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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TST | 7263 | thiosulfate sulfurtransferase (rhodanese) | 22 | RDS |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16500920 | 2006 | Cell line : HT 29 Source : - Sample Type : - No. of Sample : - Stage : - | Assays of cell viability,Immunoprecipitation of MST and TST,Immunohistochemistry,Western blotting | Down-regulation | - | Expression of both enzymes was focally lost in ulcerative colitis and markedly reduced in advanced colon cancer, the disease progression correlating with the decreased expression of MST and TST. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
| Chromosome | 22 |
| Location | 22q13.1 |
| Start | 37406900 |
| End | 37416224 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9325 |
| OMIM ID | 180370 |
| HGNC ID | HGNC:12388 |
| Unigene ID | Hs.474783 |
| Ensembl ID | ENSG00000128311 |
| PharmGKB ID | PA37055 |
mRNA Information
| mRNA ID | ?NM_001270483.1 |
|---|---|
| Exon | join(1..22,1431..2046,8859..9325) | mRNA Sequence | Download Select all |
| Length | 1111 |
Protein Information
| Protein ID | NP_001257412.1 |
|---|---|
| Protein Name | thiosulfate sulfurtransferase (rhodanese) |
| Molecular Wt. (Da) | 96813 |
| Protein Sequence | Download Select all |
| Length | 297 |
| Uniprot ID | Q9Y243 |
| Ensembl Protein ID | ENSP00000263826 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | S-Nitrosylation | 248 |
| K | Acetylation | 14 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cysteine and methionine metabolism | hsa00270 |
| Metabolic pathways | hsa01100 |
| Sulfur metabolism | hsa00920 |
| Sulfur relay system | hsa04122 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01445 | 11-136 | TST_Repeats |
| cl00125 | 11-136 | RHOD superfamily |
| cd01449 | 163-281 | TST_Repeat_2 |
| cl00125 | 163-281 | RHOD superfamily |
| cd01448 | 10-138 | TST_Repeat_1 |
| cd01445 | 163-281 | TST_Repeats |
| smart00450 | 173-285 | RHOD |
| smart00450 | 26-140 | RHOD |
| pfam00581 | 164-279 | Rhodanese |
| pfam00581 | 12-137 | Rhodanese |
| cd00158 | 167-279 | RHOD |
| cd01519 | 191-279 | RHOD_HSP67B2 |
| cd01448 | 162-279 | TST_Repeat_1 |
| cd00158 | 26-134 | RHOD |
| cd01443 | 175-281 | Cdc25_Acr2p |
| cd01524 | 169-258 | RHOD_Pyr_redox |
| COG2897 | 10-279 | SseA |
| PLN02723 | 9-279 | PLN02723 |
| PRK11493 | 11-283 | sseA |
| PRK09629 | 41-279 | PRK09629 |
Ontology Information
| HPRD ID | 9246 |
|---|---|
| Molecular Class | Enzyme: Sulphotransferase |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.