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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WNT3 | 7473 | wingless-type MMTV integration site family, member 3 | 17 | MGC131950, MGC138321, MGC138323 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11604997 | 2001 | Cell line : A549, MKN45 Source : - Sample Type : - No. of Sample : - Stage : - | Northern blotting | Up-regulation | - | WNT3 was significantly up-regulated in a case of primary breast cancer and in a case of primary rectal cancer among various types of human primary cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Wingless-type MMTV integration sites, "Endogenous ligands" |
| Description | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17q21-q22 |
| Start | 44839872 |
| End | 44896126 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 56255 |
| OMIM ID | 165330 |
| HGNC ID | HGNC:12782 |
| Unigene ID | Hs.445884 |
| Ensembl ID | - |
| PharmGKB ID | PA37383 |
mRNA Information
| mRNA ID | ?NM_030753.4 |
|---|---|
| Exon | join(1..243,44852..45093,48713..48978,49962..50449, 54140..56255) | mRNA Sequence | Download Select all |
| Length | 3385 |
Protein Information
| Protein ID | NP_110380.1 |
|---|---|
| Protein Name | wingless-type MMTV integration site family, member 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 355 |
| Uniprot ID | O43597 |
| Ensembl Protein ID | ENSP00000366306 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 301 |
| N | Glycosylation | 90 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hedgehog signaling pathway | hsa04340 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| MicroRNAs in cancer | hsa05206 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00097 | 47-355 | WNT1 |
| cl19568 | 47-355 | wnt superfamily |
| pfam00110 | 44-355 | wnt |
Ontology Information
| HPRD ID | 9802 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.