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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
VAV1 7409 vav 1 guanine nucleotide exchange factor  19- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21344162   2011Cell line : COLO205, T84, HCT116, SW480,SW403

Source : ATCC

Sample Type : CRC tumor and adjacent normal tissue

No. of Sample : 110

Stage : -

Membrane arrays, RT-PCR,oligonucleotide microarrayUp-regulation-CDC25A, VAV1, TP73, BRCA1 and ZAP70 may be novel markers for predicting the effectiveness of radiotherapy in CRC patients.


Gene Details



NC_000019.9 (6772679..6857377)

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Gene Type protein coding
Gene Family Rho guanine nucleotide exchange factors, "Pleckstrin homology (PH) domain containing", "SH2 domain containing"
Description This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]  
Chromosome 19
Location 19p13.2
Start 6772679  
End 6857377  
Strand +  
Gene Sequence

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Length 84699  
OMIM ID 164875   
HGNC ID HGNC:12657   
Unigene ID Hs.116237   
Ensembl ID -   
PharmGKB ID PA37280   

mRNA Information


mRNA ID ?NM_001258207.1
Exon join(1..347,10234..10405,10500..10665,13893..13977, 14739..14788,14911..15152,15289..15389,16215..16266, 16412..16448,16668..16713,17141..17231,18517..18574, 18711..19554)  
mRNA Sequence

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Length 2298  



CDS Information


   
Location 343..1485
CDS Sequence

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CCDS ID CCDS12174.1



Protein Information


      
Protein IDNP_001245136.1
Protein Namevav 1 guanine nucleotide exchange factor
Molecular Wt. (Da)0
Protein Sequence

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Length 845  
Uniprot IDP43490
Ensembl Protein ID ENSP00000222553  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation142
YPhosphorylation160
YPhosphorylation174
YPhosphorylation826;-
KAcetylation716
KAcetylation222
KAcetylation252
YPhosphorylation836
YPhosphorylation841
YPhosphorylation844

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
58ACTA130NP_001091.1in vivo11839310   
387RHOA1323NP_001655.1in vivo16397238   
391RHOG1537NP_001656.2in vitro12376551   
613BCR1044NP_004318.3in vitro;in vivo;yeast 2-hybrid11790798   
930CD19113NP_001761.3in vivo7528218   
998CDC42309NP_001782.1in vivo11287617   
1398CRK1267NP_058431.2in vivo8621483   
1785DNM23852NP_001005360.1in vitro;in vivo15696170   
1956EGFR579NP_005219.2in vivo10938113   
2057EPOR587NP_000112.1in vitro9162069   
2534FYN655NP_002028.1in vitro;in vivo9822663   
2547XRCC61071NP_001460.1in vivo;yeast 2-hybrid8524317   
2885GRB2150NP_002077.1in vitro;in vivo;yeast 2-hybrid780   909   016   339   550   
3643INSR975NP_000199.2in vitro;in vivo7535775   
3717JAK2993NP_004963.1in vivo75   306   569   162   069   
5879RAC13627NP_061485.1in vivo16397238   
5894RAF11265NP_002871.1in vitro;in vivo8900182   
7277TUBA4A1851NP_005991.1in vitro;in vivo8530437   
7520XRCC58935NP_066964.1in vivo10673353   
79027ZNF65511673NP_001078837.1in vitro;in vivo15558030   
203068TUBB1852NP_001060.1in vitro;in vivo8530437   


Pathway Information


                                                            
Pathway Name Pathway ID
B cell receptor signaling pathway hsa04662
cAMP signaling pathway hsa04024
Chemokine signaling pathway hsa04062
Fc epsilon RI signaling pathway hsa04664
Fc gamma R-mediated phagocytosis hsa04666
Focal adhesion hsa04510
Leukocyte transendothelial migration hsa04670
Natural killer cell mediated cytotoxicity hsa04650
Regulation of actin cytoskeleton hsa04810
T cell receptor signaling pathway hsa04660


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd10405665-767  SH2_Vav1
cl15255665-767  SH2 superfamily
cd01223385-508  PH_Vav
cl17171385-508  PH-like superfamily
cd00160195-371  RhoGEF
cl02571195-371  RhoGEF superfamily
cd11979596-658  SH3_VAV1_1
cl17036596-658  SH3 superfamily
cd11976786-839  SH3_VAV1_2
cl17036786-839  SH3 superfamily
cd00029516-563  C1
cl00040516-563  C1 superfamily
cd09940665-765  SH2_Vav_family
smart00325198-372  RhoGEF
pfam00621198-372  RhoGEF
cd10407665-767  SH2_Vav3
cd11831596-657  SH3_VAV_1
cd10406665-766  SH2_Vav2
cd11830786-839  SH3_VAV_2
cd11978785-840  SH3_VAV3_2
smart00252669-750  SH2
cd11977785-840  SH3_VAV2_2
pfam00017671-745  SH2
smart00326785-838  SH3
cd11981596-657  SH3_VAV3_1
cd00173671-745  SH2
cd11823788-839  SH3_Nostrin
cd00174786-836  SH3
pfam1197118-102  CAMSAP_CH
cl0003018-102  CH superfamily
cd11877786-839  SH3_PIX
cd09935669-764  SH2_ABL
cd11771787-839  SH3_Pex13p_fungal
cd09942663-769  SH2_nSH2_p85_like
cd11836788-838  SH3_Intersectin_1
cd11766786-839  SH3_Nck_2
cd11805787-839  SH3_GRB2_like_C
cd11827786-839  SH3_MyoIe_If_like
cd09930670-764  SH2_cSH2_p85_like
cd11951787-837  SH3_GRAP_C
pfam00018788-834  SH3_1
cd11842786-839  SH3_Ysc84p_like
cd11980596-657  SH3_VAV2_1
cd11875786-839  SH3_CD2AP-like_3
cd11781786-839  SH3_Sorbs_1
cd11883789-836  SH3_Sdc25
pfam00130516-564  C1_1
cd11762787-839  SH3_FCHSD_2
cd11804787-837  SH3_GRB2_like_N
cd09941669-749  SH2_Grb2_like
cd11840789-839  SH3_Intersectin_5
cd11948787-838  SH3_GRAP_N
pfam14604789-838  SH3_9
cd11843788-838  SH3_PACSIN
cd12058789-837  SH3_MLK4
cd11841786-837  SH3_SH3YL1_like
cd11876789-839  SH3_MLK
cd11946787-838  SH3_GRB2_N
cd11763787-839  SH3_SNX9_like
cd09931671-752  SH2_C-SH2_SHP_like
pfam07653792-839  SH3_2
cd12142791-838  SH3_D21-like
cd09932671-750  SH2_C-SH2_PLC_gamma_like
cd12060788-839  SH3_alphaPIX
cd11772788-839  SH3_OSTF1
cd11839787-838  SH3_Intersectin_4
cd12061788-839  SH3_betaPIX
cd09938671-768  SH2_N-SH2_Zap70_Syk_like
cd12059786-837  SH3_MLK1-3
cd11786787-838  SH3_SH3RF_1
cd11987788-839  SH3_Intersectin1_1
cd11873786-839  SH3_CD2AP-like_1
cd09933671-749  SH2_Src_family
cd11837786-839  SH3_Intersectin_2
cd11920787-839  SH3_Sorbs2_1
pfam00169403-504  PH
cd11874787-839  SH3_CD2AP-like_2
smart00233403-504  PH
cd11826788-838  SH3_Abi
cd11959786-838  SH3_Cortactin
cd11856789-839  SH3_p47phox_like
cd11901787-839  SH3_Nck1_2
cd11803787-838  SH3_Endophilin_A
cd11964788-840  SH3_STAM1
cd11894788-839  SH3_FCHSD2_2
cd11782787-838  SH3_Sorbs_2
cd11833789-837  SH3_Stac_1
cd11825786-839  SH3_PLCgamma
cd11819786-838  SH3_Cortactin_like
cd11995791-838  SH3_Intersectin1_5
cd11960786-838  SH3_Abp1_eu
cd12057788-838  SH3_CIN85_3
cd11858786-839  SH3_Myosin-I_fungi
cd11919787-838  SH3_Sorbs1_1
cd11882786-838  SH3_GRAF-like
cd11884787-838  SH3_MYO15
cd12056788-837  SH3_CD2AP_3
cd11996789-838  SH3_Intersectin2_5
cd11988784-839  SH3_Intersectin2_1
cd11950787-838  SH3_GRAP2_C
cd11961786-839  SH3_Abp1_fungi_C2
cd11921787-838  SH3_Vinexin_1
cd12054788-839  SH3_CD2AP_2
cd11816787-837  SH3_Eve1_3
cd11812786-837  SH3_AHI-1
cd10340681-752  SH2_N-SH2_SHP_like
cd11956787-837  SH3_srGAP4
cd09937671-749  SH2_csk_like
cd11952785-836  SH3_iASPP
cd11902787-840  SH3_Nck2_2
cd11775786-838  SH3_Sla1p_3
cd12012800-839  SH3_RIM-BP_2
cd10369671-755  SH2_Src_Frk
cd10408671-747  SH2_Nck1
cd09925665-750  SH2_SHC
cd11828786-837  SH3_ARHGEF9_like
cd11949786-838  SH3_GRB2_C
cd12052787-839  SH3_CIN85_1
cd11758788-839  SH3_CRK_N
cd11963788-840  SH3_STAM2
cd11998788-838  SH3_PACSIN1-2
cd11895787-839  SH3_FCHSD1_2
cd10409671-747  SH2_Nck2
cd12055788-839  SH3_CIN85_2
cd11997788-838  SH3_PACSIN3
cd09943671-746  SH2_Nck_family
pfam003074-118  CH
cd11935786-838  SH3_Nebulette_C
cd11793789-839  SH3_ephexin1_like
cd11820788-837  SH3_STAM
cd11800789-836  SH3_DNMBP_C2_like
cd10388671-751  SH2_SOCS7
smart00109516-564  C1
cd11818787-836  SH3_Eve1_5
cd10347670-745  SH2_Nterm_shark_like
cd11970786-839  SH3_PLCgamma1
cd11923785-838  SH3_Sorbs2_2
cd10361671-750  SH2_Fps_family
cd11806789-837  SH3_PRMT2
cd12053791-839  SH3_CD2AP_1
cd11778786-836  SH3_Bzz1_2
cd11809787-837  SH3_srGAP
cd12000787-835  SH3_CASS4
cd11864786-838  SH3_PEX13_eumet
cd11824787-838  SH3_PSTPIP1
cd11947787-838  SH3_GRAP2_N
cd10341671-751  SH2_N-SH2_PLC_gamma_like
cd12076791-839  SH3_Tks4_2
cd11974787-837  SH3_ASEF2
cd09934671-749  SH2_Tec_family
cd11832795-834  SH3_Shank
cd11844787-838  SH3_CAS
cd11999788-838  SH3_PACSIN_like
cd11769789-839  SH3_CSK
cd10352672-742  SH2_a2chimerin_b2chimerin
cd10370671-749  SH2_Src_Src42
cd11985789-838  SH3_Stac2_C
cd10343667-764  SH2_SHIP
cd11990787-838  SH3_Intersectin2_2
cd11779788-838  SH3_Irsp53_BAIAP2L
cd11972783-838  SH3_Abi2
cd11821787-836  SH3_ASAP
cd12003787-838  SH3_EFS
cd12073787-838  SH3_HS1
cd11982795-837  SH3_Shank1
cd11817787-836  SH3_Eve1_4
cd11993793-838  SH3_Intersectin1_4
cd12141789-837  SH3_DNMBP_C2
cd12046789-839  SH3_p67phox_C
cd11838789-839  SH3_Intersectin_3
cd11933786-838  SH3_Nebulin_C
cd09945671-750  SH2_SHB_SHD_SHE_SHF_like
cd11829788-837  SH3_GAS7
cd11813787-838  SH3_SGSM3
cd11969786-839  SH3_PLCgamma2
cd10387666-752  SH2_SOCS6
cd09923671-745  SH2_SOCS_family
cd09944668-748  SH2_Grb7_family
cd13243359-503  PH_PLEKHG1_G2_G3
cd09926671-771  SH2_CRK_like
cd11789788-838  SH3_Nebulin_family_C
cd12021786-838  SH3_p47phox_1
cd11975786-837  SH3_ARHGEF9
cd11991789-837  SH3_Intersectin1_3
cd11973787-837  SH3_ASEF
cd10365671-749  SH2_Src_Src
cd11992789-837  SH3_Intersectin2_3
cd11764787-838  SH3_Eps8
cd12002787-838  SH3_NEDD9
smart00326617-656  SH3
cd10348671-747  SH2_Cterm_shark_like
cd11897787-838  SH3_SNX18
cd11784789-837  SH3_SH3RF2_3
cd11927787-838  SH3_SH3RF1_1
cd11877617-657  SH3_PIX
cd10360671-745  SH2_Srm
cd11928788-838  SH3_SH3RF3_1
cd11989787-838  SH3_Intersectin1_2
cd12001787-835  SH3_BCAR1
cd000142-116  CH
cd11855786-838  SH3_Sho1p
cd11971789-838  SH3_Abi1
cd11759795-838  SH3_CRK_C
cd11929787-838  SH3_SH3RF2_1
cd11815791-838  SH3_Eve1_2
cd11845789-836  SH3_Src_like
cd10368671-755  SH2_Src_Fyn
cd11768789-839  SH3_Tec_like
cd12009789-837  SH3_Blk
cd11808788-838  SH3_Alpha_Spectrin
cd12074796-838  SH3_Tks5_1
cd11851789-839  SH3_RIM-BP
cd11896787-838  SH3_SNX33
cd12045794-837  SH3_SKAP2
cd11934788-838  SH3_Lasp1_C
cd11796787-837  SH3_DNMBP_N3
cd10354671-745  SH2_Cterm_RasGAP
cd11984800-837  SH3_Shank3
cd11986789-837  SH3_Stac3_1
cd11767789-839  SH3_Nck_3
cd10358671-750  SH2_PTK6_Brk
cd10337665-748  SH2_BCAR3
cd10366671-755  SH2_Src_Yes
smart0003332-115  CH
cd09929664-750  SH2_BLNK_SLP-76
cd10418671-753  SH2_Src_Fyn_isoform_a_like
cd12061617-656  SH3_betaPIX
cd11839617-656  SH3_Intersectin_4
cd10399671-749  SH2_Tec_Bmx
cd11866794-837  SH3_SKAP1-like
cd11785800-838  SH3_SH3RF_C
cd10383671-749  SH2_SOCS2
cd11954785-835  SH3_ASPP1
cd11962791-838  SH3_Abp1_fungi_C1
cd11914797-838  SH3_BAIAP2L2
cd12007789-837  SH3_Yes
cd11994800-838  SH3_Intersectin2_4
cd11849788-838  SH3_SPIN90
cd11898787-838  SH3_SNX9
cd12017792-839  SH3_Tks_3
cd11907788-839  SH3_TXK
cd00174617-653  SH3
cd11770789-839  SH3_Nephrocystin
pfam00018617-652  SH3_1
cd00821409-499  PH
cd11869787-838  SH3_p40phox
cd10419671-754  SH2_Src_Fyn_isoform_b_like
cd11847788-839  SH3_Brk
cd11941789-837  SH3_ARHGEF37_C2
cd10397671-749  SH2_Tec_Btk
cd10367671-745  SH2_Src_Fgr
cd12044794-837  SH3_SKAP1
cd11914607-657  SH3_BAIAP2L2
cd12015792-838  SH3_Tks_1
cd11870789-838  SH3_p67phox-like_C
cd10392669-750  SH2_SHF
cd12006789-837  SH3_Fyn_Yrk
cd11918788-837  SH3_Vinexin_3
cd10355666-745  SH2_DAPP1_BAM32_like
cd11983800-837  SH3_Shank2
cd12068793-838  SH3_MYO15B
cd10362671-749  SH2_Src_Lck
cd10414671-748  SH2_Grb14
cd11790786-838  SH3_Amphiphysin
cd10391671-776  SH2_SHE
cd12065787-838  SH3_GRAF2
cd01261406-501  PH_SOS
cd10413669-748  SH2_Grb7
cd11761785-838  SH3_FCHSD_1
cd11850789-837  SH3_Abl
cd10353653-745  SH2_Nterm_RasGAP
cd01227389-462  PH_Dbs
cd11912786-838  SH3_Bzz1_1
cd11966788-837  SH3_ASAP2
cd11911786-838  SH3_CIP4-like
cd10389669-776  SH2_SHB
cd11889787-837  SH3_Cyk3p-like
cd11979801-838  SH3_VAV1_1
cd11886789-836  SH3_BOI
cd10390671-750  SH2_SHD
cd11773787-836  SH3_Sla1p_1
cd11765789-837  SH3_Nck_1
cd11924785-838  SH3_Vinexin_2
cd12008789-837  SH3_Src
cd12064787-838  SH3_GRAF
cd12054617-656  SH3_CD2AP_2
cd12016791-838  SH3_Tks_2
cd11955787-837  SH3_srGAP1-3
cd11916786-841  SH3_Sorbs1_3
cd11779617-657  SH3_Irsp53_BAIAP2L
cd11885786-837  SH3_SH3TC
cd10382672-745  SH2_SOCS1
cd12013789-839  SH3_RIM-BP_3
cd12077793-839  SH3_Tks5_2
cd10398665-764  SH2_Tec_Txk
cd11771617-655  SH3_Pex13p_fungal
cd11807785-836  SH3_ASPP
cd11905786-839  SH3_Tec
cd12142617-657  SH3_D21-like
cd11904786-837  SH3_Nck1_3
cd11968785-838  SH3_SASH3
cd11922785-838  SH3_Sorbs1_2
cd13386409-512  PH1_FGD2
cd11780788-839  SH3_Sorbs_3
cd11848786-837  SH3_SLAP-like
cd10346663-748  SH2_SH2B_family
cd11906789-839  SH3_BTK
cd12066787-838  SH3_GRAF3
cd11837617-657  SH3_Intersectin_2
cd11926789-837  SH3_SH3RF1_3
cd12047789-837  SH3_Noxa1_C
cd11939793-839  SH3_ephexin1
cd11874617-656  SH3_CD2AP-like_2
cd12060622-658  SH3_alphaPIX
cd12062788-838  SH3_Caskin1
cd11830617-656  SH3_VAV_2
cd11917788-838  SH3_Sorbs2_3
pfam07653617-657  SH3_2
cd11831801-838  SH3_VAV_1
cd10415669-748  SH2_Grb10
cd11915788-836  SH3_Irsp53
cd11760787-840  SH3_MIA_like
cd11880788-838  SH3_Caskin
cd11835789-837  SH3_ARHGAP32_33
cd10412666-747  SH2_SH2B3
cd11783789-837  SH3_SH3RF_3
cd10344651-749  SH2_SLAP
cd11976617-656  SH3_VAV1_2
cd11846789-837  SH3_Srms
cd01224389-499  PH_Collybistin_ASEF
cd11965788-837  SH3_ASAP1
cd10718671-745  SH2_CIS
cd11913797-836  SH3_BAIAP2L1
cd11787786-836  SH3_SH3RF_2
cd12051787-837  SH3_DOCK1_5_A
cd12022792-839  SH3_p47phox_2
cd11797789-833  SH3_DNMBP_N4
cd11805622-657  SH3_GRB2_like_C
cd10396671-765  SH2_Tec_Itk
cd11822787-832  SH3_SASH_like
cd11938793-839  SH3_ARHGEF16_26
cd11766617-655  SH3_Nck_2
cd10357666-720  SH2_ShkD_ShkE
COG5422194-462  ROM1


Ontology Information


   
HPRD ID9168
Molecular ClassGuanine nucleotide exchange factor
Molecular FunctionChaperone activity (GO:0003754)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO