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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
UGT2B17 7367 UDP glucuronosyltransferase 2 family, polypeptide B17  4- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23575887   2013Cell line : -

Source : -

Sample Type : CRC tumor and adjacent normal tissue

No. of Sample : 665 CRC and 621 controls

Stage : -

GenotypingMutation-The�UGT2B17�deletion genotype (0/0) was associated with a decreased CRC risk in a Caucasian population.


Gene Details



NC_000004.11 (69402902..69434245, complement)

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Gene Type protein coding
Gene Family UDP glucuronosyltransferases
Description This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.[provided by RefSeq, Apr 2010]  
Chromosome 4
Location 4q13
Start 69402902  
End 69434245  
Strand -  
Gene Sequence

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Length 31344  
OMIM ID 601903   
HGNC ID HGNC:12547   
Unigene ID Hs.575083   
Ensembl ID ENSG00000197888   
PharmGKB ID PA37189   

mRNA Information


mRNA ID ?NM_001077.3
Exon join(1..767,2808..2956,7860..7991,16617..16704, 17632..17851,30624..31344)  
mRNA Sequence

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Length 2099  



CDS Information


   
Location44..1636
CDS Sequence

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CCDS ID CCDS3523.1



Protein Information


      
Protein IDNP_001068.1
Protein NameUDP glucuronosyltransferase 2 family, polypeptide B17
Molecular Wt. (Da)0
Protein Sequence

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Length 530  
Uniprot IDO60635
Ensembl Protein ID ENSP00000361072  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                                                  
Pathway Name Pathway ID
Ascorbate and aldarate metabolism hsa00053
Chemical carcinogenesis hsa05204
Drug metabolism - cytochrome P450 hsa00982
Drug metabolism - other enzymes hsa00983
Metabolic pathways hsa01100
Metabolism of xenobiotics by cytochrome P450 hsa00980
Pentose and glucuronate interconversions hsa00040
Porphyrin and chlorophyll metabolism hsa00860
Retinol metabolism hsa00830
Starch and sucrose metabolism hsa00500
Steroid hormone biosynthesis hsa00140


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0378445-449  GT1_Gtf_like
cl1001345-449  Glycosyltransferase_GTB_type superfamily
PLN00164356-425  PLN00164
PLN02554306-427  PLN02554
PLN02207253-449  PLN02207
PLN02448302-403  PLN02448
PLN02167273-419  PLN02167
PLN03004296-403  PLN03004
PLN02534357-403  PLN02534
PLN03007292-403  PLN03007
pfam04101373-443  Glyco_tran_28_C
PLN02670357-416  PLN02670
pfam0020124-518  UDPGT
PHA033926-508  egt
COG181932-475  YjiC
TIGR0142642-448  MGT
PLN02410278-408  PLN02410
PLN02210295-400  PLN02210
PLN02992357-417  PLN02992
PLN02555267-407  PLN02555
PLN02173302-408  PLN02173
PLN02863357-403  PLN02863
PLN03015290-420  PLN03015
PLN02562295-446  PLN02562
PLN02152270-403  PLN02152
TIGR04516347-448  glycosyl_450act
COG0707373-448  MurG
PLN02208357-451  PLN02208
TIGR01133267-443  murG
PLN00414357-435  PLN00414
PHA02857367-439  PHA02857


Ontology Information


   
HPRD ID11988
Molecular ClassEnzyme: Glycosyltransferase
Molecular FunctionGTPase activity (GO:0003924)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
O75795DB00678LosartanSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO