Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| VEGFA | 7422 | Vascular endothelial growth factor A | 6 | VPF; VEGF; MVCD1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21743435 | 2011 | Cell line : - Source : Institute of Pathology, University Hospital Basel, Institute of Clinical Pathology, Basel and the Triemli Stadtspital Sample Type : - No. of Sample : 1420 patients with primary colorectal cancer Stage : TNM Stage I-III | FISH, Immunohistochemistry, multivariable analysis. | Amplification | - | VEGFA gene locus amplification highlights a small but remarkably aggressive subgroup of colorectal cancers. |
| 22058001 | 2011 | Cell line : - Source : Department of General and Gastroenterological Surgery, University Hospital in Bialystok. Sample Type : - No. of Sample : 46 patients with colorectal carcinoma (classified due to TNM classification) and 40 controls Stage : TNM Stage I-IV | Literature search | Polymorhpism | - | C allele carrier (CC CA) of VEGF -2578C>A polymorphism appears to be a protective factor for CRC. Polymorphisms of the VEGF gene have been associated with susceptibility to colorectal cancer (CRC). |
| 22209338 | 2012 | Cell line : - Source : Mayo Clinic, Childrens Hospital Boston and Ortho Clinical Diagnostics. Sample Type : - No. of Sample : 54 CRC and 30 healthy individuals Stage : TNM Stage I-IV | ELISA | Up-regulation | - | In CRC patients significantly increased levels of soluble adhesion molecules (VCAM-1 and sICAM-1) and angiogenic factor (VEGF) as compared to control group. |
| 22402885 | 2012 | Cell line : - Source : - Sample Type : Case control study No. of Sample : 2337 CRC patients and 2032 healthy controls. Stage : - | Multivariable logistic regression analysis , | Up-regulation | - | Statistically significant differences were found in the median levels of VEGF, PF4 and PDGF in platelets of patients with cancer compared to healthy individuals. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008] |
| Chromosome | 6 |
| Location | 6p12 |
| Start | 43770209 |
| End | 43786487 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 16279 |
| OMIM ID | 192240 |
| HGNC ID | HGNC:12680 |
| Unigene ID | Hs.73793 |
| Ensembl ID | ENSG00000112715 |
| PharmGKB ID | PA37302 |
mRNA Information
| mRNA ID | NM_001025366.2 |
|---|---|
| Exon | join(1..1104,4133..4184,7261..7457,8252..8328,8681..8710, 10524..10646,11748..11879,14333..16279) | mRNA Sequence | Download Select all |
| Length | 3677 |
CDS Information
| Location | join(499..1104,4133..4184,7261..7457,8252..8328, 8681..8710,11748..11879,14399..14420) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS47432.1 |
Protein Information
| Protein ID | NP_001165094.1 |
|---|---|
| Protein Name | Vascular endothelial growth factor A |
| Molecular Wt. (Da) | 23895 |
| Protein Sequence | Download Select all |
| Length | 232 |
| Uniprot ID | Q99075 |
| Ensembl Protein ID | ENSP00000230990 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 207 | AKT1 | 1261 | NP_005154.2 | in vivo | 17318185 |
| 1490 | CTGF | 412 | NP_001892.1 | in vivo;yeast 2-hybrid | 11744618 |
| 2048 | EPHB2 | 2997 | NP_004433.2 | in vivo | 17318185 |
| 2321 | FLT1 | 1297 | NP_002010.2 | in vitro;in vivo | 8 621 427 170 511 530 000 000 |
| 3791 | KDR | 1867 | NP_002244.1 | in vivo | 862 142 717 318 185 |
| 4904 | YBX1 | 1095 | NP_004550.2 | in vitro | 16198352 |
| 6678 | SPARC | 1631 | NP_003109.1 | in vitro | 9792673 |
| 8531 | CSDA | 10347 | NP_003642.3 | in vitro | 16198352 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Bladder cancer | hsa05219 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Focal adhesion | hsa04510 |
| HIF-1 signaling pathway | hsa04066 |
| MicroRNAs in cancer | hsa05206 |
| mTOR signaling pathway | hsa04150 |
| Pancreatic cancer | hsa05212 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Proteoglycans in cancer | hsa05205 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Renal cell carcinoma | hsa05211 |
| Rheumatoid arthritis | hsa05323 |
| VEGF signaling pathway | hsa04370 |
Structure Information
| PDB ID | 1BJ1 |
|---|---|
| Resolution | 2.4 |
| Method | X-RAY DIFFRACTION |
| Chains | J,L,H |
| Molecule | FAB FRAGMENT |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00135 | 50-133 | PDGF |
| cl00116 | 50-133 | PDGF superfamily |
| pfam00341 | 52-130 | PDGF |
| smart00141 | 50-132 | PDGF |
| pfam14554 | 183-232 | VEGF_C |
| cl20565 | 183-232 | VEGF_C superfamily |
| PHA02661 | 22-133 | PHA02661 |
Ontology Information
| HPRD ID | 3690 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P15692 | DB00112 | Bevacizumab | BiotechDrug |
| P15692 | DB01017 | Minocycline | SmallMoleculeDrug |
| P15692 | DB01120 | Gliclazide | SmallMoleculeDrug |
| P15692 | DB01136 | Carvedilol | SmallMoleculeDrug |
| P15692 | DB01270 | Ranibizumab | BiotechDrug |
| P15692 | DB03754 | Tris | SmallMoleculeDrug |
| P15692 | DB05294 | Vandetanib | SmallMoleculeDrug |
| P15692 | DB06779 | Dalteparin | SmallMoleculeDrug |
| P15692 | DB08885 | Aflibercept | BiotechDrug |