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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
USP4 7375 ubiquitin specific peptidase 4 (proto-oncogene)  3Unph 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26189775   2015Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

-Up-regulation-USP4 acts as a positive regulator of the WNT/?-catenin pathway by deubiquitination and facilitates nuclear localization of ?-catenin.


Gene Details



NC_000003.11 (49314577..49377536, complement)

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Gene Type protein coding
Gene Family Ubiquitin-specific peptidases
Description The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]  
Chromosome 3
Location 3p21.3
Start 49314577  
End 49377536  
Strand -  
Gene Sequence

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Length 62960  
OMIM ID 603486   
HGNC ID HGNC:12627   
Unigene ID Hs.77500   
Ensembl ID ENSG00000114316   
PharmGKB ID PA37252   

mRNA Information


mRNA ID ?NM_001251877.1
Exon join(1..767,2808..2956,7860..7991,16617..16704, 17632..17851,30624..31344)  
mRNA Sequence

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Length 2099  



CDS Information


   
Location 44..1636
CDS Sequence

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CCDS ID CCDS2793.1



Protein Information


      
Protein IDNP_001238806.1
Protein Nameubiquitin specific peptidase 4 (proto-oncogene)
Molecular Wt. (Da)27241
Protein Sequence

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Length 963  
Uniprot IDQ92878
Ensembl Protein ID ENSP00000368100  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation675
SPhosphorylation680
SPhosphorylation628
SPhosphorylation633
TPhosphorylation677
TPhosphorylation630

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5925RB11574NP_000312.2in vivo1   157   165   211   571   650   
5933RBL1312NP_002886.2in vitro;in vivo11571651   
6737TRIM21170NP_003132.2yeast 2-hybrid11461834   
9221NOLC13864AAH01883.1in vivo11571651   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd02674776-921  Peptidase_C19R
cl02553776-921  Peptidase_C19 superfamily
cd02257766-921  Peptidase_C19
pfam14836139-226  Ubiquitin_3
cl20743139-226  Ubiquitin_3 superfamily
smart0069527-125  DUSP
cl1211627-125  DUSP superfamily
cd02660773-920  Peptidase_C19D
cd02661778-920  Peptidase_C19E
pfam0633731-123  DUSP
cd02661302-486  Peptidase_C19E
cl02553302-486  Peptidase_C19 superfamily
cd02659775-925  peptidase_C19C
cd02674303-491  Peptidase_C19R
cd02660303-485  Peptidase_C19D
cd02667756-921  Peptidase_C19K
cd02663780-921  Peptidase_C19G
cd02668778-920  Peptidase_C19L
cd02667303-482  Peptidase_C19K
cd02257303-486  Peptidase_C19
cd02658731-921  Peptidase_C19B
cd02657809-920  Peptidase_C19A
cd02671754-920  Peptidase_C19O
cd02662768-921  Peptidase_C19F
cd02669810-921  Peptidase_C19M
cd02658303-483  Peptidase_C19B
cd02669299-484  Peptidase_C19M
cd02664778-921  Peptidase_C19H
cd02657303-481  Peptidase_C19A
cd02664303-495  Peptidase_C19H
cd02663303-482  Peptidase_C19G
cd02673799-920  Peptidase_C19Q
cd02671299-407  Peptidase_C19O
cd02659300-484  peptidase_C19C
cd02665817-920  Peptidase_C19I
cd02668303-484  Peptidase_C19L
cd02662303-485  Peptidase_C19F
cd02672764-921  Peptidase_C19P
cd02666861-911  Peptidase_C19J
cd02666303-344  Peptidase_C19J
cd02670813-921  Peptidase_C19N
COG556035-923  UBP12
pfam00443301-485  UCH
pfam00443755-920  UCH
COG5533303-482  COG5533
COG5533775-922  COG5533
COG5077778-910  COG5077
COG5207301-422  UBP14
pfam13423689-902  UCH_1
COG5207756-838  UBP14
COG5077295-405  COG5077
pfam13423303-482  UCH_1


Ontology Information


   
HPRD ID5868
Molecular ClassUbiquitin proteasome system protein
Molecular FunctionHeat shock protein activity (GO:0003773)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO