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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
XPC 7508 xeroderma pigmentosum, complementation group C  3XPCC, RAD4 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22213216   2012Cell line : -

Source : -

Sample Type : Population-based case-control study

No. of Sample : 1,028 CRC cases and 1,085 controls.

Stage : -

SNP selection, Genotyping, SequencingPolymorhpism-XPC Lys939Gln and XPG Asp1104His polymorphisms might contribute to the identification of patients with increased risk for CRC.

24947936   2014Cell line : -

Source : Databases PubMed, EMBASE, and Cochrane library

Sample Type : -

No. of Sample : -

Stage : -

 Meta-analysisPolymorhpism- XPC is a candidate gene for CRC susceptibility. The XPC Lys939Gln polymorphism may play an important role in CRC development among Asians and nonsmokers.

25391773   2015Cell line : -

Source : Poland Population

Sample Type : Population-based case-control study

No. of Sample : 758 cases

Stage : -

SNP selection, Genotyping, SequencingPolymorhpism- Polymorphisms in XPC and XPD may be associated with the risk of colorectal cancer.


Gene Details



NC_000003.11 (14186647..14220172, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]  
Chromosome 3
Location 3p25.1
Start 14186647  
End 14220172  
Strand -  
Gene Sequence

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Length 33526  
OMIM ID 613208   
HGNC ID HGNC:12816   
Unigene ID Hs.475538   
Ensembl ID ENSG00000154767   
PharmGKB ID PA37413   

mRNA Information


mRNA ID ?NM_004628.4
Exon join(1..207,5611..5806,8123..8235,10293..10416, 11420..11504,13088..13245,13740..13860,18843..18932, 19781..20662,22178..22338,26257..26338,29725..29859, 29942..30111,30672..30765,31294..31383,32514..33526)  
mRNA Sequence

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Length 3729  



CDS Information


   
Location 105..2927
CDS Sequence

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CCDS ID CCDS46763.1



Protein Information


      
Protein IDNP_004619.3
Protein Namexeroderma pigmentosum, complementation group C
Molecular Wt. (Da)69367
Protein Sequence

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Length 940  
Uniprot IDQ92597
Ensembl Protein ID ENSP00000319977  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation883
SPhosphorylation884
SPhosphorylation892;-
SPhosphorylation347;-
SPhosphorylation351;-
SPhosphorylation94;-
TPhosphorylation358;-
SPhosphorylation122;-
TPhosphorylation117;-
SPhosphorylation129;-
TPhosphorylation169
SPhosphorylation891
SPhosphorylation397
SPhosphorylation398
SPhosphorylation399
TPhosphorylation876
SPhosphorylation104
SPhosphorylation140
SPhosphorylation711

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2071ERCC3593NP_000113.1in vitro;in vivo10734143   
2965GTF2H11807NP_005307.1in vivo11259578   
4086SMAD13356NP_005891.1yeast 2-hybrid15231748   


Pathway Information


      
Pathway Name Pathway ID
Nucleotide excision repair hsa03420


Structure Information


No matching records could be found.

Domain Information




ID Location Description
smart01032751-825  BHD_3
cl11064751-825  BHD_3 superfamily
pfam10405751-825  BHD_3
pfam03835515-626  Rad4
cl10615515-626  Rad4 superfamily
pfam10404684-744  BHD_2
cl11063684-744  BHD_2 superfamily
smart01031684-743  BHD_2
smart01030630-681  BHD_1
cl11062630-681  BHD_1 superfamily
pfam10403629-682  BHD_1
PRK14136355-499  recX
cl00936355-499  RecX superfamily
TIGR00605147-867  rad4
COG5535515-868  RAD4
PHA03307321-516  PHA03307
pfam04094333-500  DUF390
pfam10243346-524  MIP-T3
pfam11725333-500  AvrE
pfam05110376-474  AF-4
pfam09073351-486  BUD22


Ontology Information


   
HPRD ID6195
Molecular ClassDNA binding protein
Molecular FunctionSialyltransferase activity (GO:0008373)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO