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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21074777 | 2011 | Cell line : - Source : - Sample Type : Case control study No. of Sample : 72 patients with CRC, including 32 without lymph node metastasis (LNM) and 40 with LNM Stage : - | Matrix-Assisted Laser Desorption/Ionization Time of Flight-Mass Spectrometry (MALDI-TOF MS), ELISA | Down-regulation | - | TTR appears to be a potential CRC metastasis-specific serum biomarker, which may be of value in the clinical detection and management of CRC. TTR will not be a specific tumour marker for CRC; however, the decreased TTR concentration in CRC patients suggests that TTR could be complementary to detection of carcinoembryonic antigen in the diagnosis of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndro |
| Chromosome | 18 |
| Location | 18q12.1 |
| Start | 31591767 |
| End | 31599024 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7258 |
| OMIM ID | 176300 |
| HGNC ID | HGNC:12405 |
| Unigene ID | Hs.427202 |
| Ensembl ID | ENSG00000118271 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_000371.3 |
|---|---|
| Exon | join(1..205,1130..1260,3354..3489,6802..7258) | mRNA Sequence | Download Select all |
| Length | 938 |
CDS Information
| Location | join(137..205,1130..1260,3354..3489,6802..6909) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS11899.1 |
Protein Information
| Protein ID | NP_000362.1 |
|---|---|
| Protein Name | transthyretin |
| Molecular Wt. (Da) | 13761 |
| Protein Sequence | Download Select all |
| Length | 147 |
| Uniprot ID | P01583 |
| Ensembl Protein ID | ENSP00000263339 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 177 | AGER | 2568 | NP_001127.1 | in vitro | 16716307 |
| 468 | ATF4 | 6817 | NP_001666.2 | yeast 2-hybrid | 16189514 |
| 780 | DDR1 | 2678 | NP_054700.2 | yeast 2-hybrid | 16169070 |
| 1107 | CHD3 | 9071 | NP_001005271.2 | yeast 2-hybrid | 16169070 |
| 3339 | HSPG2 | 804 | NP_005520.4 | in vitro;in vivo | 9307034 |
| 4140 | MARK3 | 4058 | NP_001122390.1 | yeast 2-hybrid | 16169070 |
| 7431 | VIM | 1899 | NP_003371.2 | yeast 2-hybrid | 16169070 |
| 8518 | IKBKAP | 4763 | NP_003631.2 | yeast 2-hybrid | 16169070 |
| 9638 | FEZ1 | 9212 | NP_005094.1 | yeast 2-hybrid | 16169070 |
| 9796 | PHYHIP | 16345 | NP_055574.3 | yeast 2-hybrid | 16169070 |
| 9869 | SETDB1 | 6828 | NP_001138887.1 | yeast 2-hybrid | 16169070 |
| 51608 | C7orf20 | 12909 | NP_057033.2 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05821 | 24-144 | TLP_Transthyretin |
| cl21470 | 24-144 | Peptidase_M14NE-CP-C_like superfamily |
| smart00095 | 27-147 | TR_THY |
| cd05469 | 30-142 | Transthyretin_like |
| pfam00576 | 30-141 | Transthyretin |
| TIGR02962 | 31-138 | hdxy_isourate |
| cd05822 | 31-138 | TLP_HIUase |
| COG2351 | 32-138 | HiuH |
| PRK15036 | 32-138 | PRK15036 |
Ontology Information
| HPRD ID | 978 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P02766 | DB00255 | Diethylstilbestrol | SmallMoleculeDrug |
| P02766 | DB00279 | Liothyronine | SmallMoleculeDrug |
| P02766 | DB00451 | Levothyroxine | SmallMoleculeDrug |
| P02766 | DB00586 | Diclofenac | SmallMoleculeDrug |
| P02766 | DB00861 | Diflunisal | SmallMoleculeDrug |
| P02766 | DB01093 | Dimethyl sulfoxide | SmallMoleculeDrug |
| P02766 | DB01583 | Liotrix | SmallMoleculeDrug |