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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21347233 | 2011 | Cell line : HCT116, HT29, DLD1, LS180, SW480, SW620 Source : Riken Gene Bank (Japan) and American Type Culture Collection (ATCC, USA). Tissue sample from Sir Run Run Shaw Hospital, School of Medicine Zhejiang University. Sample Type : CRC Tumor and normal tissue No. of Sample : 40 Stage : TNM Stage I-IV. | cDNA microarray,real time RT-PCR,Bisulfite treatment of DNA and methylation specific PCR,Cell transfection and cell viability assay,Western blotting | Hypermethylation | - | ZIC1 may potentially function as a tumor suppressor gene, which is downregulated through promoter hypermethylation in colorectal cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type |
| Description | This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 3 |
| Location | 3q24 |
| Start | 147127181 |
| End | 147134506 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7326 |
| OMIM ID | 600470 |
| HGNC ID | HGNC:12872 |
| Unigene ID | Hs.598590 |
| Ensembl ID | ENSG00000152977 |
| PharmGKB ID | PA37461 |
mRNA Information
| mRNA ID | ?NM_003412.3 |
|---|---|
| Exon | join(1..1701,3125..3288,3961..7326) | mRNA Sequence | Download Select all |
| Length | 5231 |
Protein Information
| Protein ID | NP_003403.2 |
|---|---|
| Protein Name | Zic family member 1 |
| Molecular Wt. (Da) | 57696 |
| Protein Sequence | Download Select all |
| Length | 447 |
| Uniprot ID | O00165 |
| Ensembl Protein ID | ENSP00000329002 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 20;- |
| T | Phosphorylation | 15;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2735 | GLI1 | 1311 | NP_005260.1 | in vitro;in vivo | 11238441 |
| 2736 | GLI2 | 1312 | NP_005261.2 | in vitro;in vivo | 11238441 |
| 2737 | GLI3 | 1313 | P10071 | in vitro;in vivo | 11238441 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 318-345 | zf-H2C2_2 |
| cl22375 | 318-345 | zf-H2C2_2 superfamily |
| pfam13465 | 289-315 | zf-H2C2_2 |
| cl22375 | 289-315 | zf-H2C2_2 superfamily |
| pfam13465 | 348-373 | zf-H2C2_2 |
| cl22375 | 348-373 | zf-H2C2_2 superfamily |
| pfam00096 | 362-384 | zf-C2H2 |
| cl23491 | 362-384 | zf-C2H2 superfamily |
| COG5189 | 298-382 | SFP1 |
| COG5048 | 238-385 | COG5048 |
| COG5048 | 299-376 | COG5048 |
| COG5048 | 289-443 | COG5048 |
| COG5048 | 246-361 | COG5048 |
| COG5048 | 281-352 | COG5048 |
Ontology Information
| HPRD ID | 5269 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.