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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WIPF1 | 7456 | WAS/WASL interacting protein family, member 1 | 2 | WIP |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19399471 | 2009 | Cell line : - Source : Department of General, Vascular, and Thoracic Surgery, Campus Benjamin Franklin, Charit Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 62 Stage : - | Laser-capture microdissection,DNA chip hybridization | Down-regulation | - | Low expression of the WIPF1 module is associated with better prognosis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 2 |
| Location | 2q31.2 |
| Start | 175424302 |
| End | 175547667 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 123366 |
| OMIM ID | 602357 |
| HGNC ID | HGNC:12736 |
| Unigene ID | Hs.128067 |
| Ensembl ID | ENSG00000115935 |
| PharmGKB ID | PA162409189 |
mRNA Information
| mRNA ID | ?NM_001077269.1 |
|---|---|
| Exon | complement(join(38814..41627,45384..46511,46807..47115)) | mRNA Sequence | Download Select all |
| Length | 4251 |
Protein Information
| Protein ID | NP_001070737.1 |
|---|---|
| Protein Name | WAS/WASL interacting protein family, member 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 503 |
| Uniprot ID | O95390 |
| Ensembl Protein ID | ENSP00000257868 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 488 |
| S | Phosphorylation | 344 |
| S | Phosphorylation | 350 |
| S | Phosphorylation | 344 |
| S | Phosphorylation | 350 |
| T | Phosphorylation | 345 |
| T | Phosphorylation | 345 |
| S | Phosphorylation | 340 |
| S | Phosphorylation | 340 |
| S | Phosphorylation | 343 |
| S | Phosphorylation | 343 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 70 | ACTC1 | 15 | NP_005150.1 | in vivo | 12029088 |
| 2017 | CTTN | 1268 | NP_005222.2 | yeast 2-hybrid | 12620186 |
| 3055 | HCK | 796 | NP_002101.2 | in vivo | 12029088 |
| 4690 | NCK1 | 2740 | NP_006144.1 | in vitro;in vivo | 9694849 |
| 7454 | WAS | 2314 | NP_000368.1 | in vitro;in vivo;yeast 2-hybrid | 94 056 711 259 128 000 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Endocytosis | hsa04144 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02205 | 29-55 | WH2 |
| cl08342 | 29-55 | WH2 superfamily |
| smart00246 | 32-49 | WH2 |
| cl02527 | 32-49 | WH2 superfamily |
Ontology Information
| HPRD ID | 3916 |
|---|---|
| Molecular Class | Cytoskeletal associated protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.