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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| YWHAE | 7531 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 17 | FLJ45465 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22105787 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : 137 CRC cases Stage : - | Western blotting, Immunohistochemistry | Down-regulation | - | Nuclear 14-3-3 as a suppressor may serve as important biomarker of tumor metastasis. Nuclear expression of 14-3-3 was observed in 76.9% of normal colorectal tissue and 78.8% of all CRC samples. A trend was identified between decreasing nuclear 14-3-3 expression in CRC and worsening clinical prognosis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. |
| Chromosome | 17 |
| Location | 17p13.3 |
| Start | 1344540 |
| End | 1400375 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 55836 |
| OMIM ID | 605066 |
| HGNC ID | HGNC:12851 |
| Unigene ID | Hs.513851 |
| Ensembl ID | ENSG00000108953 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_006761.4 |
|---|---|
| Exon | join(114..329,35318..35517,38368..38474,39078..39284, 46029..46165,54877..55836) | mRNA Sequence | Download Select all |
| Length | 1827 |
CDS Information
| Location | join(266..329,35318..35517,38368..38474,39078..39284, 46029..46165,54877..54929) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS11001.1 |
Protein Information
| Protein ID | NP_006752.1 |
|---|---|
| Protein Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon |
| Molecular Wt. (Da) | 29043 |
| Protein Sequence | Download Select all |
| Length | 255 |
| Uniprot ID | P05231 |
| Ensembl Protein ID | ENSP00000258743 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 210 |
| T | Phosphorylation | 38 |
| K | Acetylation | 69 |
| K | Acetylation | 123 |
| K | Acetylation | 50 |
| K | Acetylation | 118 |
| E | Proteolytic Cleavage | 212 |
| S | Phosphorylation | 46 |
| S | Phosphorylation | 64 |
| S | Phosphorylation | 65 |
| T | Phosphorylation | 91 |
| S | Phosphorylation | 217 |
| S | Phosphorylation | 213 |
| T | Phosphorylation | 218 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 572 | BAD | 4409 | NP_004313.1 | yeast 2-hybrid | 9369453 |
| 801 | CALM1 | 241 | NP_008819.1 | in vitro;yeast 2-hybrid | 10088721 |
| 994 | CDC25B | 307 | NP_068660.1 | in vitro;in vivo | 107 136 677 644 510 |
| 1027 | CDKN1B | 2867 | NP_004055.1 | in vivo | 12042314 |
| 2959 | GTF2B | 8928 | NP_001505.1 | in vitro | 10449590 |
| 3480 | IGF1R | 932 | NP_000866.1 | in vitro;yeast 2-hybrid | 9111084 |
| 3667 | IRS1 | 943 | NP_005535.1 | in vivo | 93 121 439 111 084 |
| 3757 | KCNH2 | 1069 | NP_000229.1 | in vitro;in vivo;yeast 2-hybrid | 11953308 |
| 3875 | KRT18 | 1020 | NP_000215.1 | in vivo | 9524113 |
| 4217 | MAP3K5 | 3904 | NP_005914.1 | yeast 2-hybrid | 15023544 |
| 4294 | MAP3K10 | 2533 | NP_002437.2 | yeast 2-hybrid | 9427749 |
| 5127 | CDK16 | 2409 | NP_148978.2 | in vivo | 12154078 |
| 5894 | RAF1 | 1265 | NP_002871.1 | in vitro;in vivo | 7 644 510 870 272 110 000 000 |
| 5998 | RGS3 | 3720 | NP_652759.3 | in vivo | 11985497 |
| 6310 | ATXN1 | 3333 | NP_000323.2 | in vitro;in vivo;yeast 2-hybrid | 12757707 |
| 6622 | SNCA | 1227 | NP_000336.1 | in vivo | 10407019 |
| 6714 | SRC | 1819 | NP_005408.1 | in vivo | 8702721 |
| 6879 | TAF7 | 7196 | NP_005633.2 | in vitro | 10449590 |
| 6901 | TAZ | 2316 | NP_000107.1 | in vivo | 11118213 |
| 6908 | TBP | 2511 | NP_003185.1 | in vitro | 10449590 |
| 7040 | TGFB1 | 1821 | NP_000651.3 | in vivo | 11172812 |
| 7128 | TNFAIP3 | 1857 | NP_006281.1 | in vivo | 8702721 |
| 7153 | TOP2A | 536 | NP_001058.2 | in vivo | 10788521 |
| 7249 | TSC2 | 1850 | NP_000539.2 | in vitro | 12438239 |
| 7431 | VIM | 1899 | NP_003371.2 | in vitro;in vivo | 10887173 |
| 7532 | YWHAG | 5639 | NP_036611.2 | in vitro | 12507503 |
| 7533 | YWHAH | 215 | NP_003396.1 | in vivo | 761 508 812 507 503 |
| 8470 | SORBS2 | 12473 | NP_066547.1 | yeast 2-hybrid | 16189514 |
| 8660 | IRS2 | 2878 | NP_003740.2 | in vivo | 9312143 |
| 9721 | GPRIN2 | 13804 | NP_055511.2 | yeast 2-hybrid | 16189514 |
| 10749 | KIF1C | 4342 | NP_006603.2 | in vivo | 10559254 |
| 27018 | NGFRAP1 | 2291 | NP_055195.1 | in vitro;in vivo;yeast 2-hybrid | 11278287 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| Epstein-Barr virus infection | hsa05169 |
| Hippo signaling pathway | hsa04390 |
| Neurotrophin signaling pathway | hsa04722 |
| Oocyte meiosis | hsa04114 |
| PI3K-Akt signaling pathway | hsa04151 |
| Viral carcinogenesis | hsa05203 |
Structure Information
| PDB ID | 2BR9 |
|---|---|
| Resolution | 1.75 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | 14-3-3 PROTEIN EPSILON |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd10020 | 4-233 | 14-3-3_epsilon |
| cl02098 | 4-233 | 14-3-3 superfamily |
| pfam00244 | 4-239 | 14-3-3 |
| cd11309 | 4-234 | 14-3-3_fungi |
| cd10026 | 4-238 | 14-3-3_plant |
| COG5040 | 4-255 | BMH1 |
| smart00101 | 4-245 | 14_3_3 |
| cd08774 | 5-229 | 14-3-3 |
| cd10022 | 3-233 | 14-3-3_beta_zeta |
| cd11310 | 3-234 | 14-3-3_1 |
| cd10023 | 3-234 | 14-3-3_theta |
| cd10019 | 3-241 | 14-3-3_sigma |
| cd10024 | 3-243 | 14-3-3_gamma |
| cd10025 | 3-238 | 14-3-3_eta |
Ontology Information
| HPRD ID | 907 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.