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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20691680 | 2010 | Cell line : HCT 8 Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | UGDH can regulate cell motility through the production of GAG. The enzyme may be a potential target for therapeutic intervention of colorectal cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
| Chromosome | 4 |
| Location | 4p14 |
| Start | 39500375 |
| End | 39529218 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 28844 |
| OMIM ID | 603370 |
| HGNC ID | HGNC:12525 |
| Unigene ID | Hs.572518 |
| Ensembl ID | ENSG00000109814 |
| PharmGKB ID | PA37170 |
mRNA Information
| mRNA ID | ?NM_001184700.1 |
|---|---|
| Exon | join(1..124,1213..1369,4368..4592,4749..4959,5828..6022, 6103..6204,7174..7354,7724..8174) | mRNA Sequence | Download Select all |
| Length | 1646 |
Protein Information
| Protein ID | NP_001171629.1 |
|---|---|
| Protein Name | UDP-glucose 6-dehydrogenase |
| Molecular Wt. (Da) | 33098 |
| Protein Sequence | Download Select all |
| Length | 494 |
| Uniprot ID | Q9Y625 |
| Ensembl Protein ID | ENSP00000366246 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 476 |
| K | Acetylation | 107 |
| K | Acetylation | 173 |
| K | Acetylation | 434 |
| T | Phosphorylation | 91 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 26289 | AK5 | 10472 | NP_777283.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amino sugar and nucleotide sugar metabolism | hsa00520 |
| Ascorbate and aldarate metabolism | hsa00053 |
| Metabolic pathways | hsa01100 |
| Pentose and glucuronate interconversions | hsa00040 |
| Starch and sucrose metabolism | hsa00500 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03721 | 5-191 | UDPG_MGDP_dh_N |
| cl21454 | 5-191 | NADB_Rossmann superfamily |
| pfam00984 | 213-310 | UDPG_MGDP_dh |
| cl03053 | 213-310 | UDPG_MGDP_dh superfamily |
| pfam03720 | 332-446 | UDPG_MGDP_dh_C |
| cl21454 | 332-446 | NADB_Rossmann superfamily |
| smart00984 | 332-446 | UDPG_MGDP_dh_C |
| PLN02353 | 4-464 | PLN02353 |
| COG1004 | 6-446 | Ugd |
| TIGR03026 | 5-443 | NDP-sugDHase |
| COG0677 | 6-456 | WecC |
| PRK15057 | 6-369 | PRK15057 |
| PRK11064 | 5-359 | wecC |
| PRK15182 | 1-376 | PRK15182 |
Ontology Information
| HPRD ID | 4950 |
|---|---|
| Molecular Class | Enzyme: Dehydrogenase |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.