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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
VASP 7408 vasodilator-stimulated phosphoprotein  19- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25543053   2015Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 Confocal microscopy,measuring acridine orange and ethidium bromide staining, caspase-3 and BAD-pS112 expression and DNA fragmentationPhosphorylation-VASP Ser phosphorylation represents a unique therapeutic target to control cell survival and death behavior in colon cancer.


Gene Details



NC_000019.9 (46010688..46030247)

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Gene Type protein coding
Gene Family -
Description Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]  
Chromosome 19
Location 19q13.32
Start 46010688  
End 46030247  
Strand +  
Gene Sequence

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Length 19560  
OMIM ID 601703   
HGNC ID HGNC:12652   
Unigene ID Hs.515469   
Ensembl ID ENSG00000125753   
PharmGKB ID PA37276   

mRNA Information


mRNA ID ?NM_003370.3
Exon join(1..347,10234..10405,10500..10665,13893..13977, 14739..14788,14911..15152,15289..15389,16215..16266, 16412..16448,16668..16713,17141..17231,18517..18574, 18711..19554)  
mRNA Sequence

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Length 2298  



CDS Information


   
Location 343..1485
CDS Sequence

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CCDS ID CCDS33051.1



Protein Information


      
Protein IDNP_003361.1
Protein Namevasodilator-stimulated phosphoprotein
Molecular Wt. (Da)39699
Protein Sequence

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Length 380  
Uniprot IDQ12931
Ensembl Protein ID ENSP00000246957  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation157
SPhosphorylation239
TPhosphorylation278
SPhosphorylation157
TPhosphorylation278
SPhosphorylation239
SPhosphorylation157
SPhosphorylation239
YPhosphorylation39;-
YPhosphorylation39;-
TPhosphorylation316;-
YPhosphorylation39;-
YPhosphorylation39;-
SPhosphorylation322
SPhosphorylation323
SPhosphorylation324
TPhosphorylation327
SAcetylation2
SAcetylation2
KAcetylation283
SPhosphorylation325
TPhosphorylation249
TPhosphorylation284

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                  
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
58ACTA130NP_001091.1in vitro;yeast 2-hybrid1   088   274   010   438   530   
71ACTG117NP_001605.1in vitro;in vivo12372613   
2934GSN674NP_000168.1in vitro11093254   
4026LPP2828NP_005569.1in vitro;in vivo10637295   
5216PFN11452NP_005013.1in vitro10882740   
5217PFN21451NP_444252.1in vitro;in vivo;yeast 2-hybrid108   827   407   737   110   
5359PLSCR18855NP_066928.1yeast 2-hybrid16189514   
7414VCL1900NP_054706.1in vivo;yeast 2-hybrid10882740   
7454WAS2314NP_000368.1in vitro;in vivo1   159   800   416   055   720   
8996NOL35572NP_003937.1yeast 2-hybrid16189514   
10006ABI14336NP_005461.2in vitro;in vivo16055720   
11060WWP23812NP_008945.2yeast 2-hybrid16189514   
63948DMRTB116828NP_149056.1yeast 2-hybrid16189514   
114088TRIM95947NP_055978.4yeast 2-hybrid16189514   


Pathway Information


                                    
Pathway Name Pathway ID
cGMP-PKG signaling pathway hsa04022
Fc gamma R-mediated phagocytosis hsa04666
Focal adhesion hsa04510
Leukocyte transendothelial migration hsa04670
Platelet activation hsa04611
Rap1 signaling pathway hsa04015


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd012075-113  EVH1_Ena_VASP-like
cl171715-113  PH-like superfamily
pfam005684-110  WH1
smart004611-106  WH1
cd008376-110  EVH1_family
cd105746-113  EVH1_SPRED-like
pfam08776340-379  VASP_tetra
cl07401340-379  VASP_tetra superfamily
cd012063-113  EVH1_Homer_Vesl
cd008353-102  RanBD_family


Ontology Information


   
HPRD ID16465
Molecular ClassCytoskeletal associated protein
Molecular FunctionG-protein coupled receptor activity (GO:0004930)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO