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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
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- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26175278 | 2015 | Cell line : - Source : Shuguang Hospital affiliated to Shanghai University of Traditional Chinese medicine Sample Type : CRC tumor and adjacent normal tissue No. of Sample : - Stage : TNM Stage I -III | Mass spectrometry and Western blotting | Up-regulation | - | Cell migration related proteins vitronectin (VTN) and actin-related protein (ARP3) were up-regulated in metastasis condition. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17q11.2 |
| Start | 26694298 |
| End | 26697373 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3076 |
| OMIM ID | 193190 |
| HGNC ID | HGNC:12724 |
| Unigene ID | Hs.2257 |
| Ensembl ID | ENSG00000109072 |
| PharmGKB ID | PA37335 |
mRNA Information
| mRNA ID | ?NM_000638.3 |
|---|---|
| Exon | join(1..213,307..426,502..846,925..1064,1325..1481, 1680..1832,2294..2638,2872..3076) | mRNA Sequence | Download Select all |
| Length | 1678 |
Protein Information
| Protein ID | NP_000629.3 |
|---|---|
| Protein Name | vitronectin |
| Molecular Wt. (Da) | 34746 |
| Protein Sequence | Download Select all |
| Length | 478 |
| Uniprot ID | P61289 |
| Ensembl Protein ID | ENSP00000293362 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 169 |
| C | Disulfide Bridge | 24;28 |
| N | Glycosylation | 242 |
| C | Disulfide Bridge | 38;40 |
| C | Disulfide Bridge | 44;50 |
| C | Disulfide Bridge | 51;58 |
| N | Glycosylation | 86 |
| S | Phosphorylation | 381 |
| S | Phosphorylation | 381 |
| S | Phosphorylation | 381 |
| S | Phosphorylation | 397 |
| T | Phosphorylation | 69 |
| T | Phosphorylation | 76 |
| Y | Sulfation | 75 |
| Y | Sulfation | 78 |
| S | Phosphorylation | 312 |
| S | Phosphorylation | 171;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1950 | EGF | 578 | NP_001954.2 | in vitro | 11796824 |
| 2247 | FGF2 | 622 | NP_001997.5 | in vitro | 11796824 |
| 2266 | FGG | 621 | NP_068656.2 | in vitro;in vivo | 11744726 |
| 3481 | IGF2 | 939 | NP_001121070.1 | in vitro | 10342887 |
| 3488 | IGFBP5 | 901 | NP_000590.1 | in vivo | 11751588 |
| 5054 | SERPINE1 | 1418 | NP_000593.1 | in vitro;in vivo | 883 078 311 796 824 000 000 000 000 000 |
| 5329 | PLAUR | 1421 | NP_002650.1 | in vitro;in vivo | 8830783 |
| 5443 | POMC | 1462 | NP_000930.1 | in vitro | 2475499 |
| 5817 | PVR | 1434 | NP_006496.3 | in vitro | 11437656 |
| 7040 | TGFB1 | 1821 | NP_000651.3 | in vitro | 11796824 |
| 7042 | TGFB2 | 1828 | AAA50404.1 | in vitro | 11796824 |
| 7422 | VEGFA | 1889 | NP_001020537.2 | in vitro | 11796824 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Complement and coagulation cascades | hsa04610 |
| ECM-receptor interaction | hsa04512 |
| Focal adhesion | hsa04510 |
| PI3K-Akt signaling pathway | hsa04151 |
| Proteoglycans in cancer | hsa05205 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00094 | 154-472 | HX |
| cl02471 | 154-472 | HX superfamily |
| smart00201 | 20-62 | SO |
| cl02508 | 20-62 | Somatomedin_B superfamily |
| pfam01033 | 20-63 | Somatomedin_B |
| smart00120 | 206-251 | HX |
| pfam00045 | 206-251 | Hemopexin |
| smart00120 | 161-200 | HX |
| pfam00045 | 161-200 | Hemopexin |
| smart00120 | 428-471 | HX |
| pfam00045 | 428-473 | Hemopexin |
| smart00120 | 254-285 | HX |
Ontology Information
| HPRD ID | 4893 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Synapse organization and biogenesis (GO:0050808); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P04004 | DB00054 | Abciximab | BiotechDrug |