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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CA9 768 carbonic anhydrase IX  9MN, CAIX 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25782664   2015Cell line : NCM460, SW480, SW620, HCT 8

Source : -

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR,Immunoblotting,Colony formation assays,Wound healing assay,Cell migration assay,Matrigel invasion assay,Apoptosis analysisUp-regulation--


Gene Details



NC_000009.11 (35673915..35681156)

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Gene Type protein coding
Gene Family Carbonic anhydrases
Description Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]  
Chromosome 9
Location 9p13.3
Start 35673915  
End 35681156  
Strand +  
Gene Sequence

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Length 7242  
OMIM ID 603179   
HGNC ID HGNC:1383   
Unigene ID Hs.63287   
Ensembl ID ENSG00000107159   
PharmGKB ID PA25998   

mRNA Information


mRNA ID NM_001216.2
Exon join(1..445,1621..1650,1844..2014,2147..2289,2380..2472, 3873..3939,5268..5425,5937..6081,6196..6222,6836..6917, 7048..7242)  
mRNA Sequence

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Length 1561  



CDS Information


   
Location43..1422
CDS Sequence

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CCDS ID CCDS6585.1



Protein Information


      
Protein IDNP_001207.2
Protein Namecarbonic anhydrase IX
Molecular Wt. (Da)0
Protein Sequence

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Length 459  
Uniprot IDP42898
Ensembl Protein ID ENSP00000365767  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation448

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
999CDH11885BAA88957.1in vitro;in vivo14567991   
1495CTNNA1285NP_001894.2in vitro;in vivo14567991   
1499CTNNB1286NP_001895.1in vitro;in vivo14567991   


Pathway Information


      
Pathway Name Pathway ID
Nitrogen metabolism hsa00910


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd03150145-391  alpha_CA_IX
cl00012145-391  alpha_CA superfamily
cd03123145-390  alpha_CA_VI_IX_XII_XIV
cd00326158-387  alpha_CA
smart01057141-385  Carb_anhydrase
cd03125137-391  alpha_CA_VI
cd03126145-390  alpha_CA_XII_XIV
cd03117158-386  alpha_CA_IV_XV_like
pfam00194156-390  Carb_anhydrase
cd03122149-386  alpha_CARP_receptor_like
cd03124149-387  alpha_CA_prokaryotic_like
cd03149158-390  alpha_CA_VII
cd03119138-390  alpha_CA_I_II_III_XIII
cd03121145-386  alpha_CARP_X_XI_like
cd03118158-390  alpha_CA_V
cd03120149-390  alpha_CARP_VIII
COG3338140-386  Cah
PLN02202145-387  PLN02202
PLN02179145-349  PLN02179
PHA0316944-148  PHA03169
pfam0334446-148  Daxx
pfam0579338-139  TFIIF_alpha
COG527152-138  MDN1
pfam0414752-124  Nop14
PHA0316941-124  PHA03169


Ontology Information


   
HPRD ID1136
Molecular ClassEnzyme: Carbonic anhydrase
Molecular FunctionMethyltransferase activity (GO:0008168)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q16790DB00562BenzthiazideSmallMoleculeDrug
Q16790DB00774HydroflumethiazideSmallMoleculeDrug
Q16790DB00909ZonisamideSmallMoleculeDrug
Q16790DB00999HydrochlorothiazideSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO