Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| XRCC4 | 7518 | X-ray repair complementing defective repair in Chinese hamster cells 4 | 5 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25662981 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 200 CRC, 256 healthy individual Stage : - | Genotyping | Polymorhpism | - | G-1394T and I/D polymorphisms of XRCC4 among individuals with positive family history for colorectal cancer substantially increase the risk factor for developing colorectal cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants. [provided by RefSeq, Dec 2015] |
| Chromosome | 5 |
| Location | 5q14.2 |
| Start | 82373317 |
| End | 82649579 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 276263 |
| OMIM ID | 194363 |
| HGNC ID | HGNC:12831 |
| Unigene ID | Hs.567359 |
| Ensembl ID | ENSG00000152422 |
| PharmGKB ID | PA37423 |
mRNA Information
| mRNA ID | ?NM_003401.3 |
|---|---|
| Exon | complement(<1..45) | mRNA Sequence | Download Select all |
| Length | 4608 |
Protein Information
| Protein ID | NP_003392.1 |
|---|---|
| Protein Name | X-ray repair complementing defective repair in Chinese hamster cells 4 |
| Molecular Wt. (Da) | 44582 |
| Protein Sequence | Download Select all |
| Length | 336 |
| Uniprot ID | Q9Y274 |
| Ensembl Protein ID | ENSP00000265261 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 320;- |
| S | Phosphorylation | 328;- |
| S | Phosphorylation | 315;- |
| S | Phosphorylation | 313;- |
| S | Phosphorylation | 326;- |
| S | Phosphorylation | 318;- |
| S | Phosphorylation | 313;- |
| S | Phosphorylation | 326;- |
| S | Phosphorylation | 318;- |
| T | Phosphorylation | 323 |
| T | Phosphorylation | 321 |
| T | Phosphorylation | 321 |
| S | Phosphorylation | 327 |
| S | Phosphorylation | 325 |
| S | Phosphorylation | 325 |
| S | Phosphorylation | 256 |
| S | Phosphorylation | 256 |
| S | Phosphorylation | 256 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3981 | LIG4 | 3500 | NP_002303.2 | in vitro;in vivo | 1 170 206 910 854 420 |
| 5591 | PRKDC | 2941 | NP_008835.5 | in vitro | 9430729 |
| 79026 | AHNAK | 14684 | NP_001611.1 | in vitro;in vivo | 15177040 |
| 79840 | NHEJ1 | 7784 | NP_079058.1 | in vivo;yeast 2-hybrid | 17567543 |
| 79886 | C9orf82 | 12981 | NP_079104.3 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Non-homologous end-joining | hsa03450 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam06632 | 1-334 | XRCC4 |
| cl05919 | 1-334 | XRCC4 superfamily |
| pfam12302 | 186-317 | DUF3629 |
| cl13703 | 186-317 | DUF3629 superfamily |
Ontology Information
| HPRD ID | 5706 |
|---|---|
| Molecular Class | DNA repair protein |
| Molecular Function | Guanyl-nucleotide exchange factor activity (GO:0005085) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.