Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WNT5A | 7474 | wingless-type MMTV integration site family, member 5A | 3 | hWNT5A |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18172252 | 2008 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 29 CRC and 15 normal tissue Stage : - | real time RT-PCR,Methylation-specific PCR and bisulfite genomic sequencing,Western blotting | Methylation | - | WNT5A is frequently inactivated in CRC by tumor-specific methylation, and thus, is a potential biomarker. WNT5A could act as a tumor suppressor for CRC by antagonizing the Wnt/beta-catenin signaling. WNT5A methylation was frequently detected in CRC tumors (14 of 29, 48%), but only occasionally in paired normal colon tissues (2 of 15, 13%; P = 0.025). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Wingless-type MMTV integration sites, "Endogenous ligands" |
| Description | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. |
| Chromosome | 3 |
| Location | 3p21-p14 |
| Start | 55465715 |
| End | 55505261 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 39547 |
| OMIM ID | 164975 |
| HGNC ID | HGNC:12784 |
| Unigene ID | Hs.643085 |
| Ensembl ID | ENSG00000114251 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011534082.1 |
|---|---|
| Exon | join(1..64,3480..3663,7785..7873,11207..11432, 11515..15232,24344..24477,25698..25948,30633..30925, 34712..39547) | mRNA Sequence | Download Select all |
| Length | 5599 |
CDS Information
| Location | join(18277..18282,24344..24477,25698..25948,30633..30925, 34712..35170) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS46850.1 |
Protein Information
| Protein ID | NP_001243034.1 |
|---|---|
| Protein Name | wingless-type MMTV integration site family, member 5A |
| Molecular Wt. (Da) | 37992 |
| Protein Sequence | Download Select all |
| Length | 365 |
| Uniprot ID | P05112 |
| Ensembl Protein ID | ENSP00000231449 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hedgehog signaling pathway | hsa04340 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00097 | 71-380 | WNT1 |
| cl19568 | 71-380 | wnt superfamily |
| pfam00110 | 68-380 | wnt |
Ontology Information
| HPRD ID | 970 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.