Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ACTG2 | 72 | actin, gamma 2, smooth muscle, enteric | 2 | ACTSG |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25423035 | 2014 | Cell line : - Source : Tayside Tissue Bank, Dundee, Scotland. Sample Type : CRC tumor and normal tissues No. of Sample : - Stage : - | Immunohistochemistry,In situ hybridisation, real-time PCR | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.[provided by RefSeq, Dec 2010] |
| Chromosome | 2 |
| Location | 2p13.1 |
| Start | 74120093 |
| End | 74146780 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 26688 |
| OMIM ID | 102545 |
| HGNC ID | HGNC:145 |
| Unigene ID | Hs.516105 |
| Ensembl ID | ENSG00000163017 |
| PharmGKB ID | PA24469 |
mRNA Information
| mRNA ID | NM_001615.3 |
|---|---|
| Exon | join(1..86,8311..8472,9395..9523,15708..15818, 16090..16174,20520..20681,21715..21906,23619..23800, 26467..26688) | mRNA Sequence | Download Select all |
| Length | 1345 |
Protein Information
| Protein ID | NP_001606.1 |
|---|---|
| Protein Name | actin, gamma 2, smooth muscle, enteric |
| Molecular Wt. (Da) | 41746 |
| Protein Sequence | Download Select all |
| Length | 376 |
| Uniprot ID | P30408 |
| Ensembl Protein ID | ENSP00000304277 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 363 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6462 | SHBG | 1646 | NP_001031.2 | yeast 2-hybrid | 15862967 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Vascular smooth muscle contraction | hsa04270 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00012 | 9-182 | NBD_sugar-kinase_HSP70_actin |
| cl17037 | 9-182 | NBD_sugar-kinase_HSP70_actin superfamily |
| PTZ00281 | 1-376 | PTZ00281 |
| PTZ00004 | 1-376 | PTZ00004 |
| PTZ00466 | 9-376 | PTZ00466 |
| PTZ00452 | 3-376 | PTZ00452 |
| COG5277 | 1-376 | COG5277 |
| pfam00022 | 4-376 | Actin |
| smart00268 | 6-376 | ACTIN |
| PTZ00280 | 8-373 | PTZ00280 |
Ontology Information
| HPRD ID | 1709 |
|---|---|
| Molecular Class | Structural protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.