036   
Unigene ID Hs.444172   
Ensembl ID ENSG00000175104   
PharmGKB ID PA36713   

mRNA Information


mRNA ID ?NM_004620.3
Exon join(1..60,2486..2624,2873..3238,5382..5469,14874..14939, 15436..15846,17661..17838,19796..19944,23936..26781)  
mRNA Sequence

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Length 4303  



CDS Information


   
Location 426..1676
CDS Sequence

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CCDS ID CCDS7901.1



Protein Information


      
Protein IDNP_004611.1
Protein NameTNF receptor-associated factor 6, E3 ubiquitin protein ligase
Molecular Wt. (Da)200667
Protein Sequence

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Length 522  
Uniprot IDQ9Y278
Ensembl Protein ID ENSP00000261374  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
331XIAP2094NP_001158.2in vivo12048196   
658BMPR1B4457NP_001194.1in vivo18758450   
958CD40178NP_001241.1in vitro;in vivo104   118   881   007   566   000   000   000   
1432MAPK142619NP_001306.1in vivo10346818   
1540CYLD5427NP_056062.1in vitro;in vivo1   291   769   116   230   340   
2274FHL24026NP_001441.4in vivo16184196   
3654IRAK12235NP_001560.2in vitro;in vivo883   777   810   346   818   
3663IRF56240NP_001092099.1in vivo15665823   
3665IRF75441NP_004022.2in vivo15361868   
3784KCNQ16341NP_000209.2in vitro14743216   
4155MBP1158NP_001020272.1in vivo10346818   
4215MAP3K33965NP_976226.1in vivo14661019   
4804NGFR1197NP_002498.1in vivo105   145   119   915   784   
4915NTRK22712NP_006171.2in vitro18457658   
5531PPP4C3615NP_002711.1in vitro;in vivo18634786   
5590PRKCZ1504NP_002735.3in vivo10747026   
5599MAPK83100NP_620637.1in vivo10346818   
5609MAP2K74309AAC16273.1in vitro16313339   
5700PSMC14084NP_002793.2in vitro14743216   
5707PSMD110169NP_002798.2in vitro14743216   
5718PSMD125120NP_002807.1in vitro14743216   
5719PSMD134595NP_787128.2in vitro14743216   
6714SRC1819NP_005408.1in vivo10635328   
6850SYK2514NP_003168.2in vivo11418661   
7098TLR34324NP_003256.1in vivo12609980   
7128TNFAIP31857NP_006281.1in vivo9928991   
7314UBB6771NP_061828.1in vitro15125833   
7334UBE2N4725NP_003339.1yeast 2-hybrid15147900   
7763ZFAND55302NP_005998.1in vivo14754897   
8878SQSTM13319NP_003891.1in vivo107   470   261   124   408   000   000   000   
9618TRAF43915NP_004286.2in vivo16052631   
9861PSMD618370NP_055629.1in vitro14743216   
10906TRAFD110994NP_006691.1in vivo16221674   
55437STRADB9546NP_061041.2in vivo12048196   
57506MAVS13847NP_065797.2in vitro;in vivo16153868   
60401EDA2R2230AAN73210.1in vitro;in vivo1   206   072   215   280   350   
84231TRAF76977NP_115647.2in vivo16230348   
114609TIRAP5878AAH32474.1in vivo15247281   


Pathway Information


                                                                                                                        
Pathway Name Pathway ID
Chagas disease (American trypanosomiasis) hsa05142
Endocytosis hsa04144
Epstein-Barr virus infection hsa05169
Hepatitis C hsa05160
Herpes simplex infection hsa05168
Leishmaniasis hsa05140
MAPK signaling pathway hsa04010
Measles hsa05162
Neurotrophin signaling pathway hsa04722
NF-kappa B signaling pathway hsa04064
NOD-like receptor signaling pathway hsa04621
Osteoclast differentiation hsa04380
Pathways in cancer hsa05200
Pertussis hsa05133
RIG-I-like receptor signaling pathway hsa04622
Small cell lung cancer hsa05222
Toll-like receptor signaling pathway hsa04620
Toxoplasmosis hsa05145
Tuberculosis hsa05152
Ubiquitin mediated proteolysis hsa04120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd03776351-500  MATH_TRAF6
cl02446351-500  MATH superfamily
cd0016269-107  RING
cl1723869-107  RING superfamily
cd00270351-499  MATH_TRAF_C
cd03781351-499  MATH_TRAF4
cd03779351-500  MATH_TRAF1
cd03777299-501  MATH_TRAF3
cd03778337-499  MATH_TRAF2
cd03780351-499  MATH_TRAF5
pfam00917357-499  MATH
pfam02176204-261  zf-TRAF
cl08341204-261  zf-TRAF superfamily
cd00121351-499  MATH
cd03771354-493  MATH_Meprin
cd03783354-495  MATH_Meprin_Alpha
smart00061355-477  MATH
smart0018470-107  RING
pfam02176151-204  zf-TRAF
cl08341151-204  zf-TRAF superfamily
cd03782353-491  MATH_Meprin_Beta
pfam0009770-107  zf-C3HC4
pfam1392370-107  zf-C3HC4_2
pfam1363969-107  zf-RING_2
pfam1522770-107  zf-C3HC4_4
smart0050470-129  Ubox
COG522270-127  COG5222
TIGR0059963-128  rad18
COG557465-107  PEX10
COG543264-128  RAD18
COG515268-105  COG5152
COG554069-107  COG5540
PRK04778287-348  PRK04778
pfam01576300-345  Myosin_tail_1
pfam01576291-347  Myosin_tail_1


Ontology Information


   
HPRD ID7543
Molecular ClassAdapter molecule
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO