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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ZYX 7791 zyxin  7- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25860875   2015Cell line : DLD1 , HT 29, LoVo, NCI-H508, Caco 2

Source : Tokyo Dental College, Tokyo, Japan

Sample Type : -

No. of Sample : -

Stage : -

Plasmids and transfection,Immunofluorescence microscopy,Purification of recombinant proteins,Western blotting,RNA interference,Cell motility, invasion assayUnknown-ZYX defective binding to ACTN4, which occupies focal adhesions instead of ACTN1, induces the formation of immature focal adhesions, resulting in the enhancement of cell motility and invasion.


Gene Details



NC_000007.13 (143078338..143088204)

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Gene Type protein coding
Gene Family -
Description Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]  
Chromosome 7
Location 7q32
Start 143078338  
End 143088204  
Strand +  
Gene Sequence

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Length 9867  
OMIM ID 602002   
HGNC ID HGNC:13200   
Unigene ID Hs.490415   
Ensembl ID ENSG00000159840   
PharmGKB ID PA37765   

mRNA Information


mRNA ID ?NM_001010972.1
Exon complement(3591..3976)  
mRNA Sequence

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Length 4591  



CDS Information


   
Location 443..1441
CDS Sequence

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CCDS ID CCDS5883.1



Protein Information


      
Protein IDNP_001010972.1
Protein Namezyxin
Molecular Wt. (Da)47937
Protein Sequence

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Length 572  
Uniprot IDQ12866
Ensembl Protein ID ENSP00000295408  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation259
SPhosphorylation267
SPhosphorylation344
SPhosphorylation259
SPhosphorylation267
SPhosphorylation344
SPhosphorylation281
SPhosphorylation281
SPhosphorylation281;-
SPhosphorylation281;-
SPhosphorylation267;-
SPhosphorylation267;-
SPhosphorylation344;-
SPhosphorylation344;-
SPhosphorylation303;-
SPhosphorylation303;-
TPhosphorylation306;-
TPhosphorylation306;-
SPhosphorylation308;-
SPhosphorylation308;-
TPhosphorylation352;-
TPhosphorylation352;-
SPhosphorylation143;-
SPhosphorylation143;-
SPhosphorylation169
SPhosphorylation169
SPhosphorylation170
SPhosphorylation170
SPhosphorylation258
TPhosphorylation270
SPhosphorylation258
TPhosphorylation270
TPhosphorylation274
TPhosphorylation274
SPhosphorylation278
SPhosphorylation278
SPhosphorylation288
SPhosphorylation288
SPhosphorylation290
SPhosphorylation290
TPhosphorylation315
TPhosphorylation315
SPhosphorylation313
SPhosphorylation313
SPhosphorylation142
SPhosphorylation142
TPhosphorylation179
TPhosphorylation179
KAcetylation279
KAcetylation279
KAcetylation24
KAcetylation24
SPhosphorylation150
SPhosphorylation150
YPhosphorylation172
YPhosphorylation172

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
87ACTN120NP_001123476.1in vitro;in vivo1   022   410   511   423   540   
7408VASP3415NP_003361.1in vitro;in vivo;yeast 2-hybrid764   452   010   882   740   
7409VAV11284NP_005419.2in vitro;yeast 2-hybrid8622875   


Pathway Information


      
Pathway Name Pathway ID
Focal adhesion hsa04510


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd09435504-570  LIM3_Zyxin
cl02475504-570  LIM superfamily
cd09349351-437  LIM1_Zyxin
cl02475351-437  LIM superfamily
cd09357504-566  LIM3_Zyxin_like
cd09353444-503  LIM2_Zyxin
cl02475444-503  LIM superfamily
cd09437504-571  LIM3_LPP
cd09436504-569  LIM3_TRIP6
cd09438504-566  LIM3_Ajuba_like
cd09354444-503  LIM2_LPP
cd09356444-496  LIM2_TRIP6
cd09355444-496  LIM2_Ajuba_like
cd09372444-496  LIM2_FBLP-1
cd08368444-496  LIM
smart00132443-495  LIM
smart00132503-565  LIM
cd08368504-566  LIM
pfam00412444-500  LIM
cd09336444-497  LIM1_Paxillin_like
pfam00412504-566  LIM
pfam00412384-437  LIM
cd09350384-437  LIM1_TRIP6
cd09328443-476  LIM2_abLIM
cd09338444-497  LIM3_Paxillin_like
smart00132384-436  LIM
cd09412444-496  LIM4_Leupaxin
cd08368384-437  LIM
cd09345444-496  LIM2_FHL
cd09331444-501  LIM1_PINCH
cd09351384-437  LIM1_LPP
cd09391444-496  LIM1_Lrg1p_like
cd09373444-496  LIM1_AWH
cd09332444-494  LIM2_PINCH
cd09334444-496  LIM4_PINCH
cd09456444-496  LIM2_Enigma
cd09376444-496  LIM2_Lhx3_Lhx4
cd09461444-492  LIM3_Enigma_like_1
cd09405444-497  LIM1_Paxillin
cd09369444-496  LIM1_Lhx2_Lhx9
cd09406444-497  LIM1_Leupaxin
cd09327444-496  LIM1_abLIM
cd09375444-496  LIM2_Lhx1_Lhx5
cd09363444-492  LIM3_Enigma_like
cd09410444-497  LIM3_Leupaxin
cd09339444-496  LIM4_Paxillin_like
cd09391504-545  LIM1_Lrg1p_like
cd09396444-498  LIM_DA1
cd09331384-437  LIM1_PINCH
cd09371444-496  LIM1_Lmx1b
cd09361444-492  LIM1_Enigma_like
cd09337444-496  LIM2_Paxillin_like
cd09459444-497  LIM3_ENH
cd09378444-496  LIM2_Lmx1a_Lmx1b
cd09427443-496  LIM2_FHL3
cd09387444-473  LIM2_LMO4
cd09411444-492  LIM4_Paxillin
cd09352384-434  LIM1_Ajuba_like
cd09341444-497  LIM2_Testin_like
cd09368504-563  LIM1_Lhx3_Lhx4
cd09396384-437  LIM_DA1
cd09329384-437  LIM3_abLIM
cd09360444-486  LIM_ALP_like
cd09391384-413  LIM1_Lrg1p_like
cd09466502-563  LIM1_Lhx3a
cd09409444-497  LIM3_Paxillin
cd09336384-437  LIM1_Paxillin_like
cd09377443-477  LIM2_Lhx2_Lhx9
cd09338384-437  LIM3_Paxillin_like
cd09352444-482  LIM1_Ajuba_like
cd09472443-496  LIM2_Lhx3b
cd09426444-499  LIM2_FHL2
cd09369504-564  LIM1_Lhx2_Lhx9
cd09457444-496  LIM2_ENH
cd09330444-473  LIM4_abLIM
cd09374444-477  LIM2_Isl
cd09362444-496  LIM2_Enigma_like
cd09456384-437  LIM2_Enigma
cd09379504-566  LIM2_AWH
cd09400442-482  LIM_like_1
cd09332522-566  LIM2_PINCH
cd09468504-564  LIM1_Lhx4
cd09461384-434  LIM3_Enigma_like_1
cd09366504-566  LIM1_Isl
cd09370444-496  LIM1_Lmx1a
cd09404524-566  LIM1_MLP84B_like
cd09454444-488  LIM1_ZASP_Cypher
cd09346444-493  LIM3_FHL
cd09362384-437  LIM2_Enigma_like
cd09429444-482  LIM3_FHL1
cd09458444-492  LIM3_Enigma
cd09457384-437  LIM2_ENH
cd09340444-496  LIM1_Testin_like
cd09394504-565  LIM1_Rga
cd09405383-437  LIM1_Paxillin
cd09455444-489  LIM1_Enigma_like_1
cd09348442-488  LIM4_FHL1
cd09464444-492  LIM2_LIMK1
cd09358504-566  LIM_Mical_like
cd09432444-486  LIM6_LIMPETin
cd09361384-437  LIM1_Enigma_like
cd09377384-412  LIM2_Lhx2_Lhx9
cd09326522-566  LIM_CRP_like
cd09425444-496  LIM4_LIMPETin
cd09329444-496  LIM3_abLIM
cd09451444-486  LIM_RIL
cd09452444-482  LIM1_Enigma
cd09366444-496  LIM1_Isl
cd09329524-547  LIM3_abLIM
cd09409384-437  LIM3_Paxillin
cd09424433-500  LIM2_FHL1
cd09367504-563  LIM1_Lhx1_Lhx5
cd09375504-545  LIM2_Lhx1_Lhx5
cd09328503-565  LIM2_abLIM
cd09397444-497  LIM1_UF1
cd09383444-477  LIM2_Lhx7_Lhx8
cd09473444-496  LIM2_Lhx4
cd09397384-437  LIM1_UF1
cd09414384-412  LIM1_LIMPETin
cd09333444-494  LIM3_PINCH
cd09393504-565  LIM3_Lrg1p_like
cd09467502-563  LIM1_Lhx3b
cd09335444-477  LIM5_PINCH
cd09327504-545  LIM1_abLIM
pfam03154174-335  Atrophin-1
pfam09770290-376  PAT1
pfam09770188-345  PAT1
PRK12438177-218  PRK12438


Ontology Information


   
HPRD ID9066
Molecular ClassAdhesion molecule
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO