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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
XRCC1 7515 X-ray repair complementing defective repair in Chinese hamster cells 1  19- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25921133   2015Cell line : -

Source : PubMed and Google Scholar were search.

Sample Type : Literture survey

No. of Sample : -

Stage : -

Meta analysis,Odds ratios,Egger's and Begg's tests.Polymorhpism-This meta-analysis confirms the association between XRCC1 Arg399Gln polymorphism and CRC risk .


Gene Details



NC_000019.9 (44047464..44079730, complement)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]  
Chromosome 19
Location 19q13.2
Start 44047464  
End 44079730  
Strand -  
Gene Sequence

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Length 32267  
OMIM ID 194360   
HGNC ID HGNC:12828   
Unigene ID Hs.98493   
Ensembl ID -   
PharmGKB ID PA369   

mRNA Information


mRNA ID ?NM_006297.2
Exon join(1..171,577..669,14559..14669,20775..20933, 21896..21970,22067..22178,22488..22597,22671..22782, 23304..23562,23892..24008,28602..28695,28852..28984, 29473..29527,29622..29761,31345..31435,31892..31967, 32074..32267)  
mRNA Sequence

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Length 2102  



CDS Information


   
Location 121..2022
CDS Sequence

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CCDS ID CCDS12624.1



Protein Information


      
Protein IDNP_006288.2
Protein NameX-ray repair complementing defective repair in Chinese hamster cells 1
Molecular Wt. (Da)31825
Protein Sequence

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Length 633  
Uniprot IDP63244
Ensembl Protein ID ENSP00000426909  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation461
SPhosphorylation475
SPhosphorylation485
TPhosphorylation519
SPhosphorylation518
TPhosphorylation519
TPhosphorylation523
SPhosphorylation446;-
SPhosphorylation447;-
SPhosphorylation266;-
SPhosphorylation268;-
SPhosphorylation416;-
SPhosphorylation418;-
SPhosphorylation421;-
SPhosphorylation408;-
SPhosphorylation409;-
SPhosphorylation410;-
TPhosphorylation198
SPhosphorylation226
SPhosphorylation199
TPhosphorylation202
SPhosphorylation224
SPhosphorylation229
SPhosphorylation241
TPhosphorylation257
SPhosphorylation259
TPhosphorylation279
TPhosphorylation453
SPhosphorylation236
TPhosphorylation440
TPhosphorylation457
TPhosphorylation488
YPhosphorylation515
SPhosphorylation140
SPhosphorylation204
YPhosphorylation211

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
142PARP11435NP_001609.2in vivo;yeast 2-hybrid95   841   961   450   081   400   000   000   
328APEX1136NP_542380.1in vivo;yeast 2-hybrid11707423   
672BRCA1218NP_009231.2in vitro11352725   
5111PCNA1456NP_002583.1in vitro;in vivo;yeast 2-hybrid15107487   
54840APTX5892NP_778243.1in vitro;in vivo;yeast 2-hybrid155   555   651   671   356   000   000   000   


Pathway Information


      
Pathway Name Pathway ID
Base excision repair hsa03410


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00027322-389  BRCT
cl00038322-389  BRCT superfamily
cd00027545-615  BRCT
cl00038545-615  BRCT superfamily
pfam018341-151  XRCC1_N
cl033751-151  XRCC1_N superfamily
pfam00533318-389  BRCT
pfam12738323-385  PTCB-BRCT
smart00292318-389  BRCT
smart00292540-615  BRCT
pfam00533540-615  BRCT
PRK13700412-512  PRK13700
COG5163423-629  NOP7
pfam05505406-586  Ebola_NP
PHA0330794-321  PHA03307
PHA03169405-538  PHA03169
PRK00708254-312  PRK00708
PHA03301244-311  PHA03301
PTZ00449232-311  PTZ00449
PRK01297261-311  PRK01297
TIGR02907467-532  spore_VI_D
TIGR00927418-576  2A1904


Ontology Information


   
HPRD ID5719
Molecular ClassDNA repair protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessImmune response (GO:0006955)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO