Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DDR1 | 780 | discoidin domain receptor tyrosine kinase 1 | 6 | RTK6, CD167 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24711074 | 2014 | Cell line : Lovei, LOVO Source : HCBC, CCTCC Sample Type : - No. of Sample : - Stage : - | Luciferase reporter assay, cell proliferation, colony formation, cell cycle progression, invasion,migration, Western blotting | Up-regulation | - | Up-regulation of DDR1 induced by miR-199a-5p down-regulation may contribute to the development and progression of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] |
| Chromosome | 6 |
| Location | 6p21.33 |
| Start | 30850694 |
| End | 30867933 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 17240 |
| OMIM ID | 600408 |
| HGNC ID | HGNC:2730 |
| Unigene ID | Hs.631988 |
| Ensembl ID | ENSG00000204580 |
| PharmGKB ID | PA24348 |
mRNA Information
| mRNA ID | XM_011514887.1 |
|---|---|
| Exon | join(1..217,7780..7906,8000..8102,8294..8522,10065..10212, 10472..10571,11094..11280,11388..11634,12160..12255, 12364..12515,13598..13763,14496..14606,15713..15957, 16106..16233,16453..16689,17165..17399,17980..18129, 18248..19248) | mRNA Sequence | Download Select all |
| Length | 3879 |
Protein Information
| Protein ID | XP_011513189.1 |
|---|---|
| Protein Name | discoidin domain receptor tyrosine kinase 1 |
| Molecular Wt. (Da) | 101666 |
| Protein Sequence | Download Select all |
| Length | 919 |
| Uniprot ID | Q9UBK8 |
| Ensembl Protein ID | ENSP00000264668 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 513 |
| Y | Phosphorylation | 513 |
| Y | Phosphorylation | 755;- |
| Y | Phosphorylation | 759;- |
| Y | Phosphorylation | 792;- |
| Y | Phosphorylation | 796;- |
| Y | Phosphorylation | 802;- |
| Y | Phosphorylation | 798;- |
| Y | Phosphorylation | 760;- |
| Y | Phosphorylation | 797;- |
| Y | Phosphorylation | 803;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1280 | COL2A1 | 361 | NP_001835.3 | in vivo | 9659900 |
| 1281 | COL3A1 | 365 | NP_000081.1 | in vivo | 9659900 |
| 1290 | COL5A2 | 366 | NP_000384.2 | in vivo | 9659900 |
| 1301 | COL11A1 | 375 | NP_542196.2 | in vivo | 9659900 |
| 5335 | PLCG1 | 1398 | NP_002651.2 | in vitro;in vivo | 10783152 |
| 5781 | PTPN11 | 1470 | NP_002825.3 | in vivo;yeast 2-hybrid | 16337946 |
| 5997 | RGS2 | 2917 | NP_002914.1 | yeast 2-hybrid | 16169070 |
| 8440 | NCK2 | 5378 | NP_003572.2 | yeast 2-hybrid | 16337946 |
| 9410 | SNRNP40 | 8481 | NP_004805.2 | yeast 2-hybrid | 16169070 |
| 23557 | SNAPIN | 6111 | NP_036569.1 | yeast 2-hybrid | 16169070 |
