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• Evidence
• Gene
• mRNA
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• PTM
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Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20089989	2010	Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : -	Biochemical isolation to nano-LC-MS/MS analysis	Up-regulation	-	-
20473909	2010	Cell line : - Source : Department of Frontier Surgery, Chiba University Hospital. Sample Type : CRC tumor and normal tissue No. of Sample : 10 patients with primary colorectal and 20 patients with esophageal cancer Stage : -	real time RT-PCR, Western-blotting, Proliferation assays, Cell cycle analysis and TUNEL	Up-regulation	-	eIF4H isoform 1 plays an important role in carcinogenesis through the activation of oncogenic signaling and could be a promising molecular target for cancer therapy.

Gene Details

Chromosome: 7; NC_000007.13 (73588706..73611429)
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Gene Type	protein coding
Gene Family	RNA binding motif (RRM) containing
Description	This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	7
Location	7q11.23
Start	74174376
End	74197101
Strand	+
Gene Sequence	>gi|568815591:74174376-74197101 Homo sapiens chromosome 7, GRCh38.p2 Primary Assembly GACGGCAAATGGCGGACTTCGACACCTACGACGATCGGGCCTACAGCAGCTTCGGCGGCGGCAGAGGGTG AGGCGGGCGTGCGCGGGCCCCGTCGGGGGCTGCGGGACCGGCGGAGTCGGGGCCGTCAGGGTGGCGGCCG TCCTGCGCTCAGCCGGGGCGGCGGGAGGCGGGGGCCCGCGGAGGCCTAGGAGCGGCGCCTGGAGGGCCGG GGCCTGGAAATGGCGCGCTCGGAGACGGGGCGGCGGCGGCTGGGCTCCCGGGGTCTTGCTTGCGGGGCGG ATCCCTTCCACTGCCTCCCGCCAACGACAACGTGTTGGTTTTTGCCCTGCCTTGGCCGCGGCGGCGCCGA TGCCCGGAGACGAGCGCCCGCTTCCAGCCCCATCCCCCCTACGGTAGGACCAGTGCGGGGCTGAGCTGTG GCGCTGGGGTACGGGCCACACGGCCTGCCCCGCTCCGGTCCCGGCCTCTTTCGCGGCCCTCTGTTGCCTG CCCGCCTTGCAGGCCCCTGGCCCCTTCGCCACGAGGCCGGCCGACTGGGGAAGGTCGGCAGCCAAGAGGG GCGATTCCCTTCCCCTTACGTGTGAGGCAGGGATTTGGCGGCTCTGGCCCGGGGATGGTACGACTCCTTG CGGGCGGGGGGAGACCAAGGAGATAAATCCATCGTAGCTTCTTTGTATTAATCTTTCTTGGGTCACAGTG CCTTGACAGGTGCTACGTGCTCTTTGGCACAATTTCATTTCTCCTTGGTTTCTCGCTCTGATCTGGAGAA GGAACCGCATTTAGCGTCGTCCTGATTGTTGTCAAATGCAGACAACTATGTATAATTGAAACACTTTGCT TAAAAGAAACATCTTTGAATAGAGAGCTCATGGTGTTTAATTCCAGGACTCTGCACTTTTTTTTATTTTA TTTTTTAAATACAAGTTGCCTCGTTAGAATATAGGCTATGAACATCTTGCTGTTTGTCAAGGACACACTT GGGCTTTGTGTTTTCTTGCAGAAAGGATTACTTTCCCAGGATAACACCACAATAATACACACTGAGGTGT TCAGTCTCCTGGGTTGCAGTCCAAAAGTATCTTTGTTTGGTAAAGAATGATCACTTTTAATACCTTGGTT TGGGAACGGCTCAGACAAAAGCTTGTTTCGGGGCAGGAGTGTAGCTAATGTTCATGATACTGTAACGTGG AAGTGTGCCGGTGTAGGTGGAGCTATTGTCATTCCAAAGAACATTTTATTTGCTAATAAAAAAAGAAGTA AATGTTGGATGACATGAAATTATCGCCTTTGGGTTAGGTTTCTAAACATCAAATTTGTTCTCAAGTCATT TCGAAATTTAATAACTAGGGTTTTTTTTTTTTTCCTAGTTCCAAAAAACGTTCACAGAAGTACCCAGAAA AATTCTTCTTAAACAGCGTGGTCAATTTAAGTTTTAGTTGCATTGGGACTACAATAAGGTGACCTTATTA AACTGAGTGTGGGGATTTAAAAAAATTTCCTTCAGACACATTTGCCAGCTCTTCTGGTGTCAAATTTTGA CATTTGGGGGTGCCAGGAACAATCAGAAGTAAAATTCTATTAAGATGCTATTAATTTCAAATCTCCACAG CAGATGAAAATATTAGCCATTTGCCCCAGGTGTACTCCAAAAACTGATAGGAGAGTTTCCTAGGTAGCAC TGTGCATCACTTGAACTTCCTAATAGAAAGTCTCTTTACTGTTAAGCATCTTCTATGTCTCACTTACTTG GAATTTTCTATTTGGCTTCATATTAATGTGAAACTACATAAAGTATTGCTACTTTCAGAAGTAGTTTTAA AAACTTGTTGGTGAATTTACATATTCATTTATACATGTGTATTCTTTTTTTTTTTTTTTGAGATGGAGTT TCACTCTTGTTGCCCAAGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCCACCTCCCGGGTT TAAGCGATTCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATTAGCCACCGCGCCCGGCCTCA ATTATTTTAATTATGTCCACATGAACAAATGTCACTGCTTTACAATGCTTAAGCATCATAGAAGATTGCC ACCTATGGAAAGCAGTTTTAACACTGCATTGTTTGGTACTTGTGTAGGCACCTTCTCCCTTGTCTAAAAT GCCTCAGACAGGCTCGTACATCTCACCTCTGAATTACTTGGGTCACAGGTGAAAGAAATGGTAGGCCTAA AATGAACAGTTATCATCATAAAACATAGTTTGGTAGTTATACATCTTCCTAAGTTTATTTCGTAGTTGTG TTTAATAACCAGTGCAGTTGTCAGGAAACAGTATTGAACCACTGCTTTTTTCCCCCGAGCCTGTAAGGGC ATGTCCCCAGCAGCCAGGGAGAGAACCAGGGACTGCATTGTTCAGCAAGCAAATCAAAACAAAATTCCAA ATGATCAAGAGTTGATTGTACCAGATCTTGAATGGACTTTGTTTTGCAGTTTGCTAAATTATCTTTTTGA GGTTCCAGTTTCTCATCTACCATTGGCAGTAAAGTGCAGAGTAATACTGATTTTATATTTCTAATTGCAA CAAAGCTATGAGTGCTTAGTGGAAAACCACCGATCCTGAGAATTAGGGTGGAAATTGGAGGTGGCAAGAA TTGAGGTGGCTGAAATGGTGCCATCTAAAAACTGGCAAAACTCCAAATTTATTCTTTATCAGGATTCAGT