Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| YY1 | 7528 | YY1 transcription factor | 14 | NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19360355 | 2009 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : - Stage : - | FISH | Up-regulation | - | YY1 was over-expressed in colon cancer in the absence of gene amplification and chromosomal translocation. |
| 26185457 | 2015 | Cell line : - Source : Renji Hospital (Shanghai, People�s Republic of China) f Sample Type : CRC tumor No. of Sample : 2 Stage : - | Enrichment of methylated DNA fragments and promoter microarray hybridization,Functional annotation and pathway enrichment analysis | Up-regulation | - | MAPK14, MAPK3, HRAS, YY1, and IRF4 may be considered as potential biomarkers for early diagnosis and therapy of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | INO80 complex subunits, "Zinc fingers, C2H2-type" |
| Description | YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008] |
| Chromosome | 14 |
| Location | 14q |
| Start | 100705102 |
| End | 100745371 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 40270 |
| OMIM ID | 600013 |
| HGNC ID | HGNC:12856 |
| Unigene ID | Hs.388927 |
| Ensembl ID | ENSG00000100811 |
| PharmGKB ID | PA37445 |
mRNA Information
| mRNA ID | ?NM_003403.4 |
|---|---|
| Exon | join(1..1159,23540..23702,35934..35994,37726..37884, 38654..40270) | mRNA Sequence | Download Select all |
| Length | 3159 |
Protein Information
| Protein ID | NP_003394.1 |
|---|---|
| Protein Name | YY1 transcription factor |
| Molecular Wt. (Da) | 69742 |
| Protein Sequence | Download Select all |
| Length | 414 |
| Uniprot ID | Q01628 |
| Ensembl Protein ID | ENSP00000382707 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 247 |
| S | Phosphorylation | 118 |
| Y | Phosphorylation | 251 |
| T | Phosphorylation | 348 |
| T | Phosphorylation | 378 |
| S | Phosphorylation | 184 |
| S | Phosphorylation | 365 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2280 | FKBP1A | 1741 | NP_000792.1 | yeast 2-hybrid | 7541038 |
| 2287 | FKBP3 | 1743 | NP_002004.1 | in vitro;in vivo | 11532945 |
| 4609 | MYC | 1818 | NP_002458.2 | in vitro;yeast 2-hybrid | 8266081 |
| 4851 | NOTCH1 | 1827 | NP_060087.3 | in vitro;in vivo | 12913000 |
| 6667 | SP1 | 1796 | NP_612482.2 | in vitro;in vivo | 9278494 |
| 6720 | SREBF1 | 1701 | NP_001005291.1 | in vitro | 10224053 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 340-365 | zf-H2C2_2 |
| cl22375 | 340-365 | zf-H2C2_2 superfamily |
| pfam13465 | 369-396 | zf-H2C2_2 |
| cl22375 | 369-396 | zf-H2C2_2 superfamily |
| pfam00096 | 325-347 | zf-C2H2 |
| cl23491 | 325-347 | zf-C2H2 superfamily |
| COG5048 | 268-407 | COG5048 |
| COG5048 | 325-403 | COG5048 |
| COG5048 | 322-414 | COG5048 |
| COG5048 | 310-414 | COG5048 |
| COG5189 | 345-407 | SFP1 |
| PLN03086 | 296-361 | PLN03086 |
Ontology Information
| HPRD ID | 12075 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell migration (GO:0016477); Anti-apoptosis (GO:0006916) |
Drug Information
No matching records could be found.