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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| UCHL1 | 7345 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 4 | PGP9.5, Uch-L1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26314856 | 2015 | Cell line : - Source : Tunisian patients Sample Type : - No. of Sample : - Stage : - | Methylation Specific PCR | Methylation | - | UCHL1 was methylated in 68.57 % and correlated significantly with lymph node metastasis and transcriptional silencing in tumor tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Parkinson disease |
| Description | The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009] |
| Chromosome | 4 |
| Location | 4p13 |
| Start | 41258898 |
| End | 41270446 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11549 |
| OMIM ID | 191342 |
| HGNC ID | HGNC:12513 |
| Unigene ID | Hs.518731 |
| Ensembl ID | ENSG00000154277 |
| PharmGKB ID | PA37160 |
mRNA Information
| mRNA ID | ?NM_004181.4 |
|---|---|
| Exon | join(1..129,235..246,729..857,3767..3917,4835..4920, 4996..5043,6345..6411,7223..7281,11107..11549) | mRNA Sequence | Download Select all |
| Length | 1141 |
Protein Information
| Protein ID | NP_004172.2 |
|---|---|
| Protein Name | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
| Molecular Wt. (Da) | 33098 |
| Protein Sequence | Download Select all |
| Length | 223 |
| Uniprot ID | Q9NTJ3 |
| Ensembl Protein ID | ENSP00000341382 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 195 |
| S | Phosphorylation | 189 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3312 | HSPA8 | 7205 | NP_006588.1 | in vivo | 18550537 |
| 3320 | HSP90AA1 | 777 | NP_001017963.2 | in vivo | 18550537 |
| 3920 | LAMP2 | 2396 | NP_001116078.1 | in vivo | 18550537 |
| 10951 | CBX1 | 5149 | NP_006798.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Parkinson's disease | hsa05012 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd09616 | 5-219 | Peptidase_C12_UCH_L1_L3 |
| cl08306 | 5-219 | Peptidase_C12 superfamily |
| pfam01088 | 5-208 | Peptidase_C12 |
| cd09617 | 6-219 | Peptidase_C12_UCH37_BAP1 |
| cd02255 | 6-219 | Peptidase_C12 |
Ontology Information
| HPRD ID | 9241 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Protein binding (GO:0005515) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.