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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TYMS | 7298 | thymidylate synthetase | 18 | Tsase, TMS, HsT422 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23810585 | 2013 | Cell line : - Source : Chinese colorectal cancer patients Sample Type : - No. of Sample : 100 Chinese colorectal cancer patients Stage : - | real timeRT- PCR | Up-regulation | - | TYMS effect on lymph node metastasis in CRC might serve as a potential biomarker for LNM and a prognostic factor in CRC. Over-expression of TYMS is a predicting factor to the poor outcome in clinical colorectal cancer patients. |
| 12450430 | 2001 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | The discordant TS expression between primary and metastatic tumors is a critical factor that must be taken into account when TS is being used as a predictive biomarker for the antitumor effect of 5-FU-based chemotherapy. A significantly higher expression of TS mRNA was observed in pulmonary and lymph node metastases compared with their respective primary tumors. In contrast, TS mRNA expression in hepatic metastases was significantly lower than in primary tumors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. |
| Chromosome | 18 |
| Location | 18p11.31-p |
| Start | 657604 |
| End | 673499 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 15896 |
| OMIM ID | 188350 |
| HGNC ID | HGNC:12441 |
| Unigene ID | Hs.369762 |
| Ensembl ID | ENSG00000176890 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001071.2 |
|---|---|
| Exon | join(1..344,2038..2111,4543..4717,11469..11570, 13089..13264,13777..13848,15257..15896) | mRNA Sequence | Download Select all |
| Length | 1603 |
CDS Information
| Location | join(140..344,2038..2111,4543..4717,11469..11570, 13089..13264,13777..13848,15257..15394) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS11821.1 |
Protein Information
| Protein ID | NP_001062.1 |
|---|---|
| Protein Name | thymidylate synthetase |
| Molecular Wt. (Da) | 35585 |
| Protein Sequence | Download Select all |
| Length | 313 |
| Uniprot ID | P01584 |
| Ensembl Protein ID | ENSP00000263341 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 153;- |
| S | Phosphorylation | 6 |
Enzyme Information
| EC | 2.1.1.45 |
|---|---|
| Name | thymidylate synthase dTMP synthase thymidylate synthetase methylenetetrahydrofolate:dUMP C-methyltransferase TMP synthetase |
| Class | Transferases; Transferring one-carbon groups; Methyltransferases |
| Sysname | 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase |
| Substrate | 5,10-methylenetetrahydrofolate [CPD:C00143]; dUMP [CPD:C00365] |
| Product | dihydrofolate [CPD:C00415]; dTMP [CPD:C00364] |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Metabolic pathways | hsa01100 |
| One carbon pool by folate | hsa00670 |
| Pyrimidine metabolism | hsa00240 |
Structure Information
| PDB ID | 1HVY |
|---|---|
| Resolution | 1.9 |
| Method | X-RAY DIFFRACTION |
| Chains | A, B, |
| Molecule | THYMIDYLATE SYNTHASE |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00351 | 32-266 | TS_Pyrimidine_HMase |
| cl19097 | 32-266 | TS_Pyrimidine_HMase superfamily |
| pfam00303 | 30-313 | Thymidylat_synt |
| PRK01827 | 32-313 | thyA |
| COG0207 | 30-313 | ThyA |
| TIGR03284 | 32-313 | thym_sym |
| PRK13821 | 32-313 | thyA |
| TIGR03283 | 145-258 | thy_syn_methano |
| PRK00956 | 158-258 | thyA |
| PTZ00164 | 27-313 | PTZ00164 |
Ontology Information
| HPRD ID | 979 |
|---|---|
| Molecular Class | Enzyme: Ligase |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P04818 | DB00544 | Fluorouracil | SmallMoleculeDrug |
| P04818 | DB00563 | Methotrexate | SmallMoleculeDrug |
| P04818 | DB00293 | Raltitrexed | SmallMoleculeDrug |
| P04818 | DB00322 | Floxuridine | SmallMoleculeDrug |
| P04818 | DB00432 | Trifluridine | SmallMoleculeDrug |
| P04818 | DB00440 | Trimethoprim | SmallMoleculeDrug |
| P04818 | DB00441 | Gemcitabine | SmallMoleculeDrug |
| P04818 | DB00544 | Fluorouracil | SmallMoleculeDrug |
| P04818 | DB00642 | Pemetrexed | SmallMoleculeDrug |
| P04818 | DB00650 | Leucovorin | SmallMoleculeDrug |
| P04818 | DB01101 | Capecitabine | SmallMoleculeDrug |
| P04818 | DB06813 | Pralatrexate | SmallMoleculeDrug |