| 79656 | BEND5 | 7756 | AAH07932.2 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05096 | 604-907 | PTKc_DDR1 |
| cl21453 | 604-907 | PKc_like superfamily |
| cd00057 | 60-184 | FA58C |
| cl19067 | 60-184 | FA58C superfamily |
| cd05051 | 604-907 | PTKc_DDR |
| cd05095 | 604-907 | PTKc_DDR2 |
| cd05097 | 604-907 | PTKc_DDR_like |
| cd00192 | 614-906 | PTKc |
| cd05048 | 605-902 | PTKc_Ror |
| cd05049 | 606-907 | PTKc_Trk |
| cd05092 | 607-905 | PTKc_TrkA |
| cd05050 | 604-905 | PTKc_Musk |
| cd05032 | 605-901 | PTKc_InsR_like |
| cd05044 | 616-901 | PTKc_c-ros |
| cd05093 | 607-905 | PTKc_TrkB |
| cd05094 | 607-905 | PTKc_TrkC |
| cd05046 | 605-907 | PTK_CCK4 |
| cd05034 | 614-905 | PTKc_Src_like |
| cd05053 | 601-901 | PTKc_FGFR |
| cd05068 | 606-901 | PTKc_Frk_like |
| cd05060 | 614-908 | PTKc_Syk_like |
| cd05036 | 606-899 | PTKc_ALK_LTK |
| cd05033 | 614-905 | PTKc_EphR |
| cd05038 | 605-901 | PTKc_Jak_rpt2 |
| cd13999 | 616-905 | STKc_MAP3K-like |
| cd05090 | 604-902 | PTKc_Ror1 |
| cd05059 | 608-906 | PTKc_Tec_like |
| cd05061 | 604-908 | PTKc_InsR |
| cd05052 | 607-902 | PTKc_Abl |
| cd05091 | 608-905 | PTKc_Ror2 |
| cd05040 | 614-907 | PTKc_Ack_like |
| cd05041 | 614-905 | PTKc_Fes_like |
| cd05056 | 607-901 | PTKc_FAK |
| cd05099 | 601-901 | PTKc_FGFR4 |
| cd05066 | 608-905 | PTKc_EphR_A |
| cd05148 | 606-902 | PTKc_Srm_Brk |
| cd05075 | 609-905 | PTKc_Axl |
| cd05063 | 613-901 | PTKc_EphR_A2 |
| cd05035 | 616-907 | PTKc_TAM |
| cd05112 | 608-906 | PTKc_Itk |
| cd05084 | 614-905 | PTKc_Fes |
| cd05065 | 608-901 | PTKc_EphR_B |
| cd05058 | 614-901 | PTKc_Met_Ron |
| cd05039 | 606-906 | PTKc_Csk_like |
| cd05074 | 603-901 | PTKc_Tyro3 |
| cd05098 | 601-901 | PTKc_FGFR1 |
| cd05067 | 604-905 | PTKc_Lck_Blk |
| cd05062 | 604-901 | PTKc_IGF-1R |
| cd05055 | 604-909 | PTKc_PDGFR |
| cd05101 | 601-901 | PTKc_FGFR2 |
| cd05045 | 609-901 | PTKc_RET |
| cd05085 | 614-906 | PTKc_Fer |
| cd05100 | 601-901 | PTKc_FGFR3 |
| cd14203 | 615-908 | PTKc_Src_Fyn_like |
| cd14204 | 607-905 | PTKc_Mer |
| cd05057 | 605-909 | PTKc_EGFR_like |
| cd05115 | 652-898 | PTKc_Zap-70 |
| cd05047 | 616-901 | PTKc_Tie |
| cd05072 | 604-905 | PTKc_Lyn |
| cd05114 | 608-907 | PTKc_Tec_Rlk |
| cd05113 | 607-901 | PTKc_Btk_Bmx |
| cd05054 | 604-901 | PTKc_VEGFR |
| cd05089 | 610-901 | PTKc_Tie1 |
| cd05079 | 605-901 | PTKc_Jak1_rpt2 |
| cd05071 | 604-907 | PTKc_Src |
| cd00180 | 616-901 | PKc |
| cd05043 | 607-907 | PTK_Ryk |
| cd05073 | 604-907 | PTKc_Hck |
| cd05070 | 604-907 | PTKc_Fyn |
| cd05069 | 604-907 | PTKc_Yes |
| cd14205 | 605-903 | PTKc_Jak2_rpt2 |
| cd05106 | 604-907 | PTKc_CSF-1R |
| cd05064 | 608-907 | PTKc_EphR_A10 |
| cd05116 | 652-899 | PTKc_Syk |
| cd05088 | 608-907 | PTKc_Tie2 |
| cd05083 | 608-908 | PTKc_Chk |
| cd05107 | 604-901 | PTKc_PDGFR_beta |
| cd14206 | 614-902 | PTKc_Aatyk3 |
| cd05103 | 604-901 | PTKc_VEGFR2 |
| cd05080 | 605-901 | PTKc_Tyk2_rpt2 |
| cd05082 | 607-905 | PTKc_Csk |
| cd05105 | 602-901 | PTKc_PDGFR_alpha |
| cd05081 | 605-901 | PTKc_Jak3_rpt2 |
| cd05102 | 604-907 | PTKc_VEGFR3 |
| cd14207 | 604-901 | PTKc_VEGFR1 |
| cd05042 | 614-905 | PTKc_Aatyk |
| cd05104 | 604-901 | PTKc_Kit |
| cd05109 | 652-901 | PTKc_HER2 |
| cd05108 | 652-901 | PTKc_EGFR |
| cd06606 | 614-905 | STKc_MAPKKK |
| cd05110 | 652-901 | PTKc_HER4 |
| cd05087 | 612-906 | PTKc_Aatyk1 |
| cd14061 | 651-901 | STKc_MLK |
| cd14014 | 611-897 | STKc_PknB_like |
| cd05111 | 605-901 | PTK_HER3 |
| cd14065 | 664-905 | PKc_LIMK_like |
| cd05086 | 614-905 | PTKc_Aatyk2 |
| cd13978 | 616-898 | STKc_RIP |
| cd14058 | 651-907 | STKc_TAK1 |
| cd14066 | 616-905 | STKc_IRAK |
| cd14146 | 652-899 | STKc_MLK4 |
| cd14059 | 661-901 | STKc_MAP3K12_13 |
| cd14145 | 602-901 | STKc_MLK1 |
| cd14154 | 616-905 | STKc_LIMK |
| cd14008 | 616-895 | STKc_LKB1_CaMKK |
| cd14060 | 652-901 | STKc_MLTK |
| cd14221 | 645-905 | STKc_LIMK1 |
| cd08215 | 614-842 | STKc_Nek |
| smart00231 | 30-185 | FA58C |
| cd14147 | 610-901 | STKc_MLK3 |
| cd14148 | 652-901 | STKc_MLK2 |
| cd05117 | 612-856 | STKc_CAMK |
| cd14080 | 611-845 | STKc_TSSK-like |
| cd05122 | 611-905 | PKc_STE |
| cd14155 | 654-907 | PKc_TESK |
| cd05037 | 610-905 | PTK_Jak_rpt1 |
| cd14007 | 615-905 | STKc_Aurora |
| cd14026 | 652-898 | STKc_RIP2 |
| cd06627 | 609-838 | STKc_Cdc7_like |
| cd07829 | 614-830 | STKc_CDK_like |
| cd14222 | 650-902 | STKc_LIMK2 |
| cd14158 | 615-907 | STKc_IRAK4 |
| cd14003 | 611-896 | STKc_AMPK-like |
| cd14063 | 610-905 | PK_KSR |
| cd14062 | 652-902 | STKc_Raf |
| cd14064 | 651-907 | PKc_TNNI3K |
| cd05118 | 615-838 | STKc_CMGC |
| cd06632 | 616-905 | STKc_MEKK1_plant |
| cd07841 | 609-839 | STKc_CDK7 |
| cd13992 | 652-907 | PK_GC |
| cd06614 | 610-838 | STKc_PAK |
| cd14156 | 654-909 | PKc_LIMK_like_unk |
| cd14009 | 616-886 | STKc_ATG1_ULK_like |
| cd14027 | 616-900 | STKc_RIP1 |
| cd14025 | 614-901 | STKc_RIP4_like |
| cd08222 | 609-896 | STKc_Nek11 |
| cd13979 | 609-896 | STKc_Mos |
| cd14151 | 604-901 | STKc_B-Raf |
| cd14159 | 653-905 | STKc_IRAK1 |
| cd14053 | 651-844 | STKc_ACVR2 |
| cd14150 | 652-901 | STKc_A-Raf |
| pfam00754 | 68-182 | F5_F8_type_C |
| cd06626 | 615-905 | STKc_MEKK4 |
| cd14149 | 652-901 | STKc_C-Raf |
| cd07840 | 614-852 | STKc_CDK9_like |
| cd13997 | 609-901 | PKc_Wee1_like |
| cd14073 | 608-795 | STKc_NUAK |
| cd07830 | 614-839 | STKc_MAK_like |
