Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| UCP2 | 7351 | uncoupling protein 2 (mitochondrial, proton carrier) | 11 | SLC25A8 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25251374 | 2015 | Cell line : CaCo 2 Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | UCP2 plays a key role in mitochondrial apoptotic pathway; UCP2s inhibition by oroxylin A triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Solute carriers |
| Description | Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008] |
| Chromosome | 11 |
| Location | 11q13 |
| Start | 73685716 |
| End | 73693889 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 8174 |
| OMIM ID | 601693 |
| HGNC ID | HGNC:12518 |
| Unigene ID | Hs.80658 |
| Ensembl ID | - |
| PharmGKB ID | PA37165 |
mRNA Information
| mRNA ID | ?NM_003355.2 |
|---|---|
| Exon | join(1..124,1213..1369,4368..4592,4749..4959,5828..6022, 6103..6204,7174..7354,7724..8174) | mRNA Sequence | Download Select all |
| Length | 1646 |
Protein Information
| Protein ID | NP_003346.2 |
|---|---|
| Protein Name | uncoupling protein 2 (mitochondrial, proton carrier) |
| Molecular Wt. (Da) | 33098 |
| Protein Sequence | Download Select all |
| Length | 309 |
| Uniprot ID | Q9UKN1 |
| Ensembl Protein ID | ENSP00000368755 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7529 | YWHAB | 3184 | NP_003395.1 | in vitro;in vivo | 10785390 |
| 7532 | YWHAG | 5639 | NP_036611.2 | yeast 2-hybrid | 10785390 |
| 7534 | YWHAZ | 3183 | NP_003397.1 | in vitro;in vivo | 10785390 |
| 10971 | YWHAQ | 886 | NP_006817.1 | in vitro | 10785390 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00153 | 112-206 | Mito_carr |
| cl02813 | 112-206 | Mito_carr superfamily |
| pfam00153 | 10-111 | Mito_carr |
| cl02813 | 10-111 | Mito_carr superfamily |
| pfam00153 | 214-299 | Mito_carr |
| cl02813 | 214-299 | Mito_carr superfamily |
| PTZ00169 | 17-299 | PTZ00169 |
| PTZ00169 | 16-204 | PTZ00169 |
| PTZ00168 | 75-281 | PTZ00168 |
Ontology Information
| HPRD ID | 18232 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | - |
| Biological Process | - |
Drug Information
No matching records could be found.