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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
XRCC3 7517 X-ray repair complementing defective repair in Chinese hamster cells 3  14 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
16271954   2005Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 140 survival cases CRC and 280 controls.

Stage : -

GenotypingPolymorhpism-XRCC3 T241M polymorphism and FH of cancer may be risk factors for CRC, and the XRCC3 241Met allele may be an effective biomarker for genetic susceptibility to CRC.


Gene Details



Chromosome 14 - NC_000014.9(103697608..103715486, complement)

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Gene Type protein coding
Gene Family
Description This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.  
Chromosome 14
Location 14q32.3
Start 103697608  
End 103715486  
Strand -  
Gene Sequence

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Length 17879  
OMIM ID 600675   
HGNC ID HGNC:12830   
Unigene ID Hs.592325   
Ensembl ID ENSG00000126215   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001130107.1
Exon complement(join(<13936..14286,14760..14832))  
mRNA Sequence

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Length 2563  



CDS Information


   
Locationcomplement(join(<14284..14286,14760..14832))
CDS Sequence

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CCDS ID CCDS45168.1



Protein Information


      
Protein IDNP_001093588.1
Protein NameX-ray repair complementing defective repair in Chinese hamster cells 3
Molecular Wt. (Da)37719
Protein Sequence

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Length 346  
Uniprot IDP24394
Ensembl Protein ID ENSP00000170630  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation225;-

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2189FANCG4262NP_004620.1in vivo;yeast 2-hybrid16621732   
5889RAD51C4143NP_478123.1in vitro;in vivo;yeast 2-hybrid11   331   762   117   446   900   000   000   000   000   000   
5892RAD51L34261NP_001136043.1in vitro;in vivo11744692   


Pathway Information


      
Pathway Name Pathway ID
Homologous recombination hsa03440


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0112382-338  Rad51_DMC1_radA
cl2145582-338  P-loop_NTPase superfamily
cd0139382-330  recA_like
PRK0936181-259  radB
pfam1348187-217  AAA_25
cd0139482-338  radB
TIGR0388085-245  KaiC_arch_3
cd0098373-263  recA
TIGR0388181-217  KaiC_arch_4
cd0112176-272  Sms
pfam0674585-217  KaiC
cd01125105-217  repA
TIGR022382-337  recomb_DMC1
TIGR0223681-338  recomb_radA
PRK0430164-338  radA
COG046859-338  RecA
PLN0318613-338  PLN03186
PTZ000358-337  PTZ00035
PLN0318713-337  PLN03187
pfam0842364-337  Rad51
TIGR022398-337  recomb_RAD51
TIGR0223789-259  recomb_radB
TIGR0201269-261  tigrfam_recA
COG106623-215  Sms
COG046780-143  RAD55


Ontology Information


   
HPRD ID909
Molecular ClassDNA repair protein
Molecular FunctionCytokine activity (GO:0005125)
Biological ProcessImmune response (GO:0006955)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO