Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WNT6 | 7475 | wingless-type MMTV integration site family, member 6 | 2 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11350055 | 2001 | Cell line : SW480 Source : - Sample Type : - No. of Sample : - Stage : - | Northern blotting, real time RT-PCR | Up-regulation | - | WNT10A and WNT6 were strongly coexpressed in SW480 (colorectal cancer). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Wingless-type MMTV integration sites |
| Description | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008] |
| Chromosome | 2 |
| Location | 2q35 |
| Start | 219724546 |
| End | 219738954 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 14409 |
| OMIM ID | 604663 |
| HGNC ID | HGNC:12785 |
| Unigene ID | Hs.29764 |
| Ensembl ID | ENSG00000115596 |
| PharmGKB ID | PA37386 |
mRNA Information
| mRNA ID | ?NM_006522.3 |
|---|---|
| Exon | join(1..295,11205..11425,11663..11997,13562..14410) | mRNA Sequence | Download Select all |
| Length | 1700 |
Protein Information
| Protein ID | NP_006513.1 |
|---|---|
| Protein Name | wingless-type MMTV integration site family, member 6 |
| Molecular Wt. (Da) | 31710 |
| Protein Sequence | Download Select all |
| Length | 365 |
| Uniprot ID | O15439 |
| Ensembl Protein ID | ENSP00000366084 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hedgehog signaling pathway | hsa04340 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00097 | 43-365 | WNT1 |
| cl19568 | 43-365 | wnt superfamily |
| pfam00110 | 40-365 | wnt |
Ontology Information
| HPRD ID | 5675 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Cytoskeletal protein binding (GO:0008092) |
| Biological Process | Cell growth and/or maintenance (GO:0008151); Cell motility (GO:0006928) |
Drug Information
No matching records could be found.