CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
EZR	7430	Ezrin	6	CVL; CVIL; VIL2

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
19399936	2009	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 80 colorectal adenocarcinoma Stage : TNM Stage I-IV	Immunohistochemistry	Up-regulation	-	Ezrin expression is higher in colorectal cancer tissues than in normal colorectal mucosa tissues, and the high level of ezrin expression is closely related to the colorectal cancer invasion and metastasis process.
20872967	2010	Cell line : - Source : Department of General Surgery, Second Affiliated Hospital of Nanjing Medical University, China. Sample Type : - No. of Sample : 43 cases of moderately differentiated colorectal adenocarcinoma Stage : TNM Stage I-III	2-D Gel electrophoresis, Western blotting, immunohistochemistry	Up-regulation	-	Increased expression of hnRNP A1, Ezrin, tubulin-2C and Annexin A1 in SLN suggests a significantly elevated incidence of early CRC metastasis.
21465252	2011	Cell line : - Source : A.C. Camargo Hospital Sample Type : - No. of Sample : - Stage : -	Immunohistochemistry, Cell culture, Cell invasion assay, RT-PCR, Tautomerase activity, In vivo mice	Up-regulation	-	Higher cytoplasmatic ezrin expression correlates with higher tumor aggressiveness and a worse prognosis in colorectal cancer patients. Ezrin protein may be an important target for anti-metastatic therapies and its expression is an important prognostic factor for the disease.

Gene Details

Chromosome: 6; NC_000006.11 (159186773..159240456, complement)
View Larger Image

Gene Type	protein coding
Gene Family	A-kinase anchor proteins
Description	The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	6
Location	6q25.3
Start	158765741
End	158819424
Strand	-
Gene Sequence	>gi\|568815592:c158819424-158765741 Homo sapiens chromosome 6, GRCh38.p2 Primary Assembly GGCGTGGTCCCGGGACCCGCCCCGCCGGGGCTTTTGGGAGCGCGGGCAGCGAGCGCACTCGGCGGACGCA AGGGCGGCGGGGAGCACACGGAGCACTGCAGGCGCCGGGTGAGGCGTGCGGCGGCCGGGGTCGGGACGGG GGTTCTGGGCGGGGGGTTCCTGGTGGAGGGCCCGGGCGGGCGGCGGGGTTCGGCGGCAGGTGCGGCGGGC AGCCTAGGGGGCGCGGCGCGGGGTTCTCGCCCGGCACCCCCGGGGCAGGTGGAGCTGAGCCGGCCCGCGG CCCCGCGACCTTCCCCTCGGCGCCGGGTCCCCTCAGGTCTCTCCCGAAGGAAACGCGGAGCCTGGGTGCC TGGGCGCCGTCCCTCGGCGGCTCCCGAGCGGTTGCAGTTTTTGAAAGAGTTTCTCAAAGGCTTGACGGTT GTGACTGCAGCCGCGGGGCAACGGTTGCTACACAAAGTGAAACTTGCCGAGTGCTCGGCTTCTCACGGGC TTCCTGGCAGCCCCGGGAAGTTCCTCGGCGGACCCCGAGCCCGCGCCCCCTCTCCACGGATCCCTCCCCA GCGAGTGCCCCCCCGCCCGCCCTGTGCCCCCTCTCCCCTGACCCCTCCCTGTCGGGTGCCCCGCGGGCTC GCGCTGGCTGTCCCGGGACTCCTTCCTCCTAGGTGTTCCTCCTGCCCCTCGCCCTCTCTCTCCCAGGCGC GCGCTCCCTCTCCCCGGGCCTTTCCCCGCCGGGTATCCCTGGGCCCGCGCCCCCTCTTCTCCGCCTCTCT CCGCTGGGTGCACCTCGAGTGTCCCCCAGACCCCTCCCCGCCCGGCCGGCGCTCTCTCCCCTGACCCTCC TGGCCGAGTGTTCCCCGGGGCCCGCGCCCCCTCCCCCCGATCCTCCCCACTGAGTGTTCCCCCTGCCCTC TCTCTCCCGGGCCTGCGCCCCCCACCAGCCCCTTCATGCTGGGGGTCCCCTGGGTGCGCACCCCCTCTCC TCGGACCCACCCCCAACTGGGGGGCACCTCCAGTGCCCGCCGGCTGCCCCTTGGGCGCGCGCCCCCGCTC TCGGGCGCCTCCTCGCCGGGGGCCCGGCCCGGCCCCGCCCCGCCCGTGCCCCCTCCCCATGCCCGCAGTG CTGGGCGGGGCGCTGACTCACCCGGGCCCGGGCTGGCCGGTTCTTAAGCGGCAGCGCGCTGCGGGCGCCG AGTGTCGGGCGCGGCAGGAGGACGAGGCAGGGCGGGCGGGCGCTCTAAGGGTTCTGCTCTGACTCCAGGT TGGGACAGCGTCTTCGCTGCTGCTGGATAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAA AATGCCGAAACCAGTAAGTTGCCCAGTTTCTGGGCCGGGCGGACGGGAGAGGCTTCATTGGAGAGGGGAG GCACCTGCTCGAGGTGTTGGGGCAGTTCCTGGGGAACAGGGTTCTTCTCACACGCAGAAGACGATAGGAA TAGGAGGAGGTTTTCGCCGCTCTTTGTTACTTGTTGACCCTTTTGTGGAGCGTTAGGAAAACACCATTTT GATGCTTTTCTCTGCAGTCTTTTTCTTTGTGAGCCCCCTCCCCAGTAGTTACGGTCTTTTCTAAAAACTA GAGGCCTTTTTACACTGCTTCCGTCTGTTTTTAAAGGGTATAGTAATACAACTTAGAAGTTTCTTAAAAA GTCCAAATCACAGGGAGACTCAGATGGCTTCCGACCACACACACCAGTTCTCAGAGCTCCTAAGGGTCCG AAACCACAGGCGCCCCAGATCCAACTGGGGAGATATTAAAGGGCGTTTGGGAGAGGAGACTGGCTTTCGG AAGTTGCCTTTCAGCTTCGCTTCCTACTAGGCCCATGAAGCGGTGCCCTGTACACCAGCAAACTTGCTGG CTGCAGCAGAATTTCTGTCTCTAACAGAAGGTTAGCCATGGACTTGAATTGTAGATGCAGGCAGCCGGTG GAGTTTGATAAGAGGTTCCTGGCAGGCCGGGCCGAGCACTCCTGGTCAGCTGATGAAAGGGCTGTGCCTG CGCCTCTGTCTCCTTGAATCTGATTGTGTTGAGATTGCTGGCGAGACCTGGGGGTTGTAGGCACAAGGCA GGTTCTCTGGGACTGACGCTTCTTAGAAAGTTGTATGTATTCTACCTGCTTTTAACACTGGGGAACTGGT GACTAGACATTAGGGGGAAGGTTTAACATTTTTTGAGTTTTGAATCACAATGGACAAAATATCAGGATTC ATTACAAATTGGGATTACAGATACATCTGGAATTTTTTTTTGGTTTTTCAAACAAGTTGGTTCTGTAATC AATGCTTGTGTGCCTTTTGTGGGGGATGGGGGAGCGGAGTCTCTCTCTGTGGCCCAGGCTGGAGTGCAGT GGCATGATCTCGGCTCACTGCAACCTCTGCCTCTCAGGTTCAAGCGAATCTCCTGCCTCAGCCTCCCGAG TAGTTGGGATTACAGGCATGTGCCACCATGCCCAGCTGGTTTTTGTATTTTTATAGAGAGGGGGTTTCAC CATGTTGGCCAGGCTGGTCTAAAACTCCTGACCTCAGGTGATCTGCCTACCTCGACCTCCCAAAATGCTA GGATTACAGGCGTGAGCCACCACACCCGGCCTTGTGTGCTTCTTCTGTTACATTTTATGTTCTCTAAGAT CTTTGTTAGAGGTATTAATTTTGCTGTTAGGATAAAGAATTAATATGCCAGTAGATTCAGAAGCCAATAT AATTTTTGCCTAAGTTACATCAAGATGATTCATTTGTGATGCAGAGTATTTTCTATACAAAATTTTTCTT TTTAATTCAAACTTAAAAGTGACACGTGACATCGAGGCTTGACAGTGCATGTGGTATGAAACTGACCTAA GTACAACCCCTTACTCAGGCAGAGCTGAGTGCAACGGTATGCGGAGGAGTGGTCAAGAAGATTACCCTTC TGGGTGTGGTTTTCTTTATTTCACTAAAAGAAGAGGTGCAGAGCTCAGCTAAGATAGCACTCAGGAAAAA GTTAACCTGTTCTCCGTCACTACTTTTCTTTCTCATTTCTCATAATGAATGGTAATTTATTTTTATGGTT TCTTTTTTGTATTTTGGTAAAATATACAGTTTATCCTCTTACTTTTAGGTTTACATTTCAAGGTATTAAG TACATTTACATTGTTACATAGCCATCACCAAGGTCCATCTCCAGAACTTTATCTTCCCAGATTGAAACTC TGTACCTATTAAACTCTCCCTCCCCATCCCCACCACCAGCCCTTGGCAACCACCATTCTACTTTCTGTCT CTATGAATTCGACAACTTTAGATACCTCATGCAGGTGGAATCGTGATAGCATTTGTCCTTTTGTGACAGT CTCATTTCCTGTAGCATAATGTCTTCAAGGTTCATCCATGTTGCAATGTCAGAACTCCCTTCTCTCTCTT ATTTCTTATGGCAGGTATGTTTTCATTTCATTTTGTTTTAGAGGTCTTTTATGATAGATCAGAACTTAAA AGATGTTTCTGACATTTGATAAAGTGAAGATAGTTGTGAAACTGTTAAGGAAAGACAGTAGCCATCACCT TGTGTATTAGAGCCAGAGTTACTCTTTGAAAGACTGTATTCTGTATAATATCTACAATTAAAATTTTTAA ACTTTTTTTGAGGCCAGGCGAGGTGGCCTGATTACAGGCACGAGCCTGTAATCCCAGCACTTTGGGAGGC TGAGGCAGGCAGATCACATGAGCCCAGGAGTTCGAGACTTGCCTGGCCAACATAGACTCTGTTTCTACAA AAAATAGAAAAATTATCTGGGTGTGGTGGCTGGCGCTCTGACTGAGGCTGAAGTGGGAGGATTGCTTGAT GAGCCCTGGAGGTCAAGGCTGCAGTGAACTAAGATCAAGCCACTGCATTCCAGCCTGGGCAGCAGAGTGA GATGTTGTCTGAAAACAAACAAAACCCCTTTTTTGAGAGGCTTCCTTTTAGGTCAGCCATACCTGTCTGC CATGGGAAATTTCTCCCTGCCCCCTCTTTGGCAGAGGAGGGTCTTAGAGATAAGTTAAACACACTAAGCC TTTCTGTGTGTAAATTATATTAGAGCCATCCCACAAATCACTGAGAAGAGCATCGTAGGTTGCACATATT TGAATATGACATTTCTTAAGGCTGTTAGAGAGGATCCAGTTAGTTTTGGTTTGGTTTGGGGTTTTTTTGC TGCCTTAGTAAATGTTAAAATGAAACATCCACCAACAGCTCTGTGGATGTGTCCTTTAAACAAAGGTTTA TTGATTCTAATTATTCAAGCCTAAGTTAAGAATGTTAGCGAAGAATGTTAGGTGGTTTTCTTGGGCTTAA TGTTTAACAACTGGATTAAGGGGCAAACACACTTAAAGGATGGATACCTCTGAGTAGTTGGCCTTCCACC TGATTCATTGCAACTGTTAACCCTTGAATTCAACGGGCAAAGTATTTTTGATTGATTTGCCTGAACTGAG TGAGTGGATGACTTTATTCATAAAACAGTATAACTGAAAATACTCATTTCCTGTGTTTTCTCCTAATACT GTTTCCCAAAAGCAACAGTTACTTAAAAGACTGAGGCGGTACACAGTGGCTCATGGCAGTAATCCCAGCA CTTTGGGAGGCCGAGGTGGGCGGATCACAAGGTCAAGAGATCAAGACTATCCTGGTCAACATGGTGAAAC CCCATCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTATGGATGCCTGTAGTCCCAGCTACTTGGGA GGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGTGAAGGTTGCAGTGAGCTGAGATTGCACCACTGCAC TCCAGCCTGGCGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAAGACTTTATTCATCAGCAAGCG GAGTGACCTGCACAGAGGGCGAGGCAGACCTTGTTCTCTGGAAGCTTAGTGTCTGGTACCTGGGCCAAGA TGCGGGGTAAATGCTGAAATTGAAAACCCGCTAAGTGCTGTCAGACTGGGAAAGAGCCTAGGTAACGTCG AGAGGAAAATCTGATGGGGAAAGGAAAATCATCTGATGGGGAAATTGGCAGACTGTATTGAGAAGTAACA CTTCAGCTGAATCTTGCTTGAGGGCTGGGGGGCGCACGCGGCAGCACTCCACAGGGAGGAACAGCTGTGG TTTGTTGTCTGGTTTTGCTTTTCCCACAGCTGCTTAGGGACTCTATTCATGTGTGACTGGCTGACGTCCA AGGAGGGTGATTTGGGGTTCCAGAGGGAGCCTTGGCCTCTGTTCAGGCCAGTCCCCAGGACATGGTGTGC TGTGTGGCCTTGTGGGTCTGCCCCATCTAGGGAGAGTTGTAGGAGTTGGTGCTCAGATCATTGGTCCCGG AAGCATCCTCTCTGCCCGCCCCTTCATGTTAGGGTGACTGCGGAGCGCCTTTCTCCCACACTTGCTTTCT TCTGCCCAGTGGAAAGAAGGCATGGGGAGTGAGCAAGGAACACTGCTGTAGTTAAGCTCTGGAAGGAAAA GGGGATTGTGTTCAGGGCTGAGATCTCTTTAAGCTGTCATGAGAACCATAGAGCTGAACTGCCTTTAAGT GGCTCCAACACATCTTACCTGTTCATTTCTGAAGTGTTATAGACATTTCTAATACAAAAGCAGGTTTACC TTTCATTAGGAAAACTCTGAAAGTGTGTTCACATTTCTACTGTGCCAAAATTTTAAGGTAATTTCTGAGA TTACCTTGCCTCTTTGGGAATACATAACCTTTTCTATTAAATATTTTAACAGGGACAGTTTACTGAATGT ACTCCCCCCTCACAATCCCCTCGCAATTGAGGAGGATGCGTAGCATCTGTTTCCACCCCTCCTCCTCCAC GAGGGGCAGTGGTGAATTAGGTAGCTAACATTTTGCCATGTGGCAGTGAGAGGTGCTGGTAGGATGAGTG ATTTGCCATGATCACGCTGTAAGGCACAATGAATGTATTTGGATGTTCACAGACACAGTCCCTGTCAGTG GATTTACAGTCTGGTTTCGGGGACAGACAGCAATCCCAGAGTAAATGTAAAACTGCAGCTTCAGAGAGTA TGCCTGAAGAGGGGTACATGAGGCCTGAGAGTAGATGAAGTGTGTATGTGCTGGTGGGGGTGCAAATAGG GGAGGTCAGGAAGGCATCCTTGAGGACGTGACCTCCCTGGGCAGAGGTAACAACGTGTGCAAAGGCCCTG TGGTGGGAGGAAGTAGTGTGAGTTTGGGGTTTCACATGAAGCCCAATGTGGCTAGAGAGGAAGACAGGTC AGGCCATGCCTTGTAAGCCATTCTTGGGTGTTTTTTAGTTTAACTTGGGGTTTTGACTGGGAGGTGACAT GATCAGATTTGCCTTTTGAAAAGTTGACTGTGATCTGTAATAGGAAAATCACAGGAGGCAGGAGACAGCA AGGGTAGTTATGGTAGACCATTGAGGGAGCTCATAGCTTGGACCAAGGTGGTGGTGGTGGGAACAGAAGT GGATGCATTTGAGAGTTCTTTGGGAGGTAGAATTGATAGTGCCTGGTGATGGGTTGGATATGCAGGGCCA AGGGTGGTGTCGAGGCTGACTTCTCGTTTCTGGCTTGCGCAAGTGGATGTGTGGTGGTGCCATCGCTGAG GTAAGTAATCCTGGAGAAGGACCAGGTGTGGGGGAAGGTGGGGAGTCTGGATTTGTTGTTACATGTTAAT AAGTTTGTGACAATCGTTGATGAAAAAAGTCCTTGCCTTCTTTCATTACTACATCCACTGCCCCCCAAAA TATTAAAGGACCAGACTCCTTAAACTACGTTATTTTTAAATCCAAATAATTCAGTAGCTTTTTGTTTTCC CTAGTATATGTACACACCGTACATACCTAAAGTTAAGAGGAAGGGTTAATTTAGTGCAGTGTTCTCAAAA TTTTGTGTACACAATTGTCTGGAGACTGTTGATTCCTGGGTCCCTTGAAGAACTAATGACTTCCATCTCT AGGGTGAGGTGCAGGCTGGGTGCTTATGTTTTAAATAAGCTCTCCAGATGGTACTGCTGATTCAATAGGA AAAGGGCAGTTATTATATATTCCTTTCTCCTGCACCCCAATCAAGCCCAGTGTGATTTCAGAGCACCCAT TTGGGTGAAAGCAGTCACTTGATGCCCAGCCGCCTTACAGTCCGGCTGAAATGCCAGGAGTGCTGTTATT GGTATTTGGGACTCGAATAGGGGCTAGGATGACTCTGTGAAAAAGAGCCATAAAAACAAGAATTTCATAG CTAATTTACTGCTTACCTATACTTGGGCAGGCCATTCAACATAATATTCTTCTGACTTGAGTTTCTCTCT GCAGGGAGTCCAGTAACAGCTTCATTTGGCAGTGCCCAGTGGTCTCTCACATTTTGGCTCTTTGTTTTCA AAGAGAAAAAAAGAGGCTAGACCTTCCCTATAAATGGTAGGGAAGTAAGAGATCCCATTCCTTGTTCCTC TTTTATTCCTTCCACACTGGCCTCTTTTGTTAATGAAATAATGTGAATTTTTTTTTTTTGGAAACAGGGT CTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACAGTCACAGCTCACTGCAGCCTCAGTGCCCCGGCCC CCACCCTTGGCTCAAGTGATCTTCCCACCTCAGCCTCCTGGGTAACTGGGACCACAGGCACACACTACCA CACCCAGCTAATTTTTTATTTTTTTGTGAAACAAGATCTCACTGTGTGGCCCAGGCGGCTAGTCTCAAAT TCCTGAGCTCAAGCTATCCTCCTACCTTGGCCTTCCAAAATGTTGAGATTATAGGTGTGAGCCACCATGC CTGGCTGATAATGTGATTTCTAACAAATGTTGAATAATTATAGTTTGGGAAAGGAAAACAGTATCATTTA GTGAACTATAATTTTTTTCTTAATTTTTTTAACTTAAACTTTTATATCTCTTTGACAATTTGGAGATTCT TAGGGTGGTTTGATATACCTGCTTTCTAATGGTAGTTAGATGTTTCAGCTCTATTCTGAAGCAGTGAAAT TCAGTCTGCTTTCTAATGGTAGTTAGATGTTTCAGCTCTATTCTGAAGCAGTGAAATTCAGTCTGCTTTC AAAGTCAGTGAATGCATTTTGAATTATCCCTTATTTCATTTCAGTAGTAACTACCTTGAGACTCCCCAAG TACTCCAATTAGTTTTTAATTTCAGCAGTAAATGTGTGTTGAAAAGACCAAAGTTTGCATTATTTTCCTT CTGATGTATTTACCATCCATGCCTGTTGACATAAAAAGATTTTTCCAGACTTGGGTAGTTTTCAGAACCA AACAAAACCCTTGTGCTATAATGTGACTTAGAGACTTTTGACTGAAATGCTTGATATAGTTAATACACAT AATTTTTTTCAAAATGAAACCACAAAGAGCTATAAAGAGAATTTCATAGCTAATTTACTGCTTACCTGTA TTTGGGGAAGCCATTTAGCATCTGTGAACCTAAATTTCGTCAGCCGTAAAATGGGAGTTAGTTTTTAAGT GGAAAGAATGTTACATAAGATAAACGGAGACAAAGTTTTTATCAGTGAAATCCAAACAACTCATCTTAAG ATGCTGTAAGCTTTATGTGTTTCTTTTGTGTTTCCCTACCCCGCAAATGTTTTTCAAACTTAACCCTGTT AGGTAAAAACTCTGGGTTCCTATAAACGGGTAAAGTTTGTCCATTGGTCTTCTCAAGGAAAAAGCAATAT GAACAGTTTGGGTTATCTTAGTAAAAGGGAGGACTCTGATTTTGTCTCATGTCCATCCTCTCTCTGTGTG TTCTAGTCGGAATTCCCTTATCAGTCACATGGGTACCACCTTCATGTTTTGAAGCGCTATTATATCCCAT TATGTGCTTGGTGCAGGGACAATAAAAATAAGATTGGTTTTGCCTTTAAGGAGTTCTCAGTCTCCTAGTG AAAGCAGATATGTAAGCAATTACAATGCAGTGTAGTGCATGATAGAGGTCTTCACAGAAGAGAAGTGTGC CCTGGAGACCAGGGAGGGCCTCCCGGCTGGTAAGATCCTTTGGGTAAGTGTGGAGGGATGTGGGCTTCCC AGTCAGCAGTGGTCAGTTCTGTTTTCCTTTATTCATTAACCCGTTCTTAACACTTACAGGCAAACAGTAA TGCTGTTTCAAAGGAAATGTAAAACTTCATTAAGTTATCCTTTTAATCTAATATACTTGAAAACAAAACC TTAAAAGCAAAATAAAAAATATCTCACCATGACCCACCTTTTATTGATAGGAGAGGAACCAGTATCACCT GAGGATCAAACTCTAGTAGTCAGTATATCAGATTTTGCTCATATTTTTAAGTTAGAAGTCACTTCTGCAA CCTAATTTTGTTTTCCATTTTTGCCTGAGAGATCAATTTTAAACTGCCTGTGTGGACAGTTGTCATTTCA GATACTGTAAATAATTGTTTTTACTTTAGGATGGGGTAGGTAAACTATCATCTTAGGGCCGAGTCTGGCT GTGGCCTGTTTTTATTTGGTCTCCCAGCTAAAAATGGTTTTTATATTTTTGAAGGATTTTAAAAACAACA ATATGCAACGGACTCCAAGTAAGACCCTCAAAGCCTAAAATACTTACTGGCTGGCTCTTTAGAGAAACAA ATGGACCAACTCCTGCTTCTAGCATAAAAATAATTATTGTTAAGCATTTATTCTAACCTTGTATATATTT TATGGCTGGACTAATATTTGGAAGCAGATCCACCCCATTGGTTCCAGTTTTTAAAAAATTGTTCTCAAAG AACAGAATGTGTTTTGTTAGCCAATGTTGAGCACATCATGGACTCTGAGCATGGACTCAGAAACTACTGA GGAGAGGCATCGTGGTGCTGAGGTAATGTTTTAAACAAAGCTGGTGTTTGGGTGGGTCTTTGTGTAGAGA AAGTGGCAGTATCTTGTGTCACACTTGCTAAGCTATTGTGTAATGACAGATTTCTGGCATATGCTAAAAG AAAGCAATTTGTACCTGATGTTTGAGTTGGAAAGAGAATGTTATGTAAATGAATTGCTTTTTTCCTCATT GATAGTTTAAAATGAGCTTTTGATCTACTATAGTCTGTATGTGAATTTCTGACTGCAGATGTTTTGTAAG TCCATTCCTGATTCAGAACACCCTGTCTAAAGTACAGCTCCATCTCTGTGCCGTGCCCCACTTTACTGCA CTCATAGAACTCGGTCTCCACCTATAACGCTGTCAGGTGCTTGTTTATTTGTGCTTTTTGTCTTTTCTGG CAGCAAAGCAAGAGGATAGGTGTTGTTTTTGTGTTTTTGAGATGCGGTCTTGCTCTGTTGCTCAAGCACG AGTGCAGTGGTACAATCATAGCTCACCACAGCCTTGAACTCCTGGGGGACCGCAGGCGCTCACTACCACA CCTGACTAATCTTTTTATTTTTATTTCTATAGAGATGAAGTTTCACACTGTTTTGTGCAGGCTGGTCTCA AACACCTGGCCTCAAGCCATCCTCCTGCCTCAGTCTCTCAAAGTGTTGGCATTATAGCCATGAGCCACTA TGCCTGGCCCAAGTTTGTTTGTTTGTTGTTTAGCATTATTATTTTATAGCAAACTTTAAATTCTTGTTTA TTGGCAGGATAAATAGAGGGAAGAAGGACGAGCAAATAGGTAAACATACCTGCCTCCTAGTGGGTAATCT TGGGCAAGTTTTTTCACCTCCCTCTGCCTCCTCATCTGTAAACAAGATCCTGCGTGCCCGCCTGGGATGC CTGCTAAGATGGCACATGGGAAGCACCTGGCCTTATGCCTGGCCCTGGTCAGTAAGGGCTGTGCGGTTCC ACTTGTACCTGATAAAATTCTAATCTGATTAAAAGCTTTACTAGCTCGTGATGGTCATTCTTTTCCTCTA ACTTAGCAGCCCGATGAAATAATGTAGTAAGTAAATGTAACCTTGTTGTTTGTCCTTTTGCTGCCACGAT GAACACAGCTGTCTTGCTAGACCTCTGTTGACTTCAACAGGGATAGCATCAGGTTTATTGGAAATTTACA TATGGGACAGTCCAGTGGTGGTGGGTTGGACAGAACAGCAACTGCTTCCCGAAAGCTTGGAAAAAGCATG CAGTTTACACAGCATTCTTACTTAACATACTCCCCCTAACAGCCTCCACCTGGCAGCCTTAAAGTGCTTG TGGGCTGGGGGTTCAGATGTTCCCCATAGATAAGGAATTGATTTCAGGGTTGGCCACTAGGATTCCTTAG CTCGGAACTCCACACACGCATTCTTCTTAAGTTATTGATGTTAGGTACACCTGTACAACCACCCTGCATA AAGTTCATTCATTCAACAAATAGAGCACCTACTTTGTGCCAGGTTTTCAGGTACTGGGGAGACATTGGTG AACAAAAAGAGGCTTTTAAAGGATTATCACCTGCTTGGTTGACAGTCACATCCAGTGAATGGTGGAACCC ATTTCCTGCTAATGTGTATTTGAGCCTGAAATGCACATTGTCCCACCTTTCCTCAATGGCAAAATGCTCT GGAAAGGAGATGCTGGTCTGACTAAATAAAATGGGCTTTCTGTTTGGAGTTGTAAAGGGAGCCGTGCCTT CCTCAGCCCCTCCTGAAAGAAAGACCTGCTTTCAAGAAGCTTATATTGCAGGGGGAAAGACACATGTCTA ATACATCGTCAGGGGGTGGTGAGCGTGCTACTGTAAATTTTCACCTAGGCTTTGGCAAGAGCTAGAATTA ACTTTCATTCTTTACTGACTCTTTGAAGCGTTAAAACCACTGGGCAGAGTGACTTAGGAGTGGGCCCACT GTGATGTGTTTTTGTTGGTTTTCTGGTAAATCACTTTTGGGTTGGACAGTGAACCATGATGGTCTTTCTT CAAGAACTTGTTTTTGCAAGGGTTTGGTGATAAGTCCATCATTTCCAAACCCACTTACTCTTCCATCCTT TCTCAGGTGCTGTGGTTCAGGGAAATGATTGTTTTGATAGTATTTTACCTATTGCACCATTACTTCATCT GTAAATTTCTTATAAAATATGTCTTGGGATCCAGCCTTGTCTTTTTTGTTTGTTTTTTTTTTTTTTTTTT GAGACGGAGTCTCTGTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTGGACTCACCGCAAGCTCCAC CTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCAGCCATCACA CTCGGCTAATTTTTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGACAGTCTTGATC TCCTGACCTCATGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCT GGCCTGTTATGTTTTTAAAGAGAAAATTGAACCACAGGTCACTTGGTTAAAGCTTAGCACATAAATATGA GATTGGAATCACTTTATTTGTAAACATATATGTAGTGTATATTGGTACAGTATTTTCATTAAGGTGTGTT TCATTGCCTCAGTTAAATAATTAAGGGTGTTGGCTGCTGGGATGTTGAAGTATTTGCTTACATAATCCAT TGCTGTTTGGGTGAGACTCTTAAATGGATTTAGACAGATAATGGTGAGAAAACTGGATTTTTTATTTAGA ACGTGGCTGAACAAGGCAATGTGGAAATAGTGTGATAACAAGGTGCATTATATAACTTGAACAAATCAAC TGCAAAAAGACATTTTCAAAGAAATGGAGGAAAATTGAATAATATTTACTGAACTTGACGTATTAAGGAA TTGTTTTAAATTATGTTGGATGTGATAATGGTATTGTGATTTTTTTTTTTAGTGCTTTAGAGCAATATAC TGAAGTTTTTACAAGTGAAATAATGAATGAGGGCCTTAAAATATGCCAGCAAAAAAAAAAAAAAGTGAAA GTGGTAGAGTAGAAGAAAGAATGGTGTTGAAGCTGAAAAGAGAGTGTGGAGGATCATGGTACTACTTATT CTCTCTACTTTTATGAATGTTTTCAACTTTCCATAATAGAATATTTGCTTTTAAAAAGCATGTTATAGGG TAGAAAGGGAGAGATGCTTTACTTTTGCTCGTCATGAAGTGCCTGAGTGTTGAGGTGGGAGGATCTCAGG GCGAGGGCAGGTCCCCCATTCCCTGCTGCTGGGGCAACCTTTGTGCTCTGGATCAAATGAGTAACTGATT TGATCTCATCAAATGGCCCCACCCGGGCCATCTCACCCTCCATGCACATGTTTTAAAAGGAGGTCACTAC TCAAAATTGCAGCTGACTTGGAAACACATAGAACGATTTGTTCCCAGTTTTTTCCACTATTACTTTGTAT TCCCAATGTTTTGGGGGGCCCATAGGAATGGGGCACAGTGCTGTGACCCAACTGGGAACAGGTCATTGTC TTAATAGCGATTTTCTCAGACTTGAAAATTGAAATGAACAAAATAAGGGGCATCTACTGGGTAGGGCTTT AGCCATTTTAAGAGATCAATCTACATACTGGGGCTGTGGGCAGGGATGGGGGAAGGAAATACAGCAAACC ATGGGTTGGGGTTGGGGTGAGTGATAGGGTTGTAAAATGTACACCATGTCTTTTCCAGTCAAGTAATGAT GTACAAATTATAATGCCATTTCAGATGTAACATACTTGATACTGACAGTATAAATTGAAGAGTTTTTTTA ATTTTAATTTAGTATAATTTCAGAAATGGTGATTTTAAAAGTTTTGGCAGGGTTTGCTTATTTAAGCAAA TTTTGTAAGATTACTGATTTAGTTTGGATTTTTTAAAAGAAGCTACTTTGGTCTTGCTAATTTTTGACAC ATGGCAAAAGTAAAGACTGGGGTGAGTTCAAATCTTGTCTAATCGAAGTTTCTTACAGGAGAAATGTTCT TTAACATTGTATAATATTGCTCATGTGATCTTAACTAGGGGCAAAAATTTATCTCAGCAATGGCACAAGA CTTAAGTATGGTTTATGTCTTATGTCCTCTAAAAAACAGGTTAGCAAAGAAATTTTTCGACCTTTTTTTT TTTTTTTTTTTTTTTTTCCTGAGATGGAGTCTCTGTCACCAGGCTGGGAGTGCAGTGGCGCCATGTAGGC TCACTGCAGCCTCCGACTCCCTGGTTCAAGCGATTCTCCTGCCTCAGCCCCACGAGTAGCTGGGATTGCA GGCACACGCCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGTTTCACCATGTTGGCCAGGAT GGTCTTGGTCGCCTGACCTCGTGATCCACCCACCTCAGCCTCATTGTTTCCTAGACTCACCTTCTCACTC CCAAGATCAGAAATTGGAAATCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATA TTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGGAATATCACACTCTGGG GACTGTTGTGGGGTGGGGGGAGGGGGGAGGGATAGCATCGGGAGATATACCTAATGCTAGATGACGAGTT AGTGGGTGCAGCGCACCAGCATGGCACATGTATACATATGTAACTAACCTGCACAATGTGCACATGTACC CTAAAACTTAAAGTATAATAAAAAAAAATAAGAAAAAAAGAAAGGAAAAACTCTTCACAGGCTTCTAAAT TTGCAGAGACAACCATGCATTCCAGGTGAATAGTGATGTTTAATCTATAGGCCTTTAGTTCCCTATCTTT TCTGAGCCTACAATTAAAACCGACTCTAGCATATAATAAGCCATCTTGGCCTTGTCCCTTACTTTTGTTT ATGTGTGTAGTTACTAAGTTTACTAAGTAGTTACTAAACTTAAGTTTCTGTGTATAATTACCTGCACATT TCAGTGAAGCATGTTGGTGATGAAGTATTTATGATATACCTAGTGAAACTGAAATCACATGGTATACAAT CAAGACTTAGACTTCAGGAGTTTATTAGATAAATTCTTGTTCAAGGTCCCTTTCTCTTTATTTTGCCTGC CCTGAGGTAAGGAGATGAGAAGGATGTAGATTGTGTTTCTAGAAAGAATAGTTTCTTTTGCTGAATGTAA CATCCTTTGATTATTTCTTTTCCCTTTCTTAGGGGAAAGTGGTGTCTAAGAATTCCAGTTTACTTCCCTG TTAGATAACACACAATGTATGTTATTTCCAGTGTAGAAGAAGTTGGTTCTTAATTAGAGACACTCACCAA AAAGGGCCTTAAAAACTAGCAGCTAATAGGTATCAGGAGCATTATTTTCATACGCCATCAGCAGGTCGGA AATGGCCATCAGTGTTACTCGGCAGTGCAGGCTTGGAACTCGGGCATGACTAGCAGTCATTTCATTGTCA GACCTATGGAAAGCAGCTCCTTTCTGCCTCCCAGATGCAGTGGACAGTAGGGAGGGCTTAGCACAGAACT CTTCCCAACCTGGTTTTAAAATGACCCTCTTTTGAATGTGAATGCCCAGAAAGTTCCCTTCTAGTTCTAA GGTCATGATTTTCTTGCTGATAATAATGAGCACAGATGGGACTGGTTTGTCCGCTTTTTGTGTTTGTTAA GCAGCCTTGGTCTGACAGGATGTGGGTCTAGGGGCAGGAAGTGGCTTACTCTCAGAGGAAAAAGGAGAGC TATTTAGGATTTGAGATTTCATTACATGTTCTTGAAATTATGGGGTGGCTATTATTCTGGACTCTCTCTG TATATTTTATATATATATATGTATATATATATATATATGTATGTATATGTATATATATATATATATATGT ATATATATATATATATATATATGTATATATATATATATATATATATATATATATATATACATATATATAT ATATATAATGTTACATAATATTTACCCTGGAGTTGGTAAATACAAACTTTTCAAAAGCATAAAACCATTG GCATCTATTTAAAGATACTATTTTAGGAGTAATGTTAAAGAGCCAGAGCTACACAGATATTTTGGTAGCT GATTACCAGAAGTTGAGGGTCTCAGTTTTTGTAACCATTAAAAAAAGGTCATCAGACGAGGATAACCGTA TACCTCGTATCGAGTACTCATTTGGAGTCACTCTACCAGTTATACTTCATCACTATTCTGATTGGCTACT TAAAACATACGTTTATATAACATAAAAATGTAACATCATGTAGATACGTGAAAAGTCAGTTACTAGGAAA TTCCCAGCCCCCACTTCTGTGTCAATACTCTGCCCTGTTAACGTCTGCTGCACATTAAGAATTTAGCCTT GACATTTTAAGTTTAGCCTAATGGTGGTGCTGGAGGAAGTAGTAAGGAGAACAGTTTAGAAAAGGAGGTG TGAGTGGCATGTAGTGTTACTTTTCATCATTTAAATTACTCAAAAAGTTCCTTAAAGTGCTTCTGGCTTC TCTGGGAAATGAGTTCCTGCTTCCCTGTGGTGTCAGGAGAATCGCAGGGTAGGAGACACGGCCCCTAGGA TACTGGACATGGGCTGGATGCTGTATTCGAGGGATAAACCATGTATGGTTCTTGTGCTTAAATAAGCAAA AACCTGGCCGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATTACG AGGTCAGGAGATCGAGACCATCTAACTTAACATGGTGAAACCCCGTTTCTACTAAAAATACAAAAATTAG CTGGGCGTGGTGGCACATGCCTATAATCCCGGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCC GGGAGGTGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCAACAAGAGTGAAACTC CGCCTCAAAAAACAAACAAAACACTACCACCAAAAACCTAACTAGCCATAGTCAAGTAGAAGTATACAAA TATTCCAGAAGAACTAAACTATAAGGTGTTTGTAAATATTTAGATGTGAATGAGTATAAACAACGCATCA AAAAATCATAAAAATTGATATTTGGTAAATTTTCCTTTCTGCCAGACTTGCTGGCAGTTAAAATTTGAAA CAGTGACTGTACCGAAAGCCTTTTTATTCAGGTTAAAAGTTGTACTCCCATTTCCTAAAATAAGGACTGA ACTGAGAAACTCTAGCTACAGCTACTTGGTTTTCCATAGAGTTAAGTTGGCTCCTTAGATGCTGAAGTCT GTAGTTATGACCTTGCTTTCATTAGTAATTAGCACCTGGGCAGGTACTAACCAATGAATGCCCTTTACAC CTGGCAAGAAGGAATGGGTGGGGAGGCCAGATTGTTTCAATCTAAAGGGCACTACGTTGTGGTGGGTTAC GTTTTTTGGTAGACAGACACTGCCTACAGGCAACTAAGTCATTCCATTAACTGTCATTATCAATCCATGT GTGGCCAAGCTTGAATTGTCCTGCTGGTTTAGCTTCCTGATGGGGAACAACAGCTGTCGCAACGCACAGT GTCTGCAGCTCCATCATGGGCCCCAGGACGTCCCACAGCAGCTAACACTGGTCTGTACTCGGAACTCTGC CACCTGGCCAGTGACTTTTGTGCGTCATGTTCCTGGGAATAGTATGACTGTCCATGATTCCTAGGAAAGC TAGAGGAATAACTGAGGATGAGGAGCTAGCACTTTGACCCCTGTGGGGAGTGCTGGTTATAGTGGTTATC AGGGTTGTGACAAGTGGACTCTTGTGAGTTCCAACACTGGATGATTTTATTATTCCTATTACTCAGGCAG TAAAAGACTAGTACATATCCTGGTGTTATATAATTATATGAAAACTTATCAGAATGAGTTTTATAACTAG CGTACCCATGTTTTTGTTATTGTGCTGCAGATAAAATGGCGCACTGAAATGTTACTGAATTATGTGACAA TTTTTGTTACAATTCTGTGCACTTTTTACAAGATTTGTGGAGCTTAGATAGATGGCTGGCCTTTGGCATC TGAACATTTTCCTGAGCCCGATAGACAAGCAGATTTTTTTTGTTTGTTTTTGGAGACAGGGTTCTCATGC CTGTAATCCCAGCACCCTGCCTAGTTCAAGACCAGCCTGGCTGGCAACATGGTGAAACCCCGTCTCTACC AAAAATACAAAAGTTAGCTGGGCATGGTGATGCACGCCTGTAATCCCAGATACTCTGGAGACTGAGGCAG GAGAATCGCTTGAACCCGGGAGGTGGAGGCTACAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTTGA CAGAGCGAGACCCTGTCTCAAAAAAAATTAAAAAGACAGGGTTCTGTTACCCAGTGTGGTGGCGCAAGCA TGGCTCACTGCAGGCTCGACCTCCTAGGCCCAAGTGATCTTCCCACATTGGCCTTCCAAAGTGCTAGGGT TACAGGAGTGAGCCACTGTGCCTGGCCAAGATTTCTTTGCCTTTGCGCTCATGTTCTTCTTTAACCTTAA AAGAAGAGGTCATATAAAATAATCAGGTATAATTTAAGATACAGAAAGCTTGATAGAAAGGAGTAGCCGT GTTCTACATCTTCATCCATTGCATTTGCAGATATGCCTCAGGATTATTTTATTAGTACAATTTTTTTTTC TTTTTGAGACAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCGGCACACTGCAGCCTC CACCTCCCAGGTTCAAGCGATTGTCCTGCCTTATTCCCTGGTGTATCTGGGATTACCAATGTGCACCACC ACACCCGGCTAATATTTTGTATTTTTAGTGGAGATGGGGTTTCGCCATGTTGGCCAGGCTGGTCTCGAAC TGCTGGTCTCAAGTGATCCACCTGCCTCAGCCTCCCAAAGTGGTAGGATTATAGGCATGAGCCACCGTGC CCAGCCTAGCGTCATGTATTTATACTGTTATTTCCACCTCCTAAAAGTCAACAAGGACACTTAGCTCAAG AAGGCTGATGTTGAGAGAGAACGCTTATCAGAACAGGGATCTCTGAGGAAAAAGGGAGCTTAAATGTGTG TCCCTGGAATTTCTTCTAGCCCTTCCTTTCCTTGGTGACATGGCCACTGCTATGGGCGGGAATTAGAGAA GAGCCCTGACCAGTGGTGTTGATGTCTTTGCCAAGTATACTGTCAGGTCAGTGTCATAAATTGATGATAT ATATAGAGAGACTTCATTTAATAGAAAATAATATTTTAAGGACCACCTTGCTATTTTACTTCTCTAATAA TGTTTTGAATATTTTGATAAATACCTTTAGCAACATAGTGGTTCTCATCTCAGCCCTCTCTGTCCTTGAA AGAATGTTATTTATAACAGGGTGGTTTCTGGACTGCCCTTCTGGAGTAAAACTTGGGCATTCTAACCATA TGCTTGCTGGAAACCATAATAATGTAAAAAGTCGTCATTGGGTTTTCAATTGCAATTACATTGATATAAT TTTGTATATAAAACAGTCTGTTACTGGGAGCAGCATTGTTCATGTAAGAAAGATGTTCGCTTCATATAAT ACATGGAAACAAAGTTATATTTTCAATGTTAGCCATTACTGTGACACTCCAAAAAAGGCTGGTGATGGGG AGAAAGAAGAGCTTTAAAAAAACCTACAGACAATTCACTTGCCTCTCGGGCTTTTCTGCTTTGCCTGCCT TGACCGAATTAGAGTATCTGCATTTCTGCACTAAGCTGGTTGAGGTTTGCTAAGTCAATGGTAATGTTTT ACAGAGCTTGGCTGTTAGCCAGCATTTGTGGAAAACGACCAATGTCTGTCATAGCTAGTGCTATAATTTA TTCAGTTGGCATATTGTTTATGGAGACAGTGAGATAAGGGGATTAGGATCCAGAGAGACTATTAAAATAT GTGAGTCCATCTGTTGTGATCTGAGGTTTCATTAGAGAAAACCTGTCTGCTAGTACAACAAATGGAGACT TAGTAAGGATGTTTTTATATAAAGGATTATAAATCAGCAGAGGTAAATACATTAATCTTGGCCAAACAGG TCATGTCCTTTTGCGTTTTCCTGATGGCAGGTTCTGCCCCCTGCCGCCCGGGCACTGTTGGTCATAGCGT GACCTTGGCATCAGCTGTGAGCCGGTAAACATGGAAATGTAGGCCCCTCCCAACCTGAGTCAGACCCTTA GCCTGGGGTCCAGGAAACTGTTTTAACAAGCCCCTGGGTGATTTTTTTTCACATGTTCAAGTTTGAGCGC CTCGAGGGCCTGTGAATGGCTGCATATAAGGTACAGCTGGCCATATGTCTTAAATGACTTCAAAGGGGTG TGAGCCAGGCCTCTTCCCACACCAGACTTCATGAACCATGCCTGGTATTGTCATGTTTTTGTGAGCAGCC GTGAATAGGGCTGGGGGAGAGAGATGTTCAGCCAAGAAAGTCTAAAATAGAAAGGGAATGTTCAGTTATA ACAAAACAAATTTTTGTAATTAGAGTGCTGGGTTGTGCTCAGCATCATTGGAGTTAAATGTGGAGCAGTG GCTTACACTTGTAATCCCAGCACTTTGAGAAACTGAGGTGGGCGGATCCCTTGAGGTCAGGAGTTCGAGG CCACCCTGGGCAACATGGTGAAACTCCATCTCTACAAAAAATAGAAAAATTAGCCGGCTGTGGTGGCAGG TGCCTGTGGTCCCAGCTAAGGAGGCTAAGGTGGGAGAATCTCTTGAACCCTGGAGGCAGAGGTTGCAGTG AGCTGAGATCACGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGAGACCCTTTCTCAAAAAAAAAAAAA AAAAAAAAAAAAGCGGAGCAGCAAACTAAGTCCCTTTTCCATCGAGGGAGGTCTCTGAAGCAGAGCTGAG CCAGCCTCTCAGCTCTGCCCTGGTGGGGCACCCCATAGCGCCCAGAAGCAGTGAGGGCTAAGGCGGCAGA GTGCAGCATGGCCATGCATGATTGGAGCGCCGCTACTGTGTTGGTGTCAGTTTGGCAGCCAGCAACTTCT AAGAACATAGAATATTTTCATTTAGAACTTAAAAACAGTAAACCCAAAAAGTTTAGTTTTTAAAAATTCA TTTTGTTTCTCCCTAAAGATTTTTATTCTTTTGAAAATGACCACAGTCTAGTTTGAATGCCATTGTTTTT CAGCTGTTTCTTATTTGCAATTGCTAAAAGCAACAAGGAGCAAGTTAAATGTCCATCACCTGAATGGGTA GACAGAAGTGACAGCCACACAATGGAATATTCCTGGGCAGTAAAAAAAGAATGAAGTGCTGGTACATGCT ACAACATGAATAACCCTTTTAAACATTATGCTAAGTCATGGGATTCAGTCATGAAAGACTGCATATTACA AAATTCTGTCTCTCTGAAATGTCCAGAATAGGCCATTCCTTAGAGACAGAAAGTAGATTGGTGGTTTCCA GGGGCTGAGGGATCAGGAGGAATGCAGAGTGACTGCCAGTGGCCATGGAGTTTCTTTTTGGGCTGACAAA CTATTCCAAAACTAGATAGCAGTGTCAGTTGCATAACTCTGAATATACTAAAAACCACTGAATTATACAT TTTCCATGGGTAAATTTTATGGTAAGTTACATTTCAATAGCTGCTATTTAAAGTACATAGTGACTCAACA TGAAAGGAAAAATATACAGTTTTGTCTCTATAATTACCCAATTAAGTGAACCAAAATAGCTGCAAAGTTT TTAATTCATTTATCATTGGTTGTAAGAATTTTCCCTATCATACTCCCATTTGTGGGAGAAAATTTACTGT ATCTACTTTCTATCAGAGCATTTCTAAGTATTTGAAAGGTCTTATCCAAATATTTGAAAGCTGTTAAAAG TTGCTGAAGTGGCACCTTCGGAAGAAGGCTGGAATGTTGGAAAACAGCGTTGACATTTTAAATGATATGG AAGGTCAAGCTCGCAATGTAATCTTGGTGGTGGCTGGATGGCTCTACTCAGACTGGTTTTTGAGTAAATG GCAGGTGTGATAATATAGGGATTAATCTGTTAACCACTGAATCCACTGCCTGAAATTCAGACATTCAAAT GCTCCCATTTGAATTTCCCTTTCTTATTTTACATGGTTTTCCTGATTTTTGAGTACATAAAAAAATTATT GCAAACTTTTTTCCTGCAGTGTTCTGGCCACTGAAATTAAATCTGGTTCTTTTGTCTAAGACTCAAGGGT TGCTCTCCTGTAATGTTTGTGGAGGAACTGATCTTGGACTTTTCCCTCCTGTCTTGGGCTTTTATTACAG TTTGAATTTATGCTGTAAAAAGTGTGATTGTAGAGGTAACCTATAAGTTTAAAATATTCAGAGGAAATGG ATGCTTCCCAAAGGAAAAATTGCATACCTATATTTATTTACCAAAATGAGGAAAATACCTGGGAAATAAT TTGGCCAAATATTCAGCAATTATATTCATAGATTAGAAGCAAAATACAAAATTTGATTGTCAACTTGGTA CCTTTTTCATTCCTTACACTCTTAGAAGGCATTTTAAGATGCCATTTTGATAAAATTAAACTGGGAAGAC TCAGAAATCATGTTTTCCCAACTATATTCTGAAAAATCCTAGTTCCCTGGGATGCTCCGTGGAAATAACC TGTGGGCAGAACAATCTGTGAAGTGGAGACTGTGGCCCCGTCTTGGACTGCCACTGTTGGCATCAACATG GCAGACAGGCAACAGCCTTTCAGCTAAAGAAGGAAGAAACAGAAAACCCCACCTTAACCACTGCAGAGTT ACGTGACCTCCAAACACTGCCCCCACAGCATATCCCCATTTTTGTCCCTTTCCCTTTCAAAGCCAAATAA TTTCAAAGAGGACTACATAGCTGCTGGCTTGGGATGGTGTCAAAAGCCAGGCAAGATGATTTTAAGTCAT AGAATGATCGAGCTGGAAGATGCTCACAGATTAAATGGTCTCCAGCCACTCAATATCAGCAGCAAGGGAG AGGAACAGGGTTGGCCTGAGTGAGGCTGGGGCCACCCCTGCCGCCAGGCCTGTGTGCCAGGCTCAGGTGC TCCAGGGAATGAGCAAAGAGGATGTTGGGTTTATTTTGTTTTAATAAGGCGAATTGTTACTGAGTTTATT TAAAAATAAAGCAGCTTGGGGTTTAACACCTTGCATGTCGGTTGCATTGGAGTGGTAACACCTGTGCTGT CGTGTGTCTGCCTGGAGGGGTACTTTCCTTCTTGGGAAAGTGAACACAGGTGTGTTGTCCCTTCTCCGTG AAAACACTCTACTTGCTGGCCTTGAATAGCATTCTAGTGGGTTACTTTTCTCCTAGTGGTCAGAGAGTAT TTATTGGACCTCTGGTTCCATTGGCATGTGTCCCCTAAGGAGGGAGACCCTTCAGGGGGTACTTACACCT CTACTGTCCGATGGCACTGGCTGTGTCACACCTGGCCTGTGGGCTTTGAACCTAGCATTTCAGAGTGGGA AAAGGCCTCAAGCCATCTAGTCCAAACTCTACCTGCAGATCAGGTAGAGGCCCAGTGGCAGGAAGTCATC AGCTAGGGGTCCTCAGATTACAGAGCTAGCTCTCAAACCCAGGCCCTCTGTCTCCCGTCTCTTGCCTTCC AGTGATTCCCAAATTTGGCCTCCTCAAAATCACTTGTGGAAGTGACAGCTTCCTGGGCTGCGGGTGTTTG AAAAGCTTCTGTGGGGATTCTGATGGTGAGGCTGATGTGGGAAGCACTGTGGTGTGTGATCACTGAGGCA CACCCATCTTCATTAATGTGTAAGCCACTCGGGGATAGGAAGGGCTAATGCCTCTCTGTACTCACAGTGC CCATCGAGGTGCCTGGCACACCTTGCAGTAGTTAATTGGTATTTGTGGATCGAATGAACATGTTAGGTGC CCACTAGCAGGGGTTGGTCCTGTAGTCTGTGGCCATGGAACATTAGAAGAATAAAGCTATTGTGGTTCAT CCTGTAGTATAGTAAGTTCGAGCTGAGCTAACCTGTAATAACACAAATACAATTTTTTTTTTTACGTTTT TAAAAGTTAGAGATGGGTTCTTGCTATGTTGCCCAGGGTAGTCTCAAACTCCTCGCCTTGAGATCCTCCT GCCTTGGCTCCCCAAAGTCCTGCGATTACAGGCCTGAGCCATTATATTTGGCCAACAAATAGAATTATTT ATTTATTTATTTATTTATTTTTTGCGATGGAGTCTCACCCTGTCACCTAGGCTGGAGTGCAGTGGCGTGA TCTTGGCTCATTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCTCTCCTCAGCCTCCTGAGTAGCTGG GATTACAGGTGTGTGCCACCACATTTGGCTAATTTTTATATTTTTAGTAGAGATGGGGTTTTACCATGTT GGCCAGCGCTGGTCTTGAACTCCTGACATCAAGTGATCTGCCTGCCTTGGCCCCCCAGAGTGCTGTGATT ACAGGTGTGAGCCACTGCGCCTGGCCTAGACTTTTTTAAAGAGTAGATTATTAAGCAAAGGGAGAGTATA AACAGTATTGGTTTTTCATTAGCTTCATCTGTACCGTCAACCACATGGTTCTTTTTGTCTTGGTAGTGGT ACAGGAGTAAAGTTAAACTTAAATCACCACCAACACCCCCAAGCTAAGCATAACTTTTAAAAGTTTTTAA TATTTTGGCAAGCCTGGGAGAAATATTGCCCTTTTTTGGGTAGATCTTGGATGACTAACTGCTTACTATA CACACACCTGTACTACACGTGATTGCGTTGCCTTCACTGAACACCGTTTTTGATAACTGTGTAATCTGAG GGGAATTACTAAGACAATAAAAACTGCAGACCACGCGCTCTTTTTCTCCAGTCTGCACATAGTTTGGATA TGTGTGGTGGTGTGTTTAAGCCCATGGACTTGAGTTTTTTATGGGACAATCCTTGTGTGTATCAGAATCA TACAGTCCCAGTACCATCTTATTCCTCTGGCATTATTGAAGATACAAGAACCAGTTGGCATTCAAATATG TTGAGTTCACTAAAAACAGTTGCTGATGAGGGAAACCTAACACCCTGATAATAAAATGGAAAGTTGGGAT TTAGATGTGTTTTCTCAATTGCCAAAGCCTGGTGGTGGTGGTGCTGGTGCTGGTGCTGGTGGTAGTGCTG GTGGTGGTTGTGGTGGTTTTGAGTCTTCGCTGTATCACCCAGGCTGGAGTGCAGTGGCGCGATCTTGCTC ACTGCAAGCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGAAGCTGGGACTATGTA TGGGCACGTGGTACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGCTTCACTGTGTTGGCCA GGCCGGTCTCGAACGCCTGACCTCTAGTGAGCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGC GTGAACCACTGCATGTGGCCCCAAAGTCTGTTTTTTTTCCCCAAGCCCTTGGATAAGTAGACAAAGTATG TATGTAAATGGTCCTGTCATCTCAGTGAATGTCTCATTTTAAATTTTGGTGAAAGCTTATGCTGTATTGT AGCACATTATTTTATCTATAACATTGAAAATAATTGGCCTTTCTAAACATGGAACTGTTTATCATGCAGT AGGGTAAGGCAGTGCCATGCTGTGGTACTTAATCTGGGGAGGATCTCCTCCCTTTTCCCCATAGAGCATT TGGAAATGTGTGTGTGGATGGGGTTGCTTTTAGATGTTCCAGTGACTGGGGACACTCAGTCATTGGATGG CTTAAGGATGCTAAACGTTCCTGAGTGCTTGGGATAGTCTTGCAGAATGAATACTTGTGCTGTCCAGAAT GACAAGAGCACCCCCAGTGGGAAACACTAGTAGGGTAATGACTAATCAAGTAACAGACATGCCCTTTAAC TTAAAGCAGCTCATTAACATAGTATTCATTTACCTGTTTAGATTTTGAGTATCTTCTCTTCAATCTCTAT GTAAAGATACAGATTGTAGAGCCTGCCCTATGTATGAATATATATATATATTAAAACTGTGATTCTAAGA AGGGGTTCTTAAGGTTCTGGTGTGTCCCCAAATCAGAACTGGAAATTATTCCTTTTAACAGGGCCAATGG ATTCCTATTGCTGGTCCTAGTTTTATTACTGCAGTGCCAGAACAACTCCCTGATCATCATTTTTATTTTT TTAAAAGAGGATCTCACTCTTTCATTCAGGCTGGAGTGCAGTGGCTCGATCATAGCTCACTGCACTCCAG CCTGAATGATTTTTTGTAGAGAGATGGGGTCTTGACTTGTTGCCCAGGCTGGTCTCAAATTCCTGGACTC AAGTGATCTGCCTGCCTTGGTTTCCCACAGTGCTGGGATTACAGGCATGAGCCAATGGGCCTGGCCTCCC TGATCTTTAGACTTGCAATAATTGTTTGAGGTTGCGTACCATAGGGAATGATTGCCCATGGGTGTTGGAG CATAGGTAAAAAATTTTGTGGAATGATCGGACCAGCTAAGAGTTGGCATTGTGTTGGAGCTGCTGGTGCT CAGATGAAGTCCTTTTGTTAGGAGGTGTAGATTTGTTGACTCATGCAGAACTTCTCAGTAGCTTACTTTT TTTTTTTTTTGAGATGGAGTCTTGCCCTGTTGCCCAGGCTGGAGTGCAGTGGCCCGATCTTGGCTCACTG CAAGCTCCACCTCCCGGGTTGATGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGTGACTACAGGCGCC CGCACACCTGGATAATCTTTTCTATTTTTAGTAGAGATGGGGTTTCATCGTGTTAGCCAGGATGATCTCC ATCTCCTGACCTCGTGATCTGCCCTCCTCGGCCTCCCAAAGTGCTGGGATTACGTGAGCCACTGTGCCCA GCCAATTTTTAAGTTCACTTTCTACACGCTACTGGGTTGTTAAAACCAACCTCAGTAAAAGTATCCGTTT TACAAGTTACTTGCTTTTTCAGGCCAGGCACAGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAA CCCTGTCTCTACTAAAATTACAAAATTTAGCTGGGTGTAGTGGCTGGCATCTGTAATCCCAGCTGCTTGG GAGGCCGAGGCAGGAGAATCGTTTGAACCCAGGAGGCAGAGGTTGCAGTGCTGAGATGATGCCACTGCAC TCCAACCTGGGCGACAGAGGAGACTCCATCTCAAAAAAAGAAAACAAGTTAATTGCTTTTTAAAAGGGTT GTGTGAACTTTCAGTCAGATATGAAACTGTTTCAGAACCAAAAATAAGTTATTCTAAATTCCTGCTAGTC AGTTTGCAAAATGCTTAATATCTTTTTAATGTTAATTATTAGCTTTGGTTTCAGGAGATGTCATTTTCAC ACTGTCTTCAAACTTAGAAGAGACTCAGGTTTAGAATTTGGAGTCTGGGCCGGGCGCGGTGGCTCACGCC TGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATGACAAGATCAGGAGATTGAGACCATCCTGGCT AACACGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCTGGGTGTTGTGGCGGGCACCTGTAGT CCCAGCTACTCGGGAGGCTAAGGCAGGAGAATGGCAGGAACCTGGGAGGCGGAGCTTGCAGTGAGCCAAG ATCACACCACTGCACTCCAGCCTGGGCGACAGAGAAAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAATG GAGTCTGAAATCTCGTGTGCATGGACTCTGGTCATTTGTCTTTGTCCTAACCAGACAGTGGCCTTCAGTT CTAATTGTACTTGGGGTTCCCACTTCTGAACCAGTAGATAGCAGAGAAAGAAAGGTGGCATATCCAGGGT TCTGCATTTGTGAGCAAACGCCCCTCCACTTTAGTTTTAGTGTGTTATGTCATTGTTGGCTTCTGTGTAT GTAGCTGGAGCTGCATTTGTTATTGAGATATTTGACTTGGGGCTGGTTTTCCCATCTCTAATACATGCCC TTGGAACCATAATTGAGAGAAATGCGTGCTTTTATTTTATGCTTCATAACAGCCATTTTGTGATTTTAAA AAAATTACCAGCAGGAAATGAAAGAAAAGTAGGTTTTTATATTTTAGTATGATTAAAGACTTTAAAACAT GTCTCGTTGCCTCCTAGTAAACTTGAGTTCTTTAACTTCTGGACTTGGGGATTGTGGAGAAAACTTTTGA AACAAGATCTGGAAAACGATACTTCTGTACTTGTTGTACCAGTCGGGGAGCCTTTAAGGGCATATTGGAT GCATGTTAGAGGATCTCTCAGTCATAGTCTTAAATGTTATTGGGACGGGGTGGGAGCGGCTGGGGAGACT AATTATGTTCCTGAAGTAGGAAGTGACATTTGGTGAGTGCTTAATATTTCTGGTTCCCTGGCTGGATAAC GAAACCTCTGTCGCCATATACTGGCACAGGTAATACGTCCTTATTACATTTACACCTGTGTTAGGAAGAA TCCGGGATAGGTATCTCTCCAGCTTCTGTATATTTCACTTGAAAAATGGTGAGAAGCAAGCATTTCTTAA TATTAAGCATTATAGTTGCTATGTGGCTCTGCTGTTTTCTTTGGGACAGTGACATAAAGTAGCCAGATTT GAGTGTTTTTCATACACTTTAGTAAATCTGGGTTTTCTCAAGTGATAAATTTGAAAACTGCCTTGATGTA AGTGGGTTGTTTTGTTGTTGTGGTGGTGGGTTTTTTTTGTTTGTTTGTTTTGAGATGGAGTCTTGCTCCG GAGCCGAGGCTGGAATGCAGTGGCACAATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATT CTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGTGCGCCACTATGCCCAGCTAATTTTGTATTT TTAATAGAGATAGGGCTTCACCATGTTAGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGGTCCACCTG CCTCGGCCTCCCGAAGTGCTGGGATTACAGGTGTGTGAGCCAATGCGCCCGACAGTGTTTTGTTTTTTTA AAACAACTACATGGCAACATTAGAAATATTTTAAGGCCCTCCCATCTCCACCTCCTCAATTCTGTGTCTC ACCATCCTCATACTATTTCCATTTTTACATTTTATTTTCATGTCTTGTCTAAACAGAGTTCACATTTGCA TTGAGTGTTGCTTGTCGTATTTTTTATTTCAGAAGCAATTTGCCCAGTTTCTACTATTTTCGTAATTATA ATTTAATATCACTACATAATCCATTTTTGATGTGTCTTTGGACATTTCACCATTTCTCTCTCACTATGGT TTCTAAGGTTGCTTCAAACCTTCTGATTCAAAGCTCTTTCTCTCTTCCCTTCTCTGACTTCCTTGGTGCC TTGGGAGCCCTCCTGCCTCCCTTGGCTGTCGTAAGGCTCATATGAGATGGTGCATGGAAAAATAGGTTAA AGTATTGTTTTAACAAAAAAGAAAAAAACTGCTTAGGTTGGGCAGGGTGGCCCATGCCTATAATCTCAGC ACTATGGGAGGCTGAGATGGGAGGCTTGCTTGAGCCTAGGAGCTCAAGACCAGCCTAGGCAACATAGTGA GACCCCGTCTCTACAAAAAGTAAAAAACAAAACGAGCTAGGCATGGTGGCACCTATAGTGCCAGCTACTC AAGAGGCTGAGGTGGGAGGCGTTCGTGTGAGCCTGGGAGATCATGACTAGTGAGCTGTGATCGTGCCACT GCACTCCAGCTTGGGTGACAGAGCAAGAGCCTGTCTCAAAGAAAAGAGAAAAACTGCTTAGACCTAAGTG TCAGTGTGCTTTATTAAAGCAAAGAAGCTGCGTTTGGTTTGCACTGTGTGCCTCCTGAGACATCCCCAGC CATCTGCAGTCAGGAGTGGTGTGTGGCTTCCTGACTAGCACAGGAACTGATGTCAGGCATATGCCGTCGC CACACTGAGGAGCAGCTTATGTAGAAGGTGCAGGAGGTTATTAGAAGAAAAGAATACTCAGTTAAGCGTA ATTTGTTTCATTCTGTTTTTCAGATCAATGTCCGAGTTACCACCATGGATGCAGAGCTGGAGTTTGCAAT CCAGCCAAATACAACTGGAAAACAGCTTTTTGATCAGGTTGGTCTCTGAACTTGAGAGTTAACTCCACCT ACAAAAAAAAACTGTTTTGCAACATTTCAGTTATTTTGTTTGCGAAGCATATTACCTTGTTTTACTCACT TGAGGTAATAGATGAGAAGGATCTTTTAAAAGGTGAAAGTATTTCATGATAGCATTATAAAATGCATTAA CAGACAAGTATATCATGCCTAGGAAGTGAGGTGTATGAAAGCACACAGCTGTCTGTTGTATAAAGTCAGG CGGATTCAGTGTGTTACCAGGCATGGAAGCAAAGGACTGAAAAGAGAGTTATTGTGCTTGTCATTGTAAG GAGGTGCTGGCCTGTGTGTCTCTCACCCTGTATTAGAGACGCGGCTTCCTACCCGCAGCTGCCTCCACCT CCAGAGTAGAACCCCTCTCACTGCGTGGATGAGTGAGCCTTAGTTGTCTCAGTTGCTGCAGCTTCTCATT TCTAAGTGATCGTACCTGAACATCTATGAAAGGAAGAAATGAAGATTTAGAGAAATAATTCACTTTTTAA AATTGGAAGATTTTTTTAAATCAAGTATTTATTAGTGATATTACTACTTACTTATTAAATACTTTTTTCC CCAATAACAGCTGCTTCAAATACAGCGTTGTTTTTTTTTTTTTTCTTTGAGACTGAATCTCACTCTGTTG CCCCGGCTGGAGTGCAATGGTGCAATCTCAGCTCACTGCAACCTCTGTCTCACAGGTTCAAGCAATTCTC CTGCATCAGCTCCCCGAATAGTTGGGATTACAGGCACATGCTACCACGCCCTGCTAATTTTTGTATTTTT AATAGAGACAGGGTTTCGCCATGTTTGCCAGGCTAGTCTCGAACTCCTGAACTCAAGTGATCCACCCGTC TTGGCCTCCCAAAGTGCTGGGATTACAAGTGTGAGCCACCACGCTCAGCTTGCAGCCTTCCCCCATCCCT TTTGGGTGAGTGGGAAGAGGGGGAAGAACAGGTCAGTCCTGGGCATTTAATAAACAGACTTCTAGAGCTT TAGGGAGCCTCTGGCCTCCCTGCACCCTTCAGATGAAGAAACAGGCCCAGATCAGGAGTTAATTTGGAAT TTTAGGATTTACTTTAAGCAAATGCTCTGTATACCTGAGTTGTCATTTCTAATGTATTCAACCCTCTTTG GCATTAAATATGATAGAAGCCATGTATTTGAAGGATGGTAGCATTTTTTAAAGTTTAACATTATATATCA TGGGATTTTAAATTAGACATCTATGTATATGTAAATAGTCGAACTTGTCTGGGACTCGGTTTAGATGATG TTCAACAAATGTCCACAGCAAGTTCGACTATCACTGCTTTTCTGTTTACAAGACAGTCGTGAGACTAAGC AGCTCAGGACTCCTGTAATGCACAACAGAGGCTTGAAAATGTGAAATCTTTGCTGTGACCTAGGGTCGGG ATTCTACCTTTGCTGTATCAGAATGTCCCATTTCTGGAGGTCTATAAGATGCAGGTTCCTCTGGGCACCC CTGTGCATTGACACCCTTCCGTCCCAGAAGTCTGCCTTGCCTGTTTTCCTGCCTTTCCTAGGATTTCTTT GTCCCTGTTCCTAGTAAGTCAGACCCCTGGGCCAGCTGGCTGAGAGGCAGAGGCAGGCAGCCAGAGGAGG CTCAGGTGTGGCACTGGATGCTTTAGTCTTCTGCATGAGCACACCTGACCGGCAGCGATGCACCCACCGC ACTGTTCCCTGGGGGGCTGTGGGCTCCCATGGTTCTGTGTGTGCTGGCCATAACCCGCCCTGCTGAGTTT CATGCAGGAGAGCATCCTGGAGTACAAAGGAGTAGGAGTGAGATTTTCTAAGATTTGAAGGTAGAACCCT GAATCTGCTCAAATTTATATTAAAAATAAGTCGTTCATGGCTTTGAGATAATAGCCTCAGTTAGTAACAA GTTATTTGAGTGCAAAAAAAGATGTTGCCCAGTGGTTGGACTGAGCAGATGTCCTGGTTTCCTGGGGACT CTGCTAGACCATGTGATGAACGACAGCCAAAAGCTGTTGCCCTTTTGAGTGAGTTTCTCATGAGTGTTGA GCCTCTCTCTCTCTCACGCAGGTGGTAAAGACTATCGGCCTCCGGGAAGTGTGGTACTTTGGCCTCCACT ATGTGGATAATAAAGGATTTCCTACCTGGCTGAAGCTGGATAAGAAGGCAAGTCAGGATTAACTATTTAC AGGCTGTGGATTGGGTGTTGGTCTGCTTCATCGATAAGGAAACTGGAGCAACTCACCCTGTCTTTTGTTT TCTGTTCCTTTTTGTTTGTGTAAAAGTTTTTACAGACAAAAAGGTTGCAGGTTTCCAGTAAATGGAGATA TCGATTGGAAATCAGATCTGGCATTTCTCCATAGTGCTCACTCATTGGAGCATATGATGGTTAATTGCAT AGCTTTTAGTTGACCTTAGTTTTTTCAATGAGATTGTTAATCTTATAAACTGTGAATCATCCACCATCTT GTAAGAACCTGTTATTGCTTTGTTTGAACCTGTGACAGATTATCTTCCAACTTTAAAGAGTGGATAATTC CATTAACCAACCAAAAAGAAAAGTAGTAAGATAAACATTTTCTTCAAACTCTGAAAATTATCCTTTTTTT TTTTTTTGAAACCCCCACTGTCCTCCCAAGTCACAGCAACAAGTTAAAAAGATGATGGGAGGTGGGGAAG AGTGGAGGAGCAGGAGGAATTCTTAACAGTAAGTTTCGGGGTCCAGGGCCCGATTGGCATGTGGCCCCAT TCCAGGTCACTGGGGTCATTTCCAAATTTGAGTTCTCCAGGATTGATAGCATCATCCCATGAGGACTGGG GCTTAGTGAGGCAGTAGCTTTGATTTCCAGCTGAGCACAAGAGTGTGATAGTACTTGTTTGTTTTTTGTT GTTGTTGTTTTGAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGGGTGCAGTGGCACGATCTTGGCTCACT GCAACCTCCACCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGCTGC ATGCCATCATGCCCGGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGTCAGGCTA GTCTCGAACTCCTGACCTCGTGGTCCGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGTCGTGAGCC ACCATGCCTGGCCTGTTTTTTTGTTTTTGTTTGTTTGTTGTTGTTTTTTAAGAAGAGACAGGGTCTTGCT CTGTCACCCAGGCTGGAGTGCAGTGGCGCCATCATAGCTCACTGCAGTCTCGAACTCCTGAGCTCCAGGG TTCCTCCTGCTCAGCTTCTTGAGTAACTGGGACTATAAGCATGCATCACCATCCCCAGCTAACTTTTTTT TAAAAAATGTTGTAGAGATGGGATCTCTTCTACGTTGCCCAGGCTGGTCTTAAACTCCTGGGCTCAAGTG ATCCTCCTGCCTTGGCCTCCCAAAGCACTGGGATTATAGGCATGAGCCACCATGTCTGGCCTGTGGTAGC ACTTTTGACTAACCTTTTTTTGTCTGGAGTGCTAAAAAGATGACTTTAAGAATAAATATCTCCTGAAAAC TGGCTTGAGGGCCCCATTGAGTCTTGGTTAGAAGCCTGTGTTGGGGACAGTGGGCCTTCGTCTTCCGGAT TTGTGTGGAGAGTGTGGCTTGTTTCGTGCAGGTGTCTGCCCAGGAGGTCAGGAAGGAGAATCCCCTCCAG TTCAAGTTCCGGGCCAAGTTCTACCCTGAAGATGTGGCTGAGGAGCTCATCCAGGACATCACCCAGAAAC TTTTCTTCCTCCAAGTGAAGGAAGGAATCCTTAGCGATGAGATCTACTGCCCCCCTGAGACTGCCGTGCT CTTGGGGTCCTACGCTGTGCAGGCCAAGTTTGGGGACTACAACAAAGAAGTGCACAAGTCTGGGTACCTC AGCTCTGAGCGGCTGATCCCTCAAAGGTGAGCACAGGATGACCCGGCCTGGGCAGGAGCAGTCATGCCGT CCTCGGCAGGGAGAAGTGATTGCCTTAGAAGCACAGTTTAAAAACACAAGGACTTCGCCAGTGTCAAGTG CTCCTTCATGCTAGTCATTAAGTCACTGACCAGCGACCTGAAACATAGCCAGGGAAGGCGAGCTGCCATT CCTCATGGAAACTAAAGCGTGGCCGTGTCCTGTGGGACATGGCATAGCAAACTTCTCGACCTGACTGCTC AGCTCCTCCTGGGGTATGATAGGTTGCCCCTGTGAAATCTGTTTTTATTTAGTAATGGTCACAAAAATTA CCCCATTTGGAAGAAGAGGCCACTTAAAATACCTCTTAGTTTTTCCAGCAGAACTGAGTTCTTGTTCAAA ATGCTAAGTCTTCCAGATTAACTGTCATAAATAGAAATGCTGCACATCAGGAAATAGAAACCAAAGCTCT TTGGGATTGATTGATTTGAATGGAAAGTAAGGGTTTGAATGTGGGTGGTAAGTGGGCCTCCTTCCTTGCC TGTCACATTCCTTAAGGATGACAGTGCTGTTTCCTTTTGCATTCCAGAGTGATGGACCAGCACAAACTTA CCAGGGACCAGTGGGAGGACCGGATCCAGGTGTGGCATGCGGAACACCGTGGGATGCTCAAGTGAGTGCT GTGCCCTGCTGTTGGGATCTTGCCATCTCCGTGCGCTCCAGCATGTCTTTTCCTGTGACTCTAGTTAGTG CTTTAAAGGGCTCTGTGTCAGGCCTTGTGAAGACCTTGAGGGAACCGAGTTAAAAGTGGGGTTTTCTTAG GGAAGAGGTTTTTTTTAAACAAAGCCAGGTGTCTTGCCTGGGGAAAGAAGCAGTTTAGCTCAAGCCTTCA GGTTCTAAAAGCTTACACCCTCCCTTTGTAGAAAGTGTTGTGTCTAAACTTCATCTTAGTCAGAGGGGCA TTGTTCACCTGCAATCAGCATTATTCTGTCAAAGAGATGCTGGTTTGCTCATTATATGAAGGTACTTGTC TTACAAAGTGTATATAAATGAAAAAGGATCCCAAGTGAGAAATGCTGATGTCAGAGAACCTGGACGTGGG GCTGTTAATGTAAGACATGGCCGAGCCACCTGATTCTGGGTGTTCTCGTCCTAGAGCCTTGTCTCTGGCC TAGTCTTGCGAGTCTGCATTATTTCAGCCTCTGAAGTTTGTTTGAGGTTTGAGCCTCAGATTTTGTGCTT CAGGGTTTCCTGTCTGGCCCAAACATCCTTTATGGAAGGAAAACAACTCAAAGCCTATGAGGAGGGTTGT GGGAAGACATGTGTGGGCAAGAGAAAAAGGAGGATTGTGCTGAGTGATAAAACTTAAAAACCTGTTAGAG AAACCAGTGTGAATCAGTTCTTCTTCAAAGTGTGGGGTTTGGTGGTGAGGCTCCAGGGCAGCACGGACCC CACCCCAGGCATAGCTTCTGGGCTGTATGGGTCCCCTCCTCACCGGTCGGCTGCCCGGCCCCTGCCTGCC TGCACGCAGCACACAGCATTGAGCCCATCCTACACAAGGCGCCTTAATTTAAAAATACTGGAAAGGTTTT ACTGTTCTAGATATTGAGTGCTACCAGTGACTCTGCCTGTTTCACTCTCCCCAATTAGAGATAATGCTAT GTTGGAATACCTGAAGATTGCTCAGGACCTGGAAATGTATGGAATCAACTATTTCGAGATAAAAAACAAG AAAGGAACAGACCTTTGGCTTGGAGTTGATGCCCTTGGACTGAATATTTATGAGAAAGATGATAAGTGAG TTGAAGTTCACAGTTATCTTCAGTAGGTAGGGTGGTGGGCCTGGAAACAATGGCAAAATGGCAAATTTGT GGGTTATTTTTGAAGTATTTATTTAGCAACTTACTATCCCAAAGTAGGAAACTTTTTAAAGGGCTTTTGG ACTGCTGTGGCCCTCTCAAAGGGTGGTCCAGAGGTGTGGGTTATCCTCTCTCATGGTGGGCGGGGCCGAT AGTGGGCTCAGTCCTGGTAGAGGAAGGCAGAATAGAGCAGAGGCTGCCTCTCCTCCCCGCTGCCTCTGAG ATTCCACCCCAGCTGCCTGCAGGTACCAGCACATCCATCCATAGCTACTTCGCAGGCAGCCCAGCCAGTG CTCGACTCCTGGCTCGAGGTTTGTGCTAATCCAACCAAGAATATTGATGGTGTGATGAGAGACTTGAAAA GCTGTAAACAATAGCCTGTACGTGTAGACACTTGAGCTAAATGCTGGGAGTCTGCAGGAGATATCTTAAT TGCCTCGCATTAGTTACGTTGTTTGTTGAGTGAGGGCCTGTAAGCAAGCTGGGTAGAGCAGCAGAGCCAG GCCTCTCCACAGGGACAGGCAGTTCCGCTTTCACATACAGGGCATTTGCCTTCTTTCTGCTGAGGATAAA CAGGGAAAGTCATCCTAGTTCATGAGGGCAAGTTTCCCATGGTGAGTCTGCGACATCAGCATAATCCTAG ATTCTGGATTGATCTGATCAGAAGCTACCTGAATTTAAGAGGCAGAAGGAAACTACCTCTGGAAAGAGAA GGGAGAGGCTCCTGACTGCCTCCTGACTACCGTCTCTGCCCTGATTGTCCACAGTCAGCCTGATTGCTCT GCAGGGCTCCCCGAAACAAATCATCTGATGGCCACCAGGTTCAGGGGCCTGGCAGAGAAGGTGCCAGGGC AAGAATGCTCCTGGGGTCTTTTTGCCAAGCCCTGCCTTTTGGCCTGGGTTCCTGCTTTCCACGTAAAGAG CAGAGTGGCCCAGAGTTCCTGGATGTACCGGTTTCCTTCCCAGCCTCATGCTGTTCCTTGAAATGACAGC TCTCCCCATTTCCCACTTGAGGCTCACCCATCTCATCTGTTCTCAGATATTTTTGTTCTCAGCATCCCCA CATCTCAGGTTCCCCCAAAACCCTCTCTGGAGTTCTCAAAGGGAGTGGTGCTGCTTTCCACAAATGACCT GCATGAGTCCATCTCCATTTGCAACCACGCGGATTCCTGCCAGACCCCAGGGCACAGATCTATTTCACTT GGGCAAGTCAGGGACCTGTGCCAGCTGTGCCCAACCTCCTCTCACCTCCGGGGCCCACGTGGTGATACTG CACAGGGAGGGAGGCAGGCGCTGTCACAGGAGCTCCTCAGAGAACCTGGAAATGAGATATTGAGGACTCT CGGTTCGCTCCTACTCCAAGTGTGCTGGATGCAGCATTGGTAAAGAAGCACGGAAAAGCCAGGCACAGCG GCTCACACCTGGAATCCCAGCACTCTGGGAGGCCGAGGCAGGCGAATCCCTTGAGCTCAGGAGTCTTGCC CAGCCTGGGGAACATGGCGAAACCCCGTCTCTACCAAAATTTAAAAAATTAGCTGGCTATGGTGGTGCAC GCCTGTGGTCTCAGTCAGGTGGCTGAGGTGGGAGGATCACTTGAGCCTGGGAGGCAGAGGTTGTAGTAAG CCAAGATTGCGCCACTGCACTCTAGCCTGGGTGACAGAGCGAGACCGTGTCTCAAAAAAAATTTTAAAGA AGTGGGGAAAGTGGGTACTTGGAACCAGGACACCATCTTTCCGGGAGACCCTAGAGCTGAAGCCGTGGCT ATTAAGACAGCCATGCCAAGGAGCAGTGCACAAAGTCCTCGTGGGAACGTATGTGGGAAACTGCCTCTGC CTTGGAAATCTCTTCAATGACCAGATTTTGTAACGTGGCCAGGCCAGGGCTGTCCAAACAGGTTTTTCAA CCTGCAGGAAAACAGCCATGGGCAGGAACTTGCTGATGTCAGCTTGTAACTGCCCCAGCCCACGTAAGTG TCCATTTCTTCCAAGTAAAAACGTGAGCTGTGTGCCCTATTTAGTGCTGTTTTTGCGCTCTGCTCCCCCT CCCCCACCATTGAGCGATGAACGTGGCAACTCTCTCAGATGGTTCTTTCCCCACAGAGCATGCTGGGGTG TTGGGCAGGCTCACTTTCTGCCTCTCTTCTCCCCATTCCTGAAGGCACACCCCTCTCTTCATGAAAAAAG CATTTATGTAGATATTCAGTCATTTAATAGGCCCAAATTCTTTCCCTTTTGAACAAATATTGACAACTTG GTAGCAGCATAAGCAGGAGACTGTCCTGAAGTCTGAGGAGTGCTGAGAACTCGCCAGCTGTTGCGCTGTT ACCTCTCTCGGTAGAACTAGGAGAATTAGATATGCCTGAAACATTGTTCAGGTGAGAAAGCTGATCTATT GAATATGGAAATTGAGCTCTAAGAGATTTATACTCTGCAAGTAAAGTCTCTATTAAAACACCTGTTTTAG TATTAAATAGGGTCTGGCTGGGAAATCTGTCTCTTGGGGTTCCCTTTTCATTGTACACATAAGCATTAAG TGGGAGCATGTAGGACTATTTGTCATCTTTCTTTAAACCCTTAGCTTGGAATAGGTGGGAGTATAAAGAG GGCAAAAACAGGTAAGCGCCCTCCTGACAGGCATTGTAAGCTTGTGAACAGAGGAAGTTCAGTTTAGCTG GGTTACAATTTGAAACCTGACACTCGGACCAAAAACAAAAACTAACAAAAACTAGAGGAACCTGATCTTT AGTCCTGTAAAAGCACTTTTTCTCCCTTAGCTTCATCCCTCTTTGGGCAGATTTCATCATAGAAGTCCTT CTGTAGGTAGGAGTTTCTGGAAATGCACTAGGTCCAGGGCTTCCACCTTAAAGGGAAAGGGTGCACGGGG AGCTTGGGGACTGAAACAGGAGCCACAGAACATGTCTCTTCTTTAAATTCCTTGCGGATAGGTACTCAGG GCTTCGCTTGCTTTCTCACGTCTCTTTCCGTATGCACTCCACTGTCACCCTCTGGCCCTCTAACACATTT CCAAGAAAACTGCAGGCATCCATATCCTTCCTCAAAATGAAAGTGCATATGATATACTAGAGGTTGGTTA TGTTTTGTTCTTTTGATGTAAAATTTAAATACAATGAAATGTAATCTTAAGTGTTCATTTGTTGAGTTCT GACAAATATGCCTGAAAAATGCAAAATCTTAAGACATGTAGAACATTATCACACTCAGCTACATATTTTG GATTTACATTTTTTAATCATTCTTGGTTTTTTTTTTTTTTTTGATATGGAATCTCACTGTGTCACCCAGG GTGGAGTGCAATGGCACATTCTCAGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGCGGTTCTCCTGCCT CAGCCTCCCGAGTAGCCAGGATTACAGGCACATGCCACCACTCCTGGCTAATTTTTGTATTTTTAGTAGA GATGGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAATGATCTGCCCACCTTGGCT TCCCAAAGTGCTGGGATACAGGTGTAAGCCACCATGCCTGGCCCATTCTTGCATTTTAAAGTCATTTCAG GCTGGGCATGGTGGCTCATACCTGTAATCCCAGCACTTTGGGAGGCTAAAACAGGTAGATCCCTTGAGCT CAGGAGTTCAAGACCAGCCTGGGCTGGTCTTTGCCAACATGGCAAAACCCCGTCTCCACCAAAAGTACAA AAAATTAGCTGGGCGTGGTGGTGCATGCCTGTGGTCCTAGCTACTTGGGAGGCTGAGGTGGGAGGATCAC TTGAGCCCGGGAGGCGGAGGCTGCAGTGAGCCAAGATTGTGCCACTGCACTCTAGCCTGGGTGACAGAGT AAGACCCCATCTCAATTTAAAATATATATATTATTTCAAACTTTAAAAAGATTCTAAAAATAGTACAAAT AATTCCCATATACCCTTCACTTAGCTTCCTCAAACATTAACACCTTATGTAACCGTAGTCCAAATACCAA GATAAGAAAATTAACATTAGCAGTCTCTAGACCTCATTCCCATTTTAATCAGTTGTCTCACTGATGTCCT ATTTCTGCCCCGGGACCCTCTCTGGAGCCACACAGTTAGTTGTCAGACCTCCCTGTCTCCTTCGATGTGG GATAGTTCCAGTCTTTTTTTGTCATGACCTTGGTATTTTTGAAGAGTACTGGCCATTGACTTTGGAAAGC CCTTCAGCTTGGATTGTCTGGTGTTTTCTCATTATTTGGAGTTTTACATTTTTGGTAAGAATAAAGTGCT GTTTTGCCCTTCCAGGACCTCTTTCAAGGTGGCACATGTGGTCGGTATATCTTATCTTAGGTGGTGCTAA TTTTGATTATTAGTTAAGGTGGTGTCTGCCACGTTTCTCCACTGTAAAATCACTATCCTTCCCTTTACAA TTGGTCAGTATATTTGGGGGAGATAATTTTAAACTATGTAGATGTCCTAGTTCTAGCTACCATTGATGAG ATTACTGTGGTATTTGAGAAATTGTGATTTTTAAAAACTTTTTACGTGTATTAATTGGAATTCTATAAGG AGCCAATTTCTGTTCTCCATTTATTCAGTTATATTAATATGGACTCATGGATATGTGTTTCGGTCTTTGG GTTATGATCTATGAGTATGTATCTTCTTGCTCAGGTTGTTTGAGATTTGGCCTTTAGGAGCACCTTGAAG TGTGAGCCCTGCATTCTTTGCAGGCTTCCTTGCTGCCTGGCTCCTCGAGATGCACCAGGTTCATCCTTTG TGTTCCCTGTTCTAGTCCTGGAATCAGCCATTTCTCCAAAGGCCTCTGTCTGGTCCCTGTTATTGGAGAA TCACGCTTTTTTAATGTGTGGCCTAAGCAAGGACACTTATAAACCCTGTGGCCACCTTCTCTGTAGACCC TGTTCATGTCCTATATGTGATCTCTTAGGAAAAAGGAAATCCTTGGGCTTTAATTTTCCAACTTTGGTCA AGAATTAAAAGTTCTTTAACTCAAAAGTGAGTCATAATTTTCATGTTTAACCTTTTTGTTTTGATACTGC AGTTATGCTTATGAGTGGCTATGAATTGTTATATGAGGTTTCAAAGTCCTAAGAGGAAAAACTTTCTAGG CACACCAGAGAGCCGGAGGCCTAAATTTTCTAAGGTCAGAACCTGTTTTGAGAGTCCTGTGTAGAGACAG GAGCCGGAGAGGGGATCCCAGCCCCTTGAAGTTTCAGGATGCGGCACGCTGGCTCACAGTGCTATGTGCT GTGGGCGGAGCCTCCGGAGCTTGGATCCTAGCTTCTCTGTTGGTGCCAGCAGGCTGCTCTTGTGTTTTGG GAGAAAGTGCTCCAGAAGCAACACATGCCTACCTGGTGCCACTTTCACAGCCTTTCAATGTAAGGAGGAC ATAGGCTGAAGTCAGTAGCAGGGCAAGGTGGTATCTGGAGTTCCCCTTTAATGCTCTGAAACCTGTAAAG AAAATTACATCTCGAAGATAAAAGAACAAACTCATTGCATGTCTGTTTGAATGCCAGGTGTGTTTTTTTT TAATGGGGATTGGTGATTCTAGAGCATAGCACTGTAAAAGAAAGGATGTATACAAAAGCTTTGACATTTA GAACCATGGTCTGGCCAGTGTCCTGCCATCATTCCTGCAGGCACACCATGACTGACTGCGCTAATTCCCC AGAAGGGCCATGTCAGGCTTACATGTTTGCCCTCAGCCTACAGAGTCCACCCCACTGCCTTGATCTAGTT GATGTGATCATAACGAAACCTGTATTGCTCATCAGTATTGAAGCTGTTGGTAGGCCATAGATTGCTTGAC CTTCCTGCTACTTCTAAAATGAAGGTTTTTGTGGGATGTTGGAAAGGACTGCTTTGGAGGGCAGCATTGT TGGATGGTGGTTTTGAGGATTTGTCGTTATTTCCAGAATGGCATTATCCCTGGTAAAATGTGTTGGAAGA ATAGGGTGGGAAGTGTCAGGTGAGCAGAGCAATGTGGTCTTGAAGTCACATGATGAACTTGGGAATGCTA ATAAAAGCCAGAGTCTGGCCAGTCATGGCATTGCATTGGTTAAGTAGGATTAGCCCTGTGGGGCCTTCAT TAGGGCGGTTAGTTTGAAGGCTGTCCTGGAAGTTGGAGAGTGACATGGGAAGATGTCTGTCCAGCCAGGA GAACACACACTGGAATGAGAACCAGAGGAGCAGAATGCATAGCAAGGCCTCTGTCCGTTTCTCTTGGCAA GCTCTGTTGAGTATGGCACGTCTAGGAACGTGATGGGATCTTGGCCCTCCCTGTTGGTTTCATAGAACTA AATGATCAGTAACTTAAATAACATTCAACAGTCTGTAGCAGAAGAGCCTGTATGTTAAGAGAGGCCTCAA GGGAAAGGGAGGCAGCCCTGGGGAACTGTGTGTTGAAAGGTGGGTCTGAACCGTGGAGTTTGGGGCTGGA TTTGACAGCTCTTGGATGCTGAGTTAAGGACTGTGTTGACATGGGAGGAGAGGAAATTAATCAGATCAGC AGACTGAAAGTAGGGCTGCTCCAGCACACAGCTTGAGAGTGGGCTCTGGCAGGATGAGAGGTAGGTGAGT GTGGTGATGTGATGTGGGAATGAACAGCAGAAGATACCTGAGGGGGAGGGTCAAGGTACCTGGGTAGGAA TTTCAGTTGACCTCGAGATCACCAGCCTGGGTAATCATAGGTGCCCTAGACTGAGGAAAAACCAAAGGAA ATGGGAACAGATTAAGGTTGCAGATGCCTTGCAGCCAACCACTTGGCTTAACCTAGGACAGGTGGGAACT ATTTGATAATAGCATATAACACATTGTGCCTCTTGGGTTAGCTTCATATTATTTTAATTGAACTAATAAG AATTGATTTGCGAATCTCTCTTAGCCAATCCAAGAACATATGTATACATCTAACCATCCACTTCTTCTTT TTAACCTCAGGTTAACCCCAAAGATTGGCTTTCCTTGGAGTGAAATCAGGAACATCTCTTTCAATGACAA AAAGTTTGTCATTAAACCCATCGACAAGAAGGCACCTGTAAGTTCCAAAGGATTCTATTCAGGGGCTACT GTTTTTCATTCTTATACTTGTCAGGGTAACGGACAAGTTATACTGTGACGAGTAGCCAGTGATAGTCCAA ACTCCTCATGAGGTTACATTGAGGGCCAGAGATCCTGTGGGCCAGGCAATTGCTGCAGGGGAGACCACTT AACTTTTCAAATGATTCTCATTCCTTATGAAGAAAAGGGCAGTTCTGAGCCATTGGCCAAATGATAAGCA TTTCCCAAAATGCTGTGTTTTTGGTGTGGAGAGCCAGCCTGTCCCCTTGACCACCTGGGTGCAGGGACTC TCCCCGGCACCTGACGGACAGTGGGACCTGCGAGTCTCAAGGGCCAGATTTGCCTTTCAGAGCTGTCCTG GAACTTACCCAAGATAGGGACAGTCAGACTTGCACCCAAGCATTGCTGGTGCCCAAGGTTTCATCGGGGC TTCACCCACTTCTGTTGTCAGAGGTGTGCATCCTCACACAGGTGACACTGGCAGGCAGTCATTTTGGGAG GACATGGTAAGAAGGCGACACTTTATGTCCTGAAATCTGATAGTATTGATTGTAATAGCTGCAAAGACCA GTGCATTATGTAAATTTGGTTTTATTTATTCTGCTGACATTTAAACTTTTGTTAACTCAGAATATTTGAG ACATACGCACATAACTGTAGCATTGTAGAATGGGTAAGGATTTTGTTATCTAATCAGAAATCTAGTTCTC TAAAAAATTGCCACCTGAAGAAATTCTGTTACCACCTTAGAGCCTGTTCTGAATTTTACGAAAATTATAG ATTGGAAAGGACTTTGTGTTCTCATGTAATTTTGGTTCCTTAGTTACAGTGTTAAGCTTGGAGAGGCAAA CATGGGCTGTGGTCCATACCTTGGTTGTCTTGTTAACCCTTTTGGGACTGGGTACTGCTTAGCAATGGTA AATCCACTTAGAACAGTATGTGGTGTTATTGTCCTGTTACTTCTCCCCACATACAGGTTTGTCTAGCATA ATTTAAAATCAGCAGGTCTTGACAATTTTGTGAAAGTATTTTCTTCTTTGTTAAAAACGTCTTGGCCAGG CTCAGTGGCTCACGCCTGTAATCCCAGGACCTTGGGAGGCTGAGATGGCCGAATCACGAGGTCAGGAGTT CGAGACCAGCCTGGCCAACACAGTGAAAACCCCATCTCTACTAAAAATACAAAAATTATCTGGGCGTGGT GGTGGGCGCCTGTAATCTCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAAGCAGAG GTTGCAGTGAGCTGAGATCGCCACTGCACTCAAGCCTGGGTGACAGAGCTAGACTCCGTCTCAAAAAAAA AAAAAAAAAAGGGCTCCTGCTGTTTGCAAACTCTTGGCTGCTACTCTGTGGGTAGTTGCACGGTTATTTA AAATTAAACGCGTATTGAATGCAGACTCTAAGGCTCCATGGCAGCAGTTCATATTATGCAACAGCATGAA TGGAGGGTCATAGCGTCTTCATGTCACTTGGGTAGTAAGATTGGCACAGTTTAGAAGAGCAAGAAAATGC TGAAATCTCTTCATCAGTAGGCTACTACGTACTCTGTGACGCTACTGCCTTTTCAGAACACTTATTAAAA ATTTGACTAGAGCAGCAGCTCTGGACTAGACTGTTTCAGAATGTTTGTGCGTGTGTGTGTGTGTGTGTGT GTGTGTGTGTGTGTGTGTGTGTTTGATGATAAGTCCATCTCTTGAAAAGCTGAAGAATATTTTCATAATA AGCCCCAAGCAGAAGCCATTGTAACGCATCTCGTGCATGTGCCTTTATTATAGAGTAGCCTCATGTGAAG CCATCTCGTAAGCAAAAGAAACATTCGCTGGTGGCACGCTGTCCCAGGCACTCTTCCAGGGCTGTGTGCA CCATCAACAAGGCAAAGCTCCTACCCTGGTGAGCCTACATTTACGTGAAGGAAAGGGTTAAAAAGGCAAC TGAGATGCTTCCTGGTAGTAAATTTAACAGTACAGCTGTGATTAAAAACTAAGCCGGATCAGAAGATGGG GGTGAGATTCCTTTAGGCAGGTTGGGCAGGAGCCACACTGAGGAGGCAGCATTTGCCTTGAGTGGGCACT GCTGGTTTGAGGAGGTGGAGTTCTGTCACCCCCACAGCACCCCAGGGCTGCTCGAGGCACTGCCCCACCT CAGTCTGTAAACTTTGGGCAGAAGAAGTTCAAGTTTTCGACATCGAACTTTCTTGTAAAAAAGAAGAGGC CCAAAGTTTGAGGCGGTGGGATTCCTTATCTTGTGTTGACTTTCACGGGTCATCTTCACCCCAGGCGGTT TCTGCTGTGAACTCACAAATGAGTCTTTGTCCAGTTCTCACCCAACAACTGGCGTCTCCTTTTTAAAAGC CAGCTTCTCTTCCCTGCCAAGGTGCATACAGCAGTTTGGGGCCACACTTTGGCTCTTTAGATGGGACCTT GTATACAGCTGACACGGCCTGCCCAGGTGACACTATGAGGGGCTGAGGCGGCTGCCTTTTCCCTTTCAAA AGGGCGTTTTGTTCCTGTGGCCTTGTGGAAAAGGCAGAAGGCTCTGAGGCATCTGAAATTTGGAGAAAGT AAGCAGCGTTTCCGCTCTGACTCCTCGGACGCTTCCCCCACGTGACCTTCCCAGGAGCCCCGCTGCCTTT TTGCCTCCCGCGGCTGCCTCCTGCCATCTCTGCGGCCAGATGAGCCTTGGGATTGGCCTCTTGTGGGAGA GTTTCCTGGCATCCTGGGGACTTGAAAAGGGGCTCTTTTACCTTCTCTCCTTCTGTATTTGTAGGGTCTT GGGTTTATTTTTCTTGAACTTTCCTTGTGCCTGGTTTGCATTTTTACCTTGCTGGTCCTCGGCCAGTTTA AAAACCCTGCTCCAGGTCTTGTCGTGTTGTGGTTCTGCATCAGGAAGCTGCATCCTGCATCAGGTTAGGG ACTTGGATTTAGAAACATTTCAGTATGAGTCTTTGTTTTAACTTGAAGTGAGAAACCGGCTTCCTTCAAA GGCACTGGGAGAGATTTCCTGCCAGGCACCATCCTCCCTCACCCACTGGCAGTGGACTCCCCAAATTCTG GTTCCCGTTGCTGGCAGGACCTGTCTTCTGCAGGGAAAGGGAGAGAGGGAGACATTGTTATGTTAACCAT TGAGGTTTTTCATTGATCCCCCCACCCATGCACCCCCACAACCCCATAAAGGGGAGTTGGTGCTAATCAG CGTTTTCTGAGTCAGGGCCTATTTGGTAGAGTCCTCCAAAGCTGTAATGCAGGATTGTTTCCTCTTGTGT AATAAGGGATAGGTGGGTCATAAAAATGCCGATTGCTCCCAGCTCCACAGACTCCTCCCTGGGAAACCCA ATGACTTAACAGCAAGGGTGTGAAACCCCAAAGACAGCCCCACCCAGGAAGTTCATGGGCTCTCAGGGCT TGGCATCACCTCTCACCCTAGGATTTCTGGAACAGATGAAAAGACTGAAGCTAAATAGATTCTTCTCGGA TGTGTTGATGAGCCCGCTCAGCCGGTTCCTCGTTAGGTCTCAGAAGTTGCTGTGGGATATATCGCACTGT TTTTTTGTTTTAGCCACCCTGTCCCTCTGTTCCAAATGGTCAGAAGCTGGATGCTGGGGGCCCTGAGGTT AAGAGGAAGCCAACAGAGTCACTGAAAAATAACTTTTCATGGGAGTTTCTAAACCATATTCTTCTGTCTT GTAAGCTAATCACAGCAGTAGCAAGGAGTTGGGACCAAGATTGTCAGCTGTGTCCCAAATGTTTCCAGTC ATGGTCACGAGTTTCCCGAAGGCTGTGATTCTGCCTTGTTTTCCAGGAGGCTCCTCTGGTTGTGGTCTTG CAAGGCACTAGCAATTGGAGTGACCGCTGTGTGTGTCAGCCAGCTCTTCCTGCGCCGAGCACCTCCTGAA CGTCACCGATAAGGCGGGGACGCCAGCATCTAATGGGACTGCTGGGAGGATTGAGTCCCATATCTGAAGT CCCTTGAGATACCGGCATCCCTGCCTTATGGTTGAAGGCACTGAGCCTGGTGAAGGGATGTGCTCAAGGC TGTGGAGCTCGCACGTGGCTGTCTGTGCTGCACGAGCTGGCAGTGCCTGGCAGGTACTGCACACCTCAAA TACCCTGGGAAGATAAGAGATGAGTGAATGTGTGGCCCCTGCCCTTGGGAGCTGATGGCCTCATAGGAGT GAGATGCTGAAAGGAGTCACTGGAGTGAAGTGACAGTGCCACTGCGGCGAGTACCTGTAGCTGGTGTGGC AGGAGCAGGGCTGGATAGCTTTGAGGAGAGAGAACCGAGTGCACAGCGGAGGCTGGGCCCAGAGCTGGAA GGTCTCTGTGTGGGTTGGGCCCAGGCCCTGGAGCTCATCCTGGAGCTCCCAGGCTGGCAGTGATGGGTCG GGGTGGTGACCCAGTCAGTGTAGCAATAACAGTGTGGGAGGGGAGGCTGTGGCAGAGGAGACAGGAAGCC CAAATAGCAGCAGAGGCAGTCCAGGCAAGCATCGGGGATGGGGAGCAGCAGTGAGGCTGGAGAGGACATC ATGAAAGGTGGCTACCTGGAAGAGCAGGCAGCTCTGAGACTTGAAAGGTTTCCCAAGGCTGAGAGTTCTC ACCTTGGAAAAGCTTTGCAGTTAACGTGCAGTGGCATTTCAGTGTGCATGCAGGATGTCCCTACCCACAC ACAACTGCACACACACGCGGCACCTGCCCTTCCTCCACCCGTCCCAGAGAATGCACTTTCCCAGTGCTAC ATACCCACACATAACCGCACACACACGCGGCACGTGCCCTTCCTCCATCTGTCCTGGAGAATGCACATTC CTAGTGCCGAGATGCTGCCATCCCTGTTCTGCTACATTTGTTCTTTTAGAAAAGTTCTGGACCTTTGTGA AGGATGGTTTGGAGAAGAAAACCAAACGAAGGAGCTTGAGTCCAGGTGGCCCTGTTCTGTTTTGTAGGAC TTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAGT TGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAA GCATCAGAAGCAGCTGGAGCGGTGAGCGCGTGAGGCCAGAGTGGGGGGGGCCTGTGTTCTCCCAACTCAG CCACTGGCAGCCAGTGCCTGTCAGGTGACTGTGGAGCTGATGGGGAGAGTGTGGTGGAATGGAACCCAGT CACCACGCTGGGATCTTCGAGGCCTTTGTCTCTGGGCGGTTGCTGTGGTGCTGAGCCTGTTGTCAGCCCT GGAGCGGCTGCTCCGTCAGGCAGCTCAGGCTGGCAGCAGGCTAGGGTGGCCCTCAGGATACCAAGTCCAT CCTGGAGCTTCAAGTACCCGTGAAGTGTGTTGACCCCTCACTTTCCTGCCAGAGTCTAAATCTCCCTGTG CCTCTTTTTCCCTGCACCAGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGA AAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAA GGCAGAGAGAGGTCAGGCGCCCTGGGGCTGGCACTCTACACTGGGTCATGCATTTCCACAGAGTAGCAGG GGCCACACCCACCCACCCACTCACCAGGAAGGAAACCAAGAACGTGTCCCACAGCGCAGACTCACAGCCG AAATGATAAAATGGTTATTTGGTTTGGAAAACAGTTCTGTACTTATTTAACTTTGATGCTAGTTGTTCTA AGACTTTGTATTTTAAAATTTCCCTAGTCTTTTGCGGTAAGTGCTCAATCACCCAGTTTCCCCGATGAGG ACAGTAAGGTTTGGTGCGGTACAGTGATTTGCCCACAGTCCCCCAGCCCATGACTGACAGGGCCATGCTG CACTGCCCTCGACCTCTAGACTAAAACCCAAAGGCGTGTTCAGAGCCAGACTTCCCAGCACAGCTCCAGT CAACAACCCCAGCAGCTGGGCCGATTACACAAGGCGCCACAGATGCTGTATTCACTGGCAGCCCTTACAG CACACATGGGAAGGGTGTTCTGTGTTCTGAGTGGAGTGTGGACCACCAGCACAGCGGGCGGCTGACCTGG GGAGAGTAGCGCCAAGAGGGTTGAGTCAGGCATGCCAGAGAGAGGGCGCCTGGCTGGCGTTGGACGGGTT TCTAGCCATCTTGAGGAAGTTGTCATGGATACAGCAGCAATGAGCTCTGTGAAGTGCTTTCCTCCAGGGT CACTGGAAGACATCCCCTCAACCTGTGACTTGGTCTAGGGCTCTGTGGCTTTGGGGGTGGGAATGGAAAG CGAGGGCTCCTAGGTCCCTGGGCTGAGGGTTTGAATGGCTCTGGCTTTGTGTCTTTGCAGAGCTCTCGGA GCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAG GCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCC AGGAGCAGCTGGTAGGAATGGCCTGAGTTTCAAGATGCTGAATTATAGAGAGGCTGCTTCTGAGGATGGA AAATGTGACACCTGCCTTGTAATAATTGTCATGACTGGAAGCTGTAAACTGATCTGCTGGGGGGCTGAAG GCAGCTGGTGGGGAAGGGGCTGGGCTGTTGCCAGGGTCACCCATTGAAGGTGGGTGTGGGCATCCAGGAA GAGATGCCGGGGGTGCACAATGGACCCTGCTGGCCATGGAGTGGGGGTGGCGGGGACTCAGGTGTCACGT TGGAGACTGCTTGCCAACACACATGAACACTCATTCACAACTGGACTCCGTTGAAAGGATATCAGAACTG ACGTGAGCTTGGCATTCCCTTCCCAGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGA AGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGGTGAGTCTGCACGGGGGACAC CTCCGCACGGCCACAGCACCTGTTGCCCAATTGCCTGCGGTGGGGCCCTTCTGCAGGTGGGTGGGTTGGG GGAGAGGTCTGGCTCAAGCTGCCACATCCCACTGGAAGCTTCTGGGATGTCTCATGATCCTCTGCCAATA CCAGCTGTACTACTGAAGTAGACATCCCCAAAGAGATGGGTTTGACTTTGTACACGAGTCAGTGCAGCTG CTGGATTCATAGAGGGAGGACCTCTGATTGACTTTCACCCACTTTGCTCCCTCCACCCCGAACTGTTCAG TGCTGATCTGACAGCCCCCGGTCAGGAACTGGTTTTAAATCTAATTATATATGTGCCCCTTGCAATGGGG TCGCAGTGCCTGAAACACGACCTCCTGCAGCTAGTATATACAGCGGGCACCATGGAAAGATCCAGCTCCT TGGACGTCTCCAGGCTGGAGTGAGAGCTGGGCTCTGCTGCTCATCAGCTATTTGGGGGCTAGTAGCATCA CTTCTTCAAGCCTCATTTTCCTCATTGTAGAATGGGGGCAATACCCAACTCATAAGGTTGCTCTGCAGAT GCGAGGTCCCATGCCCAGGACCTAGCACAGAGGTTTAGTCAGCTGTAGCTCTCATTGTGGGACGCACACA GAGCTTGTCGCTCCGTCTGGGATCCCCTGTGCCCTCCAGGAAGGCACAGCCCCTGAGAAGCTCTGGGGAT GGTTCCCACTGGAGACTGCACACCAGGCTTTAAGCAGCTCCTCTCCTTCACAGACCCGCTGGCCCGTCCT TCCCCCACTGTGGCTTCTCCATCTGTGGAGGTGCCTTCTGGGGACGTGTCTCCCGGCTCTCCAGGGCTGC TGCTGCCTAGTACCTCCTTGCCTCTGTTCCAGCCCCCATTCCCGCTGCCGATCTGTATTAGGCTGTTCTC ACAACGGCTATAAAGAACAAGCTGAGACTGGGTAGTTAAAGAAAAGAGGTTTAATTGACTCACAGTCCCA CATGGCTGGGGGAGGCCTCAGGAAATTTACAATCGTGGCAGAAGGCGAAGGGGAAGCAGGCACCTCTTAC ATGAGGGCAGAAGAGAGAAAAGCAAAGGGGGGTAATGCCAAACACTGAAACCATCAGCTCTTGCTCAGAA CCCACCCACTAGCACGAGAACAGCATAGGGGAAACCACCCCGTAATCCAGTCACCTCCCACCAGGTAATG CCCCCCACCCCCAGCATGGGGGGATTACAGGTGGAGATGAGATTTGGGTGGGGACACAGCCATATCACCA TCCCAAGTTGCAAGCGGAAGACTTTGGTTCTTAGGTTTTTGGAGAAAGTACCTGTTAAGTGAGGAGAGCT GGCTACAAAGCAGATCCACACTAAGCTCAACTCTAGGGCTGGCTGGGATGGAGGCGGGCGGGACTGGGTG TGTGTGAAGCTGTTGGAAGGACTGCAAGTGGCGAGCAGGAGAGCACTTGATAATGACTGTGGCATGAAGG GAGGCTAGGAACAGAGCCCGTTACTCATGCTAACAGGATTTTTTTTCTAAAAATTATATAATGTCTAGAG TTACAGGTAAAAAAAGAAATGGTAGTTTTAAAACTGCCCAGGTTCCGGCATCACAGTTCCTCTTCCTGTC TTGGACGCAGAGGGTTGTAAACCCCCCATGCACCCTGAGGGTGCTCCTCTTCGAAGCCACAGCCCAGCAC AGTTCAGTGCTGCCTTAGCCTGCCAGGACAGAGGGAGGTGACAGTCTGTTCTCATAGCCAGGAGGATAGG ACTTCTGGGTGAGAAGTCCTCTTATTAATTTGCTTTCCAAAGGCCAAAGAAGCCCAGGATGACCTGGTGA AGACCAAGGAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCACCACCCCCCGTGTACGAGCCGGT GAGCTACCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTGTCT AGTGAGGGCATCCGGGATGACCGCAATGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGC AGCGGCAGCTGCTGGTGAGGCCCAAGGGGCTCTGTCTCCAGGGAGCCTGCCTCGCTTTTGGAGCAGACAG GCTTGGGGAGGGCAGTGATGTGAGCCAGCCCCACCCAGCACCCCTCTTGCCCTTCCTGTTTTCCTAGGGG ACGGGCCGGGCCATATGGGGAGGAAGGGACTAGACCAATGCTGCTTAATGTTACAGACGCTGAGCAGCGA GCTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAA GGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCAGGGCAACACCAAGCAGCGCATCGACGAGTTCG AGGCCCTGTAACAGCCAGGCCAGGACCAAGGGCAGAGGGGTGCTCATAGCGGGCGCTGCCAGCCCCGCCA CGCTTGTGTCTTTAGTGCTCCAAGTCTAGGAACTCCCTCAGATCCCAGTTCCTTTAGAAAGCAGTTACCC AACAGAAACATTCTGGGCTGGGAACCAGGGAGGCGCCCTGGTTTGTTTTCCCCAGTTGTAATAGTGCCAA GCAGGCCTGATTCTCGCGATTATTCTCGAATCACCTCCTGTGTTGTGCTGGGAGCAGGACTGATTGAATT ACGGAAAATGCCTGTAAAGTCTGAGTAAGAAACTTCATGCTGGCCTGTGTGATACAAGAGTCAGCATCAT TAAAGGAAACGTGGCAGGACTTCCATCTGTGCCATACTTGTTCTGTATTCGAAATGAGCTCAAATTGATT TTTTAATTTCTATGAAGGATCCATCTTTGTATATTTACATGCTTAGAGGGGTGAAAATTATTTTGGAAAT TGAGTCTGAAGCACTCTCGCACACACAGTGATTCCCTCCTCCCGTCACTCCACGCAGCTGGCAGAGAGCA CAGTGATCACCAGCGTGAGTGGTGGAGGAGGACACTTGGATTTTTTTTTTTGTTTTTTTTTTTTTTGCTT AACAGTTTTAGAATACATTGTACTTATACACCTTATTAATGATCAGCTATATACTATTTATATACAAGTG ATAATACAGATTTGTAACATTAGTTTTAAAAAGGGAAAGTTTTGTTCTGTATATTTTGTTACCTTTTACA GAATAAAAGAATTACATATGAAAAACCCTCTAAACCATGGCACTTGATGTGATGTGGCAGGAGGGCAGTG GTGGAGCTGGACCTGCCTGCTGCAGTCACGTGTAAACAGGATTATTATTAGTGTTTTATGCATGTAATGG ACTATGCACACTTTTAATTTTGTCAGATTCACACATGCCACTATGAGCTTTCAGACTCCAGCTGTGAAGA GACTCTGTTTGCTTGTGTTTGTTTGTTTGCAGTCTCTCTCTGCCATGGCCTTGGCAGGCTGCTGGAAGGC AGCTTGTGGAGGCCGTTGGTTCCGCCCACTCATTCCTTCTCGTGCACTGCTTTCTCCTTCACAGCTAAGA TGCCATGTGCAGGTGGATTCCATGCCGCAGACATGAAATAAAAGCTTTGCAAAGGCACGAAGCA Download Select all
Length	53684
OMIM ID	123900
HGNC ID	HGNC:12691
Unigene ID	Hs.487027
Ensembl ID	ENSG00000092820
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001111077.1
Exon	join(1..108,1259..1343,30054..30137,32222..32317, 33842..34116,34698..34781,35759..35905,42921..43017, 48018..48181,48531..48661,49481..49641,50007..50099, 51913..52164,52347..53684)
mRNA Sequence	>7430 GGCGTGGTCCCGGGACCCGCCCCGCCGGGGCTTTTGGGAGCGCGGGCAGCGAGCGCACTCGGCG GACGCAAGGGCGGCGGGGAGCACACGGAGCACTGCAGGCGCCGGGTTGGGACAGCGTCTTCGCT GCTGCTGGATAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACC AATCAATGTCCGAGTTACCACCATGGATGCAGAGCTGGAGTTTGCAATCCAGCCAAATACAACT GGAAAACAGCTTTTTGATCAGGTGGTAAAGACTATCGGCCTCCGGGAAGTGTGGTACTTTGGCC TCCACTATGTGGATAATAAAGGATTTCCTACCTGGCTGAAGCTGGATAAGAAGGTGTCTGCCCA GGAGGTCAGGAAGGAGAATCCCCTCCAGTTCAAGTTCCGGGCCAAGTTCTACCCTGAAGATGTG GCTGAGGAGCTCATCCAGGACATCACCCAGAAACTTTTCTTCCTCCAAGTGAAGGAAGGAATCC TTAGCGATGAGATCTACTGCCCCCCTGAGACTGCCGTGCTCTTGGGGTCCTACGCTGTGCAGGC CAAGTTTGGGGACTACAACAAAGAAGTGCACAAGTCTGGGTACCTCAGCTCTGAGCGGCTGATC CCTCAAAGAGTGATGGACCAGCACAAACTTACCAGGGACCAGTGGGAGGACCGGATCCAGGTGT GGCATGCGGAACACCGTGGGATGCTCAAAGATAATGCTATGTTGGAATACCTGAAGATTGCTCA GGACCTGGAAATGTATGGAATCAACTATTTCGAGATAAAAAACAAGAAAGGAACAGACCTTTGG CTTGGAGTTGATGCCCTTGGACTGAATATTTATGAGAAAGATGATAAGTTAACCCCAAAGATTG GCTTTCCTTGGAGTGAAATCAGGAACATCTCTTTCAATGACAAAAAGTTTGTCATTAAACCCAT CGACAAGAAGGCACCTGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTG CAGCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGC AGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTGGA AACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAG GAGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGG AGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCG CCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGAT CAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCC TGGAAGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGGCCAAAGAAGC CCAGGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCA CCACCCCCCGTGTACGAGCCGGTGAGCTACCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAG AGCCCACGGGCTACAGCGCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAATGAGGAGAA GCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGCAGCGAG CTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGA GGCAAGGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCAGGGCAACACCAAGCAGCGCAT CGACGAGTTCGAGGCCCTGTAACAGCCAGGCCAGGACCAAGGGCAGAGGGGTGCTCATAGCGGG CGCTGCCAGCCCCGCCACGCTTGTGTCTTTAGTGCTCCAAGTCTAGGAACTCCCTCAGATCCCA GTTCCTTTAGAAAGCAGTTACCCAACAGAAACATTCTGGGCTGGGAACCAGGGAGGCGCCCTGG TTTGTTTTCCCCAGTTGTAATAGTGCCAAGCAGGCCTGATTCTCGCGATTATTCTCGAATCACC TCCTGTGTTGTGCTGGGAGCAGGACTGATTGAATTACGGAAAATGCCTGTAAAGTCTGAGTAAG AAACTTCATGCTGGCCTGTGTGATACAAGAGTCAGCATCATTAAAGGAAACGTGGCAGGACTTC CATCTGTGCCATACTTGTTCTGTATTCGAAATGAGCTCAAATTGATTTTTTAATTTCTATGAAG GATCCATCTTTGTATATTTACATGCTTAGAGGGGTGAAAATTATTTTGGAAATTGAGTCTGAAG CACTCTCGCACACACAGTGATTCCCTCCTCCCGTCACTCCACGCAGCTGGCAGAGAGCACAGTG ATCACCAGCGTGAGTGGTGGAGGAGGACACTTGGATTTTTTTTTTTGTTTTTTTTTTTTTTGCT TAACAGTTTTAGAATACATTGTACTTATACACCTTATTAATGATCAGCTATATACTATTTATAT ACAAGTGATAATACAGATTTGTAACATTAGTTTTAAAAAGGGAAAGTTTTGTTCTGTATATTTT GTTACCTTTTACAGAATAAAAGAATTACATATGAAAAACCCTCTAAACCATGGCACTTGATGTG ATGTGGCAGGAGGGCAGTGGTGGAGCTGGACCTGCCTGCTGCAGTCACGTGTAAACAGGATTAT TATTAGTGTTTTATGCATGTAATGGACTATGCACACTTTTAATTTTGTCAGATTCACACATGCC ACTATGAGCTTTCAGACTCCAGCTGTGAAGAGACTCTGTTTGCTTGTGTTTGTTTGTTTGCAGT CTCTCTCTGCCATGGCCTTGGCAGGCTGCTGGAAGGCAGCTTGTGGAGGCCGTTGGTTCCGCCC ACTCATTCCTTCTCGTGCACTGCTTTCTCCTTCACAGCTAAGATGCCATGTGCAGGTGGATTCC ATGCCGCAGACATGAAATAAAAGCTTTGCAAAGGCACGAAGCAAAAAAAAAAAAAAAAAAAAAA AA Download Select all
Length	3138

CDS Information

Location	join(1332..1343,30054..30137,32222..32317,33842..34116, 34698..34781,35759..35905,42921..43017,48018..48181, 48531..48661,49481..49641,50007..50099,51913..52164, 52347..52511)
CDS Sequence	>lcl\|NM_001111077.1_cds_NP_001104547.1_1 [gene=EZR] [protein=ezrin] [protein_id=NP_001104547.1] [location=182..1942] ATGCCGAAACCAATCAATGTCCGAGTTACCACCATGGATGCAGAGCTGGAGTTTGCAATCCAGCCAAATA CAACTGGAAAACAGCTTTTTGATCAGGTGGTAAAGACTATCGGCCTCCGGGAAGTGTGGTACTTTGGCCT CCACTATGTGGATAATAAAGGATTTCCTACCTGGCTGAAGCTGGATAAGAAGGTGTCTGCCCAGGAGGTC AGGAAGGAGAATCCCCTCCAGTTCAAGTTCCGGGCCAAGTTCTACCCTGAAGATGTGGCTGAGGAGCTCA TCCAGGACATCACCCAGAAACTTTTCTTCCTCCAAGTGAAGGAAGGAATCCTTAGCGATGAGATCTACTG CCCCCCTGAGACTGCCGTGCTCTTGGGGTCCTACGCTGTGCAGGCCAAGTTTGGGGACTACAACAAAGAA GTGCACAAGTCTGGGTACCTCAGCTCTGAGCGGCTGATCCCTCAAAGAGTGATGGACCAGCACAAACTTA CCAGGGACCAGTGGGAGGACCGGATCCAGGTGTGGCATGCGGAACACCGTGGGATGCTCAAAGATAATGC TATGTTGGAATACCTGAAGATTGCTCAGGACCTGGAAATGTATGGAATCAACTATTTCGAGATAAAAAAC AAGAAAGGAACAGACCTTTGGCTTGGAGTTGATGCCCTTGGACTGAATATTTATGAGAAAGATGATAAGT TAACCCCAAAGATTGGCTTTCCTTGGAGTGAAATCAGGAACATCTCTTTCAATGACAAAAAGTTTGTCAT TAAACCCATCGACAAGAAGGCACCTGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATC CTGCAGCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCAGC AGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTGGAAACAGAGAA GAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTGCGG CTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGC AGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACT GCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAG CTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAG AGTGGCAGCACAGGGCCAAAGAAGCCCAGGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGAT GACAGCACCCCCGCCCCCACCACCCCCCGTGTACGAGCCGGTGAGCTACCATGTCCAGGAGAGCTTGCAG GATGAGGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAATG AGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGCAGCGA GCTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAA GGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCAGGGCAACACCAAGCAGCGCATCGACGAGTTCG AGGCCCTGTAA Download Select all
CCDS ID	CCDS5258.1

Protein Information

Protein ID	NP_001104547.1
Protein Name	Ezrin
Molecular Wt. (Da)	69282
Protein Sequence	>7430 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKK VSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSY AVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYL KIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFV IKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLER QQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQE EAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHR AKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDR NEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNT KQRIDEFEAL Download Select all
Length	586
Uniprot ID	P28562
Ensembl Protein ID	ENSP00000239223

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
T	Phosphorylation	235
Y	Phosphorylation	146
Y	Phosphorylation	354
Y	Dephosphorylation	146
Y	Phosphorylation	146
T	Phosphorylation	567
T	Phosphorylation	567
K	Acetylation	60
K	Acetylation	139
S	Phosphorylation	539
S	Phosphorylation	536

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
60	ACTB	32	NP_001092.1	in vivo	7876308
70	ACTC1	15	NP_005150.1	in vivo	12271120
147	ADRA1B	80	NP_000670.1	in vitro;in vivo;yeast 2-hybrid	16352594
960	CD44	115	NP_000601.3	in vitro	1 237 073 812 032 540
1499	CTNNB1	286	NP_001895.1	in vivo	10462524

Pathway Information

Pathway Name	Pathway ID
Gastric acid secretion	hsa04971
Leukocyte transendothelial migration	hsa04670
MicroRNAs in cancer	hsa05206
Pathogenic Escherichia coli infection	hsa05130
Proteoglycans in cancer	hsa05205
Regulation of actin cytoskeleton	hsa04810

Structure Information

PDB ID	1NI2
Resolution	2.3
Method	X-RAY DIFFRACTION
Chains	A,B
Molecule	Ezrin
Model	View

Domain Information

ID	Location	Description
cd13194	200-296	FERM_C_ERM
cl17171	200-296	PH-like superfamily
cd14473	98-198	FERM_B-lobe
cl09511	98-198	FERM_B-lobe superfamily
pfam09380	210-296	FERM_C
pfam00373	93-206	FERM_M
pfam09379	Sep-86	FERM_N
cl09630	Sep-86	FERM_N superfamily
cd00836	202-292	FERM_C-lobe
cd13191	202-296	FERM_C_FRMD4A_FRMD4B
cd13187	206-297	FERM_C_PTPH13
cd13185	209-293	FERM_C_FRMD1_FRMD6
cd13193	194-258	FERM_C_FARP1-like
cd13192	187-264	FERM_C_FRMD3_FRMD5
cd13189	200-257	FERM_C_PTPN4_PTPN3_like
cd13184	201-288	FERM_C_4_1_family
cd13188	201-293	FERM_C_PTPN14_PTPN21
cd00900	211-284	PH-like
cd13195	201-255	FERM_C_MYLIP_IDOL
TIGR01541	303-432	tape_meas_lam_C
cl19901	303-432	Tape_meas_lam_C superfamily
CHL00019	307-374	atpF
cl21478	307-374	Mt_ATP-synt_B superfamily
pfam00769	338-586	ERM
smart00295	7-206	B41
TIGR02168	307-583	SMC_prok_B
TIGR02168	301-464	SMC_prok_B
COG1196	299-463	Smc
COG1196	301-574	Smc
PRK09510	303-444	tolA
COG1196	273-463	Smc
TIGR02168	301-464	SMC_prok_B
COG1196	306-585	Smc
PRK09510	293-460	tolA
TIGR02168	294-544	SMC_prok_B
TIGR02168	301-465	SMC_prok_B
PTZ00121	294-547	PTZ00121
COG3064	293-462	TolA
TIGR02169	279-552	SMC_prok_A
TIGR02169	294-585	SMC_prok_A
TIGR02168	301-562	SMC_prok_B
PTZ00121	292-566	PTZ00121
COG1196	306-544	Smc
PTZ00121	292-467	PTZ00121
COG3064	321-462	TolA
PRK12704	301-427	PRK12704
COG1196	273-463	Smc
TIGR02168	300-456	SMC_prok_B
PRK02224	304-585	PRK02224
PTZ00121	294-582	PTZ00121
TIGR02168	287-464	SMC_prok_B
TIGR02169	319-586	SMC_prok_A
COG1196	301-465	Smc
COG0419	294-584	SbcC
TIGR02168	327-556	SMC_prok_B
PTZ00121	292-455	PTZ00121
TIGR01843	298-442	type_I_hlyD
TIGR02794	297-462	tolA_full
TIGR02794	303-441	tolA_full
TIGR02169	305-463	SMC_prok_A
TIGR02680	288-523	TIGR02680
COG1196	294-463	Smc
COG4372	302-454	COG4372
COG4372	292-462	COG4372
TIGR02680	301-462	TIGR02680
TIGR02169	295-463	SMC_prok_A
TIGR03319	308-427	RNase_Y
TIGR02168	301-464	SMC_prok_B
COG4372	320-453	COG4372
PTZ00121	292-585	PTZ00121
COG1196	273-552	Smc
COG4372	301-463	COG4372
COG4372	301-453	COG4372
pfam01576	302-542	Myosin_tail_1
COG0419	301-463	SbcC
PRK12704	306-462	PRK12704
TIGR02794	294-437	tolA_full
COG1842	336-444	PspA
PRK00409	298-417	PRK00409
pfam09726	292-448	Macoilin
TIGR02680	307-452	TIGR02680
TIGR02169	316-444	SMC_prok_A
PRK11448	306-410	hsdR
COG0419	302-562	SbcC
pfam07888	304-546	CALCOCO1
pfam04111	316-436	APG6
PTZ00121	300-582	PTZ00121
pfam13904	307-406	DUF4207
TIGR02169	292-452	SMC_prok_A
COG1196	301-437	Smc
pfam05262	295-462	Borrelia_P83
COG4942	301-407	EnvC
COG4942	303-530	EnvC
pfam04012	351-453	PspA_IM30
COG1566	345-460	EmrA
TIGR02169	298-444	SMC_prok_A
pfam09731	301-444	Mitofilin
PTZ00266	310-427	PTZ00266
PRK05431	357-444	PRK05431
COG1196	301-452	Smc
COG3064	292-453	TolA
COG5281	302-420	COG5281
pfam01576	306-456	Myosin_tail_1
TIGR03319	291-454	RNase_Y
TIGR03794	307-414	NHLM_micro_HlyD
COG2268	294-444	YqiK
TIGR04211	318-438	SH3_and_anchor
COG2268	293-438	YqiK
PRK02224	293-463	PRK02224
PRK03918	311-444	PRK03918
PRK05759	327-423	PRK05759
COG0711	327-441	AtpF
PLN02316	355-406	PLN02316
pfam05667	295-464	DUF812
pfam13904	341-451	DUF4207
pfam05557	308-461	MAD
PRK04863	308-449	mukB
pfam11600	310-416	CAF-1_p150
TIGR01843	295-372	type_I_hlyD
PRK03918	306-463	PRK03918
pfam04111	338-450	APG6
PRK05035	306-443	PRK05035
PTZ00121	295-410	PTZ00121
COG1842	289-465	PspA
PRK12705	294-440	PRK12705
PRK09510	316-462	tolA
TIGR02794	316-452	tolA_full
pfam13514	290-463	AAA_27
pfam01576	300-451	Myosin_tail_1
PTZ00121	287-582	PTZ00121
pfam04156	301-423	IncA
COG0497	341-464	RecN
pfam13514	293-463	AAA_27
pfam12297	271-444	EVC2_like
COG2433	298-461	COG2433
pfam05622	301-420	HOOK
PRK03918	308-451	PRK03918
COG2268	298-462	YqiK
pfam00430	327-410	ATP-synt_B
pfam12128	299-446	DUF3584
COG4942	320-455	EnvC
pfam12128	298-563	DUF3584
pfam11600	293-390	CAF-1_p150
pfam15236	292-383	CCDC66
COG1579	291-439	COG1579
COG3064	350-462	TolA
pfam01576	293-463	Myosin_tail_1
pfam09730	333-456	BicD
TIGR01843	303-390	type_I_hlyD
PRK03918	301-461	PRK03918
COG4372	270-436	COG4372
COG5281	285-548	COG5281
COG3096	301-453	MukB
pfam09756	319-433	DDRGK
TIGR03752	327-416	conj_TIGR03752
pfam01576	301-458	Myosin_tail_1
PRK05035	308-460	PRK05035
pfam15066	310-468	CAGE1
pfam13514	256-462	AAA_27
COG1579	309-463	COG1579
pfam13868	293-454	Trichoplein
pfam07767	303-463	Nop53
COG1196	354-546	Smc
pfam01576	317-463	Myosin_tail_1
pfam02463	316-575	SMC_N
PTZ00121	312-453	PTZ00121
pfam05672	308-439	MAP7
pfam12128	321-545	DUF3584
TIGR01069	330-462	mutS2
PRK07352	342-437	PRK07352
TIGR02168	273-463	SMC_prok_B
pfam02463	289-462	SMC_N
COG3883	303-407	CwlO1
PRK04863	320-465	mukB
pfam09789	301-404	DUF2353
TIGR03345	350-447	VI_ClpV1
TIGR01843	372-573	type_I_hlyD
PRK12705	301-413	PRK12705
pfam05557	290-437	MAD
pfam05557	292-443	MAD
pfam13868	292-444	Trichoplein
pfam07111	317-461	HCR
COG4026	327-403	COG4026
TIGR04523	318-414	Mplasa_alph_rch
pfam12072	301-427	DUF3552

Ontology Information

HPRD ID	3222
Molecular Class	Anchor protein
Molecular Function	Receptor signaling complex scaffold activity (GO:0030159)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO