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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| XRCC3 | 7517 | X-ray repair complementing defective repair in Chinese hamster cells 3  | 14 |   |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16271954    | 2005 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 140 survival cases CRC and 280 controls. Stage : - | Genotyping | Polymorhpism | - | XRCC3 T241M polymorphism and FH of cancer may be risk factors for CRC, and the XRCC3 241Met allele may be an effective biomarker for genetic susceptibility to CRC. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.   |
| Chromosome | 14 |
| Location | 14q32.3 |
| Start | 103697608   |
| End | 103715486   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 17879   |
| OMIM ID | 600675    |
| HGNC ID | HGNC:12830    |
| Unigene ID | Hs.592325    |
| Ensembl ID | ENSG00000126215    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_001130107.1 |
|---|---|
| Exon | complement(join(<13936..14286,14760..14832))   | mRNA Sequence |    Download   Select all |
| Length | 2563   |
CDS Information
| Location | complement(join(<14284..14286,14760..14832)) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS45168.1 |    
Protein Information
| Protein ID | NP_001093588.1 |
|---|---|
| Protein Name | X-ray repair complementing defective repair in Chinese hamster cells 3 |
| Molecular Wt. (Da) | 37719 |
| Protein Sequence |    Download   Select all |
| Length | 346   |
| Uniprot ID | P24394 |    
| Ensembl Protein ID | ENSP00000170630   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 225;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2189 |    FANCG |    4262 |    NP_004620.1 |    in vivo;yeast 2-hybrid |    16621732    |
| 5889 |    RAD51C |    4143 |    NP_478123.1 |    in vitro;in vivo;yeast 2-hybrid |    11   331   762   117   446   900   000   000   000   000   000    |
| 5892 |    RAD51L3 |    4261 |    NP_001136043.1 |    in vitro;in vivo |    11744692    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Homologous recombination |    hsa03440 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01123 | 82-338  | Rad51_DMC1_radA |
| cl21455 | 82-338  | P-loop_NTPase superfamily |
| cd01393 | 82-330  | recA_like |
| PRK09361 | 81-259  | radB |
| pfam13481 | 87-217  | AAA_25 |
| cd01394 | 82-338  | radB |
| TIGR03880 | 85-245  | KaiC_arch_3 |
| cd00983 | 73-263  | recA |
| TIGR03881 | 81-217  | KaiC_arch_4 |
| cd01121 | 76-272  | Sms |
| pfam06745 | 85-217  | KaiC |
| cd01125 | 105-217  | repA |
| TIGR02238 | 2-337  | recomb_DMC1 |
| TIGR02236 | 81-338  | recomb_radA |
| PRK04301 | 64-338  | radA |
| COG0468 | 59-338  | RecA |
| PLN03186 | 13-338  | PLN03186 |
| PTZ00035 | 8-337  | PTZ00035 |
| PLN03187 | 13-337  | PLN03187 |
| pfam08423 | 64-337  | Rad51 |
| TIGR02239 | 8-337  | recomb_RAD51 |
| TIGR02237 | 89-259  | recomb_radB |
| TIGR02012 | 69-261  | tigrfam_recA |
| COG1066 | 23-215  | Sms |
| COG0467 | 80-143  | RAD55 |
Ontology Information
| HPRD ID | 909 |    
|---|---|
| Molecular Class | DNA repair protein |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Immune response (GO:0006955)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
