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General Information
- Evidence
- Gene
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Down-regulation | - | - |
| 17192196 | 2006 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 20 paired tumor-normal colon cancer samples Stage : - | Whole genome exon array and RT-PCR. | Splicing alteration | - | Five identified splicing events affect mediators of cytoskeletal organization (ACTN1, VCL, CALD1, CTTN, TPM1). Altogether they form a pattern of colon-cancer specific alterations that may particularly impact cell motility. |
| 18353764 | 2008 | Cell line : - Source : - Sample Type : - No. of Sample : 185 tissue samples from colon, prostate, and urinary bladder Stage : - | GeneChip Human Exon 1.0 ST Array to measure whole-genome exon expression, RT-PCR | Splicing alteration | - | Cancer specific alernating splicing of ACTN1,CALD1 and VCL in colon, bladder, and prostate cancer may have diagnostic and prognostic implications. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] |
| Chromosome | 10 |
| Location | 10q22.2 |
| Start | 73998078 |
| End | 74120160 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 122083 |
| OMIM ID | 193065 |
| HGNC ID | HGNC:12665 |
| Unigene ID | Hs.643896 |
| Ensembl ID | ENSG00000035403 |
| PharmGKB ID | PA37288 |
mRNA Information
| mRNA ID | XM_005270142.1 |
|---|---|
| Exon | join(1..298,45006..45076,72593..72743,72898..73006, 74653..74775,76666..76826,84374..84467,85289..85436, 91119..91272,91946..92121,96194..96384,97579..97778, 99127..99255,102871..103020,105743..105851,106974..107276, 109153..109277,110894..111079,113832..114035, 116107..116310,116718..116822,119946..122083) | mRNA Sequence | Download Select all |
| Length | 5529 |
CDS Information
| Location | join(131..298,45006..45076,72593..72743,72898..73006, 74653..74775,76666..76826,84374..84467,85289..85436, 91119..91272,91946..92121,96194..96384,97579..97778, 99127..99255,102871..103020,105743..105851,106974..107276, 109153..109277,110894..111079,113832..114035, 116107..116310,116718..116822,119946..120092) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_003364.1 |
|---|---|
| Protein Name | Vinculin |
| Molecular Wt. (Da) | 116592 |
| Protein Sequence | Download Select all |
| Length | 1066 |
| Uniprot ID | P32926 |
| Ensembl Protein ID | ENSP00000257189 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 1101 |
| S | Phosphorylation | 1113 |
| S | Phosphorylation | 1033 |
| S | Phosphorylation | 1045 |
| Y | Phosphorylation | 100 |
| Y | Phosphorylation | 1133 |
| Y | Phosphorylation | 100 |
| Y | Phosphorylation | 1065 |
| C | S-Nitrosylation | 85 |
| C | S-Nitrosylation | 85 |
| Y | Phosphorylation | 692;- |
| Y | Phosphorylation | 692;- |
| Y | Phosphorylation | 822;- |
| Y | Phosphorylation | 822;- |
| S | Phosphorylation | 290;- |
| S | Phosphorylation | 290;- |
| S | Phosphorylation | 288;- |
| S | Phosphorylation | 288;- |
| T | Phosphorylation | 604;- |
| T | Phosphorylation | 604;- |
| S | Phosphorylation | 721;- |
| S | Phosphorylation | 721;- |
| K | Acetylation | 173 |
| K | Acetylation | 173 |
| K | Acetylation | 496 |
| K | Acetylation | 496 |
| T | Phosphorylation | 1123 |
| T | Phosphorylation | 1055 |
| S | Phosphorylation | 434 |
| S | Phosphorylation | 434 |
| S | Phosphorylation | 809 |
| S | Phosphorylation | 809 |
| S | Phosphorylation | 579 |
| S | Phosphorylation | 579 |
| S | Phosphorylation | 346 |
| S | Phosphorylation | 346 |
| S | Phosphorylation | 380 |
| S | Phosphorylation | 380 |
| T | Phosphorylation | 442 |
| S | Phosphorylation | 443 |
| T | Phosphorylation | 442 |
| S | Phosphorylation | 443 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 58 | ACTA1 | 30 | NP_001091.1 | in vitro | 7816144 |
| 1213 | CLTC | 350 | NP_004850.1 | in vitro | 8276759 |
| 1495 | CTNNA1 | 285 | NP_001894.2 | in vitro;in vivo | 9700171 |
| 2934 | GSN | 674 | NP_000168.1 | in vivo | 11577104 |
| 6401 | SELE | 566 | NP_000441.2 | in vitro | 8609175 |
| 7205 | TRIP6 | 4242 | NP_003293.2 | yeast 2-hybrid | 16189514 |
| 10152 | ABI2 | 7338 | AAF70308.1 | yeast 2-hybrid | 16189514 |
| 55660 | PRPF40A | 10995 | NP_060362.3 | yeast 2-hybrid | 15231748 |
| 79173 | C19orf57 | 14415 | NP_077299.3 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adherens junction | hsa04520 |
| Amoebiasis | hsa05146 |
| Bacterial invasion of epithelial cells | hsa05100 |
| Focal adhesion | hsa04510 |
| Leukocyte transendothelial migration | hsa04670 |
| Regulation of actin cytoskeleton | hsa04810 |
| Shigellosis | hsa05131 |
Structure Information
| PDB ID | 1RKC |
|---|---|
| Resolution | 2.7 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | Vinculin |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01044 | 3-1134 | Vinculin |
| cl20213 | 3-1134 | Vinculin superfamily |
| pfam13514 | 143-576 | AAA_27 |
| TIGR02169 | 221-465 | SMC_prok_A |
Ontology Information
| HPRD ID | 3220 |
|---|---|
| Molecular Class | Cytoskeletal associated protein |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.