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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22996014 | 2012 | Cell line : - Source : Xiangya hospitals of Central South University, Changsha, China. Sample Type : CRC tumor and Normal tissue No. of Sample : 138 Stage : TNM Stage I-IV | 2D DIGE, MALDI-TOF/TOF MS | Down-regulation | - | After survival classifier and LOOCV (leave-one-out cross-validation) analyses, the new prognostic biomarkers (Carbonic Anhydrase I (CA1)) provided good survival prediction for TNM stage I-IV patients. The study includes 138 patients with primary CRC diagnosed. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Carbonic anhydrases |
| Description | Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding the same protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature. [provided by RefSeq, Sep 2009] |
| Chromosome | 8 |
| Location | 8q21.2 |
| Start | 85328229 |
| End | 85378154 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 49926 |
| OMIM ID | 114800 |
| HGNC ID | HGNC:1368 |
| Unigene ID | Hs.23118 |
| Ensembl ID | ENSG00000133742 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001291968.1 |
|---|---|
| Exon | join(1..109,36496..36556,44535..44630,45603..45665, 48311..48466,49479..49926) | mRNA Sequence | Download Select all |
| Length | 1224 |
CDS Information
| Location | join(36520..36556,41092..41210,44535..44630,45603..45665, 48311..48466,49479..49595) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001122301.1 |
|---|---|
| Protein Name | Carbonic anhydrase I |
| Molecular Wt. (Da) | 28739 |
| Protein Sequence | Download Select all |
| Length | 261 |
| Uniprot ID | Q15389 |
| Ensembl Protein ID | ENSP00000297450 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
| EC | 4.2.1.1 |
|---|---|
| Name | carbonate dehydratase carbonic anhydrase anhydrase carbonate anhydrase carbonic acid anhydrase carboxyanhydrase carbonic anhydrase A carbonate hydro-lyase |
| Class | Lyases; Carbon-oxygen lyases; Hydro-lyases |
| Sysname | carbonate hydro-lyase (carbon-dioxide-forming) |
| Substrate | H2CO3 |
| Product | CO2 [CPD:C00011]; H2O |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Nitrogen metabolism | hsa00910 |
Structure Information
| PDB ID | 1AZM |
|---|---|
| Resolution | 2 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | CARBONIC ANHYDRASE I |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03119 | 2-261 | alpha_CA_I_II_III_XIII |
| cl00012 | 2-261 | alpha_CA superfamily |
| pfam00194 | 24-261 | Carb_anhydrase |
| smart01057 | 6-256 | Carb_anhydrase |
| cd03149 | 26-261 | alpha_CA_VII |
| cd00326 | 26-258 | alpha_CA |
| cd03118 | 26-261 | alpha_CA_V |
| cd03123 | 13-261 | alpha_CA_VI_IX_XII_XIV |
| cd03120 | 16-261 | alpha_CARP_VIII |
| cd03124 | 13-257 | alpha_CA_prokaryotic_like |
| cd03117 | 26-257 | alpha_CA_IV_XV_like |
| cd03121 | 13-258 | alpha_CARP_X_XI_like |
| cd03126 | 13-261 | alpha_CA_XII_XIV |
| COG3338 | 2-257 | Cah |
| cd03150 | 13-261 | alpha_CA_IX |
| cd03125 | 13-261 | alpha_CA_VI |
| cd03122 | 13-257 | alpha_CARP_receptor_like |
| PLN02202 | 6-257 | PLN02202 |
| PLN02179 | 4-214 | PLN02179 |
Ontology Information
| HPRD ID | 3392 |
|---|---|
| Molecular Class | Enzyme: Carbonic anhydrase |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P00915 | DB00232 | Methyclothiazide | SmallMoleculeDrug |
| P00915 | DB00381 | Amlodipine | SmallMoleculeDrug |
| P00915 | DB00423 | Methocarbamol | SmallMoleculeDrug |
| P00915 | DB00436 | Bendroflumethiazide | SmallMoleculeDrug |
| P00915 | DB00562 | Benzthiazide | SmallMoleculeDrug |
| P00915 | DB00606 | Cyclothiazide | SmallMoleculeDrug |
| P00915 | DB00703 | Methazolamide | SmallMoleculeDrug |
| P00915 | DB00774 | Hydroflumethiazide | SmallMoleculeDrug |
| P00915 | DB00819 | Acetazolamide | SmallMoleculeDrug |
| P00915 | DB00869 | Dorzolamide | SmallMoleculeDrug |
| P00915 | DB00880 | Chlorothiazide | SmallMoleculeDrug |
| P00915 | DB00909 | Zonisamide | SmallMoleculeDrug |
| P00915 | DB00999 | Hydrochlorothiazide | SmallMoleculeDrug |
| P00915 | DB01021 | Trichlormethiazide | SmallMoleculeDrug |
| P00915 | DB01031 | Ethinamate | SmallMoleculeDrug |
| P00915 | DB01119 | Diazoxide | SmallMoleculeDrug |
| P00915 | DB01144 | Diclofenamide | SmallMoleculeDrug |
| P00915 | DB01194 | Brinzolamide | SmallMoleculeDrug |
| P00915 | DB01325 | Quinethazone | SmallMoleculeDrug |