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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 12878985 | 2003 | Cell line : - Source : Arizona Cancer Center. Sample Type : - No. of Sample : - Stage : Duke Stage A-D | Immunohistochemistry | Up-regulation | - | Increased thioredoxin-1 expression is a relatively late event in colorectal carcinogenesis and provides evidence in a small group of subjects with colorectal cancer of Dukes stages A to D that thioredoxin-1 expression is an independent marker of prognosis. |
| 18505059 | 2008 | Cell line : - Source : University Hospital of Patras, Greece. Sample Type : - No. of Sample : 70 primary colorectal carcinomas and 17 specimens of normal colorectal tissue Stage : TNM Stage I-III | Microarray, RT-PCR | Up-regulation | - | The elevated expression levels of PRNP and POLR2F observed in carcinomas compared to normal tissue suggest a role for these molecules in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| Chromosome | 9 |
| Location | 9q31 |
| Start | 110243812 |
| End | 110256640 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12829 |
| OMIM ID | 187700 |
| HGNC ID | HGNC:12435 |
| Unigene ID | Hs.435136 |
| Ensembl ID | ENSG00000136810 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001244938.1 |
|---|---|
| Exon | join(1..229,5179..5283,11798..11863,12422..12829) | mRNA Sequence | Download Select all |
| Length | 826 |
CDS Information
| Location | join(206..229,5179..5283,11798..11863,12422..12484) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS59139.1 |
Protein Information
| Protein ID | NP_003320.2 |
|---|---|
| Protein Name | Thioredoxin |
| Molecular Wt. (Da) | 11606 |
| Protein Sequence | Download Select all |
| Length | 105 |
| Uniprot ID | Q14574 |
| Ensembl Protein ID | ENSP00000353608 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | S-Nitrosylation | 69 |
| C | Glutathionylation | 73 |
| K | Acetylation | 3 |
| K | Acetylation | 39 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 328 | APEX1 | 136 | NP_542380.1 | in vitro;in vivo | 11 118 054 105 854 600 000 000 |
| 1277 | COL1A1 | 362 | NP_000079.2 | in vitro;yeast 2-hybrid | 12099690 |
| 2671 | GFER | 2954 | NP_005253.3 | in vitro;in vivo | 15894171 |
| 2908 | NR3C1 | 679 | NP_001019265.1 | in vitro | 9915858 |
| 3301 | DNAJA1 | 4159 | NP_001530.1 | in vivo;yeast 2-hybrid | 16458196 |
| 4790 | NFKB1 | 1238 | NP_003989.2 | in vitro | 7788295 |
| 10987 | COPS5 | 6888 | NP_006828.2 | in vitro;in vivo | 15480426 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02947 | 11-102 | TRX_family |
| cl00388 | 11-102 | Thioredoxin_like superfamily |
| pfam00085 | 7-104 | Thioredoxin |
| PTZ00051 | 1-100 | PTZ00051 |
| TIGR01068 | 11-105 | thioredoxin |
| cd02984 | 7-102 | TRX_PICOT |
| TIGR01126 | 11-105 | pdi_dom |
| COG0526 | 1-104 | TrxA |
| cd02985 | Jun-97 | TRX_CDSP32 |
| cd02949 | 20-96 | TRX_NTR |
| cd02961 | Nov-96 | PDI_a_family |
| PRK09381 | 19-101 | trxA |
| cd03005 | 25-92 | PDI_a_ERp46 |
| cd02956 | Nov-95 | ybbN |
| cd02998 | Nov-92 | PDI_a_ERp38 |
| cd02948 | 12-104 | TRX_NDPK |
| cd02950 | 3-105 | TxlA |
| cd02995 | Feb-85 | PDI_a_PDI_a'_C |
| cd02966 | 15-61 | TlpA_like_family |
| cd01659 | 24-86 | TRX_superfamily |
| cd02962 | Oct-96 | TMX2 |
| cd03000 | 15-83 | PDI_a_TMX3 |
| cd02996 | Nov-84 | PDI_a_ERp44 |
| cd03002 | 25-96 | PDI_a_MPD1_like |
| pfam13098 | 17-99 | Thioredoxin_2 |
| cd02992 | 24-104 | PDI_a_QSOX |
| cd02997 | 20-96 | PDI_a_PDIR |
| pfam13905 | 20-61 | Thioredoxin_8 |
| cd03004 | 24-85 | PDI_a_ERdj5_C |
| cd03001 | 20-85 | PDI_a_P5 |
| cd02953 | Dec-84 | DsbDgamma |
| pfam13899 | Sep-61 | Thioredoxin_7 |
| PHA02125 | 27-76 | PHA02125 |
| cd02957 | Feb-91 | Phd_like |
| cd02964 | Dec-58 | TryX_like_family |
| cd03009 | 21-61 | TryX_like_TryX_NRX |
| PRK03147 | 21-61 | PRK03147 |
| TIGR00385 | 21-53 | dsbE |
| TIGR02196 | 24-61 | GlrX_YruB |
| cd03011 | 21-67 | TlpA_like_ScsD_MtbDsbE |
| COG3118 | Dec-95 | YbbN |
| PRK10996 | 20-103 | PRK10996 |
| PTZ00102 | 20-92 | PTZ00102 |
| TIGR01130 | Jul-92 | ER_PDI_fam |
| COG4232 | Jan-83 | DsbD |
| TIGR01130 | Feb-85 | ER_PDI_fam |
| PTZ00443 | 25-99 | PTZ00443 |
| PRK00293 | Mar-80 | dipZ |
| PTZ00102 | 20-86 | PTZ00102 |
Ontology Information
| HPRD ID | 2835 |
|---|---|
| Molecular Class | Enzyme: Reductase |
| Molecular Function | Protein tyrosine/serine/threonine phosphatase activity (GO:0008138) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.