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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CA2 760 carbonic anhydrase II  8Car2, CA-II, CAII 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23727877   2013Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 8

Stage : -

2-DE coupled with MS/MS, RT-PCR, western blotting and immunohistochemistryDown-regulation-CA II may be a potential biomarker for early diagnosis of CRC and the results may contribute to a better understanding of the molecular mechanism of CRC and colorectal cancer treatment.

overexpression of CA II remarkably suppressed tumor cell growth both in vitro and in vivo, which was in part interpreted by cell cycle arrest at G0/G1 and G2 phase.


Gene Details



Chromosome 8 - NC_000008.11 (85463902..85481492)

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Gene Type protein coding
Gene Family Carbonic anhydrases
Description The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene.  
Chromosome 8
Location 8q21.2
Start 85463902  
End 85481492  
Strand +  
Gene Sequence

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Length 17591  
OMIM ID 611492   
HGNC ID HGNC:1373   
Unigene ID Hs.155097   
Ensembl ID ENSG00000104267   
PharmGKB ID -   

mRNA Information


mRNA ID NM_000067.2
Exon join(1..214,1371..1568,9792..9910,10423..10515, 11897..11959,13219..13374,16769..17591)  
mRNA Sequence

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Length 1666  



CDS Information


   
Locationjoin(181..214,1371..1568,9792..9910,10423..10515, 11897..11959,13219..13374,16769..16888)
CDS Sequence

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CCDS ID CCDS6239.1



Protein Information


      
Protein IDNP_000058.1
Protein Namecarbonic anhydrase II
Molecular Wt. (Da)29115
Protein Sequence

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Length 260  
Uniprot IDP63096
Ensembl Protein ID ENSP00000343027  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SAcetylation2

Enzyme Information


   
EC4.2.1.1
Namecarbonate dehydratase
carbonic anhydrase
anhydrase
carbonate anhydrase
carbonic acid anhydrase
carboxyanhydrase
carbonic anhydrase A
carbonate hydro-lyase
ClassLyases; Carbon-oxygen lyases; Hydro-lyases
Sysnamecarbonate hydro-lyase (carbon-dioxide-forming)  
SubstrateH2CO3  
ProductCO2 [CPD:C00011]; H2O  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3329HSPD1318NP_002147.2in vitro989   092   610   811   634   
6508SLC4A3109NP_963868.2in vitro11606574   
6521SLC4A1175NP_000333.1in vitro97   744   711   106   357   000   000   000   
6548SLC9A1123NP_003038.2in vitro;in vivo1   213   808   516   475   830   
55139ANKZF17673NP_060559.2yeast 2-hybrid16169070   
57540PTCHD213852NP_065831.1yeast 2-hybrid16169070   


Pathway Information


                                    
Pathway Name Pathway ID
Bile secretion hsa04976
Collecting duct acid secretion hsa04966
Gastric acid secretion hsa04971
Nitrogen metabolism hsa00910
Pancreatic secretion hsa04972
Proximal tubule bicarbonate reclamation hsa04964


Structure Information


PDB ID12CA
Resolution2.4
Method?? X-RAY DIFFRACTION
Chains A  
Molecule CARBONIC ANHYDRASE II  
Model View



Domain Information




ID Location Description
cd031191-259  alpha_CA_I_II_III_XIII
cl000121-259  alpha_CA superfamily
pfam0019423-259  Carb_anhydrase
smart010575-254  Carb_anhydrase
cd0314925-259  alpha_CA_VII
cd0311825-259  alpha_CA_V
cd0032625-255  alpha_CA
cd0311725-257  alpha_CA_IV_XV_like
cd0312312-259  alpha_CA_VI_IX_XII_XIV
cd0312016-259  alpha_CARP_VIII
cd0312412-255  alpha_CA_prokaryotic_like
cd0312612-259  alpha_CA_XII_XIV
COG33384-255  Cah
cd0312112-256  alpha_CARP_X_XI_like
cd0312512-259  alpha_CA_VI
cd0315012-259  alpha_CA_IX
cd0312212-255  alpha_CARP_receptor_like
PLN022025-256  PLN02202
PLN0217912-212  PLN02179


Ontology Information


   
HPRD ID11749
Molecular ClassEnzyme: Carbonic anhydrase
Molecular FunctionPeroxidase activity (GO:0004601)
Biological ProcessAnti-apoptosis (GO:0006916)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P00918DB00232MethyclothiazideSmallMoleculeDrug
P00918DB00273TopiramateSmallMoleculeDrug
P00918DB00436BendroflumethiazideSmallMoleculeDrug
P00918DB00562BenzthiazideSmallMoleculeDrug
P00918DB00606CyclothiazideSmallMoleculeDrug
P00918DB00695FurosemideSmallMoleculeDrug
P00918DB00703MethazolamideSmallMoleculeDrug
P00918DB00774HydroflumethiazideSmallMoleculeDrug
P00918DB00819AcetazolamideSmallMoleculeDrug
P00918DB00869DorzolamideSmallMoleculeDrug
P00918DB00880ChlorothiazideSmallMoleculeDrug
P00918DB00909ZonisamideSmallMoleculeDrug
P00918DB00999HydrochlorothiazideSmallMoleculeDrug
P00918DB01021TrichlormethiazideSmallMoleculeDrug
P00918DB01031EthinamateSmallMoleculeDrug
P00918DB01119DiazoxideSmallMoleculeDrug
P00918DB01144DiclofenamideSmallMoleculeDrug
P00918DB01194BrinzolamideSmallMoleculeDrug
P00918DB01325QuinethazoneSmallMoleculeDrug
P00918DB03904UreaSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO