Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WNT2B | 7482 | wingless-type MMTV integration site family, member 2B | 1 | XWNT2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11605001 | 2001 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 18 Stage : - | real time RT-PCR | Up-regulation | - | Frequent up-regulation of WNT2 in primary gastric cancer and colorectal cancer might play a key role in carcinogenesis through activation of the WNT - beta-catenin - TCF signaling pathway. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Wingless-type MMTV integration sites |
| Description | This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| Chromosome | 1 |
| Location | 1p13 |
| Start | 113010040 |
| End | 113063910 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 53871 |
| OMIM ID | 601968 |
| HGNC ID | HGNC:12781 |
| Unigene ID | Hs.258575 |
| Ensembl ID | ENSG00000134245 |
| PharmGKB ID | PA37382 |
mRNA Information
| mRNA ID | ?NM_001291880.1 |
|---|---|
| Exon | join(1..1051,24471..24541,48334..48554,49600..49877, 50581..50845,53740..54748) | mRNA Sequence | Download Select all |
| Length | 2925 |
Protein Information
| Protein ID | NP_001278809.1 |
|---|---|
| Protein Name | wingless-type MMTV integration site family, member 2B |
| Molecular Wt. (Da) | 36441 |
| Protein Sequence | Download Select all |
| Length | 391 |
| Uniprot ID | Q9NP66 |
| Ensembl Protein ID | ENSP00000336856 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 283 |
| N | Glycosylation | 264 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hedgehog signaling pathway | hsa04340 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00110 | 71-380 | wnt |
| cl19568 | 71-380 | wnt superfamily |
| smart00097 | 74-380 | WNT1 |
Ontology Information
| HPRD ID | 5035 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | GTPase activator activity (GO:0005096) |
| Biological Process | Regulation of cell proliferation (GO:0042127); Apoptosis (GO:0006915); Regulation of cell growth (GO:0001558) |
Drug Information
No matching records could be found.