| cd14069 | 616-908 | STKc_Chk1 |
| cd05123 | 616-845 | STKc_AGC |
| cd07834 | 609-841 | STKc_MAPK |
| cd07866 | 608-835 | STKc_BUR1 |
| cd05581 | 612-856 | STKc_PDK1 |
| cd14098 | 616-855 | STKc_Rad53_Cds1 |
| cd14137 | 609-907 | STKc_GSK3 |
| cd13998 | 614-895 | STKc_TGFbR-like |
| cd14161 | 607-845 | STKc_NUAK2 |
| cd14042 | 651-905 | PK_GC-A_B |
| cd08220 | 616-842 | STKc_Nek8 |
| cd13993 | 609-895 | STKc_Pat1_like |
| cd14121 | 614-837 | STKc_ULK3 |
| cd06605 | 610-905 | PKc_MAPKK |
| cd06623 | 615-838 | PKc_MAPKK_plant_like |
| cd06641 | 606-912 | STKc_MST3 |
| cd14000 | 641-905 | STKc_LRRK |
| cd06620 | 652-903 | PKc_Byr1_like |
| cd06630 | 671-901 | STKc_MEKK1 |
| cd14002 | 614-844 | STKc_STK36 |
| cd14162 | 652-846 | STKc_TSSK4-like |
| cd05076 | 639-905 | PTK_Tyk2_rpt1 |
| cd08529 | 613-903 | STKc_FA2-like |
| cd06621 | 614-840 | PKc_Pek1_like |
| cd05077 | 652-903 | PTK_Jak1_rpt1 |
| cd06625 | 616-904 | STKc_MEKK3_like |
| cd13994 | 616-912 | STKc_HAL4_like |
| cd07860 | 614-845 | STKc_CDK2_3 |
| cd14664 | 651-837 | STK_BAK1_like |
| cd06917 | 614-903 | STKc_NAK1_like |
| cd05579 | 619-856 | STKc_MAST_like |
| cd14052 | 609-836 | PTKc_Wee1_fungi |
| cd14071 | 652-845 | STKc_SIK |
| cd13990 | 616-901 | STKc_TLK |
| cd06628 | 616-905 | STKc_Byr2_like |
| cd05580 | 610-845 | STKc_PKA_like |
| cd14079 | 611-845 | STKc_AMPK_alpha |
| cd05078 | 610-905 | PTK_Jak2_rpt1 |
| cd13987 | 616-908 | STKc_SBK1 |
| cd06611 | 616-907 | STKc_SLK_like |
| cd14119 | 616-903 | STKc_LKB1 |
| cd06609 | 614-838 | STKc_MST3_like |
| cd14045 | 652-905 | PK_GC_unk |
| cd08530 | 611-845 | STKc_CNK2-like |
| cd14167 | 607-860 | STKc_CaMKI_alpha |
| cd13968 | 616-786 | PKc_like |
| cd14104 | 612-856 | STKc_Titin |
| cd14165 | 652-845 | STKc_TSSK1_2-like |
| cd08224 | 615-904 | STKc_Nek6_7 |
| cd13983 | 610-905 | STKc_WNK |
| cd07833 | 614-838 | STKc_CDKL |
| cd06612 | 611-835 | STKc_MST1_2 |
| cd14120 | 644-904 | STKc_ULK1_2-like |
| cd06631 | 614-905 | STKc_YSK4 |
| cd06622 | 608-908 | PKc_PBS2_like |
| cd14202 | 645-905 | STKc_ULK1 |
| cd05572 | 616-852 | STKc_cGK |
| cd14076 | 616-862 | STKc_Kin4 |
| cd14056 | 614-897 | STKc_TGFbR_I |
| cd14077 | 611-845 | STKc_Kin1_2 |
| cd06619 | 610-907 | PKc_MKK5 |
| cd05577 | 616-847 | STKc_GRK |
| cd14183 | 609-852 | STKc_DCKL1 |
| cd07855 | 614-845 | STKc_ERK5 |
| cd14133 | 613-835 | PKc_DYRK_like |
| cd14084 | 615-856 | STKc_Chk2 |
| cd14054 | 651-895 | STKc_BMPR2_AMHR2 |
| cd14043 | 753-903 | PK_GC-2D |
| cd06610 | 652-835 | STKc_OSR1_SPAK |
| cd05616 | 612-851 | STKc_cPKC_beta |
| cd06629 | 614-905 | STKc_Bck1_like |
| cd06613 | 612-844 | STKc_MAP4K3_like |
| cd14105 | 614-856 | STKc_DAPK |
| cd05630 | 616-885 | STKc_GRK6 |
| cd14663 | 616-845 | STKc_SnRK3 |
| cd14006 | 616-856 | STKc_MLCK-like |
| cd14083 | 607-860 | STKc_CaMKI |
| cd14074 | 612-854 | STKc_SNRK |
| cd06653 | 611-876 | STKc_MEKK3_like_u1 |
| cd14200 | 671-895 | STKc_CaMKK1 |
| cd14118 | 671-834 | STKc_CAMKK |
| cd06642 | 614-844 | STKc_STK25 |
| cd14072 | 609-794 | STKc_MARK |
| cd08228 | 608-904 | STKc_Nek6 |
| cd14096 | 609-845 | STKc_RCK1-like |
| cd05611 | 653-856 | STKc_Rim15_like |
| cd14004 | 614-905 | STKc_PASK |
| cd07836 | 614-836 | STKc_Pho85 |
| cd06633 | 615-836 | STKc_TAO3 |
| cd13996 | 607-840 | STKc_EIF2AK |
| cd05605 | 616-845 | STKc_GRK4_like |
| cd14097 | 655-855 | STKc_STK33 |
| cd07838 | 616-911 | STKc_CDK4_6_like |
| cd06624 | 616-905 | STKc_ASK |
| cd14081 | 615-855 | STKc_BRSK1_2 |
| cd14201 | 604-905 | STKc_ULK2 |
| cd06648 | 606-906 | STKc_PAK_II |
| cd06644 | 615-911 | STKc_STK10 |
| cd14055 | 614-895 | STKc_TGFbR2_like |
| cd14001 | 653-905 | PKc_TOPK |
| cd14038 | 652-899 | STKc_IKK_beta |
| cd06607 | 667-835 | STKc_TAO |
| cd07863 | 670-879 | STKc_CDK4 |
| cd06652 | 611-903 | STKc_MEKK2 |
| cd07849 | 608-841 | STKc_ERK1_2_like |
| cd14047 | 671-905 | STKc_EIF2AK2_PKR |
| cd14186 | 652-838 | STKc_PLK4 |
| cd08219 | 616-845 | STKc_Nek3 |
| cd14152 | 652-905 | STKc_KSR1 |
| cd07852 | 652-838 | STKc_MAPK15-like |
| cd06640 | 614-844 | STKc_MST4 |
| cd14169 | 613-853 | STKc_CaMKI_beta |
| cd06635 | 615-836 | STKc_TAO1 |
| cd07861 | 614-836 | STKc_CDK1_euk |
| cd05587 | 616-851 | STKc_cPKC |
| cd05615 | 616-851 | STKc_cPKC_alpha |
| cd14208 | 610-837 | PTK_Jak3_rpt1 |
| cd07842 | 670-839 | STKc_CDK8_like |
| cd14116 | 616-898 | STKc_Aurora-A |
| cd07845 | 614-837 | STKc_CDK10 |
| cd14168 | 602-855 | STKc_CaMKI_delta |
| cd07856 | 652-837 | STKc_Sty1_Hog1 |
| cd14103 | 616-831 | STKc_MLCK |
| cd14184 | 653-845 | STKc_DCKL2 |
| cd07832 | 614-837 | STKc_CCRK |
| cd14190 | 613-864 | STKc_MLCK2 |
| cd05578 | 654-845 | STKc_Yank1 |
| cd14067 | 660-896 | STKc_LRRK1 |
| cd14142 | 652-851 | STKc_ACVR1_ALK1 |
| cd06617 | 735-909 | PKc_MKK3_6 |
| cd05631 | 616-845 | STKc_GRK4 |
| cd05619 | 616-856 | STKc_nPKC_theta |
| cd07839 | 614-836 | STKc_CDK5 |
| cd14086 | 613-845 | STKc_CaMKII |
| cd13975 | 738-896 | PKc_Dusty |
| cd08528 | 614-896 | STKc_Nek10 |
| cd05595 | 616-855 | STKc_PKB_beta |
| cd14141 | 652-895 | STKc_ACVR2a |
| cd14194 | 614-856 | STKc_DAPK1 |
| cd14198 | 613-871 | STKc_DRAK2 |
| cd14153 | 669-905 | PK_KSR2 |
| cd07862 | 615-845 | STKc_CDK6 |
| cd14041 | 652-901 | STKc_TLK2 |
| cd08221 | 616-841 | STKc_Nek9 |
| cd14040 | 655-901 | STKc_TLK1 |
| cd06643 | 615-836 | STKc_SLK |
| cd06608 | 606-832 | STKc_myosinIII_N_like |
| cd13989 | 616-845 | STKc_IKK |
| cd14099 | 652-845 | STKc_PLK |
| cd06634 | 615-836 | STKc_TAO2 |
| cd13986 | 609-901 | STKc_16 |
| cd14160 | 616-896 | PK_IRAK3 |
| cd14185 | 616-845 | STKc_DCKL3 |
| cd07846 | 614-838 | STKc_CDKL2_3 |
| cd14210 | 614-835 | PKc_DYRK |
| cd05608 | 616-845 | STKc_GRK1 |
| cd14075 | 652-788 | STKc_NIM1 |
| cd14193 | 614-856 | STKc_MLCK4 |
| cd07835 | 614-838 | STKc_CDK1_CdkB_like |
| cd14209 | 616-835 | STKc_PKA |
| cd08225 | 614-845 | STKc_Nek5 |
| cd05570 | 616-856 | STKc_PKC |
| cd05632 | 616-837 | STKc_GRK5 |
| cd14057 | 652-901 | PK_ILK |
| cd14039 | 616-845 | STKc_IKK_alpha |
| cd05612 | 604-845 | STKc_PRKX_like |
| cd14199 | 671-895 | STKc_CaMKK2 |
| cd07847 | 614-837 | STKc_CDKL1_4 |
| cd06651 | 616-903 | STKc_MEKK3 |
| cd08218 | 614-896 | STKc_Nek1 |
| cd06638 | 606-905 | STKc_myosinIIIA_N |
| cd07843 | 670-838 | STKc_CDC2L1 |
| cd14010 | 645-856 | STKc_ULK4 |
| cd07865 | 615-852 | STKc_CDK9 |
| cd14114 | 614-856 | STKc_Twitchin_like |
| cd14166 | 607-860 | STKc_CaMKI_gamma |
| cd14070 | 652-845 | STKc_HUNK |
| cd14050 | 614-836 | PKc_Myt1 |
| cd07854 | 652-837 | STKc_MAPK4_6 |
| cd14192 | 614-856 | STKc_MLCK3 |
| cd05582 | 616-845 | STKc_RSK_N |
| cd13982 | 652-911 | STKc_IRE1 |
| cd14095 | 615-852 | STKc_DCKL |
| cd06615 | 650-837 | PKc_MEK |
| cd14164 | 612-845 | STKc_TSSK6-like |
| cd14093 | 613-845 | STKc_PhKG |
| cd07871 | 651-836 | STKc_PCTAIRE3 |
| cd14157 | 648-837 | STKc_IRAK2 |
| cd14044 | 663-907 | PK_GC-C |
| cd08223 | 612-903 | STKc_Nek4 |
| cd14131 | 614-905 | PKc_Mps1 |
| cd06654 | 606-837 | STKc_PAK1 |
| cd06656 | 606-837 | STKc_PAK3 |
| cd05620 | 616-856 | STKc_nPKC_delta |
| cd08217 | 672-844 | STKc_Nek2 |
| cd07848 | 616-845 | STKc_CDKL5 |
| cd06659 | 606-910 | STKc_PAK6 |
| cd14078 | 613-845 | STKc_MELK |
| cd06655 | 606-837 | STKc_PAK2 |
| cd14113 | 615-855 | STKc_Trio_C |
| cd07853 | 749-883 | STKc_NLK |
| cd14195 | 614-856 | STKc_DAPK3 |
| cd08229 | 608-845 | STKc_Nek7 |
| cd07857 | 670-837 | STKc_MPK1 |
| cd14046 | 608-790 | STKc_EIF2AK4_GCN2_rpt2 |
| cd07877 | 650-837 | STKc_p38alpha |
| cd06650 | 650-836 | PKc_MEK1 |
| cd14087 | 653-845 | STKc_PSKH1 |
| cd13985 | 669-909 | STKc_GAK_like |
| cd06647 | 606-837 | STKc_PAK_I |
| cd05592 | 747-851 | STKc_nPKC_theta_like |
| cd14091 | 611-845 | STKc_RSK_C |
| cd06645 | 606-839 | STKc_MAP4K3 |
| cd14144 | 697-840 | STKc_BMPR1 |
| cd14140 | 652-895 | STKc_ACVR2b |
| cd07859 | 660-837 | STKc_TDY_MAPK |
| cd07872 | 614-836 | STKc_PCTAIRE2 |
| cd05593 | 616-855 | STKc_PKB_gamma |
| cd07870 | 614-844 | STKc_PFTAIRE2 |
| cd05601 | 613-855 | STKc_CRIK |
| cd14189 | 737-845 | STKc_PLK3 |
| cd07831 | 611-839 | STKc_MOK |
| cd14143 | 614-840 | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd07864 | 651-836 | STKc_CDK12 |
| cd14094 | 668-845 | STKc_CASK |
| cd07873 | 651-836 | STKc_PCTAIRE1 |
| cd05573 | 616-845 | STKc_ROCK_NDR_like |
| cd05609 | 697-856 | STKc_MAST |
| cd14163 | 646-845 | STKc_TSSK3-like |
| cd06636 | 606-848 | STKc_MAP4K4_6_N |
| cd14196 | 614-856 | STKc_DAPK2 |
| cd07878 | 652-837 | STKc_p38beta |
| cd05600 | 607-856 | STKc_Sid2p_like |
| cd07869 | 614-844 | STKc_PFTAIRE1 |
| cd06649 | 650-836 | PKc_MEK2 |
| cd14005 | 615-901 | STKc_PIM |
| cd14048 | 653-837 | STKc_EIF2AK3_PERK |
| cd07858 | 749-837 | STKc_TEY_MAPK |
| cd05571 | 616-845 | STKc_PKB |
| cd06637 | 606-848 | STKc_TNIK |
| cd07880 | 607-838 | STKc_p38gamma |
| cd05624 | 616-866 | STKc_MRCK_beta |
| cd14176 | 644-858 | STKc_RSK2_C |
| cd14175 | 613-858 | STKc_RSK1_C |
| cd05574 | 611-788 | STKc_phototropin_like |
| cd14012 | 671-901 | PK_eIF2AK_GCN2_rpt1 |
| cd14089 | 653-845 | STKc_MAPKAPK |
| cd06639 | 614-905 | STKc_myosinIIIB_N |
| cd14188 | 738-903 | STKc_PLK2 |
| cd07851 | 652-837 | STKc_p38 |
| cd05622 | 616-845 | STKc_ROCK1 |
| cd05607 | 616-845 | STKc_GRK7 |
| cd14132 | 614-853 | STKc_CK2_alpha |
| cd07879 | 652-837 | STKc_p38delta |
| cd07867 | 671-869 | STKc_CDC2L6 |
| cd05596 | 616-845 | STKc_ROCK |
| cd05621 | 616-845 | STKc_ROCK2 |
| cd14181 | 653-798 | STKc_PhKG2 |
| cd14178 | 653-851 | STKc_RSK3_C |
| cd05594 | 616-855 | STKc_PKB_alpha |
| cd14171 | 612-845 | STKc_MAPKAPK5 |
| cd14665 | 609-845 | STKc_SnRK2-3 |
| cd07868 | 671-869 | STKc_CDK8 |
| cd07876 | 652-893 | STKc_JNK2 |
| cd07850 | 652-830 | STKc_JNK |
| cd06646 | 606-844 | STKc_MAP4K5 |
| cd14220 | 697-907 | STKc_BMPR1a |
| cd14011 | 661-896 | PK_SCY1_like |
| cd14135 | 652-835 | STKc_PRP4 |
| cd14016 | 609-798 | STKc_CK1 |
| cd14212 | 613-830 | PKc_YAK1 |
| cd05590 | 616-855 | STKc_nPKC_eta |
| cd14177 | 653-846 | STKc_RSK4_C |
| cd14106 | 663-846 | STKc_DRAK |
| cd07837 | 614-844 | STKc_CdkB_plant |
| cd06616 | 604-836 | PKc_MKK4 |
| cd14068 | 652-905 | STKc_LRRK2 |
| cd05623 | 616-866 | STKc_MRCK_alpha |
| cd05602 | 608-837 | STKc_SGK1 |
| cd14111 | 606-856 | STKc_SPEG_rpt2 |
| cd14049 | 655-901 | STKc_EIF2AK1_HRI |
| cd05589 | 611-856 | STKc_PKN |
| cd14191 | 613-856 | STKc_MLCK1 |
| cd14117 | 616-788 | STKc_Aurora-B_like |
| cd14102 | 748-901 | STKc_PIM3 |
| cd14229 | 616-838 | STKc_HIPK3 |
| cd14182 | 653-795 | STKc_PhKG1 |
| cd14197 | 749-845 | STKc_DRAK1 |
| cd06657 | 606-837 | STKc_PAK4 |
| cd06658 | 652-837 | STKc_PAK5 |
| cd14219 | 697-840 | STKc_BMPR1b |
| cd14032 | 662-908 | STKc_WNK2_like |
| cd07874 | 652-837 | STKc_JNK3 |
| cd05604 | 616-837 | STKc_SGK3 |
| cd07875 | 652-837 | STKc_JNK1 |
| cd05613 | 616-883 | STKc_MSK1_N |
| cd14107 | 613-900 | STKc_obscurin_rpt1 |
| cd05591 | 616-845 | STKc_nPKC_epsilon |
| cd05610 | 642-856 | STKc_MASTL |
| cd05606 | 695-837 | STKc_beta_ARK |
| cd14228 | 614-838 | STKc_HIPK1 |
| cd05603 | 616-856 | STKc_SGK2 |
| cd13977 | 697-837 | STKc_PDIK1L |
| cd14031 | 662-908 | STKc_WNK3 |
| cd14227 | 614-838 | STKc_HIPK2 |
| cd05597 | 693-845 | STKc_DMPK_like |
| cd14037 | 607-847 | STKc_NAK_like |
| cd05617 | 747-880 | STKc_aPKC_zeta |
| cd14100 | 749-901 | STKc_PIM1 |
| cd05598 | 760-845 | STKc_LATS |
| cd05584 | 616-845 | STKc_p70S6K |
| cd14172 | 682-845 | STKc_MAPKAPK3 |
| cd13995 | 618-910 | STKc_MAP3K8 |
| cd14211 | 614-838 | STKc_HIPK |
| cd14179 | 745-845 | STKc_MSK1_C |
| cd05633 | 616-837 | STKc_GRK3 |
| cd06618 | 734-905 | PKc_MKK7 |
| cd14187 | 738-838 | STKc_PLK1 |
| cd05583 | 746-845 | STKc_MSK_N |
| cd13988 | 651-836 | STKc_TBK1 |
| cd14110 | 666-845 | STKc_obscurin_rpt2 |
| cd14109 | 670-856 | PK_Unc-89_rpt1 |
| cd05575 | 747-845 | STKc_SGK |
| cd14170 | 746-845 | STKc_MAPKAPK2 |
| cd05585 | 748-895 | STKc_YPK1_like |
| cd14223 | 616-837 | STKc_GRK2 |
| cd14082 | 614-857 | STKc_PKD |
| cd05586 | 694-845 | STKc_Sck1_like |
| cd13991 | 615-841 | STKc_NIK |
| cd14139 | 614-774 | PTKc_Wee1b |
| cd05588 | 747-880 | STKc_aPKC |
| cd14030 | 662-862 | STKc_WNK1 |
| cd14101 | 749-901 | STKc_PIM2 |
| cd14180 | 750-845 | STKc_MSK2_C |
| smart00219 | 610-905 | TyrKc |
| smart00221 | 610-905 | STYKc |
| pfam07714 | 610-905 | Pkinase_Tyr |
| smart00220 | 611-905 | S_TKc |
| pfam00069 | 610-905 | Pkinase |
| COG0515 | 611-896 | SPS1 |
| PTZ00024 | 608-837 | PTZ00024 |
| PRK13184 | 615-859 | pknD |
| PLN00034 | 587-906 | PLN00034 |
| PHA02988 | 669-905 | PHA02988 |
| PHA03209 | 645-837 | PHA03209 |
| PTZ00263 | 608-845 | PTZ00263 |
| PTZ00267 | 694-901 | PTZ00267 |
| PTZ00426 | 612-845 | PTZ00426 |
| PTZ00036 | 739-838 | PTZ00036 |
| PLN00009 | 614-837 | PLN00009 |
| PTZ00266 | 600-851 | PTZ00266 |
| TIGR03903 | 652-788 | TOMM_kin_cyc |
| PTZ00283 | 697-901 | PTZ00283 |
| PHA03211 | 672-835 | PHA03211 |
Ontology Information
| HPRD ID | 1152 |
|---|---|
| Molecular Class | Receptor tyrosine kinase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Anti-apoptosis (GO:0006916); Signal transduction (GO:0007165); Cell growth and/or maintenance (GO:0008151) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q08345 | DB00619 | Imatinib | SmallMoleculeDrug |