TAGGGAGTTTAGAATTCTTTTTTAAATAGAGATGGGTTTCACTATGTTGCCCAGGCTGGTCTTGAACTCT TGGACTCAAGTGATCCTCCCGCCTCAGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCTACCACGCCCA GCCTAGGAGTTTAGAATTCTAACCTTTGAATCTTTAAACTTAGCATGTCTGTCTAAATTTCTGAGCATAT TTTTATCCAAAATTTTTATGGTGGTAAAATATACATAACATAAAATGTGCCACTTTACCCATTTTTCAGT ATACATTTCAGGGATATTGAGTGTATTCGTAATGTATAACCATCACCACTATCCAGCTCCTTAACTCTTA CAGCTTGTAAAACTAAAACCCTGTCCCCTTTGAATAGTAATTCCCTATTGCCCTCCTTCCCCCAGGTCCC TGGCAACCACCATTCTACTTCCTGTCTCTGAGCATATTTTAAGATTTGTATGTAATAGGAAGGAAAGCAG TGTATAAAAACTACAGCTAGTTTTCACTGATGCTAGGGCCTGTAAAGCTATTGAAAAGCTTATTTTAAAA TGCTGTTTACATGTCAAATGTCAAGTCGTTTAGGTTTGTTATCCTTCTTCACTCCAAGTGTTCCATTGCT TAGTTCCAAACCATTATCCTCTATGAAAAGTGTTACCAGAAATATTTGGATTTGCTAAGAGGTCTCTGCA TGACGGTTCATGTAAAAGCCCTGGCTTTGGAATAAGGCAGACCAGAGTTTCATCAGTTCAGCCATGTGTT AGTTGTGTGATCTGAAGTAAGTTTCTTCACCTCTCTGAGCCTCGTTTTCCCCACATATGAGTTAGAAACA TGTATTTATTTATGAAATAGGCTCTCCTTCTGTCACCCAGGCTGGAGTGCAGTGGCAGGATCATAGCTCA GTGCAGCCTCGACTTCCCAGGCTCAAGCCATCCTCCCACCTCAGCCTCCCAAGTAGCTGGGATTACAGGG TGCGCCACCATGCCCAGCTAATTTTTGTATTTTTTTGTAGAGACAGAGTGTCTCTATGTTGCCCAGGCTA GTCTCAAACCCCTGGGCTCAAGGGATCTTCCTGCCTCAGCCTCCCAAGGCTCATTGTGTGAGCCACAGTA CCCAGCCTTCAATTTATGTTTCTATTAGAAATTAAGCTTTGTGGCTGGGTGCAGTGGTTCATGCCTGTTA TCCCAGCACTTTGGAAGGCCGAAGCAGGCGGATCACTTGTGGCCAGAAGTTTGAGACCACCCTGACCAAC GTGGCAAAACCCCATGTCTACTAAAAATACAAAACGGGTGTGGCGGCACATACCTGTAATCCTAGCTACT TGGGAGGCTGAGGCAGGAGAATTGCTTGAACCAGGGAGGCGGAGGTTGCATTGAGCTGAGATCATGCCAC TGCACTCCTCCAGCCTGGGCGACAGAGAGAGACTGTCTCCAAAAAAAAAAAAAGAAAAATTAAGCTTAGT GTTCTGGAAAGACTTCACAATTTTAAGGAGTCTCCCTGGAAGCTTAGAACGTACAAAGCAGACTCTGAAT GTCTTTCCAGGATCACACTCTGGCTTCCAGCTTCCCCTGGAAGGTTCAGGAGAGTATTTGTCGCCTGGTT GCTTTTACATCATGCTGATTAGACCTGCACACCCGGGCATGAAATGAGTGTGATTGCATCATTTTCATAG AACCTAATGGCAGCTGTATGTACGTCTAAGACTTCTTTTGTGTAAGTCGAATGTTCTTCGAAGTTTCCCC ACGTCATGATTTATGTGATTTTCCGTCTTGATCAGGACCTTCTGAAGGAGCTCAAGTATGTGGCTGCTCC ACGGTTGATGAGTCTCTGGTTAAGCATGGCCTTCCAGTTCAGGGCTAGGGGGGCCGTCACCTCCCTTTGT TCTGCACATTCTTCTCCTGTCTTTCATGTATACTCACATTTTTGGAGCCTTCTGTGTACTCACATTTTTG GAGCCTTCTAAATGTCTGGCTTAATAGAACACAGCTGGATTCTCATACCTGCATCTGTCTCCACTCTTGG AATGTGTTGCTTTGGTTGACTTTTATGGAGCAGCTCAATCCTTGCACAGATAAATAGTTGGAAATGGGAG GAGTAATCAAATAATTCTGGATATTCATATTTGATTCTATACCAAAACTCAATAAGCAGTAGTTTCTATG AAGGTTAGTTGCAATGTGAAACCTAAAACCTTATCAATAAACTCTTCATACTTTTACATTAGAGTTCATC ATTTGGCTGGGCGCGGTGGCTCACTCCTGTAACCCCAGGACTTTGGGAGGCCAAGGCGGGCGGATTACCT GAGGTCAGTAGTCTGAGACCAGCCTGGCTAACATGGCAAAGCCCCATCTCTACTAAAAACACAAAAACTA GCTGGGCATGGTGGTGGGCCCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCCATAGAATCACTTGAACC TGGGAGGTGGAGTTTGCAGTGAGCCCAGATTGCGCCACTGCACTCCCGCCTGGGCGACAGGGTGAGACTC TGTATCAAAAAAAAAAAAAAAAAGTCACTTTATCTTGTACTCCGACTGGATCCTTTACCAGTGCATACAT TTGTAAGGTGTTGGTGATTTGGAAAGGACCTGTTCACTGAGCCAGGCAGAGCCATGCAGATGTTCCAGAT GTTGGTACATTTTGTTATACAGTATCAAAGTCACATTCACCATAGCTGTTAGAAAAGTCTCTGAGTATTG AAAGACTGTCAGGCTTATGTTGATGGATACAGGTTTTCCGAAACTCTTTTTTGCTTGAAAGCTTAAATTT TACCATTGGCAACAAATACTGTTATTTTGGCCAGGTGCTGTGGCTCATGTCTGTAATCCCAACACTTTGG GAGGCCATGGCAGGAGGATCACTCTAGCCCAGTCTGGACAATATGTCCAGACCTGGTCTTTTCAAAAATA AAATTAGCTGGTGTGGTGGTATATGCCTATAGTCCCACCTACTTGGGAGGCTGAGGCTAGAGGATCACTT GAGTCCTGGAGATTGAGGCTGCAGTGAGCAGTGATTGCACCACAGCACTCAAATCTGGGCAACAGAGCAA GACCCTGTCTCAAAACAAAAAACCCAAATACTGTTCTTTTACTTCAAGGAACAGACTTAACTTCATTTTT AAAAAACTTAGTACCCATGTCTGAATTAACCATAGTTTGTTCTATAGAAAGAACAGCTAGTTCAGCTTGT AGCTCAAGTGCTTTTCCTGCAGCAGCCATCATGCTTGTGTATGCAGCAGAAGTGCTTTGCGTGTTTCATA ACATAGGGTACTAAAAAGTGGGTCACGATTCATTTTTACTGCTTTACCAAGGATATTCCTAATTGAAGCT GTGATTTTTCTTCCTATTTTAAATACTTCAAGTGCATGGTGGGAAAGCATGAGTAATGTAGTTTGATGCC CCTGCCTTCGTTTGTATTAACACAAAGACCTGTTGTGAGATCAGTATAGGTCTTTGCTTTATAAATGTGG AATATTGTGAACCATTCTGGGAACCATATTTTAAGGCATCAGCACACTGGAGCCTATGAAGAAGAAGGTG ATAGTGGGGATGGCCAGGCTCTGAAACTTCATCTTAGGAGGAAGGGCTGAGCAGCTTCAGTGAGGACCTT CGAAAGAAGCCTCAGCAGCAGTGATACAGCAGCTCTTAAGTCTCTGGGACTGCTGAGTGGAAGAAAGGTG TGGCCCTCCAGGCCAGAATAGGACCAAAGGATTACATCTTGGCCTTCTTCAGAGACTGCACAAATGTAAA GAACTGCTGCTTGAGCTAAATAATTGTTTTTTTAATAGAGACAGGGTCTCCCTTTGTTGCCTAAGCTGGT CTTGAACTAGCCTCAAGGGATACTCCTGCCTTGACCTCCTAAAGTGCTGGGATTGCAAGCATGAGCCACC ACGCCCAGCCTCAACCATTTTTAAGTGTACAATTTAGTGGCATGGAGTACCTTCATAGTGTTGTGTAACC ATTGCCACTATCTAGTTCCAGAACCTTTTCATAATCCAAACAGAAACTCTATACCCACTAAACAACTCCA TTCCTTTCCCAGTTTTAACCTCATAAACATTTTGGCTATTTCTGTTACATCTATCTTCCCTACTTTTGGG TGGAGGTGTGGGCTAGGATAATTTAAGGCTAATCCTAGTCACCTATCCTTCTAAAATAGTTCTTATTTTT TTAAATTTTAATCCTCATCTTTGTGTTGGTAAATATTACATACTTTAGAGCAATTTTTGTTTCAATTTTT ATGGCTACCGTAGTAGATGTATCTTATATATTCTTTCTTTGTTTTTTTTGTTTTTTGTTTTGTTTTGTTT TCTGAGGCAGAGTTTTACTCTTGTTGCCCAGGCTGGAATGCAGTGGCACTATCTCGGCTCACCACAACCT CCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATGTGCCAC CACACCTGGCAAATTTTGTATTTTTAGCAGAGATAGAGCAGAAACAGAGGGTTTCTACATGTTGGTCAGG CTGGTCTCGAACTCCCGACCTCAGGTAATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGT GAGCCACCGAGCCCGGCCTTTTTTTTTGAGATGGAGTCTCACTCTGCCTCCCAGGCTAGAGCTCAGTGGC GCGATCTCAGCTCACTGCAGCCTCCGCCACCACCCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCT GCCACTGTGCCCAGCTGATTTTTGTACTGTTAGTAGAGATGGGGTTTCACCATGTTGGCCGGGTTGGTCT TGAACTCCTGACCTTGTGATTCATCCGCTTCAGCCTCCCAAAGTGCTGGGATTATAGGTGTGAGCCACCA CACCCGGCCTCTTACATACTTTTCATACTTGAGTATGTTTCTAACAGATAAGGGCTTCTTTTTTTTCTTT AACCAACAGTTTTTCCAGTACCCAGTGTTCAGTTTTTCCCAGTTTTTGCAAAGATGACTTTGTATAGTTG GATTGTTTGAATATGCAAAACATTACAGAAAAATGTAGAAAATTTAGAACACGAACCAAAGCATAATATA GTGACCTGTATACCCATTACCTACTCTTTAAGTGACCACTCTTCTCTATACTACTATGGTTTATAATAGG TAGTATAAATGGTATTTATCAAAGGCTTGACCTTTGAAAGCTTAACCATTTTTGATGATTGTCAAAAACC CAAATGTTACCTGTTTGTAGATATGGGGTTTTGCCGTGTTCCCCACGCTGGTCTCAAACTCCTGAGCTCA AGTGATCTCCCCACCTTGGCCTCCCGAAGTGCCGGGATTGCAGGTGTGAGCCATGGCGTCCGGCCAGTCA TTTTCTTTGGTTTACACTACTTTACCCTTCTGGGCCCTACTTTCCCCAAATGAGAGCTAGAAACTCCTCT GTTGGGAGGTTTAAATGAGATGTGTCTCATAATTTGGAGGCATAGTCTTGCCCTGTTGCCCAGGCTGGAG TGCAGTTGCACAATCACAGTCCCAAAGTGCTGGGACTACAGGCCGGAGCCACATGCCCATGCCCAGCCTT GAGCACTCAACTTTCTGTTGCATCTACTTACTGGATACATCCCTACCCTCATAACATCTACTCTGTACAT TGGCTTCTTTTTATAGTTACCCTCTCTCAGTCTCCTTTGACACCTACAGATCTTTTCTGGCTCACCCTAA GGGTTCAGTATTGGCCCCATCTGCCATCTGGAAGTGGAGTCCCACTTCTGTTGCTCTCTGCTGTGCTGCA TATCCTGGCTCCCAACTGCTCCACCCTGGTGAAACTGTTCTCATTGCTATCTTCCAGATTTTCTGCAGTC CTTTGCTTGTGACGTGATTTCTCCTTTCCAAATTATCAGCTCCTTGAGGGCAGAAACCGAGTCTTAGGTT TGTGCCTTCTCTACATTCTCTCCACCCTTCATAGACATGCAGATACGTGGTTGATTTGAGTAAGGAAAAG TGATTTGCCTGTCAAGGATTTTAGTCACACTTGGAGCCGAAAGTAGGGTTTCCTAAATTACTGAGGCTGT AATTGACTACTTTAATCTTTCATAATCAATAGACTGTCCCTAATGGGCAGTAGAAAGGACACTGCTCAGT AGTGGCAGGGAGTTTGCAGCACAGACCTTGACTTCAGGTGTCCTGAATTGGCACGCTCTGCTGATCTGTT CCTGTTCTACACGCACTCCTGCCAGCCCAGTGTAGCCTCAGGCCTGTTGGGTCTACCCAGGAGCATGGCA GAATTATATAGCACTTGGTACTTAGGAAATGTTTTTATGGTCAGTTTTAAACTTATAAAATCAAGATTGA AATATAACAGACAAGAAAACATAGGTACAGAGGTAATTTGGCAGAGGTCCTACATCAAGCTAGCTAAGGT GTCAAGTGAACCTGTTCTCCCATGTGTTGTTATTGATCTGTGTAGGAATGTACTGAATTTCACGAAACAC AGCTTATTTATTTAGGTAGTAGTCCCCCAAACTTGAATCTAGTGAAAGGTGGCAGACATTTTAGCTCAGA GTTTTCTGACATTTGATTTTGTAAATGAATCGGTGGGTAACAGATCTGTGTCATCCTATGTGATGTGATG TGATGTCATCCTATGTGATGTGTACTCTGGGGTACTCACATCCTATGTGATGTGTCTCAAGTGACTGTCA CACAGTGGACACTTTACCAGTGCTAGCTTGAATGAGGTCTACCTCCATGGCCCAGCCCTGCTGCCCCCTA GTGATTTCATTGAATGGGATGAAAAGGTAAAAAGTGCTTAAGACCTGTAGAAGGGACTACATCAGGTAGG GTATGGGAATATTTAGGACTACTTTGGTAATTATTGAAAAGTCTAGAGTATTAAGCCACTGGTGGTTTTG TGAGGCACGAGTGAGTTGAACAGTTTGGTGGGCTTTGGTGTATCTTTGCTCCAGAATTATATCACCAGTT AGCTGTTAGGTGCTGCCATTTGGTAACGTGCCAACTTTTCAAAAATGGTTTGCCCCAAACTAGATTTTTC TATCTTCTCCAAAGCCAGAGCCACCTTCCTGTCCTAGTGCATTTTTAGCAGTGCCCCGTCATCTTACTGG CATTCACCTGGGCTTCCTGTGCTCAATCAGGGGTCAAGTCTGGCCTGATCTCAGTTCCACAGTTCCTCTA CTCTGTAAGTTCGAGCACAATTAGCAAGCCTTCGCACCTCCATTTTCCTTACTTAGCAACTACATCAAAC ACCCGAGAGTTTATCATCTCTCTTCATCCTCACCCTCCTTTTTAGTTTTTATGTATATGTTACACATTCA TACACACAAACATACCTGCATATATACATGTGTTTTATACGTCCCACACAACTGTGAGCTGCTTACATAC AAGACAGTCTTTTAACATCATTACGCATCACTAGATGTTTAATGTTGAGTAATGAATTTAAACTGTTTTT AACATTGACCCTCCATTTTTATGGTTTTCCACATGTTTATACTGTATCTTGTTTTTTGTTTGTTTGGTTT TGTTGTTGTTTTTTGTGCTTTTTTGTTTGTTTTTTGTGTTTTTTTGTTTTTGTTTTTTTGAGATGGAGTC TCGCTCTGTAGCCCAGGCTGAAGCGCAGTGACACAGTCTCAGCTCACTGCAAGCTCCACCTCAGCCTCTG AAGTAGCTGGGATTACAAGTGTGTGCTACCACACCTGGCTAGTTTTTGTATTTTTAGTAGAGACGGAGTT TTACCATGTTGGCCAGGCTGGTCTTGAACTTCTGGCCTCAAGTGATCCACCCACCTTGACCTCCCGAAGT GCTGGGATTACAGGTATGAGCCACTGTGCCCCGCCTTTTTGTTGTTGTTGTTGTTTCTTCAGTTGGAGAC AGTCTCCTTCTGTCACCCAGGCTGGAGTGCAGTGGTGCCATCACAGTTCACTGCAGCAACAACCTCCTGG GCTCAGGTGATCCTCCCACCTCAGCCTCCCAGGTAGCTTGGGACTACAAGTGTGGACCATCACTCCCGGC TAATTTTTTGTATTTTTTATAGAGATGGGGTCTTACTGTGTTGCCCAGGCTGGTCTTGAACTCCTGGCTT TAAGTGATCCTCCCGCCTCAGCCTCCCAAACTGTTGGGATTACAGGCATGAGCCACTGGGCCCGGCTTTA TACTGTAACTCATATATTTATTATCCCGTCCTAAATAGTATCTTACTGAAAATATTTTAGGATTTATGAT TTCGGAGATATCAGCGATAGAGTACTATTGGCAAAGGTTATTGAAATGCAAAGTAAGTCACATTTACTAG GCCCGAAAAGATGGGAGAAGTGGGCAGGTAGGATGCAATTCACTTGTAAACCTATTTTCTGGTGGTCTTA GAACAGAACGTGGAACTTCCTATTGGAAAGTACCGGAATTGTGAATTATGAAACTTAAAAGCTTTTTTTT TTTTAACCATCAAAGAATCATCACAGCTTGGTTGACCCTTCTACTTTAGAAAAATGCTTTAATGAATAAT ATTTGTCTGCAAGACACCTGGAATTTATCTTCAGGAAGAAGTGGAATTTCCATTGTGTTTCTGGCAGTAT GTAGATGAAAGACCAGGTTGCTCTCTAAGATGGATATTAATATTTCCCCTGCAAAGAGGGTGACTTTGGG CAGGTCTTGGGTTGTTGTGAAGGATCTCATTTATTTGAACGCATTTCCCGTTTAGAAAAAAAAACTGCAG TTGGCTGCCAGCACGGTATTCTTGGAGCAAACAGGAAATGGGTTAAATGTCTGTTTCAAAAAAAAATCAC CCCCTTAATTTTTTTTTCCTCCTGAGTTTTCCAAACGTTTTATTTTGGAAATTTTCAAATCTACAATAAG GTTGAAATAATGGTACAGTTGGATGACGCTAGTGGATGCAGAAGTGACTATTCTGCCTTGTTTGCTGAAT CCTTGCTGTATACCGGCACACATGCCCTTTATGCTGACCTGCTTGAAAACAAATGTTGGCCATCTTGGCA CTTCACTTCTAACGACTTTAAGTCGTTCCTGGGGCATTCTTATGGCAAATATCGTTTAATATAATAATCT ATTTATACTATATTCTGATGTCTTTTTTTTTTTTTTGAGATGGACTCTCGCTCTGTCGCCCAGGCTGGAG TGCAATGGGCTCACTACAACCTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTGCCCAGCAGC TGGGATTACAGGCATGCACCACCACACCAAGCTAATTTTGTATTTTTAGTAGAGACAGGGTTTTACCACA TTGGTCAGGCTGATCTTGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAATGCTGTATT AGGATTAACTCAGTTTTACAAATAAAATAAAGCTTAGAGAAGTTGAATAACTTCTCAAGGTCATATGCTA GTAAGTGACAGAGGCTAGATTTAAACCAATACCTATGCAGAGTAAACGACGCTTGATACAGCTGAGGAGA TGACATCGAGGTTGAAATGGATTGGTAATGCACGCCATACGCATGTATTTGAGGACCCTGTGAAGTATTG CACGAGAGTGTTAGGTACGTCAGTACTTGCTGTGTGACATCTAAAATTTTTATTAGGACATTCTTATGCC CATAATCAGGCAACAAGGAGAAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTGAGACGGAGTCTCTGTCGCGTGAGCTGAAGTGCAGTGGTGCGATCTTGGCTCACTGCAGCCTCCG CTTCCCAGGTTCAAGCGGTAGGAGAAATAATTCTATTATGTATGAATGTGTTAAACGTAAACAACTTCAG TAATCCTTCTTCTGAATACAACATTACTTCTAGACTGTCCATTTCTGTATTTCTTAGAACCACGGTGTGT GAAGGAGGGTACTTGCTTAGGTTTTAGGATGTAAATACTGCAGATACAGATTCTGAGTGAATAGGAGAGA AGCAGTTGTCTTAGGAAGGTGTGTTACGTTTGGGCTGGGCATGGTGGCTCACACCTGTAATCCCAGCACT TTGGGAGGGTGAGGCAGGCAGACCACCTGAGGTCAGAAGTTGGAGACCAGCCTGGCCAACATGGTGAAAC CCTGTTTCTACTAAAAATGCACAAATTAGCCAGGTGTGGTGGCACATGCCTGTAATCTCAGCATCCTTAG GAGGCTGAGACAGGAGAATCTCTTGAACCCGGGAAGCAGAGGTTCCAGTGAGCCAAGATTGTGCCACTGC ACTCCAGCCTGGGTGACAGAGTGACAGTCTGTCTCAAAAAATTTTTCTTTTCCTTTTTTTTTGTTTCTCC AGCCATTCTCTGTAACAGTCTTGTGGTACATCGAGCAGAGTGCCTCACCTGGGGCGCTGGCGGCGTAGCT CAGCGGAAGACCGCTTTACTTGTTTTGCTTATTCCACTCTGGGCACACTTGAATCCTGTTTGTCTCCCCT CCTAGGTCCCGCGGCAGTGCTGGTGGCCATGGTTCCCGTAGCCAGAAGGAGTTGCCCACAGAGCCCCCCT ACACAGCATACGTAGGAAATCTACCTTTCAATACGGTTCAGGGCGACATAGATGCTATCTTTAAGGATCT CAGCATAAGGAGTGTACGGCTAGTCAGAGACAAAGACACAGATAAATTTAAAGGTGAGTTTGGGGGATTC TTATTGTATATTACTGTAAAGTGTAGGGGAGGATGGGAAGGGGTTCTAAATAAAAATAGATTTGTGAACC AGAGGCTGTAATCAAGAAAGTGTTTTAAACATTTGCCTGGTCTAAGTGGCCGAAAGAAACATAACTCTTC AACTCATAGGTCTTCAGTTCACTTAGGGGAAAATGTTTTGTACACAGTGTAGTTCATAGAAATACATGGC ATATGCCCAGGTTTGTGAGCCTGACCTCTACAGCAGTCCTGTCTGCCAGTAAAGGAGTTCCCCAGGAGAG AGAGGAATAGAGCCGAGGACTCTTAGGCACATTCCTCCTGGAATGACTCGTAGATTTTCCTTGGTAGTTA ATCCAGTAATCATATGGTACTGTCATCCAGTAATCATAAAACCCAGAAGAGAAGCAGCCAGTGCTGTCAG TATGCATTTGTAAATTTGGAGAGTGTGCTTGGGAGGGCTGGCTGAGATTTCAGATATGGTGTCTATAGGT CGTGTGTCTGCAGGGTGCGGGAGCAAAGAGCAGGAAGAAGAAGGGATCCGAGCAGCATTCTCCTGCCTGC AGGGCTTCCTGAAGGAAGTGTGCCTGCTGTGTAAGTGCACGATGCTAGGACCCAGGATGTTTGGCCCGCA TAATCCACCCAAAAGCACATCTGTGACAAGTATGGGGTAACTTGGGGCGGGGAGCTGTGCCAGCAGTCGA GAAGGCCTTGCTGACCTGGGTGGTTTTGTGTGTCGGTGGCACTCTTACTCTTTTTGACTTCAGAATCTGA AGCCACATGTAGTGTGTAATCAAACAGTGAAAACAAATATATCAGTTACACTTGTGAAGTAAGCTCCAGG AAGCATTAGGAACTAAACTTTGGGTTGGAGTGTGTGGGTGAGCCTAGCCTTTGGGCTGGGTCAGTCGCTG CAGGCTTTGGAGTTTGGCTCATGAAGGACCATCTTCATTTGAGCAGCTCTAGAAGATGAGATTGGGTGTC TGTTGCTTCTGTGAAGTTGGGGGTAGTTTTCTCCATTATTCTCAACATTGAATCCACTTAGGGAGGAAAC CTGGGGGGACATCCCTCCAGCCAAGGCAGTATGTTCTTAACACACAGTTGGTAAACAGGGAAAGTTTGGA CTCAGGCCTTTAGAGCACTTGCGGTCTAGTGGGCTTCAAAGATGAAGTGTGATTATTAAGTTATTATACA CAGGGCAAGGACGCTGGGGGAGAGGGGATGCAGGGTGTAGTGCCAGCATCTGGGGAGTAATGAACTAGAT TTAGACTCCAGACAGCAAGGAAGGGGCAATGTCAGACCCCTGGCATCAGGGACACAGGTTGTCAGTAACA GGTACTTGGACCCAGGCTGCCTGTCTTTTAATTAACATTCAGAGAAGAATGCCCTGATTGCCAAGGATAT ATTTTCAGCTTTGTGAAGCAAATTTTATGTCAGTTACCTGAGTAGTAAGTTAAATCGGCACTTTAAGCCT CTTTCTTCAGAGCATTTTAGGTACCAAGTTTGAAATCTACGAAATCTAATCCTCACTTAGATTAAATAGT CATTCAGAAGTCAGAAGAGCTCTGCAGATGGCCTGAGAAAGGTTTGAATATTATGGTTAAAACATTCAAG AAGAAAGCTTTCTAGAAACGCAGCTGCTATTTCAGTGCATGTTCAGTTAGCATTTTCTGACTGATAAAAT AGAATTGAGAGGGAGGAATGCCAGTCAGGGTTCTATCTATTGAAAGGCTCTCCTAGTCTGCCATCATCTA GACAACAGAATGGTAGTTGTGACGTGGAGAAGTAGTATGAATAGGATCTTCCCACATCTTTAACCCAGAA TTACTTGAGGAAATCGGGGTCTTCTTTTCTTTTCCAGGATTCTGCTATGTAGAATTCGATGAAGTGGATT CCCTTAAGGAAGCCTTGACATACGATGGTGCAGTAAGTATCCTCGGGTTTTCTCTGTCATAGCAGTTGAG ATTGTTTTCTTTGCCAATACTTACACTATTTTCCCTTTATCATTAGCTGTTGGGCGATCGGTCACTTCGT GTGGACATTGCAGAAGGCAGAAAACAAGATAAAGGTGGCTTTGGATTCAGAAAAGGTGGACCAGATGACA GAGGTGATTGGTTCTTCTAAAGCTGAACATCATAAAGATTTGCAGTATGCCTACCAATTCCAACTCGTGA ACGTTCCTAGTAGAACTCGATTATCTCATAGGTGTGATAGGTTCTCGTGAGCTCTTAAAAGTTTGCGTAA AATCCTAGAAAGAATGGCTGATGCTTCTGCAAGCCTGGCGTTTTTTGTTTTCTGTTGGAAGCAAAAGCTC TTAAAATGATTTCATTGAACCTTCCATCACTTGAGTTGTATGTCTTCCAAATGAATTTTTCCATGTTTGC GCAGCAAGGTAATGACACGACCTCAACTTTATCTTTTTTGTGTATCCTCAGGAATGGGTAGCTCTCGAGA ATCTAGAGGTGGATGGGATTCCCGGGATGACTTCAATTCTGGTATCAGTATTTAAAGTATCACCACTTAA TTTTTCCTAGGAGCCTTGCTGCTGTTCTCTGTTTCTTACGAGTAGCCCGCCTGGCCGGACTACTTATTTA GTTCCTTTAACAAATACAACTCTCCTGCAGGGTGCCCAGGCATGCAAGTAAGCCTCTGTTAGAGCCTGTG GGGGCAGGACTTGAGCCCCATGCACCTTGTGTGGTCACCTTTGTTAGCCTGCAGCTCCTTGGATGTGTAC GGGCCTGGGTCCTTGAGCTCGCTCAGCAGTCTTTCTCAGACTCTAGCCCAGGGAAACTCCTCTGTGGTTT TGTGTATGGCACCAAGAGAAGTACTGTTCCTTCTGGAAAACATAGGATAGAGGTTTGGGTTCTTACATGG TGAAAGGTAGTCCTGATGGCCCTTTTTTTTCTTGGAGGATTGTGGGGAGGTCCAGTCCCTTGATGGTGGA CCTGATGCACTTCGCCGTTCTCTTTCTTAGCCAACCCAGGCAGAGCAGCTGGTGGTATAGCACAAAGCAT CAGTCCACACGCCAGGCCTCTGCCCTGCAGGGTGATTTTAAGCATTTTTATCATCTTTACTTTCTGTTTT TAAATTACAAAAGTATAATTTTTTATATATGCACATGATAAAAACTTCAGTTGTAACCCAGAAAGGTAGG AAGAGAAAAACAAATTTGTTTTCTTTCCCGCAAACTTGGGATGTGCTGTCAATGCTGTGCTGTATAGAAC GTCAGCACCCTCCCCCCATCAAAACAAAACCGGTGTAAAGTAGTGGGTGAGTATGGGAGGGACTGGTGCA CGCTGTCTTGTGAGTCTGAGATTTTTAAAAACTCAGCTTTGGCTGAACAGGTGACGACTACCTGTTGAAT AATATAGTTCTTAAAAGTCCTGTAGCCAGTCAGAAATGAGCTTATTCATAAAAGTGCAGTATGGTGAAGT CAATCTGTAATTTTATGTATAAGCTAGTCTCTGATTGAAACATGCAGCAGCTGTCTTCTTAGAGCCAACC AGCAGCTCAGGGAACGGCCTTTCCCCTGCCAGTTTGGTATTCGCAGGTGTTATAGAAGTTGCCCACATAC TAACGTCTTTCTACCCTTGGCTTAGCTTGGCCACTGGCGCTCAAGCAGAGACACAGTGAACACGGCCATG GCCTGGCCGCCACCAGTTCTGGTGGGAACTGCAGTGTTTTGGTGACATCTCAAACCCTATGTGGGCTCAC TCGATGGAGTAATGGCTAATTTGATACTTTATACGTTATTTGCGAGAGTAGATCTTTTTTACTTTTTAAT AGGATGGTGCTATTTTTTTTAATGATACCTGCTCATGTAAAAAACAAAATAGAGCAACAGAAAAGTACCA AGAAAGCAAAAACATTTCATCATCAGAAATAGCCAGTGTTAAACTAAGCTTTGTAAAGAAAACTCTGAAG ATTCTCATGAATAGTTTGCTTCCTAGAAACCCACCAACAGATTTTTTGTTGTTGTTTTTTTTGAGACGGA GTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAAGCTCTGCCTCCTGGG TTCATGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCACCACCACGCCCGGCTA ATTTTTTGTATTTTTAGCAGAGACGGGGTTTCATCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCG TGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCCCACCA ACAGATTTGATGAGAGATCCTTGTTCATCTGCTTCACCAGCGTGGTGTGAGCTATTTGTTTCACGCTAGA CATTGGTGGTCGAAATCATTTAATCTCATAGTAAAGGGTGTAAATTTACTTTGTACTCACGTGGAAAGGT ACACTTCACAGTTTAGTTTGGGGGAAACGTGAAGTTAAATGTTTTAATACTAACTAGGCTTGTTCACTGA ACTGTGTAATGTGGGTAAAATACTTTGTAAAGGACCTTATACTCGACTGTATGCCTCCCAGTGTATTTCC CCTAAAGCAGTGCTCTTATTGGTCTAAATCTGTTCAGACTTGCTTTCATTACTTGGTTTGTTAAAATTTA TTATTTAACTCAGTCTCTGAACTGGGTGTGAGATCCCTTGGTTTCCAAAACCCTTGCCACCTTTAAAGAA TAGAAATCGGCCCCCACCACAGGTGATGCAGTCAGCGCTTATCATTGGAGGTGGTTCTGTGGAGTTGCTA GAACACTGAATGAGCCCGTGCGGTGCTGCTCCTGTGTGCTACAGATCACAACATTTTCGTCAGCTGATCA TACCTAACATTGCTTTATGTGACTTTTTTTTTTTTCTTTTTTTTTTTTTTGAGACAGAGGCTCACTCTGT TGCCCAGGCTGGAGTGCAGTGGCATGATTTCGGTTCACTGCAATCTCCGCCTCCAGGGTTCAAGCGATTC TCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCACACCACCACACCCAGCTAATTTTTATATTT TTAGTAGAGACGGGGTCTCTCCGTGTTGGTCAGGCTGGTCTCGAACTCCCAGCCTCAGGTGATCTGCCCA CCTCTGCCTCCCAGAGTGCTGGGATTACAGGCGTGAGCCACCACACCCAGCCTATGTGACCTTGATTTTA AAGACGCCTCATTTAATGTTAGTGTTGATTCATTTAATAGTGTTAACATTGAACTCAGGGCCAGCTGTAG TAAGTAGTCTGTGGTGCCATCATTTCAGCCTGTTAGAAAGCTCATCCCACACCGGTTTTGTCTGTAAGAC ACCTGACAGCCAGCCTGCACTTAAGAACAGCAGACAGCACTTCACACTGCACCTGGGGCCACTTCAGACA GCGATGTCACCAGAAAAAGCCCAAAGGGCAAAACACCCGACACTCATCGTGAAAAGACTTGACAGCTAAT AACTGAAACAGGCAGAGCATTATCGTTTTCTGCCTCAGCTGGGATCGTCGCATCTGTGCAGGTCCAGGAC TGACTGGAGAAATGCTGCTGGTATCTAGCTTGGGATTACACATGAATTTTAGCGACTGGGTGGATTTGCA AATATGGGATCTGTGGATAATGAGGATGACTGTATAGTGCATACTGCGGGCTCTGGGGGTTCTTCTCAAA GACAAGCTCCCTGAAAGCTTGGAGCCTTGGCACCACTCTCGCAGAGAGTAGCAGTGGCACCCCCTGAGTG CGCAACCAACAGCAGCAAGCTCATTTGTTTAATTATGGTTTAACTTCTTTTCGCCAGTTTTTTTTTTTTT TCCTTGAGACAGAGTCTCACTTCATCACCCAGGCTGAAGTGTAATGGCACGATCTTGGCTCACTGCACCC TCTACCTTCCAGGTTCGAGCGATTATCCTGCCTCAGCCTCATGAGTAGCTGGAACCCCAGGCGTGCGCCA CCATGCCCAGCTAATTTTTGTGTTTTTTGTAGAGAGTGAGTCTCACTGTGTTGCCCAGTCTGGTCCTGAA CTCCTATACTCACCTCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAACCAGTCTTTTTACC AAATTTTAACATCAGTAGGTTATACAGTTAAAGTTTAGCTTTCACTGAAGTACAAGCCTGAAGGCCCCTT AAGACCATTGAGAAAATACTCTTTCCTCCTACACACCAGTGGGAATTCAGCATTTCTAAATGAGATGCAG TTTACTTCTGCCAAGAGCCCACTTAGCAGGCACACAAATGAATGGGGAAAGAACGCTTTGCCCCCACAGG AGGCGCCGGTGGGGGTGAGGCGCTGTGCTCTCTGCTCATGCCCCTCTGTGTAGGGCATGGCCAATTTCGG ATAACTGCTTTGTTTACCACACAGGTGCTTTGCTTGTAGAATGGCCCACACCTAAAACGCAGCCAAAACA GGAAAATTGGGACTTTGTGTTTTTATTTTGTCTTCATATAGCGTTTTCTTGTGATTTTTGTGTTCTGAGT TGTAAATACTTCTAAATTTCAGGTTTATCTTTTAAAATAGCTGTATAGATTTCTATTAGAAAATAGAGTT CAACCTGCTTTGAGGCTTTCTTGTTTTGCTTAAGCCGTATTAAAATACAGTTTCGTGGTATTAATATTTT TCTACTTTTCATGCAAGCTGAGCATGTAAACAGCTCGTTTGTTTGCTCTCCTAAGATCTTGATTCCTTTT TCTTTGGGAAGTCTGTTAGCGCTGTCATTACTCCACACATTGGCATTTGGACCCACTTTTAACACACTTT ATTTTGGAGAGACTTCAGATAGTGGACAAACTAAAGAATTTAAAATGAAACTCAAACAATTCCCAGAACA TTATTCTATAAGCAGCTTGGAGACGATAGTTTGAAAAGTAATTCAGTGTCCTGTTTCTTCCTCAGGCTTC AGGGATGACTTCTTAGGGGGCAGGGGAGGTAGTCGCCCAGGCGACCGGCGAACAGGCCCCCCCATGGGCA GCCGCTTCAGAGATGGCCCTCCCCTCCGTGGATCCAACATGGATTTCAGAGAACCCACAGAAGGTACGGG CTCATGTGTCAGTGGAGGGCATCTTGTCCTGATGGGATGATCATGGCCGGTTCACACCCCGTGGGGACTT GGCGTTCTACGGCACACAGAGTTGTCGGCATAGATCCCCACGTTCTCTGGAATAGCAAGTTCACCTTGGT CATTAGAGCATCTGCTGTTGGGGTAGCAGGCCAGGTGAATTTTAGAAAGTGGGCTGGTTTGCTGACAGCA ACATCAGCATGGTCGTTTTGCTGGATATGGAATGGGATCCACACTCTGACAAACTCTGCTTTTTCTCCCC CAGAGGAAAGAGCACAGAGACCACGACTCCAGCTTAAACCTCGAACAGTCGCGACGCCCCTCAATCAAGT AGCCAATCCCAACTCTGCTATCTTCGGGGGTGCCAGGCCTAGAGAGGAAGTCGTTCAAAAGGAGCAAGAA TGAGCCTGCGGTTGGGAGGGAATGGGGCGTGGGGGGTTAGAGCAGGACCACAGCCTGGTGAGTCCCCGGG CAGCCGTCCTGCAGCCGCCACTCCTGCGCCTGCCATTGGCCTCCTCACAGCGGAAACACAGCTTGTGAGT GCATGTCAGCTGTTAACAAGTGGTTTTTAGTACATTCTGGGCTTTGCTGTATCTATCTAGTGCCTGTTTG TGCGTTTTTTTCTTTCTTCCGCTGCTTCCCCATTTTCCTTCTGTCCTTTTTCTCCTGCTCCTTGTTTTCC CAGCAGCACATGGGGTTCCTCGGAGGAGCAGAGGTGGCCGCCGTGGGGGGGCGTTTGGGCTGCGGTGCTG CGTCATTTTTCCTTTGCTTTCTCTTTACTTTAGACACTGGCCCAACTCCAGGCGTTTCCTTTCATTCCCT CAGTGCTTCTCTTCTGACCTGCATGTTGAGTTCTGTATTGCTGGGGCTTCCAACAAAAACCAGAGTCACT GACAGAGGGAACAGCAGAGACCTTGTTGGTATTCAGCTGTGATGGATATAGAGAATCAGAGGCACCTTGT TTTCACAACTAGGATAAAAATATCTGCAGGGTCCTTTCCATTCCTATTTAGAGGGAGTCCTGGCTCCATG ACCCCCTCCCGAGTGGACTGTCCAAGCAGATAGGCTCACACGAGAAACAGTGAGGCTGAAAGGGGGGGCT ATGGAAGAGCGGTAGGGAGTCCACGGAGAAGATGCAGTGAATGCTTGCATGCATTCACACGTGTGTGTGT CCCAGCTAGTTCACTCCTTTCGCCGTGCGTGGTGGAGGCTGGCCTCTCTGGCTGGGTGCAGTGAATGGCC AGCGGGTTTCTTTTCTGCTGGGCCAAGGCGCTTTGGGGGTGGAGGGGGTGGTGCTGGTGCTGCACTGGGC TGACTGCGGCGCTGACGCAGCGTTTCCCCCCATCCCTGTTGCCTGTGTGTTGTGTGGATCTGTTCCTAGT ATAGGCAACATAATGAGATACTGTGCTTCCCACCTCCCCTTCAGTTCAGAGCCAAAATGGGTCTAGAATC TGGCACTTTACTCATTTCCTTTGATAAATTGTACTATGCAGAGCTGTCAGGAACCTTCAGATAGCAGTAG AGGACTGCAGCTGTCTAGGTCTGCGGCCACATCTTGGGGACACACTGGACTGTTCCCATGTGCAGGGTTC AGCAGTTATGTGGGAGTGCTAGGGGTTAGGCTTTTGAGCTTGAACGCCTGCGTGTGAACAGATGAAAAAT CCTTCAGTACCCAAGTCCCAGTCTGTCCTATGGGGAGCAGTTTGGGGGCGGCCGGCAGCAGGAGCCTGGG AAAGAGGCCCTCGCCAGGTGATGGCAGGGCCAGGGTGGCCTGGGGCACCCAGCGGAATGTGCTTAGTATT TGGTCACCAGCCGTCATCCTGGGCTTTTCCTACTGTGTCTTGTTACAAGGCCTCAGCAATCCACAGAACT CTCTCTCCTTCCTTCCACCTGTCAGCTTCTCTGCTTCTGAGATAAGAACCATTTGTGTAACACCAACACT TAACTTCAGAAAGACATGCATTATGTGGTGTAATCAAACCCGATGCTTTCAGATGACCTACTTACATCTT CAATGTGGATAAGATAAAGAACAAAACACATGCATCTAAACTGCTGGGCAATCCAGTTGACTTTTAAATG TAAGAATGGAATTCCAAACACTTAACACATTCAGCTATATGACAGAAAGTAAATCTATGGATATGGTATT TTGTGAATGATCTTTTAAATAAAAGAAAACCTTACGTAATATTTAA    Download   Select all
Length	22726
OMIM ID	603431
HGNC ID	HGNC:12741
Unigene ID	Hs.520943
Ensembl ID	ENSG00000106682
PharmGKB ID	-

mRNA Information

mRNA ID	NM_022170.1
Exon	join(1..67,13236..13423,15298..15362,15447..15543, 15872..15931,20366..20503,20794..22724)
mRNA Sequence	>7458 GACGGCAAATGGCGGACTTCGACACCTACGACGATCGGGCCTACAGCAGCTTCGGCGGCGGCAG AGGGTCCCGCGGCAGTGCTGGTGGCCATGGTTCCCGTAGCCAGAAGGAGTTGCCCACAGAGCCC CCCTACACAGCATACGTAGGAAATCTACCTTTCAATACGGTTCAGGGCGACATAGATGCTATCT TTAAGGATCTCAGCATAAGGAGTGTACGGCTAGTCAGAGACAAAGACACAGATAAATTTAAAGG ATTCTGCTATGTAGAATTCGATGAAGTGGATTCCCTTAAGGAAGCCTTGACATACGATGGTGCA CTGTTGGGCGATCGGTCACTTCGTGTGGACATTGCAGAAGGCAGAAAACAAGATAAAGGTGGCT TTGGATTCAGAAAAGGTGGACCAGATGACAGAGGAATGGGTAGCTCTCGAGAATCTAGAGGTGG ATGGGATTCCCGGGATGACTTCAATTCTGGCTTCAGGGATGACTTCTTAGGGGGCAGGGGAGGT AGTCGCCCAGGCGACCGGCGAACAGGCCCCCCCATGGGCAGCCGCTTCAGAGATGGCCCTCCCC TCCGTGGATCCAACATGGATTTCAGAGAACCCACAGAAGAGGAAAGAGCACAGAGACCACGACT CCAGCTTAAACCTCGAACAGTCGCGACGCCCCTCAATCAAGTAGCCAATCCCAACTCTGCTATC TTCGGGGGTGCCAGGCCTAGAGAGGAAGTCGTTCAAAAGGAGCAAGAATGAGCCTGCGGTTGGG AGGGAATGGGGCGTGGGGGGTTAGAGCAGGACCACAGCCTGGTGAGTCCCCGGGCAGCCGTCCT GCAGCCGCCACTCCTGCGCCTGCCATTGGCCTCCTCACAGCGGAAACACAGCTTGTGAGTGCAT GTCAGCTGTTAACAAGTGGTTTTTAGTACATTCTGGGCTTTGCTGTATCTATCTAGTGCCTGTT TGTGCGTTTTTTTCTTTCTTCCGCTGCTTCCCCATTTTCCTTCTGTCCTTTTTCTCCTGCTCCT TGTTTTCCCAGCAGCACATGGGGTTCCTCGGAGGAGCAGAGGTGGCCGCCGTGGGGGGGCGTTT GGGCTGCGGTGCTGCGTCATTTTTCCTTTGCTTTCTCTTTACTTTAGACACTGGCCCAACTCCA GGCGTTTCCTTTCATTCCCTCAGTGCTTCTCTTCTGACCTGCATGTTGAGTTCTGTATTGCTGG GGCTTCCAACAAAAACCAGAGTCACTGACAGAGGGAACAGCAGAGACCTTGTTGGTATTCAGCT GTGATGGATATAGAGAATCAGAGGCACCTTGTTTTCACAACTAGGATAAAAATATCTGCAGGGT CCTTTCCATTCCTATTTAGAGGGAGTCCTGGCTCCATGACCCCCTCCCGAGTGGACTGTCCAAG CAGATAGGCTCACACGAGAAACAGTGAGGCTGAAAGGGGGGGCTATGGAAGAGCGGTAGGGAGT CCACGGAGAAGATGCAGTGAATGCTTGCATGCATTCACACGTGTGTGTGTCCCAGCTAGTTCAC TCCTTTCGCCGTGCGTGGTGGAGGCTGGCCTCTCTGGCTGGGTGCAGTGAATGGCCAGCGGGTT TCTTTTCTGCTGGGCCAAGGCGCTTTGGGGGTGGAGGGGGTGGTGCTGGTGCTGCACTGGGCTG ACTGCGGCGCTGACGCAGCGTTTCCCCCCATCCCTGTTGCCTGTGTGTTGTGTGGATCTGTTCC TAGTATAGGCAACATAATGAGATACTGTGCTTCCCACCTCCCCTTCAGTTCAGAGCCAAAATGG GTCTAGAATCTGGCACTTTACTCATTTCCTTTGATAAATTGTACTATGCAGAGCTGTCAGGAAC CTTCAGATAGCAGTAGAGGACTGCAGCTGTCTAGGTCTGCGGCCACATCTTGGGGACACACTGG ACTGTTCCCATGTGCAGGGTTCAGCAGTTATGTGGGAGTGCTAGGGGTTAGGCTTTTGAGCTTG AACGCCTGCGTGTGAACAGATGAAAAATCCTTCAGTACCCAAGTCCCAGTCTGTCCTATGGGGA GCAGTTTGGGGGCGGCCGGCAGCAGGAGCCTGGGAAAGAGGCCCTCGCCAGGTGATGGCAGGGC CAGGGTGGCCTGGGGCACCCAGCGGAATGTGCTTAGTATTTGGTCACCAGCCGTCATCCTGGGC TTTTCCTACTGTGTCTTGTTACAAGGCCTCAGCAATCCACAGAACTCTCTCTCCTTCCTTCCAC CTGTCAGCTTCTCTGCTTCTGAGATAAGAACCATTTGTGTAACACCAACACTTAACTTCAGAAA GACATGCATTATGTGGTGTAATCAAACCCGATGCTTTCAGATGACCTACTTACATCTTCAATGT GGATAAGATAAAGAACAAAACACATGCATCTAAACTGCTGGGCAATCCAGTTGACTTTTAAATG TAAGAATGGAATTCCAAACACTTAACACATTCAGCTATATGACAGAAAGTAAATCTATGGATAT GGTATTTTGTGAATGATCTTTTAAATAAAAGAAAACCTTACGTAATATTT    Download   Select all
Length	2546

CDS Information

   

Location	join(9..67,13236..13423,15298..15362,15447..15543, 15872..15931,20366..20503,20794..20933)
CDS Sequence	>lcl|NM_022170.1_cds_NP_071496.1_1 [gene=EIF4H] [protein=eukaryotic translation initiation factor 4H isoform 1] [protein_id=NP_071496.1] [location=9..755] ATGGCGGACTTCGACACCTACGACGATCGGGCCTACAGCAGCTTCGGCGGCGGCAGAGGGTCCCGCGGCA GTGCTGGTGGCCATGGTTCCCGTAGCCAGAAGGAGTTGCCCACAGAGCCCCCCTACACAGCATACGTAGG AAATCTACCTTTCAATACGGTTCAGGGCGACATAGATGCTATCTTTAAGGATCTCAGCATAAGGAGTGTA CGGCTAGTCAGAGACAAAGACACAGATAAATTTAAAGGATTCTGCTATGTAGAATTCGATGAAGTGGATT CCCTTAAGGAAGCCTTGACATACGATGGTGCACTGTTGGGCGATCGGTCACTTCGTGTGGACATTGCAGA AGGCAGAAAACAAGATAAAGGTGGCTTTGGATTCAGAAAAGGTGGACCAGATGACAGAGGAATGGGTAGC TCTCGAGAATCTAGAGGTGGATGGGATTCCCGGGATGACTTCAATTCTGGCTTCAGGGATGACTTCTTAG GGGGCAGGGGAGGTAGTCGCCCAGGCGACCGGCGAACAGGCCCCCCCATGGGCAGCCGCTTCAGAGATGG CCCTCCCCTCCGTGGATCCAACATGGATTTCAGAGAACCCACAGAAGAGGAAAGAGCACAGAGACCACGA CTCCAGCTTAAACCTCGAACAGTCGCGACGCCCCTCAATCAAGTAGCCAATCCCAACTCTGCTATCTTCG GGGGTGCCAGGCCTAGAGAGGAAGTCGTTCAAAAGGAGCAAGAATGA    Download   Select all
CCDS ID	CCDS5564.1

Protein Information

      

Protein ID	NP_071496.1
Protein Name	Eukaryotic translation initiation factor 4H
Molecular Wt. (Da)	27254
Protein Sequence	>7458 MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKD LSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGF RKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRG SNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE    Download   Select all
Length	248
Uniprot ID	O14641
Ensembl Protein ID	ENSP00000005340

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	12
Y	Phosphorylation	12
Y	Phosphorylation	101;-
Y	Phosphorylation	101;-
Y	Phosphorylation	101;-
Y	Phosphorylation	101;-
Y	Phosphorylation	45;-
Y	Phosphorylation	45;-
S	Phosphorylation	193
S	Phosphorylation	173
K	Acetylation	245
K	Acetylation	225
S	Phosphorylation	13
S	Phosphorylation	13
S	Phosphorylation	14
S	Phosphorylation	14
S	Phosphorylation	21
S	Phosphorylation	21
S	Phosphorylation	24
S	Phosphorylation	24
S	Phosphorylation	110
S	Phosphorylation	110

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

               

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
83638	C11orf68	12553	NP_001129107.1	yeast 2-hybrid	16189514

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd12401	41-116	RRM_eIF4H
cl17169	41-116	RRM_SF superfamily
cd12402	41-116	RRM_eIF4B
cd12272	43-114	RRM2_PHIP1
cd12395	43-113	RRM2_RBM34
cd12399	43-117	RRM_HP0827_like
cd12450	43-119	RRM1_NUCLs
cd12400	42-114	RRM_Nop6
cd12306	45-113	RRM_II_PABPs
pfam00076	45-112	RRM_1
cd00590	45-114	RRM_SF
cd12391	43-114	RRM1_SART3
cd12411	45-114	RRM_ist3_like
cd12448	45-114	RRM2_gar2
cd12398	45-116	RRM_CSTF2_RNA15_like
cd12413	43-119	RRM1_RBM28_like
cd12284	45-113	RRM2_RBM23_RBM39
cd12271	44-113	RRM1_PHIP1
cd12392	41-117	RRM2_SART3
cd12236	43-119	RRM_snRNP70
cd12415	43-116	RRM3_RBM28_like
cd12283	43-113	RRM1_RBM39_like
cd12371	45-116	RRM2_PUF60
cd12313	48-114	RRM1_RRM2_RBM5_like
cd12298	45-113	RRM3_Prp24
cd12240	45-114	RRM_NCBP2
cd12254	45-113	RRM_hnRNPH_ESRPs_RBM12_like
cd12397	45-117	RRM2_Nop13p_fungi
cd12674	43-119	RRM1_Nop4p
cd12550	45-113	RRM_II_PABPN1
cd12225	43-113	RRM1_2_CID8_like
cd12671	45-116	RRM_CSTF2_CSTF2T
cd12260	43-113	RRM2_SREK1
cd12393	43-116	RRM_ZCRB1
cd12449	45-116	RRM_CIRBP_RBM3
cd12670	45-113	RRM2_Nop12p_like
cd12366	66-116	RRM1_RBM45
cd12382	45-116	RRM_RBMX_like
cd12347	45-113	RRM_PPIE
cd12451	67-114	RRM2_NUCLs
cd12370	45-113	RRM1_PUF60
cd12329	45-99	RRM2_hnRNPD_like
cd12394	43-114	RRM1_RBM34
cd12447	43-116	RRM1_gar2
cd12551	43-113	RRM_II_PABPN1L
cd12297	43-115	RRM2_Prp24
cd12291	43-106	RRM1_La
cd12318	43-111	RRM5_RBM19_like
cd12237	39-120	RRM_snRNP35
cd12375	46-116	RRM1_Hu_like
cd12242	43-113	RRM_SLIRP
cd12404	43-114	RRM2_NCL
cd12613	42-116	RRM2_NGR1_NAM8_like
cd12307	45-113	RRM_NIFK_like
cd12378	45-100	RRM1_I_PABPs
cd12650	46-116	RRM1_Hu
cd12676	42-99	RRM3_Nop4p
cd12235	53-114	RRM_PPIL4
cd12345	42-116	RRM2_SECp43_like
cd12566	45-113	RRM2_MRD1
cd12290	43-100	RRM1_LARP7
cd12514	44-113	RRM4_RBM12_like
cd12344	56-99	RRM1_SECp43_like
cd12320	46-99	RRM6_RBM19_RRM5_MRD1
cd12409	45-113	RRM1_RRT5
cd12552	43-117	RRM_Nop15p
cd12365	45-113	RRM_RNPS1
cd12316	44-113	RRM3_RBM19_RRM2_MRD1
pfam13893	67-116	RRM_5
cd12389	45-117	RRM2_RAVER
cd12534	45-116	RRM_SARFH
cd12353	45-112	RRM2_TIA1_like
cd12372	45-99	RRM_CFIm68_CFIm59
cd12323	45-98	RRM2_MSI
pfam06273	134-243	eIF-4B
cl05660	134-243	eIF-4B superfamily
cd12396	45-99	RRM1_Nop13p_fungi
cd12354	43-90	RRM3_TIA1_like
cd12296	46-115	RRM1_Prp24
cd12502	49-113	RRM2_RMB19
cd12770	46-116	RRM1_HuD
cd12363	46-118	RRM_TRA2
cd12328	45-99	RRM2_hnRNPA_like
cd12384	45-99	RRM_RBM24_RBM38_like
cd12408	46-117	RRM_eIF3G_like
cd12617	42-116	RRM2_TIAR
cd12656	66-113	RRM3_HuD
cd12772	46-116	RRM1_HuC
cd12561	40-101	RRM1_RBM5_like
cd12654	66-113	RRM3_HuB
cd12771	46-116	RRM1_HuB
cd12376	45-100	RRM2_Hu_like
cd12651	45-100	RRM2_SXL
cd12231	45-113	RRM2_U2AF65
cd12583	45-99	RRM2_hnRNPD
cd12511	45-113	RRM2_RBM12_like
cd12367	57-119	RRM2_RBM45
cd12412	41-113	RRM_DAZL_BOULE
cd12241	45-98	RRM_SF3B14
smart00360	43-113	RRM
COG0724	37-121	RRM
pfam14259	45-112	RRM_6
TIGR01622	40-227	SF-CC1
TIGR01661	46-116	ELAV_HUD_SF
TIGR01622	43-120	SF-CC1
TIGR01628	45-113	PABP-1234
TIGR01645	45-113	half-pint
TIGR01642	45-122	U2AF_lg
PRK14286	153-185	PRK14286

Ontology Information

   

HPRD ID	2693
Molecular Class	Translation regulatory protein
Molecular Function	Transcription factor activity (GO:0003700)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report   

Drug Information

No matching records could be found.

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO