Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WNT2 | 7472 | wingless-type MMTV integration site family member 2 | 7 | IRP |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 10507776 | 1999 | Cell line : - Source : John Radcliffe Hospital, Oxford. Sample Type : CRC Tumor and normal tissue No. of Sample : 14 Stage : - | In situ hybridization,Immunostaining | Up-regulation | - | Wnt 2 and wnt 5a were significantly up-regulated in the progression from normal through adenoma to carcinoma. |
| 12147710 | 2002 | Cell line : HT29,Colo205 Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 20 Stage : - | In situ RNA hybridisation,immunoperoxidase based antibody staining. | Up-regulation | - | Wnt2, and possibly Wnt5a, may be involved in the progression from normal mucosa to�cancer�and the expression of Fz1/2 receptors may be involved in processes associated with tumour invasion |
| 18600204 | 2008 | Cell line : - Source : BD BioSciences (Clontech Laboratories, USA) Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | real time RT-PCR, Sequence Analysis | Up-regulation | - | The wingless-type MMTV integration site family member 2 (WNT2) is potentially important in the Wnt/beta-catenin pathway and upregulation of WNT2 is not uncommon in human cancers. |
| 19239325 | 2009 | Cell line : - Source : College of Medicine The Catholic University of Korea. Sample Type : CRC tumor and normal tissue No. of Sample : 120 Stage : Duke stage A, B, C, D | - | Up-regulation | - | �Up-regulation of the Wnt-2 protein might play a role in the development of�colorectal�cancers, as an early event of carcinogenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Wingless-type MMTV integration sites, "Endogenous ligands" |
| Description | This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 7 |
| Location | 7q31 |
| Start | 116916685 |
| End | 116963343 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 46659 |
| OMIM ID | 147870 |
| HGNC ID | HGNC:12780 |
| Unigene ID | Hs.567356 |
| Ensembl ID | ENSG00000105989 |
| PharmGKB ID | PA37381 |
mRNA Information
| mRNA ID | ?NM_003391.2 |
|---|---|
| Exon | join(1..383,2497..2723,7942..8219,25414..25678, 44906..46659) | mRNA Sequence | Download Select all |
| Length | 2907 |
Protein Information
| Protein ID | NP_003382.1 |
|---|---|
| Protein Name | wingless-type MMTV integration site family member 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 360 |
| Uniprot ID | Q9NQX3 |
| Ensembl Protein ID | ENSP00000312771 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 8321 | FZD1 | 4558 | NP_003496.1 | in vitro;in vivo | 10557084 |
| 8326 | FZD9 | 3460 | NP_003499.1 | in vivo | 12138115 |
| 89780 | WNT3A | 5897 | NP_149122.1 | in vitro | 10557084 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hedgehog signaling pathway | hsa04340 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00110 | 40-349 | wnt |
| cl19568 | 40-349 | wnt superfamily |
| smart00097 | 43-349 | WNT1 |
Ontology Information
| HPRD ID | 6232 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Ligase activity (GO:0016874) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.