Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25782664    | 2015 | Cell line : NCM460, SW480, SW620, HCT 8 Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR,Immunoblotting,Colony formation assays,Wound healing assay,Cell migration assay,Matrigel invasion assay,Apoptosis analysis | Up-regulation | - | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Carbonic anhydrases |
| Description | Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]   |
| Chromosome | 9 |
| Location | 9p13.3 |
| Start | 35673915   |
| End | 35681156   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 7242   |
| OMIM ID | 603179    |
| HGNC ID | HGNC:1383    |
| Unigene ID | Hs.63287    |
| Ensembl ID | ENSG00000107159    |
| PharmGKB ID | PA25998    |
mRNA Information
| mRNA ID | NM_001216.2 |
|---|---|
| Exon | join(1..445,1621..1650,1844..2014,2147..2289,2380..2472, 3873..3939,5268..5425,5937..6081,6196..6222,6836..6917, 7048..7242)   | mRNA Sequence |    Download   Select all |
| Length | 1561   |
CDS Information
| Location | 43..1422 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS6585.1 |    
Protein Information
| Protein ID | NP_001207.2 |
|---|---|
| Protein Name | carbonic anhydrase IX |
| Molecular Wt. (Da) | 0 |
| Protein Sequence |    Download   Select all |
| Length | 459   |
| Uniprot ID | P42898 |    
| Ensembl Protein ID | ENSP00000365767   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 448 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 999 |    CDH1 |    1885 |    BAA88957.1 |    in vitro;in vivo |    14567991    |
| 1495 |    CTNNA1 |    285 |    NP_001894.2 |    in vitro;in vivo |    14567991    |
| 1499 |    CTNNB1 |    286 |    NP_001895.1 |    in vitro;in vivo |    14567991    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Nitrogen metabolism |    hsa00910 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03150 | 145-391  | alpha_CA_IX |
| cl00012 | 145-391  | alpha_CA superfamily |
| cd03123 | 145-390  | alpha_CA_VI_IX_XII_XIV |
| cd00326 | 158-387  | alpha_CA |
| smart01057 | 141-385  | Carb_anhydrase |
| cd03125 | 137-391  | alpha_CA_VI |
| cd03126 | 145-390  | alpha_CA_XII_XIV |
| cd03117 | 158-386  | alpha_CA_IV_XV_like |
| pfam00194 | 156-390  | Carb_anhydrase |
| cd03122 | 149-386  | alpha_CARP_receptor_like |
| cd03124 | 149-387  | alpha_CA_prokaryotic_like |
| cd03149 | 158-390  | alpha_CA_VII |
| cd03119 | 138-390  | alpha_CA_I_II_III_XIII |
| cd03121 | 145-386  | alpha_CARP_X_XI_like |
| cd03118 | 158-390  | alpha_CA_V |
| cd03120 | 149-390  | alpha_CARP_VIII |
| COG3338 | 140-386  | Cah |
| PLN02202 | 145-387  | PLN02202 |
| PLN02179 | 145-349  | PLN02179 |
| PHA03169 | 44-148  | PHA03169 |
| pfam03344 | 46-148  | Daxx |
| pfam05793 | 38-139  | TFIIF_alpha |
| COG5271 | 52-138  | MDN1 |
| pfam04147 | 52-124  | Nop14 |
| PHA03169 | 41-124  | PHA03169 |
Ontology Information
| HPRD ID | 1136 |    
|---|---|
| Molecular Class | Enzyme: Carbonic anhydrase |
| Molecular Function | Methyltransferase activity (GO:0008168) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q16790 | DB00562 | Benzthiazide | SmallMoleculeDrug |
| Q16790 | DB00774 | Hydroflumethiazide | SmallMoleculeDrug |
| Q16790 | DB00909 | Zonisamide | SmallMoleculeDrug |
| Q16790 | DB00999 | Hydrochlorothiazide | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
