Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| XPA | 7507 | xeroderma pigmentosum, complementation group A | 9 | XPAC, XP1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18204222 | 2007 | Cell line : - Source : - Sample Type : Peripheral blood cells No. of Sample : 42 Stage : TNM Stage III,IV | Allelic discrimination assay | Polymorhpism | - | Polymorphism in XPG combined with XPA may be an important prognosticator of clinical outcome following oxaliplatin/ fluoropyrimidine chemotherapy |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] |
| Chromosome | 9 |
| Location | 9q22.3 |
| Start | 100437191 |
| End | 100459691 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 22501 |
| OMIM ID | 611153 |
| HGNC ID | HGNC:12814 |
| Unigene ID | Hs.654364 |
| Ensembl ID | ENSG00000136936 |
| PharmGKB ID | PA368 |
mRNA Information
| mRNA ID | ?NM_000380.3 |
|---|---|
| Exon | complement(join(<23662..26324,27704..27817,28436..28564, 30533..30647,32967..33070,34363..34456,35266..35368, 36342..36464,38667..38770,41325..41399,41646..41708, 42466..42530)) | mRNA Sequence | Download Select all |
| Length | 5381 |
Protein Information
| Protein ID | NP_000371.1 |
|---|---|
| Protein Name | xeroderma pigmentosum, complementation group A |
| Molecular Wt. (Da) | 105822 |
| Protein Sequence | Download Select all |
| Length | 273 |
| Uniprot ID | Q96QB1 |
| Ensembl Protein ID | ENSP00000276297 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 173 |
| S | Phosphorylation | 196 |
| S | Phosphorylation | 173 |
| S | Phosphorylation | 196 |
| S | Phosphorylation | 173 |
| S | Phosphorylation | 196 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2067 | ERCC1 | 533 | NP_973730.1 | in vitro;in vivo;yeast 2-hybrid | 759 872 881 971 749 000 000 |
| 2074 | ERCC6 | 596 | NP_000115.1 | in vitro | 8999876 |
| 2961 | GTF2E2 | 1800 | NP_002086.1 | in vitro | 7876263 |
| 2965 | GTF2H1 | 1807 | NP_005307.1 | in vitro | 9698541 |
| 6117 | RPA1 | 1565 | NP_002936.1 | in vitro;in vivo | 7565690 |
| 6118 | RPA2 | 1566 | NP_002937.1 | in vitro | 11081631 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Nucleotide excision repair | hsa03420 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam05181 | 134-186 | XPA_C |
| cl04970 | 134-186 | XPA_C superfamily |
| pfam01286 | 100-133 | XPA_N |
| cl03148 | 100-133 | XPA_N superfamily |
| TIGR00598 | 105-273 | rad14 |
| COG5145 | 105-273 | RAD14 |
Ontology Information
| HPRD ID | 9068 |
|---|---|
| Molecular Class | DNA repair protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.